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Jeffrey Chen
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Prof. Cole Group
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Scientist
nationality: Canadian
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office(s):
SV3535
phone(s): [+41 21 69] 31833
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MISSION
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Elucidating virulence mechanisms of Mycobacterium tuberculosis to develop novel anti-TB therapeutic agents.
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Academic History
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Ph.D. Dept. of Molecular Genetics, University of Toronto. Canada.
B.Sc.(Hons). Marine Biology/Biochemistry. Dalhousie University. Canada.
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Main Publications
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Chen, J.M., H. Ren, J.E. Shaw, Y.J. Wang, M. Li, A.S. Leung, V. Tran, N.M. Berbenetz, D. Kocíncová, C.M. Yip, J-M. Reyrat and J. Liu. (2008) Lsr2 of Mycobacterium tuberculosis is a DNA-bridging protein. Nucleic Acids Research. 36: 2123-2135.
Chen, J.M., S.T. Islam, H. Ren and J. Liu. (2007) Differential production of lipid virulence factors among BCG vaccine strains and implications for BCG safety. Vaccine. 25: 8114-8122.
Ren, H., L.G. Dover, S.T. Islam, D.C. Alexander, J.M. Chen, G.S. Besra and J. Liu. (2007) Identification of the biosynthetic gene cluster of lipooligosaccharides from Mycobacterium marinum. Mol. Microbiol. 63: 1345-1359.
Chen, J.M., G.J. German, D.C. Alexander, H. Ren, T. Tan and J. Liu. (2006) Roles of Lsr2 in colony morphology and biofilm formation of Mycobacterium smegmatis. J. Bacteriol. 188: 633-641.
Alexander, D.C., J.R.W. Jones, T. Tan, J.M. Chen and J. Liu. (2004) PimF, a mannosyltransferase of mycobacteria, is involved in the biosynthesis of phosphatidylinositol mannosides and lipoarabinomannan. J Biol Chem. 279: 18824-18833.
Chen, J.M., D.C. Alexander, M.A. Behr and Jun Liu. (2003) Mycobacterium bovis BCG vaccines exhibit defects in alanine and serine catabolism. Infect Immun. 71: 708-716.
Flaman A.S., J.M. Chen, S.C. Van Iderstine and D.M. Byers. (2001) Site-directed mutagenesis of acyl carrier protein reveals amino acid residues involved in ACP structure and acyl-ACP synthetase activity. J Biol Chem. 276: 35934-35939.
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Scientist