Master and semester Projects

We offer projects for Master's and Bachelor students in the areas of Computational Neuroscience and Neurorbotics.

Master projects

Interplay between topology and activity in biological neural networks

Keywords:Neural networks, dynamical systems, computational topology Neural networks generally face what is known as the plasticity-stability dilemma: Neural activity changes the topology of the network, which then in turn changes the activity dynamics which of the network. The aim of this project is to investigate the interplay between the topology of a neural network and the activity dynamics which is supported by this topology. Your aim will be to work on the edge between two disciplines - computational topology and neuroscience. You will use methods from computational topology to generate various topologically different networks and then measure the properties of the network activity which can be supported by the specific topology. You will be supervised by the team from the Blue Brain Project, mathematicians from EPFL and from partnering institutions. If successful, this line of research can be continue and eventually turned into a Phd program. Skills: linear algebra, algorithms, Python, C++ Contact: Marc-Oliver Gewaltig, marc-oliver.gewaltig@epfl.ch Pawel Dlotko, pawel.dlotko@inria.fr

Evolutionary optimization of neural morphology synthesis in high-dimensional parameter spaces

Keywords: evolutionary optimization, neurons, neuron morphologies, classification The Blue Brain Project has developed algorithms to synthesize neuron morphologies (the synthesizer). Depending on a set of parameters, the synthesizer generates different classes of neuron morphologies where each class is determined by a number of empirical distributions that capture particular features of a morphology. To generate morphologies for a particular neuron class, one needs to find an appropriate set of parameters through a non-convex and high-dimensional optimization procedure. The objective of this project is to test and compare different optimization algorithms in their ability to determine morphology class specific parameter sets for the synthesizer. The fitness function for the optimization is constructed from the distances between the feature distributions of biological and synthesized neurons. Contact: Marc-Oliver Gewaltig

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From detailed to simplified models of neuronal microcircuits

Keywords: neuronal microcircuits, simulation, model selection, model validation The Blue Brain Project is developing morphologically and electrically detailed models of cortical microcircuits. The objective of this project is to investigate how detailed microcircuit models can be mapped to less complex network models while preserving the response properties of the circuit to a range of biologically meaningful stimuli. Complexity levels to be studied in the project are point neuron networks as well as population-level networks. Contact: Marc-Oliver Gewaltig