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Jeffrey Alan Hubbell
Merck Serono Chair in Drug Delivery
Professor
web site: http://lmrp.epfl.ch

office(s): AI1106
phone(s): [+41 21 69] 39681,39682
fax: [+41 21 69] 39685
MISSION
Our research is in the field of biomaterials and protein engineering, with applications in tissue engineering, drug delivery, and immunotherapeutics in mind. We develop novel hydrogel and nanoparticle biomaterials and novel protein therapeutics in (i) regenerative medicine, (ii) immunotherapeutics (vaccines in infectious diseases and cancer; tolerance induction in transplant medicine and autoimmunity), and (iii) delivery of small molecule and gene drugs. As molecular targets, we (i) explore molecular variants of a number of growth factors and adhesion protein morphogens, (ii) develop new release vehicles for hydrophobic immunosuppressant, anticancer and anti-proliferative small molecule drugs, and (iii) investigate new product forms of nitric oxide; further, we develop novel nonviral vectors for delivering (iv) siRNA and (v) plasmid DNA. As clinical targets (where we have reached the human clinic, so indicated; otherwise work in development), we address novel materials for (i) type-I diabetes (in cell transplantation to pilot clinical trials; others in immunosuppression and tolerization in development), (ii) immunosuppression, (iii) restenosis prevention, (iv) postoperative adhesion prevention, (v) cartilage protection, (vi) cancer chemotherapy, (vii) cancer immunotherapy, and (viii) infectious diseases vaccination; and novel bioactives for (i) bone repair (presently to Phase II clinical trials), (ii) chronic wound repair (presently to Phase II clinical trials), (iii) restenosis prevention, (iv) bladder repair, and (v) cartilage repair. Historically, we have taken a surgical sealant to the clinic and marketplace, although we no longer work in this area academically. As such, our philosophy is to target important conditions of human and animal health, to develop novel materials and biomolecules to address them, and to investigate interesting biological questions with the tools that we develop along the way. Approximately 40% of the laboratory is focused on protein engineering in regenerative medicine, 40% on materials and protein engineering in immunotherapeutics, and the remainder on other topics in biomaterials engineering and drug delivery. More information about our research can be found on our group’s home page at Http://lmrp.epfl.ch
BIOGRAPHY
EDUCATION
Ph.D. Chemical Engineering, Rice University, 1986 (Mentor: Larry V. McIntire)
B.S. Chemical Engineering, Kansas State University, 1982


EXPERIENCE
2004-Present Professor, Institute of Bioengineering (Faculty of Life Sciences and Faculty of Engineering) and the Institute of Chemical Sciences and Technology (Faculty of Basic Sciences);
Director, Institute of Bioengineering (http://ibi.epfl.ch)
1997-2003 Professor of Biomedical Engineering in the Department of Materials (ETH) and the Faculty of Medicine (University of Zurich); Director, Institute for Biomedical Engineering (ETH and Univ. Zurich)
1995-1997 Professor of Chemical Engineering, California Institute of Technology
1991-1994 Associate Professor of Chemical Engineering, University of Texas
1986-1991 Assistant Professor of Chemical Engineering, University of Texas



EDITORIAL ACTIVITIES
Associate Editor, Journal of Biomaterials Science, Polymer Edition Board of Reviewing Editors, Science
Editorial Board, Annals of Biomedical Engineering
Editorial Board, Acta Biomaterialia
Editorial Board, Biomacromolecules
Editorial Board, Cell Transplantation
Editorial Board, Journal of Controlled Release
Editorial Board, Journal of Polymer Science
Editorial Board, European Journal of Pharmaceutics and Biopharmaceutics


AWARDS AND HONORS
2010 Elected to National Academy of Engineering, USA
2008 Alpha Chi Sigma Award, American Institute of Chemical Engineers
2008 Food, Pharmaceutical and Bioengineering Award, American Institute of
Chemical Engineers
2008 Merck-Serono Chair in Drug Delivery
2007 Distinguished Alumnus Award, Rice University
2006 Gordon Conference, Biointerface Science, Co-founder and Chair
2006 George Winter Award, European Society for Biomaterials
2004 Gaden Award, John Wiley and Sons, and the American Chemical Society
2002 Körber Foundation Award for European Science
2002 Distinguished Lecturer, Institute for Biosciences and Bioengineering, Rice University
2002 Benjamin Zweifach Lecturer, University of California San Diego
2001 Skinner Lecturer, Northwestern University
2000 Elected Fellow of Biomaterials Science and Engineering
2000 Elected Fellow of the American Association for the Advancement of Science
2000 Distinguished Lecturer, Massachusetts Institute of Technology, Department of Materials Science and Engineering
1999 Britton Chance Lecturer, University of Pennsylvania
1996 Clemson Award for Applied Research, Society for Biomaterials
1996 Chair, Keystone Symposium on Tissue Engineering
1995 Elected Fellow, American Institute of Medical and Biological Engineering
1993-5 Gordon Conference, Biocompatibility of Biomaterials, Vice Chair, Chair 1995-7
1992 W.J. Kolff Award for Outstanding Research, Am. Soc. Artif. Intern. Organs
1991 American Society of Engineering Education Dow Outstanding Young Faculty Award
1991 Department of Chemical Engineering Teaching Award
1990 National Science Foundation Presidential Young Investigator Award
1990 College of Engineering Award for Outstanding Teaching by an Assistant Professor
1988 National Institutes of Health, First Independent Research Support and Transition Award
1988 Department of Chemical Engineering Teaching Award
1988 Dow Chemical Company Junior Faculty Award
1988 University of Texas College of Engineering, Faculty Leadership Award
1986 Outstanding Dissertation in Chemical Engineering, Rice University
1982 Atlantic Richfield Company Fellow, Rice University




MAIN PUBLICATIONS

I. Kourtis, M. Swartz, and J. A. Hubbell. Therapeutic Immunomodulation of the Lymphoidlike Tumor Micro/macro Environment Using Nanoparticulate Formulations. PhD thesis, Lausanne, 2012. [ DOI | Details | Link ]

K. M. Lorentz, L. Yang, P. Frey, and J. A. Hubbell. Engineered insulin-like growth factor-1 for improved smooth muscle regeneration. Biomaterials, 33(2):494-503, 2012. [ Details | Full Text ]

K. M. Lorentz, L. Yang, P. Frey, and J. A. Hubbell. Engineered insulin-like growth factor-1 for improved smooth muscle regeneration. Biomaterials, 33:494-503, 2012. [ DOI | Details | Full Text ]

T. P. Kraehenbuehl, L. S. Ferreira, A. M. Hayward, M. Nahrendorf, A. J. van der Vlies, E. Vasile, R. Weissleder, R. Langer, and J. A. Hubbell. Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction. Biomaterials, 32:1102-1109, 2011. [ DOI | Details ]

J. Patterson and J. A. Hubbell. SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels. Biomaterials, 32:1301-1310, 2011. [ DOI | Details ]

S. S. Yu, R. L. Scherer, R. A. Ortega, C. S. Bell, C. P. O'Neil, J. A. Hubbell, and T. D. Giorgio. Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs). Journal Of Nanobiotechnology, 9:-, 2011. [ DOI | Details ]

E.-M. Engelhardt, L. A. Micol, S. Houis, F. M. Wurm, J. Hilborn, J. A. Hubbell, and P. Frey. A collagen-poly(lactic acid-co-epsilon-caprolactone) hybrid scaffold for bladder tissue regeneration. Biomaterials, 32:3969-3976, 2011. [ DOI | Details ]

J. A. Hubbell. Engineering Peptide and Protein Domain-Based Biofunctional Materials. In Biopolymers, volume 96, pages 411-411, 2011. [ Details ]

S. A. Eming and J. A. Hubbell. Extracellular matrix in angiogenesis: dynamic structures with translational potential. Experimental Dermatology, 20:605-613, 2011. [ DOI | Details ]

C. Nembrini, A. Stano, K. Y. Dane, M. Ballester, A. J. van der Vlies, B. J. Marsland, M. A. Swartz, and J. A. Hubbell. Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination. Proceedings Of The National Academy Of Sciences Of The United States Of America, 108:E989-E997, 2011. [ DOI | Details ]

D. Velluto, S. N. Thomas, E. Simeoni, M. A. Swartz, and J. A. Hubbell. PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: Tumor immunotoxicity in B16F10 melanoma. Biomaterials, 32:9839-9847, 2011. [ DOI | Details ]

M. M. Martino, F. Tortelli, M. Mochizuki, S. Traub, D. Ben-David, G. A. Kuhn, R. Müller, E. Livne, S. A. Eming, and J. A. Hubbell. Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing. Science translational medicine, 3(100):100ra89, 2011. [ DOI | Details ]

R. B. Pisarek and J. A. Hubbell. New/Surface-Modified Biocompatible Polymer for ICD Lead Insulation. PhD thesis, Lausanne, 2011. [ DOI | Details | Full Text | Link ]

M. Ballester, C. Nembrini, N. Dhar, A. de Titta, C. de Piano, M. Pasquier, E. Simeoni, A. J. van der Vlies, J. D. McKinney, J. A. Hubbell, and M. A. Swartz. Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis. Vaccine, 29(40):6959-66, 2011. [ DOI | Details ]

L. A. Micol, J. A. Hubbell, and P. Frey. Hydrogels for Urinary Tract Tissue Engineering. PhD thesis, Lausanne, 2011. [ DOI | Details | Link ]

S. Kontos and J. A. Hubbell. Engineering Erythrocyte Affinity for Improved Pharmacokinetics and Immune Tolerogenesis. PhD thesis, Lausanne, 2011. [ DOI | Details | Full Text | Link ]

K. Lorentz, J. A. Hubbell, and P. Frey. Biofunctional Scaffold Design for Soft Tissue Regeneration. PhD thesis, Lausanne, 2011. [ DOI | Details | Full Text | Link ]

L. A. Micol, M. Ananta, E.-M. Engelhardt, V. C. Mudera, R. A. Brown, J. A. Hubbell, and P. Frey. High-density collagen gel tubes as a matrix for primary human bladder smooth muscle cells. Biomaterials -Guildford-, 32(6):1543-1548, 2011. [ DOI | Details | Full Text ]

M. Martino and J. A. Hubbell. Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration. PhD thesis, Lausanne, 2011. [ DOI | Details | Full Text | Link ]

S. Thomas, A. Van der Vlies, C. O'Neil, S. Reddy, S. S. Yu, T. D. Giorgio, M. Swartz, and J. A. Hubbell. Engineering complement activation on polypropylene sulfide vaccine nanoparticles. Biomaterials, 32(8):2194-203, 2011. [ DOI | Details ]

A. Stano, A. J. van der Vlies, M. M. Martino, M. A. Swartz, J. A. Hubbell, and E. Simeoni. PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration. Vaccine, 29(4):804-12, 2011. [ DOI | Details ]

D. Meo, E. Maria, A. Di Crescenzo, D. Velluto, C. P. O'Neil, D. Demurtas, J. A. Hubbell, and A. Fontana. Assessing the Role of Poly(ethylehe glycol-bl-propylene sulfide) (PEG-PPS) Block Copolymers in the Preparation of Carbon Nanotube Biocompatible Dispersions. Macromolecules, 43:3429-3437, 2010. [ DOI | Details ]

A. J. van der Vlies, C. P. O'Neil, U. Hasegawa, N. Hammond, and J. A. Hubbell. Synthesis of Pyridyl Disulfide-Functionalized Nanoparticles for Conjugating Thiol-Containing Small Molecules, Peptides, and Proteins. Bioconjugate Chemistry, 21:653-662, 2010. [ DOI | Details ]

D. Missirlis and J. A. Hubbell. In vitro uptake of amphiphilic, hydrogel nanoparticles by J774A.1 cells. Journal Of Biomedical Materials Research Part A, 93A:1557-1565, 2010. [ DOI | Details ]

J. A. Hubbell. Morphogen And Material Engineering In Regenerative Medicine. In Wound Repair And Regeneration, volume 18, pages A72-A72, 2010. [ Details ]

A. M. Popa, S. Angeloni, T. Buergi, J. A. Hubbell, H. Heinzelmann, and R. Pugin. Dynamic Perspective on the Function of Thermoresponsive Nanopores from in Situ AFM and ATIZ-IR Investigations. Langmuir, 26:15356-15365, 2010. [ DOI | Details ]

J. A. Hubbell. DRUG DEVELOPMENT Longer-lived proteins. Nature, 467:1051-1052, 2010. [ Details ]

U. Hasegawa, V. der Vlies, J. André, E. Simeoni, C. Wandrey, and J. A. Hubbell. Carbon Monoxide-Releasing Micelles for Immunotherapy. J. Am. Chem. Soc., 132(51):18273-18280, 2010. [ DOI | Details | Full Text ]

C. Wandrey, U. Hasegawa, A. J. van der Vlies, C. O'Neil, N. Angelova, and J. A. Hubbell. Analytical ultracentrifugation to support the development of biomaterials and biomedical devices. Methods, Epub ahead of print, 2010. [ DOI | Details | Link ]

S. Hirosue, I. Kourtis, A. Van der Vlies, J. A. Hubbell, and M. Swartz. Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation. Vaccine -Guildford then London then Oxford-, 28(50):7897-906, 2010. [ DOI | Details ]

A. Di Crescenzo, D. Velluto, J. A. Hubbell, and A. Fontana. Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs. Nanoscale, Epub ahead of print, 2010. [ DOI | Details ]

A. Di Crescenzo, D. Velluto, J. A. Hubbell, and A. Fontana. Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs. Nanoscale, Epub ahead of print, 2010. [ DOI | Details ]

M. M. Martino and J. A. Hubbell. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(12):4711-21, 2010. [ DOI | Details ]

A. Vasdekis, J. Cuennet, W. Song, J.-W. Choi, L. De Sio, C. O'Neil, J. Hubbell, and D. Psaltis. Surface optofluidics. In Proceedings of SPIE - The International Society for Optical Engineering, volume 7762 of Proceedings of SPIE-The International Society for Optical Engineering, page null. Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa, 2010. [ DOI | Details ]

A. Vasdekis, C. O'Neil, J. Hubbell, and D. Psaltis. Microfluidic assays for DNA manipulation based on a block copolymer immobilization strategy. Biomacromolecules, 11(3):827-831, 2010. [ DOI | Details | Full Text ]

S. Metzger and J. A. Hubbell. Designing a new approach for the engineering of fibrin-binding proteins using naturally-occuring binding peptide sequences. Laboratory for Regenerative Medicine & Pharmacobiology, EPFL, 2010. [ Details ]

A. P. Leonidova, J. A. Hubbell, U. Hasegawa, and A. Chilkoti. Carbon monoxide releasing micelles for drug delivery application. GR-53 646; EPFL - SV - IBI-SV - LMRP, 2010. [ Details ]

Z. Julier and J. A. Hubbell. Evaluation of the potential of the extra domain a of fibronectin as an adjuvant. Laboratory for Regenerative Medicine & Pharmacobiology, Institute of Bioengineering, EPFL, 2010. [ Details ]

K. Javor and J. A. Hubbell. Biomimetic matrices for controlling cell differentiation. 2010. [ Details ]

S. T. Lee, J. I. Yun, Y. S. Jo, M. Mochizuki, V. D. Vlies, J. André, S. Kontos, J. E. Ihm, J. M. Lim, and J. A. Hubbell. Engineering integrin signaling for promoting embryonic stem cell self-renewal in a precisely defined niche. Biomaterials, 31(6):1219-1226, 2010. [ DOI | Details | Full Text ]

K. M. Lorentz, S. Kontos, P. Frey, and J. A. Hubbell. Engineered aprotinin for improved stability of fibrin biomaterials. Biomaterials, 2010. [ DOI | Details | Full Text ]

L. Lavanant, B. Pullin, J. A. Hubbell, and H.-A. Klok. A facile strategy for the modification of polyethylene substrates with non-fouling, bioactive poly(poly(ethylene glycol) methacrylate) brushes. Macromolecular bioscience, 10(1):101-8, 2010. [ DOI | Details ]

S. Kontos and J. A. Hubbell. Improving Protein Pharmacokinetics by Engineering Erythrocyte Affinity. Molecular Pharmaceutics, page 100917154754042, 2010. [ DOI | Details | Full Text ]

K. Bott, Z. Upton, K. Schrobback, M. Ehrbar, J. A. Hubbell, M. Lutolf, and S. Rizzi. The effect of matrix characteristics on fibroblast proliferation in 3D gels. Biomaterials -Guildford-, 2010. [ DOI | Details | Full Text ]

J. Patterson and J. A. Hubbell. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials, 2010. [ DOI | Details ]

J. Patterson, M. Martino, and J. A. Hubbell. Biomimetic materials in tissue engineering. Materials Today, 13(1):14-22, 2010. [ DOI | Details ]

P. Ramseyer, L. A. Micol, E.-M. Engelhardt, M.-C. Osterheld, J. A. Hubbell, and P. Frey. In vivo study of an injectable poly(acrylonitrile)-based hydrogel paste as a bulking agent for the treatment of urinary incontinence. Biomaterials, 31(17):4613-4619, 2010. [ DOI | Details ]

A. Mercanzini, S. T. Reddy, D. Velluto, P. Colin, A. Maillard, J.-C. Bensadoun, J. A. Hubbell, and P. Renaud. Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses. Journal of Controlled Release, 145(3):196-202, 2010. [ DOI | Details | Full Text ]

E.-M. Engelhardt, E. Stegberg, R. A. Brown, J. A. Hubbell, F. M. Wurm, M. Adam, and P. Frey. Compressed collagen gel: a novel scaffold for human bladder cells. Journal of Tissue Engineering and Regenerative Medicine, 4(2):123-130, 2010. [ DOI | Details ]

Y. S. Jo, A. J. van der Vlies, J. Gantz, T. N. Thacher, S. Antonijevic, S. Cavadini, D. Demurtas, N. Stergiopulos, and J. A. Hubbell. Micelles for delivery of nitric oxide. Journal of the American Chemical Society, 131(40):14413-8, 2009. [ DOI | Details ]

J. P. Bearinger, G. Stone, A. L. Hiddessen, L. C. Dugan, L. Wu, P. Hailey, J. W. Conway, T. Kuenzler, L. Feller, S. Cerritelli, and J. A. Hubbell. Phototocatalytic Lithography of Poly(propylene sulfide) Block Copolymers: Toward High-Throughput Nanolithography for Biomolecular Arraying Applications. Langmuir, 25:1238-1244, 2009. [ DOI | Details ]

M. M. Martino, M. Mochizuki, D. A. Rothenfluh, S. A. Rempel, J. A. Hubbell, and T. H. Barker. Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials, 30:1089-1097, 2009. [ DOI | Details ]

A. R. Lowery, A. Finka, D. C. Dorset, J. A. Hubbell, and T. D. Giorgio. Novel 7-mer peptide mediates nuclear targeting in MCF7 breast cancer cells. In Cancer Research, volume 69, pages 354S-354S, 2009. [ Details ]

I. Arrighi, S. Mark, M. Alvisi, B. von Rechenberg, J. A. Hubbell, and J. C. Schense. Bone healing induced by local delivery of an engineered parathyroid hormone prodrug. Biomaterials, 30:1763-1771, 2009. [ DOI | Details ]

J. P. Bearinger, L. C. Dugan, L. Wu, H. Hill, A. T. Christian, and J. A. Hubbell. Chemical tethering of motile bacteria to silicon surfaces. Biotechniques, 46:209-+, 2009. [ DOI | Details ]

D. A. Rothenfluh, M. Martino, and J. Hubbell. Recombinant FGF-18 with a collagen II binding domain prevents cartilage degeneration in mice over five weeks after two intra-articular injections. In Swiss Medical Weekly, volume 139, pages 24S-24S, 2009. [ Details ]

R. Pugin, N. Blondiaux, A. M. Popa, P. Niedermann, M. Liley, M. Giazzon, N. Matthey, J. A. Hubbell, and H. Heinzelmann. Surface Nanopatterning by Polymer Self-Assembly: from Applied Research to Industrial Applications. Journal Of Photopolymer Science And Technology, 22:223-228, 2009. [ DOI | Details ]

D. A. Rothenfluh and J. A. Hubbell. Integration column: Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications. Integrative Biology, 1:446-451, 2009. [ DOI | Details ]

C. P. O'Neil, T. Suzuki, D. Demurtas, A. Finka, and J. A. Hubbell. A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration. Langmuir, 25:9025-9029, 2009. [ DOI | Details ]

J. P. Bearinger, G. Stone, L. C. Dugan, B. El Dasher, C. Stockton, J. W. Conway, T. Kuenzler, and J. A. Hubbell. Porphyrin-based Photocatalytic Nanolithography A NEW FABRICATION TOOL FOR PROTEIN ARRAYS. Molecular & Cellular Proteomics, 8:1823-1831, 2009. [ DOI | Details ]

T. P. Kraehenbuehl, L. S. Ferreira, P. Zammaretti, J. A. Hubbell, and R. Langer. Cell-responsive hydrogel for encapsulation of vascular cells. Biomaterials, 30:4318-4324, 2009. [ DOI | Details ]

S. Cerritelli, C. P. O'Neil, D. Velluto, A. Fontana, M. Adrian, J. Dubochet, and J. A. Hubbell. Aggregation Behavior of Poly(ethylene glycol-bl-propylene sulfide) Di- and Triblock Copolymers in Aqueous Solution. Langmuir, 25:11328-11335, 2009. [ DOI | Details ]

E. Guc, C.-L. E. Helm, D. Foretay, M. Pasquier, W. Kilarski, A. H. Zisch, J. A. Hubbell, and M. A. Swartz. Engineered fibrin-binding VEGF-C variant promotes lymphangiogenesis in vitro and in vivo in a dermal wound healing model. In Journal Of Vascular Research, volume 46, pages 43-43, 2009. [ Details ]

A.-M. Popa, P. Niedermann, H. Heinzelmann, J. A. Hubbell, and R. Pugin. Fabrication of nanopore arrays and ultrathin silicon nitride membranes by block-copolymer-assisted lithography. Nanotechnology, 20:-, 2009. [ DOI | Details ]

J. A. Hubbell, S. N. Thomas, and M. A. Swartz. Materials engineering for immunomodulation. Nature, 462:449-460, 2009. [ DOI | Details | Full Text ]

T. Wills and J. A. Hubbell. Study of loading and delivery of drugs from various hydrogel matrices for orthopaedic applications. Kuros Biosurgery AG, Zürich; Laboratoire de Médecine Régénérative et de Pharmacobiologie (LMRP), EPFL, 2009. [ Details ]

K. Ciapala and J. A. Hubbell. A new non-toxic chemically cross-linked ELP hydrogel for in situ protein delivery. Laboratory for Biologically Inspired Materials and Material Systems, Duke University, Durham NC, USA; Laboratory for Regenerative Medicine & Pharmacobiology, EPFL, 2009. [ Details ]

E. Nguyen and J. A. Hubbell. Nitric oxide release from Polydimethylsiloxane-based Polyurethanes. Cardiovascular Research Unit, University of Cape Town, Cape Town - South Africa; Institute of Bioengineering, EPFL, 2009. [ Details ]

c. Hasselmann and J. A. Hubbell. Isolation and characterisation of a porcine cardiac adherent cell population from heart biopsies. Tissue Engineering Laboratory, Charité-Universitätsmedizin, Berlin (DE); Regenerative Medicine and Pharmacobiology Laboratory, SV/SB/STI, EPFL, Lausanne (CH), 2009. [ Details | Link ]

A. Gaussin, J. A. Hubbell, and N. Mermod. Identification of genetic insulator elements to increase the safety of viral gene therapy vectors. PhD thesis, Lausanne, 2009. [ DOI | Details | Full Text | Link ]

S. de Picciotto and J. A. Hubbell. HER receptor dimerization controlled with bivalent ligands. Griffith Laboratory, Massachusetts Institute of Technology (MIT), Cambridge (USA); Laboratory for Regenerative Medicine & Pharmacobiology (LMRP), SV/SB/STI, EPFL, Lausanne (CH), 2009. [ Details ]

R. Luisier and J. A. Hubbell. Mathematical modeling of the re-epithelialization of a 3 dimensional (3d) human skin equivalent. Laboratory of Cells and Tissue, Queensland University of Technology, Brisbane (AU); Laboratoire de Medecine Régénérative et Pharmacobiologie (LMRP), SV/SB/STI, EPFL (CH), 2009. [ Details ]

T. Razafiarison and J. A. Hubbell. Understanding effect of network structure of PolyEthylene Glycol Diacrylate hydrogels on cellular activities using bovine chondrocytes as a model system. Department of Bioengineering: Biomaterials and Stem Cell Engineering, University of California, San Diego (USA); Laboratory for Regenerative Medicine & Pharmacobiology (LMRP), SV/SB/STI, EPFL, Lausanne (CH), 2009. [ Details ]

J. Kerschgens, J. A. Hubbell, and N. Mermod. Protein-binding microarray technology and ChIP-sequencing for the identification of novel targets of the human tumor suppressor AP2[alpha]. PhD thesis, Lausanne, 2009. [ DOI | Details | Full Text | Link ]

D. A. Rothenfluh and J. A. Hubbell. Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage. PhD thesis, Lausanne, 2009. [ DOI | Details | Full Text | Link ]

C. P. ONeil, A. J. van der Vlies, D. Velluto, C. Wandrey, D. Demurtas, J. Dubochet, and J. A. Hubbell. Extracellular matrix binding mixed micelles for drug delivery applications. JOURNAL OF CONTROLLED RELEASE, 137:146-151, 2009. [ DOI | Details | Link ]

S. J. Jo, S. C. Rizzi, M. Ehrbar, F. E. Weber, J. A. Hubbell, and M. P. Lutolf. Biomimetic PEG hydrogels crosslinked with minimal plasmin-sensitive tri-amino acid peptides. Journal of Biomedical Materials Research Part A, 93A(3):870 - 877, 2009. [ DOI | Details | Full Text | Link ]

L. Yang and J. A. Hubbell. Rat bladder muscle regeneration induced by local delivery of an engineered insulin-like growth factor 1 in fibrin gels. PhD thesis, Lausanne, 2009. [ DOI | Details | Full Text | Link ]

C. Adelöw, J. A. Hubbell, and P. Frey. Tissue engineering of the bladder. PhD thesis, Lausanne, 2009. [ DOI | Details | Full Text | Link ]

T. Krähenbühl, J. A. Hubbell, and R. S. Langer. Stem cell-based cardiovascular tissue engineering. PhD thesis, Lausanne, 2009. [ DOI | Details | Full Text | Link ]

A. M. Popa, J. A. Hubbell, and R. Pugin. Stimuli-responsive nanostructured surfaces. PhD thesis, Lausanne, 2009. [ DOI | Details | Full Text | Link ]

Y. S. Jo, J. Gantz, J. A. Hubbell, and M. P. Lutolf. Tailoring hydrogel degradation and drug release via neighboring amino acid-controlled ester hydrolysis. Soft Matter, 5:440 - 446, 2009. [ DOI | Details | Link ]

J. E. Ihm and J. A. Hubbell. Development of an in vitro microenvironment for maturing oocytes. PhD thesis, Lausanne, 2009. [ DOI | Details | Full Text | Link ]

C. v. Blitterswijk and J. A. Hubbell. Controlled release strategies in tissue engineering. In Tissue engineering, pages 455-482. Academic Press, London, 2008. [ Details ]

J. Salaklang, B. Steitz, A. Finka, C. P. O'Neil, M. Moniatte, A. J. van der Vlies, T. Giorgio, H. Hofmann, J. A. Hubbell, and A. Petri-Fink. Superparamagnetic Nanoparticles as a Powerful Systems Biology Characterization Tool in the Physiological Context. Angewandte Chemie, 47:7857 -7860, 2008. [ DOI | Details | Full Text ]

M. M. Martino, M. Mochizuki, D. A. Rothenfluh, S. A. Rempel, J. A. Hubbell, and T. H. Barker. Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials, 30(6):1089-97, 2008. [ DOI | Details ]

C. Adeloew, T. Segura, J. A. Hubbell, and P. Frey. The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype. Biomaterials, 29:314-326, 2008. [ DOI | Details ]

I. R. Degano, M. Vilalta, J. R. Bago, A. M. Matthies, J. A. Hubbell, H. Dimitriou, P. Bianco, N. Rubio, and J. Blanco. Bioluminescence imaging of calvarial bone repair using bone marrow and adipose tissue-derived mesenchymal stem cells. Biomaterials, 29:427-437, 2008. [ DOI | Details ]

Y. S. Jo, A. J. van der Vlies, J. Gantz, S. Antonijevic, D. Demurtas, D. Velluto, and J. A. Hubbell. RAFT homo- and copolymerization of N-acryloyl-morpholine, piperidine, and azocane and their self-assembled structures. Macromolecules, 41:1140-1150, 2008. [ DOI | Details ]

M. Ehrbar, S. M. Zeisberger, G. P. Raeber, J. A. Hubbell, C. Schnell, and A. H. Zisch. The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis. Biomaterials, 29:1720-1729, 2008. [ DOI | Details ]

D. A. Rothenfluh, H. Bermudez, C. P. O'Neil, and J. A. Hubbell. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nature Materials, 7:248-254, 2008. [ DOI | Details ]

M. Ehrbar, M. P. Luetolf, S. C. Rizzi, J. A. Hubbell, and F. E. Weber. Artificial extracellular matrices for bone tissue engineering. In Bone, volume 42, pages S72-S72, 2008. [ DOI | Details ]

A. Rehor, H. Schmoekel, N. Tirelli, and J. A. Hubbell. Functionalization of polysulfide nanoparticles and their performance as circulating carriers. Biomaterials, 29:1958-1966, 2008. [ DOI | Details ]

S. Cerritelli, D. Velluto, J. A. Hubbell, and A. Fontana. Breakdown kinetics of aggregates from poly(ethylene glycol-bl-propylene sulfide) di- and triblock copolymers induced by a non-ionic surfactant. Journal Of Polymer Science Part A-Polymer Chemistry, 46:2477-2487, 2008. [ DOI | Details ]

J. P. Bearinger, G. Stone, A. T. Christian, L. Dugan, A. L. Hiddessen, K. J. J. Wu, L. Wu, J. Hamilton, C. Stockton, and J. A. Hubbell. Porphyrin-based photocatalytic lithography. Langmuir, 24:5179-5184, 2008. [ DOI | Details ]

L. A. Micol, M. Ananta, V. Mudera, J. A. Hubbell, R. A. Brown, and P. Frey. Novel cell-seeded, tubular-shaped and highly dense collagen gel for tissue engineering. In Tissue Engineering Part A, volume 14, pages 888-888, 2008. [ Details ]

K. M. Lorentz, P. Frey, and J. A. Hubbell. Expression and purification of recombinant aprotinin for enhanced stability of fibrin biomaterials. In Tissue Engineering Part A, volume 14, pages 852-852, 2008. [ Details ]

C. Adeloew, T. Segura, J. A. Hubbell, and P. Frey. Bioactive poly(ethylene glycol) hydrogels for modulation of the smooth muscle cell phenotype. In Tissue Engineering Part A, volume 14, pages 811-811, 2008. [ Details ]

F. E. Weber, M. P. Lutolf, S. Rizzi, J. A. Hubbell, and M. Ehrbar. Synthetic fibrin-like matrix for bone tissue engineering. In Tissue Engineering Part A, volume 14, pages 784-784, 2008. [ Details ]

L. R. Yang, P. Frey, T. H. Barker, and A. Hubbell. Fibrin delivery systems for elastic tissue regeneration. In Tissue Engineering Part A, volume 14, pages 736-737, 2008. [ Details ]

Teaching
Life Sciences and Technologies

Phd programs
Phd Students
Ballester Marie
Ciapala Karine
Damo Martina
Eby Jackson
Jeanbart Laura
Julier Ziad
Kiveliö Anna-Sofia Johanna
Kourtis Iraklis Thesis details
Larsson Hans Mattias
Metzger Stéphanie Elisabeth
Panagiotou Vasiliki
Raghunathan Sandeep
Stano Armando
Vardar Elif
de Titta Alexandre


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