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Martinus Gijs
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Microsystems Laboratory 2
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MISSION
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The Laboratory of Microsystems 2 of Prof. Martin Gijs was established in 1997 and has as mission the development of new microfabrication technologies and to exploit these for applications of industrial interest. We actively participate in national and international research programs. The research of LMIS2 is centered on four themes:
- Novel microfabrication technologies
- Magnetic applications
- Microfluidics
- Bio-Micro-Electro-Mechanical Systems (BioMEMS)
Novel microfabrication technologies
We have developed a clean room spin-on-polyimide/Cu multilayer technology for the realization of high-resolution and high-quality factor flex-foil electrical components. We also have established a sol-gel process for the replication of three-dimensional and thin film glass nanostructures. Moreover, we have discovered a new sol-gel process to synthesize borosilicate nanoparticles.
Magnetic applications
We are working on miniaturised systems for the handling and magnetic transport of magnetic micro- and nanoparticles in microfluidic devices. We have realized high-efficiency and self-priming active-valve micropumps consisting of a microfluidic chamber structure that is assembled with a polydimethylsiloxane (PDMS) elastic sheet with an integrated permanent magnet. The choice of this actuation principle allows very low-voltage (0.7 V) and low power (a few 10 mW) operation of the micropump.
Microfluidics
Chemists and biologists have recognized the utility of microfabricated devices for transporting and manipulating liquids on a sub-μL scale. We are active in the realisation and use of glass and polymer microfluidic chips and demonstrated, for example, microfluidic mixers and glass and plastic micropumps based on various actuation and valving principles.
BioMEMS
We have developed microsystems for automated cell patch-clamp measurements, with which we performed experiments on mammalian cells and Xenopus oocytes. We are developing microfluidic channel- and droplet-based microsystems for the handling of magnetic beads for biomedical and mixing applications. We also have realized DNA-chips, where DNA hybridization reactions are monitored either by fluorescence or impedance measurements. We have combined PDMS-based microfluidic devices with luminescent lanthanide-based immunoreaction detection. Our system has been successfully tested for the multiplex detection of biomarkers on cancerous tissues. We demonstrated a variety of on-chip immuno- and cell-based- assays using magnetic beads in a microfluidic channel as substrate.
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BIOGRAPHY
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Martin A.M. Gijs received his degree in physics in 1981 from the Katholieke Universiteit Leuven, Belgium and his Ph.D. degree in physics at the same university in 1986. He joined the Philips Research Laboratories in Eindhoven, The Netherlands, in 1987. Subsequently, he has worked there on micro-and nano-fabrication processes of high critical temperature superconducting Josephson and tunnel junctions, the microfabrication of microstructures in magnetic multilayers showing the giant magnetoresistance effect, the design and realisation of miniaturised motors for hard disk applications and the design and realisation of planar transformers for miniaturised power applications. He joined EPFL in 1997. His present interests are in developing technologies for novel magnetic devices, new microfabrication technologies for microsystems fabrication in general and the development and use of microsystems technologies for microfluidic and biomedical applications in particular.
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MAIN PUBLICATIONS
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Droplet-based DNA purification in a magnetic lab-on-a-chip, U. Lehmann, C. Vandevyver, V.K. Parashar, and M.A.M. Gijs, Angewandte Chemie Int. Ed. 45, 3062-3067 (2006); Angewandte Chemie 118, 3132-3137 (2006)
Will fluidic electronics take off?, M.A.M. Gijs, Nature Nanotechnology 2, 268-270 (2007)
Borosilicate nanoparticles prepared by exothermic phase separation, Virendra K. Parashar, Jean-Baptiste Orhan, Abdeljalil Sayah, Marco Cantoni, and Martin A.M. Gijs, Nature Nanotechnology 3, 589-594 (2008)
Full on-chip nanoliter immuno-assay by geometrical magnetic trapping of nanoparticle chains , F. Lacharme, C. Vandevyver, and M.A.M. Gijs, Analytical Chemistry 80, 2905-2910 (2008)
Label-free detection of DNA with interdigitated micro-electrodes in a fluidic cell, D. Berdat, A.C. Martin Rodriguez, F. Herrera, and M.A.M. Gijs, Lab on a Chip 8, 302-308 (2008)
Rapid fluidic exchange microsystem for recording of fast ion channel kinetics in Xenopus oocytes, E. Dahan, V. Bize, T. Lehnert, J.-D. Horisberger, and M.A.M. Gijs, Lab on a Chip 8, 1809-1818 (2008)
On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns, Venkataragavalu Sivagnanam , Bo Song, Caroline Vandevyver, and Martin A. M. Gijs, Analytical Chemistry 81, 6509-6515 (2009)
On-chip immuno-agglutination assay with analyte capture by active manipulation of superparamagnetic beads, Y. Moser, T. Lehnert, and M.A.M. Gijs, Lab-on-a-Chip 9, 3261-3267 (2009)
Monolithic micro-direct methanol fuel cell in PDMS with microfluidic channel-integrated Nafion strip, M. Shen, S. Walter, and M.A.M. Gijs, Journal of Power Sources 193, 761-765 (2009)
Monolithic CMOS chip for immunofluorescent detection of single magnetic beads, Emile P. Dupont, Estelle Labonne, Caroline Vandevyver, Ulrike Lehmann, Edoardo Charbon and Martin A. M. Gijs, Analytical Chemistry 82, 49-52 (2010)
Microfluidic protein preconcentrator using microchannel-integrated Nafion strip: experiment and modeling
, M. Shen, H. Yang, V. Sivagnanam, and M.A.M. Gijs
, Analytical Chemistry 82, 9989-9997 (2010)
Microfluidic applications of magnetic particles for biological analysis and catalysis , Martin A. M. Gijs, Frédéric Lacharme, and Ulrike Lehmann, Chemical Reviews 110, 1518-1563 (2010)
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Full Professor