A non-negligible cause of mortality and morbidity nowadays, especially in underdeveloped countries, cholera still represents a challenge, when it comes to the prediction and control of epidemics. Particular climatological conditions of endemic regions and uncertainties regarding the ecology of Vibrio cholerae all call for a better understanding of the phenomena involved in the spreading of the disease.
In this research, supported by funds provided by the ERC Advanced Grant RINEC-227612, the development of spatially referred models, aimed at the description of the mechanics of cholera propagation, is a key objective. Being it a waterborne disease, the study of ecohydrological systems well fits the analysis of cholera spatial and temporal evolution. A progressively detailed framework, involving human movement and mechanistically described hydrological processes, is established, in order to provide a tool for the prediction and control of sudden epidemics. It is often the case, in fact, that cholera emerges in non-endemic areas, with unexpected outbursts.
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L. Mari, E. Bertuzzo, L. Righetto, R. Casagrandi, M. Gatto,
I. Rodriguez-Iturbe, and A. Rinaldo.
Modelling cholera epidemics: the role of waterways, human mobility
and sanitation.
Journal Of The Royal Society Interface, 9:376-388,
2012.
[ DOI |
Details ]
E. Bertuzzo, L. Mari, L. Righetto, M. Gatto, R. Casagrandi, M. Blokesch,
I. Rodriguez-Iturbe, and A. Rinaldo.
Prediction of the spatial evolution and effects of control measures
for the unfolding Haiti cholera outbreak.
Geophysical Research Letters, 38:L06403, 2011.
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Details ]
A. Rinaldo, M. Blokesch, E. Bertuzzo, L. Mari, L. Righetto, M. Murray,
M. Gatto, R. Casagrandi, and I. Rodriguez-Iturbe.
A transmission model of the 2010 cholera epidemic in haiti.
Annals of internal medicine, 155(6):403-4, 2011.
[ DOI |
Details ]
L. Righetto, E. Bertuzzo, R. Casagrandi, M. Gatto, I. Rodriguez-Iturbe, and
A. Rinaldo.
Modelling human movement in cholera spreading along fluvial systems.
Ecohydrology, 4:49-55, 2011.
[ DOI |
Details |
Full Text ]
L. Mari, E. Bertuzzo, L. Righetto, R. Casagrandi, M. Gatto,
I. Rodriguez-Iturbe, and A. Rinaldo.
Modeling cholera epidemics: the role of human mobility and sanitation
conditions.
Journal of the Royal Society Interface.
[ DOI |
Details ]
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