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Ata Tuna Ciftlik
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Microsystems Laboratory 2
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Researcher and IT Responsible
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office(s):
BM3131
phone(s): [+41 21 69] 36761
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MISSION
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I am specialized in microfabrication of high-pressure resistant microfluidic devices and their applications to clinical diagnosis. Using devices realized with the fabrication methods I have developed until now, I am currently working on elaborating a method for fast diagnosis of cancer with protein biomarkers using microfluidic immunohistofluorescence. The system is being characterized by multidimensional fluorescent signal acquisition.
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BIOGRAPHY
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Ata Tuna CIFTLIK was born in Ankara in 1984. He recieved his B.S. degrees in Electrical and Electronics Engineering and Mathematics from Middle East Technical University (METU) in 2006 and 2007 respectively. From 2006 to 2008 he joined to METU-MEMS group where he studied dielectrophoretic seperation and gravimetric detection systems for MEMS based cytometry devices for his master's thesis in aspects of design, microfabrication and read-out electronics, which had resulted in two patents together with international conference and journal publications. This thesis was awarded as "thesis of the year" in the category of "most industrially applicable technological innovation" among many Ph.D. and M.Sc. theses applied countrywide.
Since October 2008, he is studying towards his Ph.D degree in Laboratory of Microsystems (LMIS2) at EPFL under supervision of Prof. Gijs, where he is developing high pressure microfluidic systems for clinical and industrial applications. He is currently developing rapid tissue cancer screening microdevices for in surgery utilization, as a part of SystemsX initative, in collaboration with Institute Universitaire de Pathologie de Lausanne, IUP. Having a background in engineering and mathematics and being mentored by a team of professors from physics, medicine and biochemistry, his main mission is to achieve excellency in developing microsystems for clinical diagnosis. His research interests also include Biomedical Microdevices (BioMEMS) development, alternative microsystems fabrication and integration techniques for BioMEMS devices.
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Education
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Ph.D., Microsystems & Microelectronics, M.A.M. Gijs, Ecole Polytechnic Federale de Lausanne, 2008 - Present
M.Sc., Electrical & Electronics Engineering, METU, 2006 - 2008
B.S., Electrical & Electronics Engineering, METU, 2002-2006
B.S., Mathematics , METU, 2003 - 2007 (Double Major)
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Professional course
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Research Assistant, Laboratory of Microsystems 2, EPFL, October 2008 - Present
IT Responsible, Laboratory of Microsystems 2, EPFL, October 2008 - Present, Part-Time
Teaching and Research Assistant, METU-MEMS Research Centre, METU, September 2006 - September 2008
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Journal Papers
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A.T. Ciftlik and M.A.M. Gijs, "Parylene to silicon nitride bonding for post-integration of high pressure microfluidics to CMOS devices," Lab on a Chip, 2012, 12 (2), 396 - 400. doi:10.1039/c1lc20727j.
A.T. Ciftlik and M.A.M. Gijs, "A low temperature parylene-to-silicon dioxide bonding technique for high pressure microfluidics," Journal of Micromechanics and Microengineering, volume 21, number 3, page 035011, 2011.
H.C. Tekin, V. Sivagnanam, A.T. Ciftlik, A. Sayah, C. Vandevyver, and M.A.M. Gijs, "Chaotic mixing using source-sink microfluidic flows in a PDMS chip," Journal of Microfluidics and Nanofluidics, doi:10.1007/s10404-010-0706-0, 2010
G.Yilmaz, A.T.Ciftlik and H.Kulah, "A MEMS-based spiral channel dielectrophoretic chromatography system for cytometry applications", Biotechnology Journal, volume 6, issue 2, pp. 185–194, 2011.
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Conference Papers
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A.T. Ciftlik, M. Ettori and M.A.M. Gijs, "Parylene to silicon-nitride bonding for easy post-integration of high-pressure microfluidics to CMOS devices," Proc. of 15th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences (microTAS '11), pp. 443-445, October 2011, Seattle, U.S.A.
A.T. Ciftlik and M.A.M. Gijs, "Low temperature pyrex/silicon wafer bonding via a single intermediate parylene layer," Proc. 16th Int. Conf. on Solid-State Sensors, Actuators, and Microsystems (TRANSDUCERS'11) , June 2011, Beijing, China.
A.T. Ciftlik, B. Song, C. Vandevyver, J.-C. Bünzli, H.-A. Lehr, and M.A.M. Gijs, "Fast Immunohistochemical BioMarker Detection Device for Cancer Tissue Slices," Proc. of 14th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences (microTAS '10), pp. 699-701, October 2010, Groningen, Netherlands.
A.T. Ciftlik, "Polymer-bonded Microfluidic Chip with Double Metal Layer For High-pressure Biomedical Applications." EPFL MicroNanoFabrication Annual Review Meeting, May 2010, Switzerland.
V. Sivagnanam, A.T. Ciftlik, B. Song, C. Vandevyver, J. Bünzli, and M.A.M. Gijs, "Time-resolved luminescence for immunohistochemical detection of cancer biomarkers in a lab-on-a-chip," In Digest NanoBioTech Montreux, November 2009, Switzerland.
E.Bayraktar, D.Eroglu, A.T.Ciftlik and H.Kulah, "A MEMS based gravimetric resonator for mass sensing applictions", Proc. of. 24th Int. Conf. on Micro Electro Mechanical Systems, (MEMS 2011), pp. 817-820, January 2011, Cancun, Mexico.
G.Yilmaz, A.T.Ciftlik and H.Kulah, "A dielectrophoratic cell/particle separator fabricated by spiral channels and concentric gold electrodes", Proc. of 15th Int. Conf. on Solid-State Sensors, Actuators, and Microsystems (TRANSDUCERS'09), pp. 73-76, June 2009.
A.T.Ciftlik and H.Kulah, "A direct injection method for blood cells into microchannels from pure blood droplets with switchable in-situ distillation of erythrocytes", proc. IEEE-PRIME 2008, pp. 29-32, June 2008.
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Thesis
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A.T.Ciftlik, “Design and Implementation of A Dielectrophoretic Seperator and A Gravimetric Detector for MEMS Based Cytometry Applications”, M.Sc Thesis, September 2008
In december 2009 selected as "Thesis of the year" by Mustafa Parlar education and resarch foundation among more than 200 PhD and Masters theses applied.
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Patents Pending
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A.T. Ciftlik and H.Kulah, "A microfluidic-channel embeddable, laterally oscillating gravimetric sensor device fabricated with micro-electro-mechanical systems (MEMS) technology", PCT.TR2009.000106, WO.2011.021984, 2011
A.T. Ciftlik and H.Kulah, "Dielectrophoretic cell chromatography device with spiral microfluidic channels and concentric electrodes, fabricated with MEMS technology", PCT.TR2009.000005, WO.2010.021604, 2010 (in press)
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Supervised Master Student Projects
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Fall 2011
- Loek Verhees, title to be announced, master project, in collaboration with TU Eindhoven, Prof. Leo J. van Ijzendoorn.
Spring 2011
- Ioannis Lignos, "On-chip synthesis of oxide nanoparticles in microfluidic droplets with subsequent size detection.", master project, in collaboration with Josias Wacker.
- Maxime Ettori, "A microfluidic device with high throughput per footprint for mass particle and cell focusing", semester project.
- M. Amine Ben Chikh el-Fegoun, "Fast electro-mechanical DNA size detection on microchip by slalom chromatography", semester project.
In you are a student willing to perform your semester or master diploma project in following topics please contact me via e-mail. To follow the following links you should be inside the EPFL campus.
1) Rapid detection of breast cancer on chip
2) Optimization of polymer bonding strength for high pressure microfluidics
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| Skills |
Biomedical Microsystems
Microfabrication Technologies
Microelectromechanics
High-Pressure Microfluidics
Clinical Diagnosis
Immunohisto- chemistry & fluorescence |
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| DashBoard |
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| Events Log |
Want to meet in person? I was, am and will be:
September 2011 to June 2012 in Lausanne, attending Venture Challenge @ EPFL
October 01 to 07, 2011 in Seattle, USA for MicroTas 2011 Conference
October 07 to 10, 2011 in New York, USA
June 05 to 09, 2011 in Beijing, China for Transducers 2011 Conference
October 02 to 08, 2010 in Groningen, Netherlands for MicroTas 2010 Conference
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| PROJECT |
Rapid detection of cancer biomarkers on cancer tissue slices for in-surgery applications
Developed lab-on-a-chip enables detection of cancer in tissue samples in a few minutes.More...
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| Project |
Development of a polymer bonding technique for high- pressure microfluidics
Low temperature polymer bonding enables very high throughput electrochemical analysis together with precision in feature size.More...
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