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Jeffrey Chen
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Prof. Cole Group
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Scientist
nationality: Canadian
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office(s):
SV3535
phone(s): [+41 21 69] 31833
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MISSION
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Understanding how the ESX-1 protein secretion system works, how it is regulated and how it mediates the virulence of Mycobacterium tuberculosis.
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SUPPORT
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1) EU FP7 - NOVSEC-TB.
2) Swiss National Science Foundation.
3) Canadian Thoracic Society/Lung Association Post-doctoral fellowship.
4) Canadian Institutes of Health Research Post-doctoral fellowship.
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ACADEMIC HISTORY
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Ph.D. Dept. of Molecular Genetics, University of Toronto. Canada.
B.Sc.(Hons). Marine Biology/Biochemistry. Dalhousie University. Canada.
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PUBLICATIONS
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Chen J.M., S. Boy-Röttger, N. Dhar, N. Sweeney, R.S. Buxton, F. Pojer, I. Rosenkrands and S.T. Cole. (2011) EspD is critical for the virulence-mediating ESX-1 secretion system in Mycobacterium tuberculosis. J. Bacteriol. In press.
Chen J.M., F. Pojer, B. Blasco and S.T. Cole. (2010) Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis. Drug Discovery Today – Disease Mechanisms. In press.
Hartkoorn R.C., C.Sala, S.J. Magnet, J.M. Chen, F. Pojer and S.T. Cole. (2010) Sigma factor F does not prevent rifampin inhibition of RNA polymerase or cause rifampin tolerance in Mycobacterium tuberculosis. J. Bacteriol. In press.
Bottai D., L. Majlessi, R. Simeone, W. Frigui, C. Laurent, P. Lenormand, J.M. Chen, I. Rosenkrands, M. Huerre, C. Leclerc, S.T. Cole and R. Brosch. (2010) ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis. J. Infect. Dis. In press.
Chen, J.M., H. Ren, J.E. Shaw, Y.J. Wang, M. Li, A.S. Leung, V. Tran, N.M. Berbenetz, D. Kocíncová, C.M. Yip, J-M. Reyrat and J. Liu. (2008) Lsr2 of Mycobacterium tuberculosis is a DNA-bridging protein. Nucleic Acids Research. 36: 2123-2135.
Chen, J.M., S.T. Islam, H. Ren and J. Liu. (2007) Differential production of lipid virulence factors among BCG vaccine strains and implications for BCG safety. Vaccine. 25: 8114-8122.
Ren, H., L.G. Dover, S.T. Islam, D.C. Alexander, J.M. Chen, G.S. Besra and J. Liu. (2007) Identification of the biosynthetic gene cluster of lipooligosaccharides from Mycobacterium marinum. Mol. Microbiol. 63: 1345-1359.
Chen, J.M., G.J. German, D.C. Alexander, H. Ren, T. Tan and J. Liu. (2006) Roles of Lsr2 in colony morphology and biofilm formation of Mycobacterium smegmatis. J. Bacteriol. 188: 633-641.
Alexander, D.C., J.R.W. Jones, T. Tan, J.M. Chen and J. Liu. (2004) PimF, a mannosyltransferase of mycobacteria, is involved in the biosynthesis of phosphatidylinositol mannosides and lipoarabinomannan. J Biol Chem. 279: 18824-18833.
Chen, J.M., D.C. Alexander, M.A. Behr and Jun Liu. (2003) Mycobacterium bovis BCG vaccines exhibit defects in alanine and serine catabolism. Infect Immun. 71: 708-716.
Flaman A.S., J.M. Chen, S.C. Van Iderstine and D.M. Byers. (2001) Site-directed mutagenesis of acyl carrier protein reveals amino acid residues involved in ACP structure and acyl-ACP synthetase activity. J Biol Chem. 276: 35934-35939.
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Scientist