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Martinus Gijs
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Microsystems Laboratory 2
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MISSION
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The Microsystems Laboratory 2 of Prof. Martin Gijs has as mission the development of new microfabrication technologies and to exploit these for applications of industrial interest. The research is centered around three themes:
Novel microfabrication technologies
We study the resolution limits of powder blasting micro-erosion as a process for three-dimensional microstructuring of glass and ceramic materials. We are developing protein and DNA immobilisation procedures on solid substrates. We have developed a spin-on-polyimide/Cu multilayer technology for the realization of high-resolution and high-quality factor flex-foil circuits. We have established a process for the replication of three-dimensional and thin film glass nanostructures by moulding and thermally curing of in-house prepared spin-on-glass solutions.
Magnetic applications
We have realised three-dimensional millimetre-size power transformers using a patented ferrite wafer - flex foil batch fabrication and assembly process. We are working on miniaturised systems for the handling and magnetic transport of magnetic micro- and nanoparticles in microfluidic devices.
Microfluidics and Bio-MEMS
We are active in the realisation and use of glass and polymer microfluidic chips and demonstrated a new pressure pulse sample injection method for electrophoresis and electrochromatography applications. We have developed glass and plastic micropumps using various magnetic actuation and valving principles. We are developing microsystems for automated cell patch-clamp measurements, with which we performed experiments on mamalian cells and Xenopus oocytes. We are developing microfluidic channel- and droplet-based microsystems for the handling of magnetic beads for biomedical and mixing applications. We also have realized DNA-chips, where DNA hybridization reactions are monitored either by fluorescence or impedance measurements.
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BIOGRAPHY
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Martin A.M. Gijs received his degree in physics in 1981 from the Katholieke Universiteit Leuven, Belgium and his Ph.D. degree in physics at the same university in 1986. He joined the Philips Research Laboratories in Eindhoven, The Netherlands, in 1987. Subsequently, he has worked there on micro-and nano-fabrication processes of high critical temperature superconducting Josephson and tunnel junctions, the microfabrication of microstructures in magnetic multilayers showing the giant magnetoresistance effect, the design and realisation of miniaturised motors for hard disk applications and the design and realisation of planar transformers for miniaturised power applications. He joined EPFL in 1997. His present interests are in developing technologies for novel magnetic devices, new microfabrication technologies for microsystems fabrication in general and the development and use of microsystems technologies for microfluidic and biomedical applications in particular.
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MAIN PUBLICATIONS
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Droplet-based DNA purification in a magnetic lab-on-a-chip, U. Lehmann, C. Vandevyver, V.K. Parashar, and M.A.M. Gijs, Angewandte Chemie Int. Ed. 45, 3062-3067 (2006); Angewandte Chemie 118, 3132-3137 (2006)
LF55GN photosensitive flexopolymer: a new material for ultra-thick and high aspect-ratio MEMS fabrication, Abdeljalil Sayah, Virendra K. Parashar, and Martin A.M. Gijs, J. of Microelectromechanical Systems 16, 564-570 (2007)
Pumping of mammalian cells with a nozzle-diffuser micropump, C. Yamahata, C. Vandevyver, F. Lacharme, P. Izewska, H. Vogel, R. Freitag, and M.A.M. Gijs, Lab on a Chip 5, 1083-1088 (2005)
Manipulation of self-assembled structures of magnetic beads for microfluidic mixing and assaying, A. Rida and M.A.M. Gijs, Analytical Chemistry 76, 6239 (2004)
Will fluidic electronics take off?, M.A.M. Gijs, Nature Nanotechnology 2, 268-270 (2007)
Dynamics of magnetically retained supraparticle structures in a liquid flow, A. Rida and M.A.M. Gijs, Appl. Phys. Lett. 85, 4986-4988 (2004)
Borosilicate nanoparticles prepared by exothermic phase separation, Virendra K. Parashar, Jean-Baptiste Orhan, Abdeljalil Sayah, Marco Cantoni, and Martin A.M. Gijs, Nature Nanotechnology 3, 589-594 (2008)
Full on-chip nanoliter immuno-assay by geometrical magnetic trapping of nanoparticle chains , F. Lacharme, C. Vandevyver, and M.A.M. Gijs, Analytical Chemistry 80, 2905-2910 (2008)
Pressure pulse injection: a powerful alternative to electrokinetic sample loading in electrophoresis microchips, Solignac, D. and M. A. M. Gijs , Analytical Chemistry 75, 1652-1657 (2003)
Label-free detection of DNA with interdigitated micro-electrodes in a fluidic cell, D. Berdat, A.C. Martin Rodriguez, F. Herrera, and M.A.M. Gijs, Lab on a Chip 8, 302-308 (2008)
Rapid fluidic exchange microsystem for recording of fast ion channel kinetics in Xenopus oocytes, E. Dahan, V. Bize, T. Lehnert, J.-D. Horisberger, and M.A.M. Gijs, Lab on a Chip 8, 1809-1818 (2008)
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Full Professor 