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Hongxia Lei
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Laboratory of functional and metabolic imaging
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office(s):
CHF1627
phone(s): [+41 21 69] 37964
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MAIN PUBLICATIONS
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Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo:
On the correlation of total glucose consumption with glutamatergic action, Choi I-Y, Lei H, Gruetter R , J. Cereb. Blood Flow Metab. 22:1343-1351 (2002)
Localized in vivo 13C NMR spectroscopy of the brain, Gruetter R, Adriany G, Choi IY, Henry PG, Lei H, Oz G., NMR Biomed. 16(6-7):313-38 (2003)
Effect of chronic hypoglycemia on glucose concentration and glycogen content in rat brain: A localized 13C NMR study , Lei H, Gruetter R, J. Neurochem. 99:260-268 (2006)
Direct validation of in vivo localized 13C MRS measurements of brain glycogen , Lei H, Morgenthaler F, Yue T, Gruetter R, Magn. Reson. Med. 57:243-248 (2007)
Snapshot gradient-recalled echo-planar images with very long echo time of rat brain at 9.4-T, Lei H, Mlynárik V, Just N, Gruetter R, Mag. Reson. Imaging 26:954-60 (2008)
Non-invasive quantification of brain glycogen absolute concentration, Morgenthaler FD, van Heeswijk RB, Xin L, Laus S, Frenkel H, Lei H, Gruetter R, J. Neurochem, 107:1414-23 (2008)
Evolution of the neurochemical profile following transient focal cerebral ischemia in the mouse brain, Lei H, Berthet C, Hirt L, Gruetter R, J. Cereb. Blood Flow and Metab. 29:811-819 (2009)
The rate-limiting step for glucose transport into the hypothalamus is across the blood-hypothalamus interface, Poitry-Yamate C, Lei H, Gruetter R, J. Neurochem. 109(s1): 38-45 (2009)
Neuroprotective role of lactate after cerebral ischemia, Berthet C, Lei H, Thevenet J, Gruetter R, Magistretti P.J., Hirt L., J. Cereb. Blood Flow and Metab.29: 1780-1789 (2009)
Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex, Lei H, Duart J.M.N., Mlynárik V, Python A, Gruetter R. , J Neurosci Res 88(2):413-419 (2010)
Minimization of Nyquist ghosting for fMRI at ultra-high fields based on a “negative read-out gradient”, van der Zwaag W, Marques JP, Lei H, Just N, Kober T, Gruetter R., J Magn Reson Imaging 30(5):1171-1178 (2009)
Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational model, Duarte J.M.N., Morgenthaler F.D., Lei H, Poitry-Yamate C, Gruetter R. , Front Neuroenergetics. 1:6 (2009)
Neurochemical profile of the mouse hypothalamus using in vivo 1H MRS at 14.1T, Lei H, Poitry-Yamate C, Preitner F, Thorens B, Gruetter R, NMR Biomed. 23(6):578-583 (2010)
Early predictive biomarkers for lesion development after transient cerebral ischemia, Berthet C, Lei H, Gruetter R, Hirt Lorenz, Stroke. 42(3):799-805 (2011)
High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice, Alf FM, Lei H, Berthet C, Hirt L, Gruetter R and Mlynarik V, NMR Biomed., 2012 Feb;25(2):247-54. doi: 10.1002/nbm.1740. Epub 2011 Jul 15.
Effect of manganese on the neurochemical profile of the hypothalamus, Just N, Cudalbu C, Lei H, Gruetter R, J. Cereb. Blood Flow and Metab. 31:2324-2333 (2011)
Continuous arterial spin labeling of mouse cerebral blood flow using an actively-detuned two-coil system at 9.4T, Lei H, Pilloud Y, Magill AW, Gruetter R., Conf Proc IEEE Eng Med Biol Soc. 2011 Aug;2011:6993-6996.
The neurochemical profile qauntified by in vivo 1H NMR spectroscopy, Duarte JMN, Lei H, Mlynarik V, Gruetter R, NeuroImage (Published online, Dec 2011)
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OTHERS PUBLICATIONS
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Book chapter entitled “In-vivo NMR Spectroscopy of the Brain at High Fields” in “Ultra High Field Magnetic Resonance Imaging”
Gruetter R., Henry P.G., Lei H., Mangia S., Oz G., Terpstra M. and Tkac I.
Series: Biological Magnetic Resonance , Vol. 26
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PEER-REVIEWED ABSTRACTS (2010-present)
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Lei H, Preitner F, Thorens B and Gruetter R (2012) Metabolic studies of glucose transporter 2 knockout (RIPGLUT1GLUT2-/-) mice using in vivo 1H MRS and CASL. Proceedings 20th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2012
Magill AW, Lei H and Gruetter R (2012) A high-pass birdcage coil for small animal imaging at 600MHz/14.1T. Proceedings 20th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2012
Magill AW, Lei H and Gruetter R (2012) A high-power RF switch for arterial spin labelling with a separate tagging coil. Proceedings 20th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2012
Lei H, Pilloud Y and Gruetter R (2011) Continuous Arterial Spin Labeling (CASL) of Cerebral Blood Flow of Mouse at 9.4T. Proceedings 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011
Lei H, Berthet C, Hirt L and Gruetter R (2011) Early metabolic biomarkers identifying permanent stroke in mouse brain using 1H MRS. Proceedings 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011
Lei H, Dirren E, Poitry-Yamate C, Schneider BL, Aebischer P and Gruetter R (2011) Early metabolic changes in the amyotrophic lateral sclerosis SOD1 mouse brain are revealed using 1H MRS rather than CASL and 18FDG PET. Proceedings 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011
Alf M, Lei H, Berthet C, Hirt L, Gruetter R and Mlynarik V. High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice. Proceedings 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011
Xin L, Lei H, Lanz B and Gruetter (2011) In Vivo Assessment of Neuronal Metabolic Fluxes in Mouse Brain by 1H-[13C] NMR Spectroscopy. Proceedings 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011
Mlynarik V, Sun-Reimer L, Janssens S, Cacquevel M, Lei H, Schneider BL, Aebischer P and Gruetter (2011) Proton and phosphorus MRS of a 5xFAD mouse model of Alzheimer's disease. Proceedings 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011
Lei H, Magill A.W., Mlynarik V and Gruetter R (2010) In vivo 1H MR studies of cortical metabolic response during insulin-induced hypoglycemia Proceedings 18th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2010
Lei H, Van de Looij Y, Kunz N, Berthet C, Hirt L and Gruetter R (2010) Diffusion tensor echo planar imaging of mouse brain after brief focal middle cerebral artery occlusion at 14T Proceedings 18th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2010
Lei H, Xin L, Berthet C, Hirt L and Gruetter R (2010) In vivo 1H MRS measurements of acetate in mouse striatum after permanent focal middle cerebral artery occlusion Proceedings 18th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2010
Xin L, Mlynarik V, Lei H, and Gruetter R (2010) Influence of regional macromolecule baseline on the quantification of neurochemical profile in rat brain Proceedings 18th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2010
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REVIEWING ACTIVITY
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NMR in Biomedicine
Neurology
Cerebrovascular Diseases
Journal of Pediatric Neurology
PLoS One
International Society for Magnetic Resonance in Medicine (ISMRM)
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Society Membership
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International Society of Magnetic Resonance in Medicine (ISMRM)
International Society for Neurochemistry (ISN)
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Scientist