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Sandro Carrara Integrated Systems Laboratory (IC/STI) nationality: Italian web site: http://si2.epfl.ch/~scarrara/ office(s): INF338 phone(s): [+41 21 69] 30915 private phone: [+41 79] 24 88 632 fax: [+41 21 69] 34 225 BIOGRAPHY Sandro Carrara is Senior Scientist and Lecturer at the École Polytechnique Fédérale de Lausanne, and Professor of nano-bio-sensing and micro/nano interfaces at the Department of Electrical Engineering and Biophysics (DIBE) of the University of Genoa. He was a Professor in biophysics at the University of Genoa and a Professor of nanobiotechnology at the University of Bologna. Sandro Carrara graduated in Electronics in Technical school of Albenga, got a Master in Physics from University of Genoa and received his Ph.D. in Biochemistry and Biophysics from University of Padoa. His main scientific interest is on electrical phenomena mediated by nano-structured molecular thin-films. He currently has a special focus on development of Protein and DNA based CMOS bio-chips. He has more then 90 scientific publications and 10 patents. His work was awarded at the NanoEurope Symposium in 2009 (Rapperswil), at the IEEE International Conference PRIME with the bronze leaf prize in 2010 (Berlin), and with the golden leaf prize in 2009 (Cork). In 2006, he received the best referees’ award from Biosensor and Bioelectronics journal. He also won a NATO Advanced Research prize in 1996 for his original contribution to the physics of single-electron conductivity in nano-particles. From 1997 to 2000, he was a member of an international committee at the ELETTRA Synchrotron in Trieste. From 2000 to 2003, he was scientific leader of a National Research Program (PNR) in the filed of Nanobiotechnology. He is now an internationally esteemed expert of the evaluation panel of the Academy of Finland in a research program for the years 2010-2013. Sandro Carrara is the Founder and Editor-in-Chief of the new journal BioNanoScience. He also is an Associate Editor of the IEEE Transactions on Biomedical Circuits and Systems and of the IEEE Sensors Journals. He is referee of other eleven international journals. He is in several Boards of International Conferences such as IEEE-IWASI/Bari-2011, ISMICT/Montreux-2011, and he was in the Boards of BioCAS/Beijing-2009, BioCAS/Cyprus-2010, NanoNets/Luzern-2009 Education Diploma in Electronics, Technical Institute of Albenga (Italy), Master in Physics, Unversity of Genoa (Italy), Ph.D. in Biochemistry and Biophysics, Universsity of Padoa (Italy), Books Sandro Carrara (Ed), Nano-Bio-Sensing, Springer, New York, 2011 Sandro Carrara (Aut), Che cosa è il tempo? (italian), Simonelli, Milan, 2011 Alexander Schmid, al. et S.Carrara (Eds), Nano-Net, Springer, Berlin, 2009 C.A. Nicolini, S. Carrara, et al. (Auts), Molecular Bioelectronics, World Scientific, Singapore, 1996 Some Relavant Scientific Results 1. New experimental research starts recently focused on cell cultures on-line monitoring. The system under development is for continuous monitoring of secretoma during proliferation, switching, and differentiation of stem cells. Key point is to identify the right metabolites that follow cell differentiation in order to provide powerful nano-bio-chip for non-invasive cell monitoring. This work won the golden leaf prize at the IEEE Conference PRIME in 2009 (Cork). 2. Development of new biosensors based on Cytochrome P450 for sensing metabolites, published in in case of Electron-Transfer by using Carbon Nanotubes, gold nano-particles, and molecular mediators [Biosensors and Bioelectronics 24(2008) 148-150, 21 (2005) 217–222, and 19 (2004) 971-976]. Development of new biosensors based on Cytochrome P450 for sensing different drug compounds: the case of Cyclophosphamide, Dextrometrophane, Benzphentamine with Multi-Walled Carbon Nanotubes as Electron-Transfer mediator was presented at the Conference IEEE-ICME-09 and the case of Benzphentamine with Single-Walled Carbon Nanotubes was presented at the Conference IEEE-BioCAS-08. This work won the best poster prize at the NanoEurope Symposium in 2009 (Rapperswil) and the bronz leaf prize at IEEE Conference PRIME 2010 (Berlin). 3. New design architectures for electrochemical biochips based on capacitance and amperometric detection. Multiplexing for multi-panel deteciton, integration with pH and T measures, and remote powering aspects are considered as well. Parts of this work has been communicated to IEEE Sensors Conference (2010), IEEE Sensor Journal in press, and 7(2007)577-585, Microelectronics Journal, (2010) 41(2010)711–717, and 40(2009)1358-1365, IEEE Journal of Solid-State Circuits 41(2006) 2956-2964, Conference IEEE-IWASI-09, IEEE Conference BioCAS (editions 2008, 2009, and 2010), IEEE Sensors Conference 2010. 4. New insights on the interface behaviour of new kind of probes immobilization for application to capacitance biosensors have been outlined during recent years. In particular, new results in detection of DNA (Biosensors and Bioelectronics, 24 (2009) 3425–3429), and cancer-markers (Sensors and Actuators B: Chemical, 136 (2009) 163–172) have been shown by using Ethylene-glycol monolayers. The new probes properties had been related to nano-scale properties of the films structure by using AFM imaging (Surface Science, 603(2009)L75–L77, and 604(2010)L71-L74). Different strategies for probes immobilization have been considered and investigated at the nano-scale (Results presented at the Conferences IEEE-IWASI-09). Different electrochemical interface behaviours in frequency have been published in different papers appeared in Sensors and Transducers Journal in case of anti-body probes (101(2009) 104-111), DNA probes immobilized onto ethylene-glycol monolayers (88(2008) 31-39), and directly immobilized onto gold (76 (2007), 969-977). To see more details on the research, please, link to the page: http://si2.epfl.ch/~scarrara/ MAIN PUBLICATIONS I. Taurino, S. Carrara, M. Giorcelli, A. Tagliaferro, and G. De Micheli. Comparison of Two Different Carbon Nanotube-based Surfaces with Respect to Potassium Ferricyanide Electrochemistry. Surface Science, 606(3-4):156-160, 2012. [ DOI | Details | Full Text ] C. Boero, S. Carrara, G. Del Vecchio, L. Calza, and G. De Micheli. Highly Sensitive Carbon Nanotube-Based Sensing for Lactate and Glucose Monitoring in Cell Culture. IEEE Transactions on Nanobioscience, 10:59-67, 2011. [ DOI | Details | Full Text ] C. Boero, S. Carrara, G. Del Vecchio, L. Calza, and G. De Micheli. Targeting of multiple metabolites in neural cells monitored by using protein-based carbon nanotubes. Sensors And Actuators B-Chemical, 157:216-224, 2011. [ DOI | Details | Full Text ] I. Taurino, S. Carrara, M. Giorcelli, A. Tagliaferro, and G. De Micheli. Comparing Sensitivities of Differently Oriented Multi-walled Carbon Nanotubes Integrated on Silicon Wafer for Electrochemical Biosensors. Sensors and Actuators B: Chemical, B 160:327-333, 2011. [ DOI | Details | Full Text ] L. Zhu, G. Del Vecchio, G. De Micheli, Y. Liu, S. Carrara, L. Calzà, and C. Nardini. Biochips for Regenerative Medicine: Real-time Stem Cell Continuous Monitoring as Inferred by High-Throughput Gene Analysis. BioNanoScience, 1(4):183-191, 2011. [ DOI | Details | Full Text ] S. Carrara, L. Bolomey, C. Boero, A. Cavallini, E. Meurville, G. De Micheli, T. Rezzonico, M. Proietti, and F. Grassi. Single-Metabolite Bio-Nano-Sensors and System for Remote Monitoring in Animal Models. In Proceedings of IEEE Sensors 2011 Conference, pages 716-719, 2011. [ Details | Full Text ] M. Beltrandi, A. Vachoux, S. Carrara, Y. Leblebici, and G. De Micheli. VHDL-AMS Model of an Electrochemical Cell to Design VLSI Bio-Chips. In IEEE Biomedical Circuits and Systems Conference (BioCAS), 2011. [ Details | Full Text ] J. Olivo, S. Carrara, and G. De Micheli. Biofuel Cells and Inductive Powering as Energy Harvesting Techniques for Implantable Sensors. Science of Advanced Materials, 3(3):420-425, 2011. [ DOI | Details | Full Text ] Q. Ramadan, H. Jafarpoorchekab, K. Bolanz, F. Schwander, P. Silacci, S. Carrara, J. Ramsden, G. Vergeres, and M. Gijs. Nutrichip: an integrated microfluidic system for in vitro investigation of the immunemodulatory function of dairy products. In Proceedings of the 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), 2011. [ Details ] I. Taurino, S. Carrara, M. Giorcelli, A. Tagliaferro, and G. De Micheli. Comparing the enhanced sensing interfaces of differently oriented carbon nanotubes onto silicon for bio-chip applications. In Proceedings of the 4th International Workshop on Advances in Sensors and Interfaces (IWASI), pages 90-93, 2011. [ Details | Full Text | Link ] D. Sacchetto, M.-A. Doucey, G. De Micheli, Y. Leblebici, and S. Carrara. New Insight on Bio-sensing by Nano-fabricated Memristors. BioNanoScience, 1(1-2):1-3, 2011. [ DOI | Details | Full Text ] S. Carrara, A. Cavallini, V. Erokhin, and G. De Micheli. Multi-panel drugs detection in human serum for personalized therapy. Biosensors and Bioelectronics, 26(9):3914-3919, 2011. [ DOI | Details | Full Text ] S. S. Ghoreishizadeh, C. Baj-Rossi, S. Carrara, and G. De Micheli. Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection. In Proceedings of the IEEE7NIH 5th Life Science Systems and Applications Workshop, 2011. [ Details | Full Text ] G. Köklü, Y. Leblebici, and S. Carrara. A Switched Capacitor Fully Differential Correlated Double Sampling Circuit for CMOS Image Sensors. In Proceedings of the 5th International Symposium on Medical Information and Communication Technology, pages 113-116, 2011. [ Details | Full Text ] J. Olivo, S. Carrara, and G. De Micheli. Modeling of Printed Spiral Inductors for Remote Powering of Implantable Biosensors. In Proceedings of the 5th International Symposium on Medical Information and Communication Technology, pages 29-32, 2011. [ Details | Full Text ] P. A. Serra, C. Baj-Rossi, G. De Micheli, and S. Carrara. P450-Based Nano-Bio-Sensors for Personalized Medicine. In Biosensors for Health, Environment and Biosecurity / Book 1. Intech, 2011. [ Details | Full Text | Link ] G. De Micheli, S. S. Ghoreishizadeh, C. Boero, F. Valgimigli, and S. Carrara. An Integrated Platform for Advanced Diagnostics. In Proceedings of Design, Automation and Test in Europe Conference, 2011. [ Details | Full Text ] J. Olivo, S. Carrara, and G. De Micheli. Energy Harvesting and Remote Powering for Implantable Biosensors. IEEE Sensors Journal, 11(7):1573 - 1586, 2011. [ DOI | Details | Full Text ] S. Carrara. Nano-Bio-Technology and Sensing Chips: New Systems for Detection in Personalized Therapies and Cell Biology. 2010. [ DOI | Details ] V. Bhalla, S. Carrara, C. Stagni, and B. Samori. Chip cleaning and regeneration for electrochemical sensor arrays. Thin Solid Films, 518:3360-3366, 2010. [ DOI | Details ] S. Carrara, M. D. Torre, A. Cavallini, D. De Venuto, and G. De Micheli. Multiplexing pH and Temperature in a Molecular Biosensor. In Proceedings of the IEEE BIOCAS 2010 Conference, 2010. [ Details | Full Text ] D. De Venuto, M. D. Torre, C. Boero, S. Carrara, and G. De Micheli. A Novel Multi-Working Electrode Potentiostat for Electrochemical Detection of Metabolites. In Proceedings of the IEEE Sensors 2010 Conference, number 1, pages 1572-1577, 2010. [ Details | Full Text ] J. Olivo, S. Carrara, and G. De Micheli. Optimal Frequencies for Inductive Powering of Fully Implantable Biosensors for Chronic and Elderly Patients. In Proceedings of the IEEE Sensors 2010 Conference, volume 1 of IEEE Sensors, pages 99-103. Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa, 2010. [ Details | Full Text ] A. Cavallini, S. Carrara, G. De Micheli, and V. Erokhin. P450-mediated electrochemical sensing of drugs in human plasma for personalized therapy. In Proceedings of the 6th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME), pages 1-4, 2010. [ Details | Full Text ] S. Carrara, A. Cavallini, Y. Leblebici, G. De Micheli, V. Bhalla, F. Valle, B. Samorì, L. Benini, B. Riccò, I. Vikholm-Lundin, and T. Munter. Capacitance DNA bio-chips improved by new probe immobilization strategies. MicroelectronicsJournal, (41):711-717, 2010. [ DOI | Details | Full Text ] C. Boero, S. Carrara, G. Del Vecchio, G. D. Albini, L. Calzà, and G. De Micheli. Carbon Nanotubes-Based Electrochemical Sensing for Cell Culture Monitoring. In Proceedings of the 2010 IEEE/ICME International Conference on Complex Medical Engineering, volume 1, pages 288-293, 2010. [ Details | Full Text ] D. Sacchetto, H. Ben-Jamaa, S. Carrara, G. De Micheli, and Y. Leblebici. Memristive Devices Fabricated with Silicon Nanowire Schottky Barrier Transistors. In Proceedings of the IEEE International Symposium on Circuits and Systems (ISCAS 2010), volume 1 of IEEE International Symposium on Circuits and Systems, pages 9-12. Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa, 2010. [ Details | Full Text ] S. Carrara, A. Cavallini, Y. Maruyama, E. Charbon, and G. De Micheli. A new ethylene glycol-silane monolayer for highly-specific DNA detection on Silicon Chips. Surface Science Letters, 604(23-24):L71-L74, 2010. [ DOI | Details | Full Text ] S. Carrara, V. Bhalla, C. Stagni, and B. Samori. Nanoscale film structure related to capacitive effects in ethylene-glycol monolayers. Surface Science, 603:L75-L77, 2009. [ DOI | Details ] D. De Venuto, S. Carrara, and B. Ricco. Design of an integrated low-noise read-out system for DNA capacitive sensors. In Microelectronics Journal, volume 40, pages 1358-1365, 2009. [ DOI | Details ] S. Carrara, V. V. Shumyantseva, A. I. Archakov, and B. Samori. Screen-printed electrodes based on carbon nanotubes and cytochrome P450scc for highly sensitive cholesterol biosensors. Biosensors & Bioelectronics, 24:148-150, 2008. [ DOI | Details ] S. Carrara, A. Cavallini, G. De Micheli, J. Olivo, L. Benini, V. V. Shumyantseva, and A. I. Arhakov. Circuits Design and Nano-Structured Electrodes for Drugs Monitoring in Personalized Therapy. In Proceedings of the IEEE Biomedical Circuits and Systems Conference (BioCAS). IEEE, 2008. [ Details | Full Text ] S. Carrara, F. K. Gürkaynak, C. Guiducci, C. Stagni, L. Benini, Y. Leblebici, B. Samorì, and G. De Micheli. Interface Layering Phenomena in Capacitance Detection of DNA with Biochips. Sensors & Transducers Journal, 76(2):969 - 977, 2007. [ DOI | Details | Full Text ]

Skills Research 1. Thin Film Biophysics 2. Nanotechnology 3. CMOS design Teaching 1. EDMI Doctoral School - Course titled: Electrochemical nano-bio-sensing and bio/CMOS interfaces Phd Students Baj-Rossi Camilla Boero Cristina Cavallini Andrea Ghaye Julien Michel Ghoreishizadeh Seyedeh Sara Köklü Gözen Olivo Jacopo Taurino Irene PhD Students - Visiting Alice Dimonte Master Students Madura Kamat Francesca Puppo Maria Laura Beltrandi Akshat Dave Cosmo Matteo Former Students Richa Bharadwaj Pietro Dalmastro Giulio Carrafa Daniel Torre Zhang Kun Elzibeta L. Rauss Giovanna De Vecchio Perumal U. Dharanipathy Pasquale Grosso Apoorv Joshi Manas Jain National and International Collaborations Martin Gijs Yusuf Leblebici Catherine Dehollain Qiuting Huang Fabio Grassi Paolo Silacci Ursula von Mandach Linda Toeny Edoardo Charbon Inger Vikhol-Lundig Laura Calzà Christine Nardini Daniela De Venuto Dino Giuseppe Albini Luca Benini Editor-in-chief BioNanoScience by Springer Associate Editor IEEE Sensors Journal IEEE T. on Biomedical Circuits and Systems Board of Conferences IEEE IWASI (2011) IEEE ISMICT (2011) IEEE BioCAS (2009-2011) Nano-Net (2009)