Neeraj Dhar

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neeraj.dhar@epfl.ch +41 21 693 18 34

EPFL SV GHI UPKIN
SV 3832 (Bâtiment SV)
Station 19
CH-1015 Lausanne

+41 21 693 18 34
Local: SV 3832
EPFL > SV > GHI > UPKIN

Web site: Site web: https://mckinney-lab.epfl.ch/

EPFL VPRHO DSPS COSEC-SV
SV 3832 (Bâtiment SV)
Station 19
CH-1015 Lausanne

+41 21 693 18 34
Local: SV 3832
EPFL > RHO > RHO-DSPS > COSEC-SV

EPFL > CDH > CDH-SHS > SHS-ENS

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Publications

Publications Infoscience

Infoscience

A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

V. V. Thacker; N. Dhar; K. Sharma; R. Barrile; K. Karalis et al.

eLife. 2020-11-24. DOI : 10.7554/eLife.59961.

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Elicitation of efficient, protective immune responses by using DNA vaccines against tuberculosis (vol 23, pg 5655, 2005)

A. Khera; R. Singh; H. Shakila; V. Rao; N. Dhar et al.

Vaccine. 2020-11-17. DOI : 10.1016/j.vaccine.2020.10.011.

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Bacteria: Driving polar growth

N. Dhar

eLife. 2020-05-07. DOI : 10.7554/eLife.57043.

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Computational Analysis of the Mutual Constraints between Single‐Cell Growth and Division Control Models

G. Vuaridel‐Thurre; A. R. Vuaridel; N. Dhar; J. D. McKinney

Advanced Biosystems. 2019-12-16. DOI : 10.1002/adbi.201900103.

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Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress

G. Manina; A. Griego; L. K. Singh; J. D. McKinney; N. Dhar

EMBO Journal. 2019-10-04. DOI : 10.15252/embj.2019101876.

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Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development

R. C. Sommer / S. Cole; A. C. Oates (Dir.)

Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9248.

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Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria

R. Sommer; J. Neres; J. Piton; N. Dhar; A. van der Sar et al.

ACS Chemical Biology. 2018-11-01. DOI : 10.1021/acschembio.8b00790.

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Functional characterization of the virulence determinant ESX-1 from Mycobacterium tuberculosis

P. J. Soler Arnedo / S. Cole (Dir.)

Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-9011.

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Single-cell division and killing dynamics of bacteria exposed to isocratic and time-dependent concentrations of antibiotic

K. E. Schneider / J. McKinney; N. Dhar (Dir.)

Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8585.

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Division site selection linked to inherited cell surface wave troughs in mycobacteria

H. A. Eskandarian; P. D. Odermatt; J. X. Y. Ven; M. T. M. Hannebelle; A. P. Nievergelt et al.

Nature Microbiology. 2017. DOI : 10.1038/nmicrobiol.2017.94.

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An Amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase is required for mycobacterial cell division

S. Senzani; D. Li; A. Bhaskar; C. Ealand; J. Chang et al.

Scientific Reports. 2017. DOI : 10.1038/s41598-017-01184-7.

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Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

V. Singh; N. Dhar; J. Pato; G. S. Kolly; J. Kordulakova et al.

Molecular Microbiology. 2017. DOI : 10.1111/mmi.13535.

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The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

V. Singh; S. Donini; A. Pacitto; C. Sala; R. C. Hartkoorn et al.

Acs Infectious Diseases. 2017. DOI : 10.1021/acsinfecdis.6b00102.

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Phenotypic Heterogeneity in Mycobacterium tuberculosis

N. Dhar; J. Mckinney; G. Manina

Microbiology Spectrum. 2016. DOI : 10.1128/microbiolspec.TBTB2-0021-2016.

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Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

M. Martinez-Hoyos; E. Perez-Herran; G. Gulten; L. Encinas; D. Alvarez-Gomez et al.

Ebiomedicine. 2016. DOI : 10.1016/j.ebiom.2016.05.006.

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Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose Oxidase

S. M. Batt; M. Cacho Izquierdo; J. Castro Pichel; C. J. Stubbs; L. Vela-Glez Del Peral et al.

Acs Infectious Diseases. 2015. DOI : 10.1021/acsinfecdis.5b00065.

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Bioluminescence for Assessing Drug Potency against Nonreplicating Mycobacterium tuberculosis

A. Vocat; R. C. Hartkoorn; B. Lechartier; M. Zhang; N. Dhar et al.

Antimicrobial Agents And Chemotherapy. 2015. DOI : 10.1128/Aac.00528-15.

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Combinations of beta-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

J. Rullas; N. Dhar; J. D. Mckinney; A. Garcia-Perez; J. Lelievre et al.

Antimicrobial Agents And Chemotherapy. 2015. DOI : 10.1128/Aac.01063-15.

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Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable beta-Lactam Antibiotic

N. Dhar; V. Dubee; L. Ballell; G. Cuinet; J.-E. Hugonnet et al.

Antimicrobial Agents And Chemotherapy. 2015. DOI : 10.1128/Aac.03461-14.

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2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1

J. Neres; R. C. Hartkoorn; L. R. Chiarelli; R. Gadupudi; M. R. Pasca et al.

Acs Chemical Biology. 2015. DOI : 10.1021/cb5007163.

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Stressed Mycobacteria Use the Chaperone ClpB to Sequester Irreversibly Oxidized Proteins Asymmetrically Within and Between Cells

J. Vaubourgeix; G. Lin; N. Dhar; N. Chenouard; X. Jiang et al.

Cell Host & Microbe. 2015. DOI : 10.1016/j.chom.2014.12.008.

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Stress and Host Immunity Amplify Mycobacterium tuberculosis Phenotypic Heterogeneity and Induce Nongrowing Metabolically Active Forms

G. Manina; N. Dhar; J. D. Mckinney

Cell Host & Microbe. 2015. DOI : 10.1016/j.chom.2014.11.016.

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Simple and Rapid Method To Determine Antimycobacterial Potency of Compounds by Using Autoluminescent Mycobacterium tuberculosis

S. Sharma; E. Gelman; C. Narayan; D. Bhattacharjee; V. Achar et al.

Antimicrobial Agents And Chemotherapy. 2014. DOI : 10.1128/Aac.03205-14.

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The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo (vol 196, pg 3441, 2014)

F. Boldrin; M. Ventura; G. Degiacomi; S. Ravishankar; C. Sala et al.

Journal Of Bacteriology. 2014. DOI : 10.1128/Jb.02332-14.

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EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis

M. Zhang; J. M. Chen; C. Sala; J. Rybniker; N. Dhar et al.

Molecular Microbiology. 2014. DOI : 10.1111/mmi.12718.

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The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo

F. Boldrin; M. Ventura; G. Degiacomi; S. Ravishankar; C. Sala et al.

Journal Of Bacteriology. 2014. DOI : 10.1128/Jb.01346-13.

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In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

M. Zhang; C. Sala; N. Dhar; A. Vocat; V. K. Sambandamurthy et al.

Antimicrobial Agents And Chemotherapy. 2014. DOI : 10.1128/Aac.02410-14.

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4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity

M. Naik; V. Humnabadkar; S. J. Tantry; M. Panda; A. Narayan et al.

Journal Of Medicinal Chemistry. 2014. DOI : 10.1021/jm5005978.

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Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants

G. S. Kolly; F. Boldrin; C. Sala; N. Dhar; R. C. Hartkoorn et al.

Molecular Microbiology. 2014. DOI : 10.1111/mmi.12546.

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Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations

M. Elitas; R. Martinez-Duarte; N. Dhar; J. D. Mckinney; P. Renaud

Lab on a Chip. 2014. DOI : 10.1039/c4lc00109e.

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Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

A. Koul; L. Vranckx; N. Dhar; H. W. H. Gohlmann; M. E. Özdemir et al.

Nature Communications. 2014. DOI : 10.1038/ncomms4369.

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Antibiotic-Induced Killing and Persistence of Mycobacteria

E. Gelman / J. McKinney; N. Dhar (Dir.)

Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6056.

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Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion In Vitro Does Not Always Correlate with Attenuation of Virulence

J. M. Chen; M. Zhang; J. Rybniker; L. Basterra; N. Dhar et al.

Journal Of Bacteriology. 2013. DOI : 10.1128/Jb.00967-13.

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Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence

J. M. Chen; M. Zhang; J. Rybniker; S. Boy-Röttger; N. Dhar et al.

Molecular Microbiology. 2013. DOI : 10.1111/mmi.12336.

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Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria

I. Santi; N. Dhar; D. Bousbaine; Y. Wakamoto; J. D. McKinney

Nature Communications. 2013. DOI : 10.1038/ncomms3470.

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Dynamic Persistence of Antibiotic-Stressed Mycobacteria

Y. Wakamoto; N. Dhar; R. Chait; K. E. Schneider; F. Signorino-Gelo et al.

Science. 2013. DOI : 10.1126/science.1229858.

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Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

J. Neres; F. Pojer; E. Molteni; L. R. Chiarelli; N. Dhar et al.

Science Translational Medicine. 2012. DOI : 10.1126/scitranslmed.3004395.

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Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis

M. Zhang; C. Sala; R. C. Hartkoorn; N. Dhar; A. Mendoza-Losana et al.

Antimicrobial Agents And Chemotherapy. 2012. DOI : 10.1128/Aac.01125-12.

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Malachite Green Interferes with Postantibiotic Recovery of Mycobacteria

E. Gelman; J. D. McKinney; N. Dhar

Antimicrobial Agents And Chemotherapy. 2012. DOI : 10.1128/AAC.00406-12.

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EspD Is Critical for the Virulence-Mediating ESX-1 Secretion System in Mycobacterium tuberculosis

J. M. Chen; S. Boy-Röttger; N. Dhar; N. Sweeney; R. S. Buxton et al.

Journal of bacteriology. 2011. DOI : 10.1128/JB.06417-11.

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Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis

M. Ballester; C. Nembrini; N. Dhar; A. de Titta; C. de Piano et al.

Vaccine. 2011. DOI : 10.1016/j.vaccine.2011.07.039.

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Development of a repressible mycobacterial promoter system based on two transcriptional repressors

F. Boldrin; S. Casonato; E. Dainese; C. Sala; N. Dhar et al.

Nucleic acids research. 2010. DOI : 10.1093/nar/gkq235.

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A Simple Model for Testing Drugs against Non-replicating Mycobacterium tuberculosis

C. Sala; N. Dhar; R. C. Hartkoorn; M. Zhang; Y. H. Ha et al.

Antimicrobial agents and chemotherapy. 2010. DOI : 10.1128/AAC.00821-10.

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Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice

N. Dhar; J. D. McKinney

Proceedings of the National Academy of Sciences of the United States of America. 2010. DOI : 10.1073/pnas.1003219107.

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Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacterium tuberculosis infection in guinea pigs

B. Dey; R. Jain; A. Khera; V. Rao; N. Dhar et al.

Vaccine. 2009. DOI : 10.1016/j.vaccine.2009.09.121.

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Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

V. Makarov; G. Manina; K. Mikusova; U. Möllmann; O. Ryabova et al.

Science (New York, N.Y.). 2009. DOI : 10.1126/science.1171583.

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Enhanced and Enduring Protection against Tuberculosis by Recombinant BCG-Ag85C and Its Association with Modulation of Cytokine Profile in Lung

R. Jain; B. Dey; N. Dhar; V. Rao; R. Singh et al.

Plos One. 2008. DOI : 10.1371/journal.pone.0003869.

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Microbial phenotypic heterogeneity and antibiotic tolerance

N. Dhar; J. D. McKinney

Current opinion in microbiology. 2007. DOI : 10.1016/j.mib.2006.12.007.

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Enseignement & Phd

Enseignement

Programme Sciences humaines et sociales

Programmes doctoraux

Programme doctoral en biotechnologie et génie biologique

Programme doctoral Approches moléculaires du vivant

Doctorants

Normandeau Frédéric, Sharma Kunal, Von Schultz Sofia Ulrika Magnusdotter, Vuaridel Gaëlle Madeleine,

A dirigé les thèses EPFL de

Gelman Ekaterina , Schneider Katrin Esther ,

Cours

Enjeux mondiaux: santé B

Le cours présente l'enjeu mondial de la santé. Il aborde les défis posés par les maladies infectieuses et les maladies neurodégénératives. L'approche interdisciplinaire intègre les SHS et les sciences de l'ingénieur et initie au travail de groupe et à la méthodologie scientifique.

Neeraj Dhar

Publications

Publications Infoscience

Infoscience

A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

Elicitation of efficient, protective immune responses by using DNA vaccines against tuberculosis (vol 23, pg 5655, 2005)

Bacteria: Driving polar growth

Computational Analysis of the Mutual Constraints between Single‐Cell Growth and Division Control Models

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress

Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development

Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria

Functional characterization of the virulence determinant ESX-1 from Mycobacterium tuberculosis

Single-cell division and killing dynamics of bacteria exposed to isocratic and time-dependent concentrations of antibiotic

Division site selection linked to inherited cell surface wave troughs in mycobacteria

An Amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase is required for mycobacterial cell division

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

Phenotypic Heterogeneity in Mycobacterium tuberculosis

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose Oxidase

Bioluminescence for Assessing Drug Potency against Nonreplicating Mycobacterium tuberculosis

Combinations of beta-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable beta-Lactam Antibiotic

2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1

Stressed Mycobacteria Use the Chaperone ClpB to Sequester Irreversibly Oxidized Proteins Asymmetrically Within and Between Cells

Stress and Host Immunity Amplify Mycobacterium tuberculosis Phenotypic Heterogeneity and Induce Nongrowing Metabolically Active Forms

Simple and Rapid Method To Determine Antimycobacterial Potency of Compounds by Using Autoluminescent Mycobacterium tuberculosis

The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo (vol 196, pg 3441, 2014)

EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis

The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity

Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

Antibiotic-Induced Killing and Persistence of Mycobacteria

Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion In Vitro Does Not Always Correlate with Attenuation of Virulence

Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence

Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis

Malachite Green Interferes with Postantibiotic Recovery of Mycobacteria

EspD Is Critical for the Virulence-Mediating ESX-1 Secretion System in Mycobacterium tuberculosis

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis

Development of a repressible mycobacterial promoter system based on two transcriptional repressors

A Simple Model for Testing Drugs against Non-replicating Mycobacterium tuberculosis

Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice

Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacterium tuberculosis infection in guinea pigs

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

Enhanced and Enduring Protection against Tuberculosis by Recombinant BCG-Ag85C and Its Association with Modulation of Cytokine Profile in Lung

Microbial phenotypic heterogeneity and antibiotic tolerance

Enseignement & Phd

Enseignement

Programmes doctoraux

Doctorants

A dirigé les thèses EPFL de

Cours

Enjeux mondiaux: santé B

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