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Laboratory of functional and metabolic imaging
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Cristina Ramona Cudalbu
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Scientist
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office(s):
CHF1602
phone(s): [+41 21 69] 30580
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BIOGRAPHY
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2007- present
Laboratory for Functional and Metabolic Imaging (LIFMET), Lausanne, Switzerland.
www.cibm.ch
2003 – 2006 Ph.D.
Title - Localized Proton MRS and time domain quantification of cerebral metabolites at 7T and 4.7T
University Lyon 1, RMN Laboratory MIB, UMR CNRS 5012, ESCPE, Villeurbanne, France.
2002 – 2003 Master of Science “Biophysics and Medical Physics”
University Babes-Bolyai, Cluj-Napoca, Romania.
1998 – 2002 University of Physics Babes-Bolyai, department “Medical Physics”, Cluj- Napoca, Romania,
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Field of research
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- in vivo proton, carbon and nitrogen MR Spectroscopy in small animals
- brain metabolites quantification
- brain tumors
- hyperammonemia
- liver failure
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Publications
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Kunz N, Cudalbu C, Mlynarik V, Hüppi PS, Sizonenko SV, Gruetter R. "Diffusion-weighted spectroscopy: a novel approach to determine macromolecule resonances in short-echo time 1H-MRS". Magn Reson Med. 2010 Oct;64(4):939-46.
Cudalbu C, Comment A, Kurdzesau F, van Heeswijk RB, Uffmann K, Jannin S, Denisov V, Kirik D, Gruetter R. "Feasibility of in vivo(15)N MRS detection of hyperpolarized (15)N labeled choline in rats". Phys Chem Chem Phys. 2010 Jun 14;12(22):5818-23.
Clément V, Marino D, Cudalbu C, Hamou MF, Mlynarik V, de Tribolet N, Dietrich PY, Gruetter R, Hegi ME, Radovanovic I. "Marker-independent identification of glioma-initiating cells". Nat Methods, 2010 Mar;7(3):224-8.
C.Cudalbu, V. Mlynárik, L. Xin and R. Gruetter, "Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum", Meas. Sci. Technol. 20:104034 (2009)
van Heeswijk RB, Uffmann K, Comment A, Kurdzesau F, Perazzolo C, Cudalbu C, Jannin S, Konter JA, Hautle P, van den Brandt B, Navon G, van der Klink JJ, Gruetter R. "Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents". Magn Reson Med. 2009 Jun;61(6):1489-93.
C Cudalbu, V Mlynarik, L Xin, R Gruetter. "Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4T and 14.1T". Magn Reson Med. 2009 Oct;62(4):862-7.
V Mlynarik, C Cudalbu, L Xin, R Gruetter. "1H NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile" JMR 2008 Oct;194(2):163-8
C. Cudalbu, O. Beuf, S. Cavassil. "In vivo short echo time localized 1H MRS of the rat brain at 7T: influence of two strategies of background-accommodation on the metabolite concentration estimation using QUEST". Journal of VLSI Signal Processing Systems, Volume 55, Issue1 (2009), Page 25.
C. Cudalbu, A. Montavont, P. Ryvlin, S. Cavassila. "Brain metabolite concentration estimates using MRS in a chronic model of temporal lobe epilepsy". CR Chimie, Volume 11, Issues 4-5, April-May 2008, Pages 434-441.
C. Cudalbu, S. Cavassila, H. Rabeson, D. van Ormondt, D. Graveron-Demilly. "Influence of Measured and Simulated Basis-Sets on the Metabolite Concentration Estimates". NMR Biomed, 2008, 21: 627-636.
C. Cudalbu, A. Rengle, O. Beuf, S. Cavassila. "Rat brain metabolite relaxation time estimates using Magnetic Resonance Spectroscopy at two different field strengths". C.R. Chimie, Volume 11, Issues 4-5, April-May 2008, Pages 442-447
H. Rabeson, H. Ratiney, F. Fauvelle, C. Cudalbu, S. Cavassila, A. Bernard, P. Giraudon, D. van Ormondt, D. Graveron-Demilly. "Quantitation for in vivo and ex vivo NMR Spectroscopy, Journal of Optoelectronics and Advanced Materials". 2007, 9 (3): 505-511.
C. Cudalbu, S. Cavassila, H. Ratiney, D. Grenier, A. Briguet, D. Graveron-Demilly. "Estimation of metabolite concentrations of healthy mouse brain by Magnetic Resonance Spectroscopy at 7 Tesla" C. R. Chimie, 9, 2006, pp 534-538.
Cristina Cudalbu, Andrada Stan, O. Cozar, D. Ristoiu. "Dose distribution in the irradiation of medulloblastoma with two adjacent fields". Studia UBB, Physica, 2003, Vol 2, pp 3-11.
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Reviewing Activity
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Magnetic Resonance in Medicine
NMR in Biomedicine
Journal of Magnetic Resonance Imaging
International Society for Magnetic Resonance in Medicine (ISMRM)
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Educational courses
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- “Image à résonance magnétique nucléaire et son application en expérimentation animale “ held during « Cours d’Introduction à l’Expérimentation Animale (Module 1) » 19 March 2010, Lausanne.
- “Metabolite quantification” within “Potentials and challenges of high-field MRS –sunrise course”, held at the ISMRM-ESMRMB 2009 Meeting in Stockholm, Sweden, 1-7 May, 2010.
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Supervised Thesis
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" Methodological aspects of 15N-1H-NMR in vitro and in vivo". Melanie Craveiro, TP-IV Project, EPFL, 2008
"Short-echo-time 1H MRS of mice lacking PPAR beta at 14.1T". Melanie Craveiro, TP-IV Project, EPFL, 2008
"Short-echo-time 1H MRS of ischemic evolution in mice lacking PPAR beta at 14.1T". Melanie Craveiro, Master Thesis, EPFL, 2009
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Abstracts (Peer-Reviewed at Int. Conf.)
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- BRAIN’11 & BRAINPET’11, 24-28 May 2011, Barcelona -
"Imaging the in vivo effect of hyperammonemia in the rat brain: a Spectroscopic Imaging and Diffusion Tensor Imaging study".
Cristina Cudalbu, Nicolas Kunz, Bernard Lanz, Yohan Van de Looij, Vladimir Mlynárik, and Rolf Gruetter
- ISMRM 19th Annual Scientific Meeting, 7-13 May 2011, Montreal, Canada -
"Impact of the prior knowledge on the quantification of in vivo 13C spectra using two different algorithms: LCModel and AMARES".
C. Cudalbu, B. Lanz, J. M. Duarte, N. Kunz, and R. Gruetter
"In vivo localized 15N MRS detection of hyperpolarized 15N labeled choline in the rat brain".
C. Cudalbu, A. Comment, T. Cheng, M. Mishkovsky, and R. Gruetter
"In vivo longitudinal 1H MRS study of transgenic mouse models of prion disease in the hippocampus and cerebellum at 14.1T".
C. Cudalbu, M. Craveiro, V. Mlynárik, J. Bremer, A. Aguzzi, and R. Gruetter
"Early post-ischemic neuroprotective mechanisms: a MR spectroscopic imaging study on PPARβ-deficient mice".
M. Craveiro, L. Quignodon, C. Berthet, M. Hall, C. Cudalbu, L. Hirt, B. Desvergne, and R. Gruetter
- 9th International Conference on Brain Energy Metabolism, 7-10 July 2010, Budapest -
"In vivo Magnetic Resonance Spectroscopy (MRS) studies of brain metabolism during ammonia infusion".
C. Cudalbu, B. Lanz, H. Frenkel, V. Mlynárik and R. Gruetter
- ISMRM-ESMRMB 2009 Meeting in Stockholm, Sweden, 1-7 May, 2010 -
"Imaging glutamine synthesis rates in the hyperammonemic rat brain".
C. Cudalbu, V. Mlynárik, B. Lanz, H. Frenkel, N. Costers and R. Gruetter
"In vivo simultaneous measurement of glutamine synthetase and glutamate dehydrogenase activity in the hyperammonemic rat brain using localized 1H and 15N MRS".
C. Cudalbu, B. Lanz, P. R. Vasos, Y. Pilloud, V. Mlynárik and R. Gruetter
"Localized 31P saturation transfer in rat brain".
V. Mlynarik, C. Cudalbu, Y. Pilloud and R. Gruetter
"Investigation of spatial distribution of metabolites in rat brain at elevated plasma glucose levels".
V. Mlynarik, C. Cudalbu, H. Frenkel, N. Costers and R. Gruetter
"Hyperammonemia and edema: a DTI study in the adult rat brain".
N. Kunz, C. Cudalbu, Y. Van de Looij, P. Hüppi, S. Sizonenko, and R. Gruetter
- ESMRMB 2009, Antalya, TR, from October 1-3, 2009 -
"In vivo localized 15N and 1H MRS in the hyperammonaemic rat brain at 9.4T".
C. Cudalbu, B. Lanz, F. Morgenthaler, Y. Pilloud, V. Mlynarik, R. Gruetter
- INTERNATIONAL SYMPOSIUM ON HEPATIC ENCEPHALOPATHY September 17-19, 2009, Valencia, Spain -
"MEASUREMENT OF GLUTAMINE SYNTHESIS RATE IN THE HYPERAMMONAEMIC RAT BRAIN USING IN VIVO 1H AND 15N MRS".
C Cudalbu, B Lanz, F Morgenthaler, V Mlynárik and R Gruetter
- XXIVth International Symposium on Cerebral Blood Flow, Metabolism and Function and the IXth International Conference on Quantification of Brain Function with PET, Chicago Illinois—USA, 29th of June- 3rd of July, 2009 -
"GLUTAMINE SYNTHESIS RATE IN THE HYPERAMMONAEMIC RAT BRAIN USING SIMULTANEOUS LOCALIZED IN VIVO 1H AND 15N MRS".
C. Cudalbu, B. Lanz, F. Morgenthaler, Y. Pilloud, V. Mlynárik, R. Gruetter
- ISMRM 17th Annual Scientific Meeting, 18-19 April 2009, Hawaii -
"Short-echo-time 1H MRS of the mouse lacking prion protein (Prnp-/-) at 14.1T".
C. Cudalbu, V. Mlynárik, J. Bremer, A. Aguzzi, and R. Gruetter
"Simultaneous Localized in vivo 1H and 15N MRS of Glutamine Synthesis in the hyperammonaemic rat brain".
C. Cudalbu, B. Lanz, F. D. Morgenthaler, Y. Pilloud, V. Mlynárik, and R. Gruetter
"Sub-micromolar concentrations of contrast agent have a quantifiable influence on the hyperpolarized lithium-6 relaxation time in vivo".
Ruud B. van Heeswijk, Fiodar Kurdzesau, Cristina Cudalbu, Arnaud Comment, Jacques J. van der Klink, Gil Navon and Rolf Gruetter
"Mapping glucose and lactate concentrations with microliter resolution in rat brain using short-echo-time spectroscopic imaging".
V. Mlynarik, C. Cudalbu, H. Frenkel, and R. Gruetter
"Proton MRS investigation of human glioma models in nude mice at 14.1 T".
V. Mlynarik, C. Cudalbu, V. Clément, D. Marino, I. Radovanovic, and R. Gruetter
- IEEE IST Workshop in Crete September 2008 -
"Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE 1H MRS spectra".
Cristina Cudalbu, Vladimir Mlynárik, Lijing Xin, Rolf Gruetter
- 25th Annual Scientific Meeting of ESMRMB, Valencia, 2008 -
"MRS study of human glioma-initiating cells grown in the brain of nude Mice".
Mlynarik V, Cudalbu V, Clément V, Radovanovic I, Gruetter R
"Comparison of the T1 of the neurochemical profile in rat brain at 9.4T and 14.1T".
Cudalbu C, Mlynárik V, Xin L, Gruetter R
- 16th Annual ISMRM Meeting, Toronto, 2008 -
"1H NMR T1 Relaxation Times of the Neurochemical Profiles in Rat Brain at 14.1T".
Cudalbu C; Mlynárik V; Xin L; Gruetter R
"Comparison of Two Approaches to Model the Macromolecule Spectrum for the Quantification of Short TE 1H MRS Spectra at 14.1T".
Cudalbu C; Mlynárik V; Xin L; Gruetter R
"Diffusion Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances at 14T".
Kunz N; Cudalbu C; Mlynárik V; Sizonenko SV; Gruetter R
"Improved Spectral Dispersion in Proton MR Spectroscopy of the Neurochemical Profile in the Rat Brain at 14.1 Tesla".
Mlynárik V; Cudalbu C; Xin L; Gruetter R
"In Vivo Detection of Hyperpolarized 15N Choline in the Rat".
Cudalbu C; Comment A; Uffmann K; van Heeswijk RB; Perazzolo C; Kurdzesau F; Jannin S; Denisov V; Kirik D; van der Klink JJ; Gruetter Rolf
"Hahn T2 Relaxation Times of the Neurochemical Profile at 14.1T in the in Vivo Rat Brain".
Xin L; Gambarota G; Cudalbu CR; Mlynárik V; Gruetter R
"Phase Imaging of the in vivo Rat brain at 14.1 Tesla".
Marques JP, Cudalbu C, Poitry-Yamate C, Mlynarik V, Gruetter R.
"Detection and imaging of hyperpolarized 6-lithium in the rat brain in vivo".
van Heeswijk RB, Uffmann K, Comment A, Kurdzesau F, Perazzolo C, Cudalbu C, Jannin S, Konter T, Hautle P, van den Brandt B, van der Klink JJ, Navon G, Gruetter R.
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