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Florence Pojer
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Prof. Cole Group
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pHD
nationality: french
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office(s):
SV3632
SV3533
phone(s): [+41 21 69] 31839,31772
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MISSION
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Structural studies of a novel secretion system of Mycobacterium tuberculosis.
Structure-based design of new antituberculosis drugs.
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Education
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Pharmacy school, Franche-comté (France), 1992-1998
Ph.D., Antibiotic research, Prof. Lutz Heide, Tuebingen (Germany), 1999-2003
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Professional course
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Post-doctoral, Structural Biology lab-Prof. Joseph Noel, The Salk Institute (La Jolla, USA), 2004-2007
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MAIN PUBLICATIONS
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CloQ, a prenyltransferase involved in clorobiocin biosynthesis, F. Pojer, E. Wemakor, B. Kammerer, H. Chen, C.T. Walsh, S.-M. Li and L. Heide , PNAS 100, 2316-2321, 2003
CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis., F. Pojer, R. Kahlich, B. Kammerer, S.-M. Li and L. Heide , JBC, 278(33),30661-8, 2003
Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A synthases, Pojer F., Ferrer J.-L., Richard S.B., Nagedowda D.A., Chye M-L., Bach T.J. and Noel J.P, PNAS 1:103(31):11491-6, 2006
Discovery and characterization of a marine bacterial SAM-dependent chlorinase, Eustáquio, A.S.*, Pojer F.*, Noel J.P., and Moore B.S.
*co-first authors, Nat Chem Biol. (1):69-74, 2008
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Scientist