My research lies at the intersection between Systems Neuroscience and Neuroengineering. I am interested in understanding how the dynamics of neuronal networks become altered in neurological disorders or after injury, and how to restore their natural behaviour using closed-loop neuromodulation approaches. I have investigated the cortical dynamics underlying the transition to epileptic seizures in rodent models and epileptic patients, and the spinal cord dynamics that control locomotion in non-human primates and patients with spinal cord injury. To this end, I have developed technological tools that enable to link neural signals recorded with intracortical microelectrode arrays to either optogenetic cortical stimulation or epidural electrical stimulation of the spinal cord. My main achievement has been the restoration of leg motor control and walking capabilities in patients with chronic spinal cord injury using spatiotemporal stimulation of the spinal cord. My overall goal is to leverage our understanding of the natural dynamics of neuronal networks to create neuroprosthetic systems that assist and repair their dysfunctional parts, both in animal models and clinical settings.