Hongxia Lei


hongxia.lei@epfl.ch +41 21 693 79 64

CH F1 627 (Bâtiment CH)
Station 6
CH-1015 Lausanne

Administrative data



Choi I-Y, Lei H, Gruetter R
J. Cereb. Blood Flow Metab. 22:1343-1351 (2002)
Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: On the correlation of total glucose consumption with glutamatergic action
Gruetter R, Adriany G, Choi IY, Henry PG, Lei H, Oz G.
NMR Biomed. 16(6-7):313-38 (2003)
Localized in vivo 13C NMR spectroscopy of the brain
Lei H, Gruetter R
J. Neurochem. 99:260-268 (2006)
Effect of chronic hypoglycemia on glucose concentration and glycogen content in rat brain: A localized 13C NMR study
Lei H, Morgenthaler F, Yue T, Gruetter R
Magn. Reson. Med. 57:243-248 (2007)
Direct validation of in vivo localized 13C MRS measurements of brain glycogen
Lei H, Mlynarik V, Just N, Gruetter R
Mag. Reson. Imaging 26:954-60 (2008)
Snapshot gradient-recalled echo-planar images with very long echo time of rat brain at 9.4-T
Morgenthaler FD, van Heeswijk RB, Xin L, Laus S, Frenkel H, Lei H, Gruetter R
J. Neurochem, 107:1414-23 (2008)
Non-invasive quantification of brain glycogen absolute concentration
Lei H, Berthet C, Hirt L, Gruetter R
J. Cereb. Blood Flow and Metab. 29:811-819 (2009)
Evolution of the neurochemical profile following transient focal cerebral ischemia in the mouse brain
Poitry-Yamate C, Lei H, Gruetter R
J. Neurochem. 109(s1): 38-45 (2009)
The rate-limiting step for glucose transport into the hypothalamus is across the blood-hypothalamus interface
Berthet C, Lei H, Thevenet J, Gruetter R, Magistretti P.J., Hirt L.
J. Cereb. Blood Flow and Metab.29: 1780-1789 (2009)
Neuroprotective role of lactate after cerebral ischemia
Lei H, Duart J.M.N., Mlynarik V, Python A, Gruetter R.
J Neurosci Res 88(2):413-419 (2010)
Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex
van der Zwaag W, Marques JP, Lei H, Just N, Kober T, Gruetter R.
J Magn Reson Imaging 30(5):1171-1178 (2009)
Minimization of Nyquist ghosting for fMRI at ultra-high fields based on a negative read-out gradient
Duarte J.M.N., Morgenthaler F.D., Lei H, Poitry-Yamate C, Gruetter R.
Front Neuroenergetics. 1:6 (2009)
Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational model
Lei H, Poitry-Yamate C, Preitner F, Thorens B, Gruetter R
NMR Biomed. 23(6):578-583 (2010)
Neurochemical profile of the mouse hypothalamus using in vivo 1H MRS at 14.1T
Berthet C, Lei H, Gruetter R, Hirt Lorenz
Stroke. 42(3):799-805 (2011)
Early predictive biomarkers for lesion development after transient cerebral ischemia
Alf FM, Lei H, Berthet C, Hirt L, Gruetter R and Mlynarik V
NMR Biomed., 25(2):247-54. (2012)
High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice
Just N, Cudalbu C, Lei H, Gruetter R
J. Cereb. Blood Flow and Metab. 31:2324-2333 (2011)
Effect of manganese on the neurochemical profile of the hypothalamus
Lei H, Pilloud Y, Magill AW, Gruetter R.
Conf Proc IEEE Eng Med Biol Soc. 2011 Aug;2011:6993-6996.
Continuous arterial spin labeling of mouse cerebral blood flow using an actively-detuned two-coil system at 9.4T
Duarte JMN, Lei H, Mlynarik V, Gruetter R
Neuroimage. 2012 Jun;61(2):342-62. Epub 2011 Dec 28. Review.
The neurochemical profile qauntified by in vivo 1H NMR spectroscopy
Mlynarik V, Cacquevel M, Sun-Reimer L, Janssens S, Cudalbu C, Lei H, Schneider BL, Aebischer P, Gruetter R
J Alzheimers Dis. 2012 Jan 1;31(0):S87-99.
Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease
ALF M, Duarte JMN, Lei H, Kr�mer SD, Mlynarik V, Schibli R, Gruetter R
J Neurochem. 2014 May;129(4):672-82
MRS glucose mapping and PET joining forces: Re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia
Cudalbu C, McLin VA, Lei H, Duarte JMN, Rougemont AL, Oldani G, Terraz S, Toso C and Gruetter R
PLoS ONE 8(7): e69782. doi:10.1371/journal.pone.0069782
The C57BL/6J mouse exhibits sporadic congenital portosystemic shunts
Berthet C, Xin LJ, Buscemi L, Benakis C, Gruetter R, Hirt L, and Lei H
J. Cereb. Blood Flow and Metab. (2014) 34, 1848-1855
Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia
Cheng T, Magill AW, Comment A, Gruetter R and Lei H
Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:2360-3. doi: 10.1109/EMBC.2014.694409
Ultra-high field birdcage coils: A comparison study at 14.1T
Xin LJ, Lanz B, Lei H and Gruetter R
J. Cereb. Blood Flow and Metab. (2015) 35, 759-765
Assessment of Metabolic Fluxes in the Mouse Brain in vivo using 1H-[13C] NMR Spectroscopy at 14.1 Tesla
Soares A, Lei H and Gruetter R
NMR Biomed. (2015)28,1009-1020
Characterization of hepatic fatty acids in mice with reduced liver fat by ultra-short echo time 1H-MRS at 14.1 T in vivo
Bastiaansem J, Cheng T, Lei H, Gruetter R and Comment A
J Mol Cell Cardiol. 2015 Aug 19;87:129-137. doi: 10.1016/j.yjmcc.2015.08.012.
Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance
Porcari P, Hegi M, Lei H , Hamou MF, Vassallo I, Capuani S, Gruetter R and Mlynarik V
NMR Biomed. 29(11): 1577–1589 (2016)
Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 Tesla
Soares A, Gruetter R and Lei H
Anal. Biochem, 529:117-126 (2017)
Technical and experimental features of Magnetic Resonance Spectroscopy of brain glycogen metabolism
Soares A, Paz-Montoya J, Lei H, Moniatte M and Gruetter R
NMR Biomed. 2017 Oct;30(10). doi: 10.1002/nbm.3761
Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice
Larrieu T, Cherix A, Duque Moreno A, Rodrigues J, Lei H, Gruetter R and Sandi C
Current Biology, 27(14): 2202–2210.e4 (2017)
Hierarchical status predicts behavioral vulnerability and nucleus accumbens metabolic profile following chronic social defeat stress
Soares A, Lei H
NMR Biomed. 2018 Feb;31(2). doi: 10.1002/nbm.3873. Epub 2017 Dec 20.
Non-invasive diagnosis and metabolic consequences of congenital portosystemic shunts in C57BL/6J mice
Lei H, Dirren E, Poitry-Yamate C, Schneider, BL, Gruetter R, and Aebischer P
J Cereb Blood Flow Metab. 2019 Jul;39(7):1283-1298. doi: 10.1177/0271678X18756499. Epub 2018 Feb 5.
Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
Lizarbe B, Lei H, Duarte JMN, Lanz B, Cherix A and Gruetter R
Magn Reson Med. 2018 Sep;80(3):874-884. doi: 10.1002/mrm.27129. Epub 2018 Feb 9
Feasibility of the in vivo measurement of glucose metabolism by 1H-[13C] MRS at 14.1T in mouse hypothalamus
Lei H, Preitner F, Labouebe G, Gruetter R and Thorens B
J Cereb Blood Flow Metab. 2019 Sept; 39(9), 1725-1736; doi: 10.1177/0271678X18766743. Epub 2018 Jan
Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow
Sanches EF, van de Looij Y, Toulotte A, Sizonenko SV, Lei H
Front Physiol. 2019 Jun 5;10:634. doi: 10.3389/fphys.2019.00634. eCollection 2019.
Mild Neonatal Brain Hypoxia-Ischemia in Very Immature Rats Causes Long-Term Behavioral and Cerebellar Abnormalities at Adulthood.
Lei H, Montessuit S, Herzig S, and Martinou JC
MR Biomed. 2019 Nov;32(11):e4163. doi: 10.1002/nbm.4163. Epub 2019 Aug 19.
Feasibility of neurochemical profiling mouse embryonic brain and its development in utero using 1H MRS at 14.1T
Dehghani M, Kunz N and Lei H
NMR Biomed 2019, DOI:10.1002/nbm.4198, accepted on Sept 13th, 2019
Diffusion Behaviours of Cerebral Metabolites of the Congenital Portal Systemic Shunt Mice Assessed Non-Invasively by Diffusion-Weighted 1H Magnetic Resonance Spectroscopy


Book chapter entitled “In-vivo NMR Spectroscopy of the Brain at High Fields” in “Ultra High Field Magnetic Resonance Imaging” Gruetter R., Henry P.G., Lei H., Mangia S., Oz G., Terpstra M. and Tkac I. Series: Biological Magnetic Resonance , Vol. 26 Book chapter entitled "Localized Single Voxel MR Spectroscopy, Water Suppression and Novel Approaches for Ultra-short Echo-Time Measurements" in "Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications" Lei H.,. Xin LJ, Gruetter R. and Mlynarik V