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Senior Scientist SV SV-SSV SSV-ENS Senior Scientist SB ISIC GR-VDB2 Senior Scientist AA AA-DOC EDCH-ENS

Georges Wagnières SSV - Teaching Dr. MER birth date: 02.05.1962 nationality: Swiss web site: http://lpas.epfl.ch/PDT/ office(s): CHH5595 phone(s): [+41 21 69] 33120 private phone: + 41 21 7911343 fax: + 41 21 6933626 MISSION - Research and teaching in the field of biomedical optics and photomedicine - Technology transfer BIOGRAPHY Georges Wagnières received his diploma degree (MSc) in physics from the University of Lausanne, Switzerland, in 1986. He obtained his doctorate in science (PhD) in physics (Biomedical optics) from the Swiss Federal Institute of Technology at Lausanne (EPFL) in 1992 and did a postdoctoral work in the Wellman Laboratories of Photomedicine (Harvard Medical School), Boston, USA, from 1993 to 1994. He also obtained a Master degree in Management of Technology delivered by the Ecole des Hautes Etudes Commerciales (HEC) of Lausanne University and the EPFL in 2001. Georges Wagnières took the lead in 1994 of a research group involving about ten coworkers in the fields of: - Tissue characterization and detection of malignancies by fluorescence spectroscopy and imaging. - Photodynamic therapy for the treatment of cancers and other conditions associated with vascular or immune disorders. - Biomedical optical spectroscopy and imaging. - Light dosimetry. - Preclinical and clinical development of photosensitizers, fluorescing markers and photodiagnostic instruments. Georges Wagnières is also co-founder and chairman of two spin-off companies: - Medlight SA, founded in July 1997, which develops, produces and commercializes light distributors for photodynamic therapy. - PhotoDerma SA, founded in Mai 2003, which develops a technology for permanent hair removal using photodynamic depilation. Georges Wagnières has currently authored more than 200 papers (more than 100 in international journals with review board) and is inventor of 15 patents. He supervised 13 PhD students up to now, and currently teaches in the Master program on biomedical optics and gives a doctoral course on advanced topics in photomedicine. MAIN PUBLICATIONS Please visit: http://lpas.epfl.ch/PDT/pdt_publi.html MAIN PUBLICATIONS P. Nowak-Sliwinska, J.-P. Ballini, G. Wagnieres, and H. van den Bergh. Processing of Fluorescence Angiograms for the Quantification of Vascular Effects Induced by Anti-angiogenic Agents in the CAM model (vol 79, pg 21, 2010). Microvascular Research, 80:177-177, 2010. [ DOI | Details ] L. VEYA, O. WAGNIERES, and M. SOLLBERGER. Chimie: Autonomie or réduction? 2010. [ Details ] F. Schmitt, L. Lagopoulos, P. Kaeuper, N. Rossi, N. Busso, J. Barge, G. Wagnieres, C. Laue, C. Wandrey, and L. Juillerat-Jeanneret. Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints. Journal Of Controlled Release, 144:242-250, 2010. [ DOI | Details | Full Text ] F. Schmitt, L. Lagopoulos, P. Käuper, N. Rossi, N. Busso, J. Barge, G. Wagnières, C. Laue, C. Wandrey, and L. Juillerat-Jeanneret. Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints. Journal of controlled release : official journal of the Controlled Release Society, 144(2):242-50, 2010. [ DOI | Details ] S. H. Lim, C. Thivierge, P. Nowak-Sliwinska, J. Han, H. van den Bergh, G. Wagnières, K. Burgess, and H. B. Lee. In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy. Journal of Medicinal Chemistry, 53(7):2865-74, 2010. [ DOI | Details ] S. H. Lim, P. Nowak-Sliwinska, F. A. Kamarulzaman, H. Van Den Bergh, G. Wagnières, and H. B. Lee. The Neovessel Occlusion Efficacy of 15(1)-hydroxypurpurin-7-lactone dimethyl ester induced with photodynamic therapy. Photochemistry and Photobiology, 86(2):397-402, 2010. [ DOI | Details ] P. Nowak-Sliwinska, G. Wagnières, H. Bergh, and A. W. Griffioen. Angiostasis-induced vascular normalization can improve photodynamic therapy. Cellular and Molecular Life Sciences, 67(9):1559-1560, 2010. [ DOI | Details ] P. Nowak-Sliwinska, J.-P. Ballini, G. Wagnières, and H. Van Den Bergh. Processing of fluorescence angiograms for the quantification of vascular effects induced by anti-angiogenic agents in the CAM model. Microvascular Research, 79(1):21-28, 2010. [ DOI | Details ] C. Cheng, E. Debefve, A. Haouala, S. Andrejevic-Blant, T. Krueger, J.-P. Ballini, S. Peters, L. Decosterd, H. van den Bergh, G. Wagnieres, J. Y. Perentes, and H.-B. Ris. Photodynamic Therapy Selectively Enhances Liposomal Doxorubicin Uptake in Sarcoma Tumors to Rodent Lungs. Lasers In Surgery And Medicine, 42:391-399, 2010. [ DOI | Details ] B. Lovisa, A. M. Novello, P. Jichlinski, H. van den Bergh, and G. Wagnieres. Fluorescence of the bladder washout fluid following cystoscopy: a preliminary study. In Photonic Therapeutics And Diagnostics Vi, volume 7548 of Proceedings of SPIE-The International Society for Optical Engineering, pages -. Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa, 2010. [ DOI | Details ] B. W. Pogue, G. A. Wagnieres, and L. D. Lilge. Pioneers in Biomedical Optics: Special Section Honoring Professor Tayyaba Hasan. Journal Of Biomedical Optics, 15:-, 2010. [ DOI | Details ] F. Piffaretti and G. Wagnières. Development of Minimally-Invasive Optical Methods to Individualize the Doses Used for Therapeutic Applications of Light. PhD thesis, Lausanne, 2010. [ DOI | Details | Full Text | Link ] B. Lovisa and G. Wagnières. Endoscopic Fluorescence Imaging. PhD thesis, Lausanne, 2010. [ DOI | Details | Full Text | Link ] T. Gabrecht, A. Radu, P. Grosjean, B. Weber, G. Reichle, L. Freitag, P. Monnier, H. van den Bergh, and G. Wagnières. Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light. Photodiagnosis and photodynamic therapy, 5(1):2-9, 2009. [ DOI | Details ] D. Hüttenberger, T. Gabrecht, G. Wagnières, B. Weber, A. Linder, H.-J. Foth, and L. Freitag. Autofluorescence detection of tumors in the human lung-spectroscopical measurements in situ, in an in vivo model and in vitro. Photodiagnosis and photodynamic therapy, 5(2):139-47, 2009. [ DOI | Details ] P. Uehlinger, T. Gabrecht, T. Glanzmann, J.-P. Ballini, A. Radu, S. Andrejevic, P. Monnier, and G. Wagnières. In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence. Journal of biomedical optics, 14(2):024011, 2009. [ DOI | Details ] B. Lovisa, P. Jichlinski, D. Aymon, B.-C. Weber, H. Van Den Bergh, and G. Wagnieres. Detection of early bladder carcinoma by fluorescence cystoscopy with Hexvix: optical characterization of a high magnification cystoscope. In Proceedings of SPIE, Proceedings of SPIE-The International Society for Optical Engineering, pages 716118-716118-6. SPIE, 2009. [ DOI | Details ] B. Lovisa, P. Jichlinski, D. Aymon, B.-C. Weber, H. Van Den Bergh, and G. Wagnieres. Bladder cancer detection by fluorescence imaging with Hexvix: optimization of the excitation light during high magnification cystoscopy. Proceedings of SPIE, pages 73681I-73681I-5, 2009. [ DOI | Details ] T. Gabrecht, B. Lovisa, H. van den Bergh, and G. Wagnieres. Autofluorescence bronchoscopy: quantification of inter-patient variations of fluorescence intensity. Lasers In Medical Science, 24:45-51, 2009. [ DOI | Details ] J. Barge, T. Glanzmann, D. Salomon, H. van den Bergh, and G. Wagnieres. Photodynamic Hair Re-Growth Inhibition With Ala Derivatives. In Lasers In Surgery And Medicine, pages 38-38, 2009. [ Details ] T. Gabrecht, A. Radu, P. Grosjean, B. Weber, G. Reichle, L. Freitag, P. Monnier, H. Vandenbergh, and G. Wagnieres. Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light. Photodiagnosis and Photodynamic Therapy, 5(1):2-9, 2008. [ DOI | Details ] B. Lovisa, P. Jichlinski, D. Aymon, H. Van Den Bergh, and G. Wagnières. Detection of early bladder carcinoma by fluorescence cystoscopy with Hexvix. In Proceedings of SPIE, volume 6842, pages 684218-8. SPIE, 2008. [ DOI | Details ] P. Jichlinski, B. Lovisa, C. Erling, D. Aymon, H. van den Berg, and G. Wagnieres. Fluorescence cystoscopy. perspective in clinical practice and research. Der Urologe. Ausg. A, 47(8):975-7, 2008. [ DOI | Details ] E. Debefve, B. Pegaz, H. van den Bergh, G. Wagnières, N. Lange, and J.-P. Ballini. Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne(r)), in the CAM model. Angiogenesis, 11(3):235-43, 2008. [ DOI | Details ] N. Dögnitz, D. Salomon, M. Zellweger, J.-P. Ballini, T. Gabrecht, N. Lange, H. van den Bergh, and G. Wagnières. Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma. Journal of photochemistry and photobiology.B.Biology, 93(3):140-8, 2008. [ DOI | Details ] R. Vallinayagam, F. Schmitt, J. Barge, G. Wagnieres, V. Wenger, R. Neier, and L. Juillerat-Jeanneret. Glycoside esters of 5-aminolevulinic acid for photodynamic therapy of cancer. Bioconjugate Chemistry, 19:821-839, 2008. [ DOI | Details ] B. Lovisa, P. Jichlinski, D. Aymon, H. van den Bergh, and G. Wagnieres. Detection of early bladder carcinoma by fluorescence cystoscopy with Hexvix (R): Improvement of the specificity by microcystoscopy - art. no. 684218. In Photonic Therapeutics And Diagnostics Iv, volume 6842 of Proceedings Of The Society Of Photo-Optical Instrumentation Engineers (Spie), pages 84218-84218. Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa, 2008. [ Details ] D. Huettenberger, T. Gabrecht, G. Wagnieres, B. Weber, A. Linder, H. J. Foth, and L. Freitag. Autofluorescence detection of tumors in the human lung - Spectroscopical measurements in situ, in an in vivo model and in vitro. Photodiagnosis And Photodynamic Therapy, 5:139-147, 2008. [ DOI | Details ] T. Gabrecht, B. Lovisa, F. Borle, and G. Wagnières. Design of an endoscopic optical reference to be used for autofluorescence bronchoscopy with a commercially available diagnostic autofluorescence endoscopy (DAFE) system. Physics in medicine and biology, 52(8):N163-71, 2007. [ DOI | Details ] T. Gabrecht, F. Borle, H. Van Den Bergh, P. Michetti, M.-A. Ortner, and G. Wagnières. Design of a light delivery system for the photodynamic treatment of the Crohn's disease. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 6632, page null, 2007. [ DOI | Details ] T. Gabrecht, A. Radu, M. Zellweger, B. Lovisa, D. Goujon, P. Grosjean, H. Van Den Bergh, P. Monnier, and G. Wagnières. Detection of early bronchial cancer by autofluorescence: Results in patients with H&N cancer. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 6628, page null, 2007. [ Details ] T. Gabrecht, A. Radu, M. Zellweger, B. Lovisa, D. Goujon, P. Grosjean, H. van den Bergh, P. Monnier, and G. Wagnieres. Autofluorescence bronchoscopy: Clinical experience with an optimized system in head and neck cancer patients. Medical Laser Application, 22(3):185-192, 2007. [ DOI | Details ] V. Ramakrishnan, F. Schmitt, J. Barge, G. Wagnières, V. Wenger, R. Neier, and L. Juillerat-Jeanneret. Glycoside functionalization of aminolevulinic acid for targeted photodynamic therapy of cancer. 2007. [ DOI | Details ] T. Glanzmann, F. Borle, R. Conde, A. Radu, Y. Jaquet, R. Pilloud, H. van den Bergh, P. Monnier, and G. Wagnières. Pharmacokinetic of mTHPC in the sheep model for photodynamic therapy in the oesophagus. 2007. [ DOI | Details ] L. Favre, D. Velin, F. Borle, P. Michetti, H. Bouzouréne, D. Bachmann, C. Felley, G. Wagnières, H. van den Bergh, S. Schreiber, and M.-A. Ortner. Low dose photodynamic therapy ameliorates colitis in a murine Crohn's disease like colitis. 2007. [ DOI | Details ] T. Gabrecht, T. Glanzmann, L. Freitag, B.-C. Weber, H. van den Bergh, and G. Wagnières. Optimized autofluorescence bronchoscopy using additional backscattered red light. Journal of biomedical optics, 12(6):064016, 2007. [ DOI | Details | Link ] B. Lovisa, T. Gabrecht, S. Andrejevic, P. Grosjean, A. Radu, P. Monnier, H. van den Bergh, and G. Wagnières. Improvement of the Contrast in Cancer Detection by Autofluorescence Bronchoscopy using a narrow spectral violet Excitation: A preliminary study. Biomedical Signal Processing and Control, 2(3):234-238, 2007. [ DOI | Details | Link ] P. Uehlinger, T. Glanzmann, J. Ballini, A. Radu, T. Gabrecht, P. Monnier, H. van den Bergh, and G. Wagnières. Time-Resolved Autofluorescence Spectroscopy of the Bronchial Mucosa for the Detection of Early Cancer: Ex vivo and Clinical Results. 2007. [ DOI | Details ] M. Zellweger, D. Goujon, A. Radu, P. Grosjean, T. Stepinac, H. van den Bergh, P. Monnier, and G. Wagnières. Detection of early bronchial cancer by autofluorescence: first clinical results with an improved system. 2007. [ DOI | Details ] T. Glanzmann, M. Zellweger, F. Borle, R. Conde, A. Radu, J. Ballini, Y. Jaquet, R. Pilloud, H. van den Bergh, P. Monnier, and G. Wagnières. Assessment of a sheep animal model to optimize photodynamic therapy with Foscan in the esophague. Lasers In Surgery And Medicine, 41:643-652, 2007. [ DOI | Details ] I. Opitz, T. Krueger, Y. Pan, H.-J. Altermatt, G. Wagnières, and H.-B. Ris. Preclinical comparison of mTHPC and verteporfin for intracavitary photodynamic therapy of malignant pleural mesothelioma. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes, 38(3):333-9, 2006. [ DOI | Details ] B. Pegaz, E. Debefve, J.-P. Ballini, G. Wagnières, S. Spaniol, V. Albrecht, D. V. Scheglmann, N. E. Nifantiev, H. van den Bergh, and Y. N. Konan-Kouakou. Photothrombic activity of m-THPC-loaded liposomal formulations: pre-clinical assessment on chick chorioallantoic membrane model. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 28(1-2):134-40, 2006. [ DOI | Details ] T. Gabrecht, S. Andrejevic-Blant, and G. Wagnières. Blue-violet excited autofluorescence spectroscopy and imaging of normal and cancerous human bronchial tissue after formalin fixation. Photochemistry and photobiology, 83(2):450-8, 2006. [ DOI | Details ] P. Uehlinger, J. P. Ballini, H. van den Bergh, and G. Wagnieres. On the role of iron and one of its chelating agents in the production of protoporphyrin IX generated by 5-aminolevulinic acid and its hexyl ester derivative tested on an epidermal equivalent of human skin. Photochemistry and Photobiology, 82(4):1069-1076, 2006. [ DOI | Details ] T. Gabrecht and G. Wagnières. Clinical fluorescence spectroscopy and imaging for the detection of early carcinoma by autofluorescence bronchoscopy and the study of the protoporphyrin IX pharmacokinetics in the endometrium. PhD thesis, Lausanne, 2006. [ DOI | Details | Full Text | Link ] File Upload You can upload files with the form below (max. 300MB)

Skills - Fluorescence spectroscopy and imaging. - Photodynamic therapy. - Biomedical optical spectroscopy and imaging. - Light dosimetry. - Preclinical and clinical development of photosensitizers and photodiagnostic instruments. - Technology transfer and entrepreneurship. Teaching Life Sciences and Technologies Advanced topics in photomedicine [en] Biomedical optics [en] (SPH SSV) Phd programs Environment Photonics Chemistry and Chemical Engineering (edoc) Biotechnology and Bioengineering Phd Students Kratzer Gilles Past Phd students: Gabrecht Tanja Lovisa Blaise Piffaretti Filippo Stepinac Thomas Uehlinger Pascal Zellweger Matthieu GROUP HOMEPAGE http://lpas.epfl.ch/PDT/ START-UPs Medlight SA http://www.medlight.com/ PhotoDerma SA http://www.photoderma.com/ Past PhD students (co-supervised) Dögnitz Nora Glanzmann Thomas Mizeret Jérôme Nowak-Sliwinska Patrycja Santhakumar Kannappan