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Karl Gademann
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SCGC - Teaching
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BIOGRAPHY
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Karl Gademann was born in Zurich, Switzerland (June 1972). His interest in chemistry was fueled by an internship in the process research group at CILAG pharmaceuticals from 1991-1992. This then led him to study chemistry at ETH Zurich from 1992 to 1996 working as an undergraduate with Prof. Dr. Steven A. Benner and Prof. Dr. Dieter Seebach. Shortly after the diploma thesis, he joined the group of Prof. Dr. Dieter Seebach carrying out graduate studies for which he got the doctorate awarded in 2000.
A first postdoctoral appointment was at Givaudan Fragrance Research. He then moved to Harvard University (2000-2001), where he was a postdoctoral fellow working in the group of Prof. Dr. Eric N. Jacobsen. In January 2002, Karl Gademann started his independent research (habilitation associated with Prof. Dr. Erick M. Carreira) at ETH Zurich and received the venia legendi in 2006. He moved in October 2006 to EPF Lausanne, where he founded the Chemical Synthesis Laboratory.
His research interests are located at the interface of chemistry and biology, where fundamental problems in science are investigated using synthetic natural products. The research group is thus working on the total synthesis of natural products, their isolation from natural sources (bioprospecting) and is carrying out in vivo biological investigations.
Karl Gademann received several awards (A. F. Schläfli Prize 2006, Lilly Lecture Award 2005, Latsis Prize ETH 2004), most recently the prestigious European Young Investigator Award (EURYI) 2007, and the research on nostocarboline received global media coverage in 2006. He is a member of several professional societies, the editorial board of CHIMIA and was recently elected in the presidency of the platform chemistry of the Swiss Academy of Sciences.
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KEY PUBLICATIONS
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For a complete list of publications, see ResearcherID.com or Pubmed.
55. Henning J. Jessen, Damien Barbaras, Matthias Hamburger, Karl Gademann
Total Synthesis and Neuritotrophic Activity of Farinosone C and Derivatives
Org. Lett. 2009, 11, 3446-3449. Abstract/Fulltext>>
54. William Okello, Cyril Portmann, Marcel Erhard, Karl Gademann, Rainer Kurmayer
Occurrence of Microcystin-Producing Cyanobacteria in Ugandan Freshwater Habitats
Environmental Toxicology 2009, published online. Abstract/Fulltext>>
50. Cyril Portmann, Cora Prestinari, Theresa Myers, Judith Scharte, Karl Gademann
Directed Biosynthesis of Phytotoxic Alkaloids in Nostoc 78-12A
ChemBioChem 2009, 10, 889-895. Abstract/Fulltext>>
49. Cyril Portmann, Judith F. Blom, Marcel Kaiser, Reto Brun, Friedrich Jüttner, Karl Gademann
Isolation of Aerucyclamides C and D and Structure Revision of Microcyclamide 7806A: Heterocyclic Ribosomal Peptides from Microcystis aeruginosa PCC 7806 and their Antiparasite Evaluation
J. Nat. Prod. 2008, 71, 1891-1896. Abstract/Fulltext>>
48. Guntram Christiansen, Wesley Yoshida, Judith F. Blom, Cyril Portmann, Karl Gademann, Thomas Hemscheidt, Rainer Kurmayer
Isolation and Structure Determination of Two Microcystins and Sequence Comparisons of the McyABC Adenylation Domains in Planktothrix species
J. Nat. Prod. 2008, 71, 1881-1886. Abstract/Fulltext>>
47. Jean-Yves Wach, Barbora Malisova, Simone Bonazzi, Samuele Tosatti, Marcus Textor, Stefan Zürcher, Karl Gademann
Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization
Chem Eur. J. 2008, 14, 10579-10584. Abstract/Fulltext>>
46. Damien Barbaras and Karl Gademann
Stable Beta Turns of Tripeptides in Water through Cation-Pi Interactions
ChemBioChem 2008, 9, 2398-2401.Abstract/Fulltext>>
45. Jean-Yves Wach, Simone Bonazzi, Karl Gademann
Antimicrobial Surfaces Through Natural Product Hybrids
Angew. Chem. 2008, 120, 7232-7235; Angew. Chem. Int. Ed. 2008, 47, 7123-7126. Abstract/Fulltext>>
44. Damien Barbaras, Marcel Kaiser, Reto Brun, Karl Gademann
Potent and Selective Antiplasmodial Activity of the Cyanobacterial Alkaloid Nostocarboline and its Dimers
Bioorg. Med. Chem. Lett. 2008, 18, 4413-4415. Abstract/Fulltext>>
43. Cyril Portmann, Judith F. Blom, Karl Gademann, Friedrich Jüttner
Aerucyclamides A and B: Isolation and Synthesis of Toxic Ribosomal Heterocyclic Peptides from the Cyanobacterium Microcystis aeruginosa PCC 7806
J. Nat. Prod. 2008, 71, 1193-1196. Abstract/Fulltext>>
42. Simone Bonazzi, Stephan Güttinger, Ivo Zemp, Ulrike Kutay, Karl Gademann
Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C
Angew. Chem. Int. Ed. 2007, 46, 8707-8710. Abstract/Fulltext
41. Karl Gademann, Yann Bethuel, Hans H. Locher, Christian Hubschwerlen
Biomimetic Total Synthesis and Antimicrobial Evaluation of Anachelin
J. Org. Chem. 2007, 72, 8361-8370. Abstract/Fulltext
30. Stefan Zürcher, David Wäckerlin, Yann Bethuel, Barbora Malisova, Marcus Textor, Samuele Tosatti and Karl Gademann
Biomimetic Surface Modifications Based on the Cyanobacterial Iron Chelator Anachelin
J. Am. Chem. Soc. 2006, 128, 1064-1065. Abstract/Fulltext>>
29. Paul G. Becher, Julien Beuchat, Karl Gademann, and Friedrich Jüttner
Nostocarboline: Isolation and Synthesis of a New Cholinesterase Inhibitor from Nostoc 78-12A
J. Nat. Prod. 2005, 68, 1793-1795. Abstract/Fulltext>>
23. Karl Gademann and Yann Bethuel
A Biomimetic Route to the Peptide Alkaloid Anachelin
Angew. Chem. 2004, 116, 3389-3391; Angew. Chem. Int. Ed. Engl. 2004, 43, 3327-3329. Fulltext English>> / Fulltext German>>
Review articles
39. Karl Gademann and Simone Bonazzi
Total Synthesis of Complex Cyanobacterial Alkaloids Without Using Protecting Groups
Angew. Chem. Int. Ed. 2007, 46, 5656-5658.
Abstract/Fulltext
37. Karl Gademann and Cyril Portmann
Secondary Metabolites from Cyanobacteria: Complex Structures and Powerful Bioactivities
Curr. Org. Chem., in print.
36. Karl Gademann
Cyanobacterial Natural Products for the Inhibition of Biofilm Formation and Biofouling
Chimia 2007, 61, 373-377. Abstract/fulltext.
34. Karl Gademann
Natural Product Hybrids
Chimia 2006, 60, 841-845.Abstract/fulltext.
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