Caroline Vandevyver

Responsable d'unité
EPFL AVP-R REO
BI A2 443 (Bâtiment BI)
Station 7
CH-1015 Lausanne
Web site: Site web: https://www.epfl.ch/research/services/units/research-office/
Domaines de compétences
Scientific expertise: Cell culture; Biomedical Imaging, Recombinant DNA and Protein Technology
Teaching expertise: Biochemistry, Toxicology
Mission
Build up and manage the Research Office at EPFL regarding its concept, processes, method of evaluation/statistics and resource management in collaboration with the team specific coordinators having the ReOTravail en cours
As Head of the Research Office- Contribute with high quality implementation work of the duties and initiatives for improving ReO
Biographie
Caroline Vandevyver received her degree in biochemistry in 1985 from the Katholieke Universiteit Leuven, Belgium and her Ph.D. degree in biotechnology at the same university in 1989.She joined the Biomedical Research Institute "Dr. L- Willems Instituut" in Hasselt, Belgium, in 1989. Subsequently, she has worked there on T cell mediated autoimmune diseases (Multiple Sclerosis, Rheumatoid Arthritis), genetic association and linkage studies in multifactorial diseases, mutation analysis of genetic disorders (Phenylketonuria, alpha 1 anti-trypsine deficiency, congenital adrenal hyperplasia) and the development of active and passive immune therapies for cancer.
She joined EPFL in 2000 at the Laboratory of Chemical Biotechnology headed by Prof. Ruth Freitag, where she was responsible for the cell culture lab and the (recombinant) protein purification and characterization. She joined the Laboratory of Lanthanide Supramolecular Chemistry (LCSL) in May 2006, where she was responsible for the live cell imaging project with Lanthanide complexes.
In 2005, she joined the Office of the Research Commission. Her duties there were the management of national and international fellowship programs, the management of local research awards and the promotion of research performed at EPFL. In August 2013, she was nominated coordinator of the International Funding, one of the pillars of the Research Office at EPFL. Since January 2017, she is the Head of EPFL
Parcours professionnel
Head of Unit
Research Office (ReO)
Vice‐presidency for Research, École Polytechnique Fédérale de Lausanne (EPFL)
January 2017 ÃÂâÃÂÃÂÃÂàpresent
Research Office (ReO), Coordinator International Funding
Vice‐presidency of Academic Affairs
École Polytechnique Fédérale de Lausanne (EPFL)
August 2013 ÃÂâÃÂÃÂÃÂàDecember 2016
Research Commission Office SNSF EPFL
Vice‐presidency of Academic Affairs
École Polytechnique Fédérale de Lausanne (EPFL)
September 2009 ÃÂâÃÂÃÂÃÂàAugust 2013
Senior Scientist
Faculty of Basic Sciences, “Institute of Chemical Sciences and Engineering” (ISIC, Laboratory of Lanthanide Supramolecular Chemistry (LCSL)
École Polytechnique Fédérale de Lausanne (EPFL)
September 2005 ÃÂâÃÂÃÂÃÂàSeptember 2009
Scientist
Faculty of Basic Sciences, “Institute of Chemical Sciences and Engineering” (ISIC), Laboratory of Chemical Biotechnology (LBCH)
École Polytechnique Fédérale de Lausanne (EPFL)
September 2000 ÃÂâÃÂÃÂÃÂàAugust 2005
Department Head of Biotechnology Unit and Member of the Board
Biomedical Research Institute “Dr. L. Willems‐Instituut”
University of Hasselt (B)
January 1990 ÃÂâÃÂÃÂÃÂàJune 1997
Department Head of Clinical Chemistry
Biomedical Research Institute “Dr. L. Willems‐Instituut”
University of Hasselt (B)
June 1989 ÃÂâÃÂÃÂÃÂàDecember 1989
Publications
Publications Infoscience
Synthesis and cell localization of self-assembled dinuclear lanthanide bioprobes
Philosophical Transactions Of The Royal Society A-Mathematical Physical And Engineering Sciences. 2013. DOI : 10.1098/rsta.2012.0295.Fluorescent magnetic bead and cell differentiation/counting using a CMOS SPAD matrix
Sensors and Actuators B. 2012. DOI : 10.1016/j.snb.2012.06.049.Lighting-up cancerous cells and tissues with lanthanide luminescence
Chimia. 2011. DOI : 10.2533/chimia.2011.361.Chaotic mixing using source-sink microfluidic flows in a PDMS chip
Microfluidics and Nanofluidics. 2011. DOI : 10.1007/s10404-010-0706-0.Increasing the efficiency of lanthanide luminescent bioprobes: bioconjugated silica nanoparticles as markers for cancerous cells
New Journal Of Chemistry. 2010. DOI : 10.1039/c0nj00440e.Active microfluidic mixer using virtual source-sink pairs for DNA purification
2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010), Groningen, Netherlands, October 3 - 7, 2010. p. 1841-1843.Fast Immunohistochemical BioMarker Detection Device for Cancer Tissue Slices
2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS 2010), Groningen, Netherlands, October 3-7, 2010.Selective Breast Cancer Cell Capture, Culture, and Immunocytochemical Analysis Using Self-Assembled Magnetic Bead Patterns in a Microfluidic Chip
Langmuir. 2010. DOI : 10.1021/la9045572.Microfluidic Immunoassays Based on Self-Assembled Magnetic Bead Patterns and Time-Resolved Luminescence Detection
Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4644.Monolithic Silicon Chip for Immunofluorescence Detection on Single Magnetic Beads
Analytical Chemistry. 2010. DOI : 10.1021/ac902241j.Bioconjugated lanthanide luminescent helicates as multilabels for lab-on-a-chip detection of cancer biomarkers
Analyst. 2010. DOI : 10.1039/b922124g.Time-Resolved Luminescence for Immunohistochemical Detection of Cancer Biomarkers in a Lab-on-a-Chip
2009. NanoBioTech 2009, Montreux, Switzerland, November 16-18, 2009.On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns
2009. NanoBioTech 2009, Montreux, Switzerland, November 16-18, 2009.Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues
Analyst. 2009. DOI : 10.1039/b911301k.On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns
Analytical Chemistry. 2009. DOI : 10.1021/ac9009319.Luminescent Bimetallic Lanthanide Bioprobes for Cellular Imaging with Excitation in the Visible-Light Range
Chemistry-A European Journal. 2009. DOI : 10.1002/chem.200801868.Sandwich immunoassay on a microfluidic chip using patterns of electrostatically self-assembled streptavidin-coated beads
2009. 34th International Conf. on Micro and Nanoengineering, Athens, Greece, September 15-18, 2008. p. 1404-1406. DOI : 10.1016/j.mee.2008.11.087.Magnetic beads retention device for sandwich immunoassay: comparison of off-chip and on-chip antibody incubation
Microfluidics and Nanofluidics. 2009. DOI : 10.1007/s10404-009-0424-7.Screening of a Human Antibody Phage Display Library Against a Peptide Antigen Using Stimuli-Responsive Bioconjugates
Biotechnology Progress. 2008. DOI : 10.1021/bp.60.On-chip nanoliter immunoassay by geometrical trapping of magnetic nanoparticle chains
2008. 12th Annual European Conference On Micro & Nanoscale Technologies for the Biosciences, Montreux, Switzerland, November 17-19, 2008.A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence
Analyst. 2008. DOI : 10.1039/b807959e.Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells
Org. Biomol. Chem.. 2008. DOI : 10.1039/b811427g.Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes
New Journal of Chemistry. 2008. DOI : 10.1039/b800516h.Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing
Annals of the New York Academy of Sciences. 2008. DOI : 10.1196/annals.1430.010.A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes
Chemistry - A European Journal. 2008. DOI : 10.1002/chem.200701357.Magnetic bead retention device for full on-chip sandwich immuno-assay
2008. MEMS 2008, Tucson, AZ (USA), January 13-17, 2008. p. 184-187. DOI : 10.1109/MEMSYS.2008.4443623.Full on-chip nanoliter immuno-assay by geometrical magnetic trapping of nanoparticle chains
Analytical Chemistry. 2008. DOI : 10.1021/ac7020739.Micropatterning of protein-functionalized magnetic beads on glass using electrostatic self-assembly
Sensors and Actuators B: Chemical. 2008. DOI : 10.1016/j.snb.2007.09.076.A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells
Chemistry - A European Journal. 2007. DOI : 10.1002/chem.200700883.Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments
Chemistry, a European Journal. 2007. DOI : 10.1002/chem.200700819.New Opportunities for Lanthanide Luminescence
Journal of Rare Earths. 2007. DOI : 10.1016/S1002-0721(07)60420-7.Micropatterning of Streptavidin-Functionalized Magnetic Beads on Glass Using Electrostatic Self-Assembly
2007. IEEE Transducers 2007, Lyon, France, June 10-14, 2007. p. 525-528. DOI : 10.1109/SENSOR.2007.4300183.On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system
Microelectronic Engineering. 2007. DOI : 10.1016/j.mee.2007.01.212.Luminescent lanthanide bimetallic triple-stranded helicates as potential cellular imaging probes
Chemical Communications. 2007. DOI : 10.1039/B701482A.A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range
Chemistry - A European Journal. 2007. DOI : 10.1002/chem.200600964.Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications
2007. MEMS 2007, Kobe, Japan, January 21-25, 2007. p. 521-524. DOI : 10.1109/MEMSYS.2007.4433119.Microfluidic system for analytical applications : a magnetic droplet-based Lab-on-a-Chip
2006. Nanozoom ''Applications industrielles des nanotechnologies'', Besançon, France, September 27-28 2006.Droplets and DNA: Extracting and Purifying DNA in a Magnetic Droplet Manipulation System
2006. NanoTech Montreux 2006, Montreux, Switzerland, 14-16 November 2006.On-chip antibody handling and detection in a magnetic droplet manipulation system
2006. MNE 2006, Barcelona, Spain, 17-20 September 2006. p. 45-46.Magnetic on-chip DNA Extraction in a Droplet-Based Microsystem
2006. MicroTAS 2006, Tokyo, November 5-9, 2006. p. 428-430.A magnetic droplet-based Lab-on-a-Chip
2006. Third Asia Forum on Magnetics, Shimane, Japan, September 11-14, 2006.DNA capture and elution in a magnetic droplet manipulation system
2006. 6th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Krems, Austria, May 17 - 20, 2006.A Lab-on-a-Chip using magnetic droplets
2006. Nanotech 2006, Boston, MA, USA, May 7-11 2006.Magnetic particles as mobile substrates on biochips
2006. pHealth2006, International workshop on wearable micro- and nanosystems for personalized Health, Luzern, Switzerland, January 30 – February 1 2006.Two-dimensional magnetic manipulation of microdroplets on a chip as a platform for bioanalytical applications
Sensors and Actuators B. 2006. DOI : 10.1016/j.snb.2005.12.053.Droplet-Based DNA Purification in a Magnetic Lab-on-a-Chip
Angewandte Chemie International Edition. 2006. DOI : 10.1002/anie.200503624.Selection of antibodies against a Muc1 peptide by phage display using a novel antigen presentation procedure
2005In vitro microsomal metabolism and in vivo pharmacokinetics in rats of four anti-tuberculosis drugs
2005Caractérisation de la matrice organique des coraux constructeurs de récifs
2005Sélection d'anticorps contre le peptide MUC1 par phage display selon deux types de présentation du peptide: sur un immunotube et à la surface de billes magnétiques streptavidine
2005On-chip Enzyme-Based Bioanalytical Detection in a Magnetic Droplet Manipulation System
2005. NanoTech 2005, the 9th Annual European Conference on MicroNanoscale Technologies for the Biosciences, Montreux, 15.-17.11.2005.Pumping of mammalian cells with a nozzle-diffuser micropump
Lab On a Chip. 2005. DOI : 10.1039/b504468e.DNA biosensor for detection of genetically modified food
2003. Abstract Korea-Switzerland Workshop on Materials for Medical Diagnostic and Bio-Applications, KAIST, Daejeon, Republic of Korea, October 5 - 7.DNA biosensor for detection of genetically modified food
2003. Abstract book Nanotech 2003, the 7th Annual European Conference on MicroNanoscale Technologies for the Biosciences, Montreux, Switzerland, November 25-27.Infoscience
Synthesis and cell localization of self-assembled dinuclear lanthanide bioprobes
Philosophical Transactions Of The Royal Society A-Mathematical Physical And Engineering Sciences. 2013. DOI : 10.1098/rsta.2012.0295.Fluorescent magnetic bead and cell differentiation/counting using a CMOS SPAD matrix
Sensors and Actuators B. 2012. DOI : 10.1016/j.snb.2012.06.049.Lighting-up cancerous cells and tissues with lanthanide luminescence
Chimia. 2011. DOI : 10.2533/chimia.2011.361.Chaotic mixing using source-sink microfluidic flows in a PDMS chip
Microfluidics and Nanofluidics. 2011. DOI : 10.1007/s10404-010-0706-0.Increasing the efficiency of lanthanide luminescent bioprobes: bioconjugated silica nanoparticles as markers for cancerous cells
New Journal Of Chemistry. 2010. DOI : 10.1039/c0nj00440e.Active microfluidic mixer using virtual source-sink pairs for DNA purification
2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010), Groningen, Netherlands, October 3 - 7, 2010. p. 1841-1843.Fast Immunohistochemical BioMarker Detection Device for Cancer Tissue Slices
2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS 2010), Groningen, Netherlands, October 3-7, 2010.Selective Breast Cancer Cell Capture, Culture, and Immunocytochemical Analysis Using Self-Assembled Magnetic Bead Patterns in a Microfluidic Chip
Langmuir. 2010. DOI : 10.1021/la9045572.Microfluidic Immunoassays Based on Self-Assembled Magnetic Bead Patterns and Time-Resolved Luminescence Detection
Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4644.Monolithic Silicon Chip for Immunofluorescence Detection on Single Magnetic Beads
Analytical Chemistry. 2010. DOI : 10.1021/ac902241j.Bioconjugated lanthanide luminescent helicates as multilabels for lab-on-a-chip detection of cancer biomarkers
Analyst. 2010. DOI : 10.1039/b922124g.Time-Resolved Luminescence for Immunohistochemical Detection of Cancer Biomarkers in a Lab-on-a-Chip
2009. NanoBioTech 2009, Montreux, Switzerland, November 16-18, 2009.On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns
2009. NanoBioTech 2009, Montreux, Switzerland, November 16-18, 2009.Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues
Analyst. 2009. DOI : 10.1039/b911301k.On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns
Analytical Chemistry. 2009. DOI : 10.1021/ac9009319.Luminescent Bimetallic Lanthanide Bioprobes for Cellular Imaging with Excitation in the Visible-Light Range
Chemistry-A European Journal. 2009. DOI : 10.1002/chem.200801868.Sandwich immunoassay on a microfluidic chip using patterns of electrostatically self-assembled streptavidin-coated beads
2009. 34th International Conf. on Micro and Nanoengineering, Athens, Greece, September 15-18, 2008. p. 1404-1406. DOI : 10.1016/j.mee.2008.11.087.Magnetic beads retention device for sandwich immunoassay: comparison of off-chip and on-chip antibody incubation
Microfluidics and Nanofluidics. 2009. DOI : 10.1007/s10404-009-0424-7.Screening of a Human Antibody Phage Display Library Against a Peptide Antigen Using Stimuli-Responsive Bioconjugates
Biotechnology Progress. 2008. DOI : 10.1021/bp.60.On-chip nanoliter immunoassay by geometrical trapping of magnetic nanoparticle chains
2008. 12th Annual European Conference On Micro & Nanoscale Technologies for the Biosciences, Montreux, Switzerland, November 17-19, 2008.A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence
Analyst. 2008. DOI : 10.1039/b807959e.Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells
Org. Biomol. Chem.. 2008. DOI : 10.1039/b811427g.Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes
New Journal of Chemistry. 2008. DOI : 10.1039/b800516h.Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing
Annals of the New York Academy of Sciences. 2008. DOI : 10.1196/annals.1430.010.A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes
Chemistry - A European Journal. 2008. DOI : 10.1002/chem.200701357.Magnetic bead retention device for full on-chip sandwich immuno-assay
2008. MEMS 2008, Tucson, AZ (USA), January 13-17, 2008. p. 184-187. DOI : 10.1109/MEMSYS.2008.4443623.Full on-chip nanoliter immuno-assay by geometrical magnetic trapping of nanoparticle chains
Analytical Chemistry. 2008. DOI : 10.1021/ac7020739.Micropatterning of protein-functionalized magnetic beads on glass using electrostatic self-assembly
Sensors and Actuators B: Chemical. 2008. DOI : 10.1016/j.snb.2007.09.076.A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells
Chemistry - A European Journal. 2007. DOI : 10.1002/chem.200700883.Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments
Chemistry, a European Journal. 2007. DOI : 10.1002/chem.200700819.New Opportunities for Lanthanide Luminescence
Journal of Rare Earths. 2007. DOI : 10.1016/S1002-0721(07)60420-7.Micropatterning of Streptavidin-Functionalized Magnetic Beads on Glass Using Electrostatic Self-Assembly
2007. IEEE Transducers 2007, Lyon, France, June 10-14, 2007. p. 525-528. DOI : 10.1109/SENSOR.2007.4300183.On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system
Microelectronic Engineering. 2007. DOI : 10.1016/j.mee.2007.01.212.Luminescent lanthanide bimetallic triple-stranded helicates as potential cellular imaging probes
Chemical Communications. 2007. DOI : 10.1039/B701482A.A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range
Chemistry - A European Journal. 2007. DOI : 10.1002/chem.200600964.Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications
2007. MEMS 2007, Kobe, Japan, January 21-25, 2007. p. 521-524. DOI : 10.1109/MEMSYS.2007.4433119.Microfluidic system for analytical applications : a magnetic droplet-based Lab-on-a-Chip
2006. Nanozoom ''Applications industrielles des nanotechnologies'', Besançon, France, September 27-28 2006.Droplets and DNA: Extracting and Purifying DNA in a Magnetic Droplet Manipulation System
2006. NanoTech Montreux 2006, Montreux, Switzerland, 14-16 November 2006.On-chip antibody handling and detection in a magnetic droplet manipulation system
2006. MNE 2006, Barcelona, Spain, 17-20 September 2006. p. 45-46.Magnetic on-chip DNA Extraction in a Droplet-Based Microsystem
2006. MicroTAS 2006, Tokyo, November 5-9, 2006. p. 428-430.A magnetic droplet-based Lab-on-a-Chip
2006. Third Asia Forum on Magnetics, Shimane, Japan, September 11-14, 2006.DNA capture and elution in a magnetic droplet manipulation system
2006. 6th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Krems, Austria, May 17 - 20, 2006.A Lab-on-a-Chip using magnetic droplets
2006. Nanotech 2006, Boston, MA, USA, May 7-11 2006.Magnetic particles as mobile substrates on biochips
2006. pHealth2006, International workshop on wearable micro- and nanosystems for personalized Health, Luzern, Switzerland, January 30 – February 1 2006.Two-dimensional magnetic manipulation of microdroplets on a chip as a platform for bioanalytical applications
Sensors and Actuators B. 2006. DOI : 10.1016/j.snb.2005.12.053.Droplet-Based DNA Purification in a Magnetic Lab-on-a-Chip
Angewandte Chemie International Edition. 2006. DOI : 10.1002/anie.200503624.Selection of antibodies against a Muc1 peptide by phage display using a novel antigen presentation procedure
2005In vitro microsomal metabolism and in vivo pharmacokinetics in rats of four anti-tuberculosis drugs
2005Caractérisation de la matrice organique des coraux constructeurs de récifs
2005Sélection d'anticorps contre le peptide MUC1 par phage display selon deux types de présentation du peptide: sur un immunotube et à la surface de billes magnétiques streptavidine
2005On-chip Enzyme-Based Bioanalytical Detection in a Magnetic Droplet Manipulation System
2005. NanoTech 2005, the 9th Annual European Conference on MicroNanoscale Technologies for the Biosciences, Montreux, 15.-17.11.2005.Pumping of mammalian cells with a nozzle-diffuser micropump
Lab On a Chip. 2005. DOI : 10.1039/b504468e.DNA biosensor for detection of genetically modified food
2003. Abstract Korea-Switzerland Workshop on Materials for Medical Diagnostic and Bio-Applications, KAIST, Daejeon, Republic of Korea, October 5 - 7.DNA biosensor for detection of genetically modified food
2003. Abstract book Nanotech 2003, the 7th Annual European Conference on MicroNanoscale Technologies for the Biosciences, Montreux, Switzerland, November 25-27.Sélection de publications
Lodewyckx L, Vandevyver C, Vandervorst C, Van Steenbergen W, Raus J, Michiels L. Hum Mutat, 18(3), 2001 |
Mutation detection in the alpha-1 antitrypsin gene (PI) using denaturing gradient gel electrophoresis. |
VanderBorght A, Geusens P, Vandevyver C, Raus J, Stinissen P. Reumatology (Oxford), 39(11), 2000 |
Skewed T-cell receptor variable gene usage in the synovium of early and chronic rheumatoid arthritis patients and persistence of clonally expanded T cells in a chronic patient. |
Vandevyver C, Vanhoof J, Declerck K, Stinissen P, Vandervorst C, Michiels L, J Bone Miner Res, 14(9), 1999 |
Lack of association between estrogen receptor genotypes and bone mineral density, fracture history, or muscle strength in elderly women. |
Motmans K, Thirion S, Janssens J, Raus J, Vandevyver C. Eur J Cancer Prev, 7 S72, 1998 |
Redirecting human T-cell specificity by functional expression of a chimeric T-cell receptor. |
VanderBorght A, van der Aa A, Geusens P, Vandevyver C, Raus J, Stinissen P. J Immunol Methods, 223(1), 1999 |
Identification of overrepresented T cell receptor genes in blood and tissue biopsies by PCR-ELISA. |