Neeraj Dhar
neeraj.dhar@epfl.ch +41 21 693 18 34
EPFL SV GHI UPKIN
SV 3832 (Bâtiment SV)
Station 19
CH-1015 Lausanne
Web site: Site web: https://mckinney-lab.epfl.ch/
Publications
Publications Infoscience
Infoscience
Bacteria: Driving polar growth
eLife. 2020-05-07. DOI : 10.7554/eLife.57043.Computational Analysis of the Mutual Constraints between Single‐Cell Growth and Division Control Models
Advanced Biosystems. 2019-12-16. DOI : 10.1002/adbi.201900103.Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress
EMBO Journal. 2019-10-04. DOI : 10.15252/embj.2019101876.Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9248.Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria
ACS Chemical Biology. 2018-11-01. DOI : 10.1021/acschembio.8b00790.Functional characterization of the virulence determinant ESX-1 from Mycobacterium tuberculosis
Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-9011.Single-cell division and killing dynamics of bacteria exposed to isocratic and time-dependent concentrations of antibiotic
Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8585.Division site selection linked to inherited cell surface wave troughs in mycobacteria
Nature Microbiology. 2017. DOI : 10.1038/nmicrobiol.2017.94.An Amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase is required for mycobacterial cell division
Scientific Reports. 2017. DOI : 10.1038/s41598-017-01184-7.Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria
Molecular Microbiology. 2017. DOI : 10.1111/mmi.13535.The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis
Acs Infectious Diseases. 2017. DOI : 10.1021/acsinfecdis.6b00102.Phenotypic Heterogeneity in Mycobacterium tuberculosis
Microbiology Spectrum. 2016. DOI : 10.1128/microbiolspec.TBTB2-0021-2016.Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor
Ebiomedicine. 2016. DOI : 10.1016/j.ebiom.2016.05.006.Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose Oxidase
Acs Infectious Diseases. 2015. DOI : 10.1021/acsinfecdis.5b00065.Bioluminescence for Assessing Drug Potency against Nonreplicating Mycobacterium tuberculosis
Antimicrobial Agents And Chemotherapy. 2015. DOI : 10.1128/Aac.00528-15.Combinations of beta-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection
Antimicrobial Agents And Chemotherapy. 2015. DOI : 10.1128/Aac.01063-15.Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable beta-Lactam Antibiotic
Antimicrobial Agents And Chemotherapy. 2015. DOI : 10.1128/Aac.03461-14.2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1
Acs Chemical Biology. 2015. DOI : 10.1021/cb5007163.Stressed Mycobacteria Use the Chaperone ClpB to Sequester Irreversibly Oxidized Proteins Asymmetrically Within and Between Cells
Cell Host & Microbe. 2015. DOI : 10.1016/j.chom.2014.12.008.Stress and Host Immunity Amplify Mycobacterium tuberculosis Phenotypic Heterogeneity and Induce Nongrowing Metabolically Active Forms
Cell Host & Microbe. 2015. DOI : 10.1016/j.chom.2014.11.016.Simple and Rapid Method To Determine Antimycobacterial Potency of Compounds by Using Autoluminescent Mycobacterium tuberculosis
Antimicrobial Agents And Chemotherapy. 2014. DOI : 10.1128/Aac.03205-14.The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo (vol 196, pg 3441, 2014)
Journal Of Bacteriology. 2014. DOI : 10.1128/Jb.02332-14.EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis
Molecular Microbiology. 2014. DOI : 10.1111/mmi.12718.The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo
Journal Of Bacteriology. 2014. DOI : 10.1128/Jb.01346-13.In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis
Antimicrobial Agents And Chemotherapy. 2014. DOI : 10.1128/Aac.02410-14.4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity
Journal Of Medicinal Chemistry. 2014. DOI : 10.1021/jm5005978.Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants
Molecular Microbiology. 2014. DOI : 10.1111/mmi.12546.Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations
Lab on a Chip. 2014. DOI : 10.1039/c4lc00109e.Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism
Nature Communications. 2014. DOI : 10.1038/ncomms4369.Antibiotic-Induced Killing and Persistence of Mycobacteria
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6056.Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion In Vitro Does Not Always Correlate with Attenuation of Virulence
Journal Of Bacteriology. 2013. DOI : 10.1128/Jb.00967-13.Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence
Molecular Microbiology. 2013. DOI : 10.1111/mmi.12336.Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria
Nature Communications. 2013. DOI : 10.1038/ncomms3470.Dynamic Persistence of Antibiotic-Stressed Mycobacteria
Science. 2013. DOI : 10.1126/science.1229858.Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis
Science Translational Medicine. 2012. DOI : 10.1126/scitranslmed.3004395.Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis
Antimicrobial Agents And Chemotherapy. 2012. DOI : 10.1128/Aac.01125-12.Malachite Green Interferes with Postantibiotic Recovery of Mycobacteria
Antimicrobial Agents And Chemotherapy. 2012. DOI : 10.1128/AAC.00406-12.EspD Is Critical for the Virulence-Mediating ESX-1 Secretion System in Mycobacterium tuberculosis
Journal of bacteriology. 2011. DOI : 10.1128/JB.06417-11.Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis
Vaccine. 2011. DOI : 10.1016/j.vaccine.2011.07.039.Development of a repressible mycobacterial promoter system based on two transcriptional repressors
Nucleic acids research. 2010. DOI : 10.1093/nar/gkq235.A Simple Model for Testing Drugs against Non-replicating Mycobacterium tuberculosis
Antimicrobial agents and chemotherapy. 2010. DOI : 10.1128/AAC.00821-10.Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice
Proceedings of the National Academy of Sciences of the United States of America. 2010. DOI : 10.1073/pnas.1003219107.Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacterium tuberculosis infection in guinea pigs
Vaccine. 2009. DOI : 10.1016/j.vaccine.2009.09.121.Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
Science (New York, N.Y.). 2009. DOI : 10.1126/science.1171583.Enhanced and Enduring Protection against Tuberculosis by Recombinant BCG-Ag85C and Its Association with Modulation of Cytokine Profile in Lung
Plos One. 2008. DOI : 10.1371/journal.pone.0003869.Microbial phenotypic heterogeneity and antibiotic tolerance
Current opinion in microbiology. 2007. DOI : 10.1016/j.mib.2006.12.007.Enseignement & Phd
Enseignement
Programme Sciences humaines et sociales