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João Miguel das Neves Duarte
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office(s):
CHF1625
phone(s): [+41 21 69] 37681
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BIOGRAPHY
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February 2009
Ph.D. in Biochemistry (speciality in Bioenergetics), University of Coimbra, Portugal.
Thesis: “Beneficial effects of caffeine consumption on diabetes-induced alterations in the hippocampus”.
July 2004
B.Sc. in Biochemistry, University of Lisbon, Portugal.
Thesis: “Relation between metabolism and neuromodulation by adenosine”.
curriculum vitae
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RESEARCH INTERESTS
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Cerebral injury and cognitive decline upon metabolic insults such as hyperglycaemia, hypoglycaemia, hypoxia and redox deregulation, and disorders like diabetes mellitus.
Metabolic features of neuromodulation and neuroprotection in the central nervous system.
Intermediary metabolism studied by nuclear magnetic resonance techniques and mathematical modelling of metabolic processes.
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RECENT WORK
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Duarte JMN, Kulak A, Gholam-Razaee MM, Cuenod MR, Gruetter R, Do KQ (2012) “N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development”. Biological Psychiatry. article here
Duarte JMN, Kulak A, Gruetter R, Do KQ, “Metabolic alterations in the cortex of a mouse model with glutathione deficit – relevance to schizophrenia”, Schizophrenia research 117 (2-3) (2010), 201. abstract
Duarte JMN, Gruetter R, “Dynamics of cerebral glucose analysed in vivo with a four-state conformational model”, ISMRM 19th Scientific Meeting & Exibition, Montréal, Québec, Canada, May 7-13, 2011; Proc Intl Soc Mag Reson Med 19 (2011), 4175.
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SELECTED PUBLICATIONS
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Duarte JMN, Gruetter R (2012) “Cerebral glucose transport and homeostasis”, in Neural Metabolism In Vivo (Choi I-Y and Gruetter R, eds.), Springer.
Duarte JMN, Lei H, Mlynárik V, Gruetter R (2012) “The neurochemical profile quantified by in vivo 1H NMR spectroscopy”. NeuroImage in press
Duarte JMN, Ferreira SG, Carvalho RA, Cunha RA, Köfalvi A (2012) “CB1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus”. Neurochemistry International 60(1), 1-8. article here
Duarte JMN, Lanz B, Gruetter R (2011) “Compartmentalised cerebral metabolism of [1,6-13C]glucose determined by in vivo 13C NMR spectroscopy at 14.1 T”. Frontiers in Neuroenergetics 3, 3. free online
Kulak A, Duarte JMN, Do KQ, Gruetter R (2010) “Neurochemical profile of the developing mouse cortex determined by in vivo 1H NMR spectroscopy at 14.1 T and the effect of recurrent anaesthesia”. Jounal of Neurochemistry 115, 1466-1477.
Duarte JMN, Morgenthaler FD, Lei H, Poitry-Yamate C, Gruetter R (2009) “Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational model”. Frontiers in Neuroenergetics 1, 6. free online
Duarte JMN, Carvalho RA, Cunha RA, Gruetter R (2009) “Glucose transport and neurochemical profile in the hippocampus of streptozotocin-induced diabetic rats - effect of caffeine consumption”. Journal of Neurochemistry 111(2), 368-379.
Duarte JMN, Oses JP, Rodrigues RJ, Cunha RA (2007) “Modification of purinergic signalling in the hippocampus of streptozotocin-induced diabetic rats”. Neuroscience 149(2), 382-391.
Duarte JMN, Nogueira C, Mackie K, Oliveira CR, Cunha RA, Köfalvi A (2007) “Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats”. Experimental Neurology 204(1), 479-484.
Duarte JMN, Cunha RA, Carvalho RA (2007) “Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy”. Neuroscience 144(4), 1305-1313.
Duarte JMN, Oliveira CR, Ambrósio AF, Cunha RA (2006) “Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats”, Neurochemistry International 48(2), 144-150.
Publication list in Pubmed
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