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Senior Scientist SV IBI-SV LMRP Senior Scientist SB ISIC LMRP2 Senior Scientist SB SB-SCGC SCGC-ENS Senior Scientist AA AA-DOC EDCH-ENS

Christine Wandrey Merck Serono Chair in Drug Delivery PD Dr rer nat habil nationality: German office(s): CHJ2494 AAB042 phone(s): [+41 21 69] 33672,39661 MISSION Polyelectrolytes, charged macromolecules, and their organized structures - belong to an emerging class of materials and are one of the key topics, internationally, in polymer chemistry and physics. - include synthetic compounds but also biopolymers, such as proteins, nucleic acids, or polysaccharides. - play a central role in the life sciences and have increasing importance as specialty polymers in many fields including environmental technologies, biotechnology, and materials development. Function and application are primarily based on electrostatic interactions with either low molar mass counterions, charged surfaces, or oppositely charged molecules. However, the interactions and related structure-property relationships are still far from being fully understood. The aim of our research is to study polyelectrolyte interactions as a function of the macromolecular parameters, on one hand, and medium conditions and characteristics of the interacting partner, on the other hand. The research includes the synthesis of defined molecule architectures, their characterization, fundamental interaction studies, and the development of novel materials for various applications, preferably in the medical and biotechnological field. Of specific interest are hydrogels and hydrocolloids for tissue engineering, immobilization, and delivery systems with micro and nano dimensions. Vision of Future Projects and Activities Materials development has become the primary intention of the research. Materials development for two principal application directions is intended. These are materials for separation technologies and materials based on polyelectrolyte complex formation. The latter may range from containers for cell and/or drug immobilization to flat membranes and ionotropic gels, all of them goal-directed designed based on the knowledge of fundamental relationships between composition and performance parameters. Intelligent surfaces shall increase the biocompatibility. Applying designed polyelectrolytes and modified biopolymers, as well as advanced technologies, devices with defined and selective transport and delivery properties will be created. For such development specific characterization is essential, which has to include the determination of colloidal, macromolecular and electrochemical parameters. Appropriate methods and techniques such as light scattering, analytical ultracentrifugation, chromatography, spectroscopy, rheology, or potentiometry are serving to establish parameter-properties relationships. Analytical ultracentrifugation is one of our favored techniques. BIOGRAPHY - Study of Chemistry at the Martin Luther University of Halle-Wittenberg, Germany - Doctoral studies at the Institute of Polymer Chemistry of the Academy of Sciences, Teltow, Germany, Dr. rer. nat. - Habilitation for Physical Chemistry at the Max Planck Institute of Colloids and Interfaces, Teltow, Germany, and at the University of Potsdam, Germany; Dr. rer. nat. habil.: 1997; Thesis: “Polyelectrolytes - Macromolecular parameters and electrolyte behavior” ISBN 3-89588-814-1 since 1996 at the EPFL, Private Docent since 1999 1996-2002 Laboratory of Polyelectrolytes and BioMacromolecules (LPBM), 2002-2004 Laboratory of Chemical Biotechnology (LBCH) 2004 Laboratory of Regenerative Medicine and Pharmacobiology (LMRP2) Publications: more than 100 Patents: 38 Memberships/Activities o Swiss Society for Biomaterials, EC member o European Society for Biomaterials o Colloid Society, Germany o Swiss Chemical Society, Polymer & Colloid Devision o Gesellschaft Deutscher Chemiker o Associate Editor of Artificial Cells, Blood Substitutes, and Biotechnology, o Editorial Board Polymers o Contributing Editor for the international magazine Polymer News o Reviewer for (Selection): Biomacromolecules, Biotechnol & Bioeng., Colloids and Surfaces, Interface, J. Appl. Polym. Sci., J. Bioact Biocomp. Polym., JCICS, JCTB, J. Membrane Sci., J. Phys. Chem., J. Polym. Sci., Langmuir, Macromolecules, Polymer, Progr. Colloid & Polym.Sci., Xenotransplant. o One of the two Swiss representatives in the European program COST 865: Member of the management committee of COST 865 "Bioencapsulation multiscale interaction analysis" o Organizer and Chair of the Symposium "Hydrocolloids and hydrogels - Alginate and other biopolymers" in the framework of the 7th World Biomaterials Congress, May 15-21, 2004, Sydney, Australia o Organizer and Chair of the “14th International Symposium on Analytical Ultracentrifugation - AUC 2005” and Workshop, March 1-4, 2005, Lausanne, Switzerland o Organizer of the XIVth International Workshop on Bioencapsulation, BRG 2006, October 5-7, 2006 - Lausanne, Switzerland o One of three organizers of the 22nd European Conference on Biomaterials - ESB 2009, Sept. 7-11, 2009, Lausanne, Switzerland o Member of the "Commission scientifique pour l'enseignement du 3e cycle en Chimie" of the "Conference Universitaire de Suisse Occidentale" o Vice-president Fondation InsuLeman, Switzerland o Co-founder of Medipol SA, Lausanne MAIN PUBLICATIONS I. Rintoul and C. Wandrey. Magnetic field effects on the free radical solution polymerization of acrylamide. Polymer, 48(7):1903-1914, 2007. [ DOI | Details ] V. Malinova and C. Wandrey. Loading polyelectrolytes onto porous microspheres: Impact of molecular and electrochemical parameters. J. Phys. Chem. B, (111):8494-9501, 2007. [ DOI | Details ] L. Bourdillon, D. Hunkeler, and C. Wandrey. The analytical ultracentrifuge for the characterization of polydisperse polyelectrolytes. Progr. Colloid Polym. Sci., pages 141-149, 2006. [ DOI | Details ] L. Bourdillon, R. Freitag, and C. Wandrey. Association and temperature-induced phase transition studied by analytical ultracentrifugation. Progr. Colloid Polym. Sci., pages 150-157, 2006. [ DOI | Details ] W. Wandrey. Polyelektrolyte - Funktionalität durch Synergismus von elektrostatischer Wechselwirkung und Kettenarchitektur. KGK – Kautschuk, Gummi, Kunststoffe, 59:669-677, 2006. [ DOI | Details ] D. Sainz-Serp and C. Wandrey. Purification of natural anionic polymers. Minerva Biotechnol., pages 215-229, 2005. [ DOI | Details ] C. Wandrey and A. Renken. Ignition and Extinction of Autothermal Reactors at Periodic Operation. Chemical Engineering Science, 32(4):448-451, 1977. [ DOI | Details | Full Text ] C. Wandrey and A. Renken. Influence of periodic concentration variations on the product distribution during the oxidation of hydrocarbons. Chemie Ingenieur Technik, 45(12):854-859, 1973. CAN 79:78178 24-5 Alicyclic Compounds Inst. Tech. Chem.,Tech. Univ. Hannover,Hanover,Fed. Rep. Ger. Journal 0009-286X written in German. 124-38-9P; 630-08-0P Role: PREP (Preparation) (by hydrocarbon oxidn., periodic concn. variations in relation to); 106-97-8; 110-83-8 Role: RCT (Reactant), RACT (Reactant or reagent) (oxidn. of, periodic concn. variations in relation to); 115-07-1 Role: RCT (Reactant), RACT (Reactant or reagent) (oxidn. of, temp. hysteresis). [ DOI | Details ] C. Wandrey and A. Renken. Kinetics of dehydration of ethanol on gamma aluminium oxide. Chemiker Zeitung, 95(8):343-349, 1971. Written in German. [ DOI | Details ] C. Wandrey and A. Renken. Kinetics of the dehydration of ethanol on g-aluminum oxide. Chemiker-Zeitung, Chemische Apparatur, 95(8):343-9, 1971. CAN 75:34787 22 Physical Organic Chemistry Inst. Tech. Chem.,Tech. Univ. Hanover,Hanover,Fed. Rep. Ger. Journal 0375-8710 written in German. 1344-28-1 Role: CAT (Catalyst use), USES (Uses) (catalysts, for dehydration of ethyl alc.); 64-17-5 Role: RCT (Reactant), RACT (Reactant or reagent) (dehydration of, kinetics of). [ DOI | Details ] A. Bartkowiak, L. Canaple, I. Ceausoglu, N. Nurdin, A. Renken, L. Rindisbacher, C. Wandrey, B. Desvergne, and D. Hunkeler. New multicomponent capsules for immunoisolation. Annals of the New York Academy of Sciences, 875(Bioartificial Organs II):135-145, 1999. [ DOI | Details ] C. Wandrey. Concentration regimes in polyelectrolyte solutions. Langmuir, 15(12):4069-4075, 1999. [ DOI | Details ] C. Wandrey. Polyelectrolytes. Polymer News, 22(5):171-173, 1997. [ DOI | Details ] C. Wandrey. Molecular mass and ionic strength dependence of electrochemical properties of flexible polyelectrolytes. Berichte der Bunsen-Gesellschaft, 100(6):869-875, 1996. [ DOI | Details ] C. Wandrey and E. Goernitz. Molecular characterization of synthetic cationic polyelectrolytes. Polymer News, 20(12):377-84, 1995. [ DOI | Details ] C. Wandrey. Electrochemical properties of polyelectrolytes in solution. GIT Fachzeitschrift fuer das Laboratorium, 38(10):1123-7, 1994. [ DOI | Details ] W. Jaeger, M. Hahn, and C. Wandrey. Poly(dimethyldiallylammonium chloride) - synthesis and uses. Mitteilungsblatt - Chemische Gesellschaft der Deutschen Demokratischen Republik, 35(7):151-7, 1988. [ DOI | Details ] W. Jaeger, M. Hahn, and C. Wandrey. Synthesis and uses of cationic polyelectrolytes. Mitteilungsblatt - Chemische Gesellschaft der Deutschen Demokratischen Republik, 33(9):199-206, 1986. [ DOI | Details ] C. Wandrey, W. Jaeger, W. Starke, and J. Wotzke. New cationic polyelectrolyte as an aid in water management. Wasserwirtschaft Wassertechnik, 34(8):185-7, 1984. [ DOI | Details ] W. Jaeger, C. Wandrey, G. Reinisch, and K. J. Linow. Determination of conversion during homogeneous phase polymerization. Faserforschung und Textiltechnik, 29(10):647, 1978. [ DOI | Details ] C. Toso, J. Oberholzer, I. Ceausoglu, F. Ris, B. Rochat, A. Rehor, P. Bucher, C. Wandrey, U. Schuldt, J. Belenger, D. Bosco, P. Morel, and D. Hunkeler. Intra-portal injection of 400- microm microcapsules in a large-animal model. Transplant international, 16(6):405-10, 2003. [ DOI | Details ] C. Wandrey, G. Grigorescu, and D. Hunkeler. Study of polyelectrolyte complex formation applying the synthetic boundary technique of analytical ultracentrifugation. Progress in Colloid & Polymer Science, 119:84-91, 2002. [ DOI | Details ] D. Hunkeler, C. Wandrey, I. Ceausoglu, D. S. Vidal, and D. Espinosa. Downstream processing of microcapsules: Quality control of capsule morphology, permeability and mechanical properties as a function of raw material endotoxin levels. Landbauforschung Voelkenrode, Sonderheft, (241 (Practical Aspects of Encapsulation Technologies)):59-62, 2002. [ DOI | Details ] C. Wandrey and D. S. Vidal. Purification of polymeric biomaterials. Annals of the New York Academy of Sciences, 944(Bioartificial Organs III):187-198, 2001. [ DOI | Details ] D. Hunkeler and C. Wandrey. Polyelectrolytes: Research, development, and applications. Chimia, 55(3):223-227, 2001. [ DOI | Details ] C. Wandrey and R. Freitag. Polyelectrolytes. Polymer News, 25(2):54-56, 2000. [ DOI | Details ] C. Wandrey and A. Bartkowiak. Polyelectrolytes. Polymer News, 25(9):299-301, 2000. [ DOI | Details ] W. Jaeger, U. Wendler, A. Lieske, J. Bohrisch, and C. Wandrey. Novel polyelectrolytes with regular structure-synthesis, properties and applications. Macromolecular Symposia, 161(Controlled Synthesis of Functionalized Polymers):87-96, 2000. [ DOI | Details ] C. Wandrey, D. Hunkeler, U. Wendler, and W. Jaeger. Counterion Activity of Highly Charged Strong Polyelectrolytes. Macromolecules, 33(19):7136-7143, 2000. [ DOI | Details ] C. Wandrey, A. Bartkowiak, and D. Hunkeler. Partial Molar and Specific Volumes of Polyelectrolytes: Comparison of Experimental and Predicted Values in Salt-free Solutions. Langmuir, 15(12):4062-4068, 1999. [ DOI | Details ] C. Toso, Z. Mathe, P. Morel, J. Oberholzer, D. Bosco, D. Sainz-Vidal, D. Hunkeler, H. Buhler Leo, C. Wandrey, and T. Berney. Effect of microcapsule composition and short-term immunosuppression on intraportal biocompatibility. Cell transplantation, 14(2-3):159-67, 2005. [ DOI | Details ] I. Rintoul and C. Wandrey. Approach To Predict Copolymer Compositions in Case of Variable Monomer Reactivity. Macromolecules, 38(19):8108-8115, 2005. [ DOI | Details ] L. Bourdillon and C. Wandrey. On-line study of polyelectrolyte network formation by interfacial reaction. Colloid and Polymer Science, 282(11):1247-1257, 2004. [ DOI | Details ] V. Malinova, H. Menzel, and C. Wandrey. Interactions of highly charged polyelectrolytes with monolayers of oppositely charged amphiphiles. Progress in Colloid & Polymer Science, 129:1-8, 2004. [ DOI | Details ] M. Lekka, D. Sainz-Serp, A. J. Kulik, and C. Wandrey. Hydrogel Microspheres: Influence of Chemical Composition on Surface Morphology, Local Elastic Properties, and Bulk Mechanical Characteristics. Langmuir, 20(23):9968-9977, 2004. [ DOI | Details ] S. Dragan, L. Ghimici, and C. Wandrey. Charge density, solvent polarity and counterion nature effects on the solution properties of some polycations. Macromolecular Symposia, 211(9th Dresden Polymer Discussion: Polyelectrolytes, 2003):107-119, 2004. [ DOI | Details ] D. Hunkeler, C. Wandrey, S. Rosinski, D. Lewinska, and A. Werynski. Characterization of microcapsules. Focus on Biotechnology, 8A(Fundamentals of Cell Immobilisation Biotechnology):389-409, 2004. [ DOI | Details ] C. Wandrey. Biocompatibility of alginate. Artificial cells, blood substitutes, and immobilization biotechnology, 32(4):503-5; author reply 506-8, 2004. [ DOI | Details ] V. Malinova, R. Freitag, and C. Wandrey. Adsorption of charged macromolecules on oppositely charged porous column materials. Journal of Chromatography A, 1036(1):25-32, 2004. [ DOI | Details ] B. Schmidt, C. Wandrey, and R. Freitag. Investigation of particle-based and monolithic columns for cation exchange protein displacement chromatography using poly(diallyl-dimethylammonium chloride) as displacer. Journal of Chromatography A, 1018(2):155-167, 2003. [ DOI | Details ] A. Lübbert, V. Castelletto, I. W. Hamley, H. Nuhn, M. Scholl, L. Bourdillon, C. Wandrey, and H.-A. Klok. Nonspherical assemblies generated from polystyrene-b-poly(L-lysine) polyelectrolyte block copolymers. Langmuir, 21(14):6582-6589, 2005. 07437463 (ISSN), Cited By (since 1996): 10, Export Date: 25 September 2007, Source: Scopus, CODEN: LANGD, doi: 10.1021/la0502600. [ DOI | Details | Link ] I. Rintoul and C. Wandrey. Polymerization of ionic monomers in polar solvents: kinetics and mechanism of the free radical copolymerization of acrylamide/acrylic acid. Polymer, 46(13):4525-4532, 2005. [ DOI | Details ] V. Malinova and C. Wandrey. Polyelectrolytes: Adsorption of polyelectrolytes on oppositely charged surfaces. Polymer News, 30(12):378-380, 2005. [ DOI | Details ] C. Wandrey. Hydrogels and hydrocolloids-part of the symposia program of the 7th World Biomaterials Congress, May 17-21, 2004, Sydney, Australia. Journal of Materials Science: Materials in Medicine, 16(6):489, 2005. [ DOI | Details ] I. Rintoul and C. Wandrey. Limit Of Applicability Of The Monomer-Enhanced Mechanism For Radical Generation In Persulfate Initiated Polymerization Of Acrylamide. Latin American Applied Research, 40:365-372, 2010. [ DOI | Details ] R. Losada Mateo, H. Ahmadloo, and C. Wandrey. Homo- and copolymers of cationic double-charged monomers. CHIMIA, 64(4):268, 2010. [ DOI | Details | Full Text ] M. G. Rasteiro, F. A. P. Garcia, P. J. Ferreira, E. Antunes, D. Hunkeler, and C. Wandrey. Flocculation by Cationic Polyelectrolytes: Relating Efficiency with Polyelectrolyte Characteristics. Journal Of Applied Polymer Science, 116:3603-3612, 2010. [ DOI | Details | Full Text ] F. Schmitt, L. Lagopoulos, P. Kaeuper, N. Rossi, N. Busso, J. Barge, G. Wagnieres, C. Laue, C. Wandrey, and L. Juillerat-Jeanneret. Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints. Journal Of Controlled Release, 144:242-250, 2010. [ DOI | Details | Full Text ] C. Wandrey, M. Bohner, and G. Richards. The 22nd European Conference on Biomaterials: retrospective view, facts and figures. Journal Of Materials Science-Materials In Medicine, 21:843-845, 2010. [ DOI | Details | Full Text ] R. Mahou and C. Wandrey. Alginate-Poly(ethylene glycol) Hybrid Microspheres with Adjustable Physical Properties. Macromolecules, 43:1371-1378, 2010. [ DOI | Details | Full Text ] C. Wandrey, U. Hasegawa, A. J. van der Vlies, C. O'Neil, N. Angelova, and J. A. Hubbell. Analytical ultracentrifugation to support the development of biomaterials and biomedical devices. Methods, Epub ahead of print, 2010. [ DOI | Details | Link ] U. Hasegawa, V. der Vlies, J. André, E. Simeoni, C. Wandrey, and J. A. Hubbell. Carbon Monoxide-Releasing Micelles for Immunotherapy. J. Am. Chem. Soc., 132(51):18273-18280, 2010. [ DOI | Details | Full Text ] A. S. Shaplov, E. I. Lozinskay, R. Losada Mateo, C. Wandrey, A. T. Zdvizhkov, A. A. Korlyukov, K. A. Lyssenko, I. A. Malyshkina, and Y. S. Vygodskii. Polymerization of the new double-charged monomer bis-1,3(N,N,N trimethylammonium dicyanamide)-2-propylmethacrylate and ionic conductivity of the novel polyelectrolytes. Polymers Advanced Technologies, Epub ahead of print, 2009. [ DOI | Details | Full Text ]

Teaching Chemistry and Chemical Engineering Analytical ultracentrifugation [en] Introduction to chemical engineering Laboratory Works [fr] (SCGC) Macromolecules in solution [en] Polyelectrolytes and biopolymers [en] (SMX SCGC) Phd programs Chemistry and Chemical Engineering (edoc) Biotechnology and Bioengineering Phd Students Ahmadloo Hamideh Alumni Dianelys Sainz-Serp, PhD 2004 Vesela Malinova, PhD 2005 Laurent Bourdillon, PhD 2005 Ignacio Rintoul, PhD 2006 Dr. Nela Anguelova. 2005-2007 Dr. Peter Käuper 2006-2008 Loic Wagniere 2007-2008 Ricardo Losada, PhD 2009 Theresa Chimamkpam, 2008-2009 Catherine A. Schütz, PhD 2011