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Carl Petersen
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office(s):
AI3211
phone(s): [+41 21 69] 31721,31817
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MISSION
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My goal is to obtain a causal and mechanistic understanding of sensory perception and associative learning at the level of individual neurons and their synaptic interactions within complex neural circuits of the mammalian brain.
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CONTACT
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Prof. Carl Petersen,
Laboratory of Sensory Processing,
Brain Mind Institute,
Faculty of Life Science,
Ecole Polytechnique Federale de Lausanne (EPFL),
EPFL-SV-BMI-LSENS, Station 19,
CH-1015 Lausanne,
Switzerland.
tel: ++41 21 693 1721
fax: ++41 21 693 8353
email: carl.petersen@epfl.ch
www: http://lsens.epfl.ch/
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BIOGRAPHY
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2010-present. Associate Professor. Head of the Laboratory of Sensory Processing, Brain Mind Institute, EPFL, Switzerland.
2003-2009. Assistant Professor. Head of the Laboratory of Sensory Processing, Brain Mind Institute, EPFL, Switzerland.
1999-2003. Research Scientist. Advisor Prof Bert Sakmann, Department of Cell Physiology, Max-Planck-Institute for Medical Research, Heidelberg, Germany.
1996-1998. Post Doctoral Research Fellow. Advisor Prof Roger Nicoll, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA.
1991. Research Assistant. Advisor Prof Yasunobo Okada, Department of Physiology, Kyoto University, Japan.
1990. Research Assistant. Advisor Prof Ole Petersen, The Physiological Laboratory, University of Liverpool, England, UK.
Education
1992-1996. Doctoral Student. Advisor Prof Sir Michael Berridge, The Babraham Institute, Department of Zoology, Cambridge University, England, UK.
1989-1992. Bachelor Student of Physics (1st class degree) at Oxford University, England, UK.
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PUBLICATIONS
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Five Key Recent Original Papers:
Crochet S, Poulet JFA, Kremer Y, Petersen CCH (2011) Synaptic mechanisms underlying sparse coding of active touch. Neuron 69: 1160-1175.
Matyas F, Sreenivasan V, Marbach F, Wacongne C, Barsy B, Mateo C, Aronoff R, Petersen CCH (2010) Motor control by sensory cortex. Science 330: 1240-1243.
Gentet LJ, Avermann M, Matyas F, Staiger JF, Petersen CCH (2010) Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice. Neuron 65: 422-435. Video Abstract
Lefort S, Tomm C, Sarria JCF, Petersen CCH (2009) The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. Neuron 61: 301-316.
Poulet JFA, Petersen CCH (2008) Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice. Nature 454: 881-885.
Key Review:
Petersen CCH (2007) The functional organization of the barrel cortex. Neuron 56: 339-355.
Original Papers:
40. Mateo C, Avermann M, Gentet LJ, Zhang F, Deisseroth K, Petersen CCH (2011) In vivo optogenetic stimulation of neocortical excitatory neurons drives brain-state-dependent inhibition. Curr Biol 21: 1593-1602.
39. Crochet S, Poulet JFA, Kremer Y, Petersen CCH (2011) Synaptic mechanisms underlying sparse coding of active touch. Neuron 69: 1160-1175.
38. Matyas F, Sreenivasan V, Marbach F, Wacongne C, Barsy B, Mateo C, Aronoff R, Petersen CCH (2010) Motor control by sensory cortex. Science 330: 1240-1243.
37. Gentet LJ, Avermann M, Matyas F, Staiger JF, Petersen CCH (2010) Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice. Neuron 65: 422-435. Video Abstract
36. Lefort S, Tomm C, Sarria JCF, Petersen CCH (2009) The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. Neuron 61: 301-316.
35. Gersbach M, Boiko DL, Niclass C, Petersen CCH, Charbon E (2009) Fast-fluorescence dynamics in nonratiometric calcium indicators. Optics Letters 34: 362-364.
34. Badel L, Lefort S, Berger TK, Petersen CCH, Gerstner W, Richardson MJ (2008) Extracting non-linear integrate-and-fire models from experimental data using dynamic I-V curves. Biol Cybern 99: 361-370.
33. Poulet JFA, Petersen CCH (2008) Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice. Nature 454: 881-885.
32. Badel L, Lefort S, Brette R, Petersen CCH, Gerstner W, Richardson MJ (2008) Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces. J Neurophysiol 99: 656-666.
31. Aronoff R, Petersen CCH (2007) Layer- and column-specific knockout of NMDA receptors in pyramidal neurons of the mouse barrel cortex. Front Integr Neurosci 1: 1. doi: 10.3389/neuro.07.001.2007
30. Ferezou I, Haiss F, Gentet LJ, Aronoff R, Weber B, Petersen CCH (2007) Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice. Neuron 56: 907-923.
29. Berger T, Borgdorff AJ, Crochet S, Neubauer FB, Lefort S, Fauvet B, Ferezou I, Carleton A, Luscher HR, Petersen CCH (2007) Combined voltage and calcium epifluorescence imaging in vitro and in vivo reveals subthreshold and suprathreshold dynamics of mouse barrel cortex. J Neurophysiol 97: 3751-3762.
28. Accolla R, Bathellier B, Petersen CCH, Carleton A (2007) Differential spatial representation of taste modalities in the rat gustatory cortex. J Neurosci 27: 1396-1404.
27. Borgdorff AJ, Poulet JFA, Petersen CCH (2007) Facilitating sensory responses in developing mouse somatosensory barrel cortex. J Neurophysiol 97: 2992-3003.
26. Ferezou I, Bolea S, Petersen CCH (2006) Visualizing the cortical representation of whisker touch: voltage-sensitive dye imaging in freely moving mice. Neuron 50: 617-629.
25. Crochet S, Petersen CCH (2006) Correlating whisker behavior with membrane potential in barrel cortex of awake mice. Nat Neurosci 9: 608-610.
24. Kvajo M, Albrecht H, Meins M, Hengst U, Troncoso E, Lefort S, Kiss JZ, Petersen CCH, Monard D (2004) Regulation of brain proteolytic activity is necessary for the in vivo function of NMDA receptors. J Neurosci 24: 9734-9743.
23. Petersen CCH, Hahn TTG, Mehta M, Grinvald A, Sakmann B (2003) Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex. Proc Natl Acad Sci USA 100: 13638-13643.
22. Petersen CCH, Grinvald A, Sakmann B (2003) Spatiotemporal dynamics of sensory responses in layer 2/3 of rat barrel cortex measured in vivo by voltage-sensitive dye imaging combined with whole-cell voltage recordings and anatomical reconstructions. J Neurosci 23: 1298-1309.
21. Petersen CCH (2002) Short-term plasticity within the excitatory neuronal network of layer 4 barrel cortex. J Neurophysiol 87: 2904-2914.
20. Petersen CCH, Sakmann B (2001) Functionally independent columns of rat somatosensory barrel cortex revealed with voltage-sensitive dye imaging. J Neurosci 21: 8435-8446.
19. Petersen CCH, Sakmann B (2000) The excitatory neuronal network of layer 4 barrel cortex. J Neurosci 20: 7579-7586.
18. Zhou Q, Petersen CCH, Nicoll RA (2000) Effects of reduced vesicular filling on synaptic transmission in rat hippocampal neurones. J Physiol 525: 195-206.
17. Tian N, Petersen CCH, Kash S, Baekkeskov S, Copenhagen D, Nicoll RA (1999) The role of the synthetic enzyme GAD65 in the control of neuronal gama-aminobutyric acid release. Proc Natl Acad Sci USA 96: 12911-12916.
16. Frerking M, Petersen CCH, Nicoll RA (1999) Mechanisms underlying kainate receptor-mediated disinhibition in the hippocampus. Proc Natl Acacd Sci USA 96: 12917-12922.
15. Bobanovic LK, Laine M, Petersen CCH, Bennett DL, Berridge MJ, Lipp P, Ripley SJ, Bootman MD (1999) Molecular cloning and immunolocalisation of a novel vertebrate trp homologue from Xenopus. Biochem J 340: 593-599.
14. Petersen CCH, Malenka RC, Nicoll RA, Hopfield JJ (1998) All-or-none potentiation at CA3-CA1 synapses. Proc Natl Acad Sci USA 95: 4732-4737.
13. Petersen CCH, Berridge MJ (1996) Capacitative calcium entry is colocalised with calcium release in Xenopus oocytes: evidence against a highly diffusible calcium influx factor. Pflügers Arch 432: 286-292.
12. Petersen CCH, Borgese MF, Berridge MJ, Bennett DL (1995) Putative capacitative entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologs. Biochem J 311: 41-44.
11. Petersen CCH, Berridge MJ (1995) G-protein regulation of capacitative calcium entry in Xenopus oocytes may be mediated by protein kinases A and C. Biochem J 307: 663-668.
10. Okada Y, Kubo M, Oiki S, Petersen CCH, Tominaga M, Hazama A, Morishima S (1994) Properties of volume-sensitive Cl- channels in a human epithelial cell line. Jpn J Physiol 44: S31-35.
9. Okada Y, Petersen CCH, Kubo M, Morishima S, Tominaga M (1994) Osmotic swelling activates intermediate-conductance Cl- channels in human intestinal epithelial cells. Jpn J Physiol 44: 403-409.
8. Petersen CCH, Kubo M, Morishima S, Tominaga M, Okada Y (1994) Single-channel recordings of volume-sensitive Cl- channels in human intestinal epithelial cells. Jpn J Physiol 44: S73-75.
7. Verjans B, Petersen CCH, Berridge MJ (1994) Overexpression of Ins(1,4,5)P3 3-kinase in Xenopus oocytes inhibits agonist-evoked capacitative calcium entry. Biochem J 304: 679-682.
6. Petersen CCH, Berridge MJ (1994) Regulation of capacitative calcium entry in Xenopus oocytes by calcium and PKC. J Biol Chem 269: 32246-32253.
5. Petersen CCH, Dupont G (1994) The initiation of a calcium signal in Xenopus oocytes. Cell Calcium 16: 391-403.
4. Petersen CCH, Petersen OH, Berridge MJ (1993) The role of endoplasmic reticulum calcium pumps during cytosolic calcium spiking in pancreatic acinar cells. J Biol Chem 268: 22262-22264.
3. Petersen CCH, Toescu EC, Potter BVL, Petersen OH (1991) Inositol trisphosphate produces different patterns of cytoplasmic Ca2+ spiking depending on its concentration. FEBS Letts 293: 179-182.
2. Petersen CCH, Petersen OH (1991) Receptor-activated Ca2+ spikes in communicating clusters of pancreatic acinar cells. FEBS Letts 284: 113-116.
1. Petersen CCH, Toescu EC, Petersen OH (1991) Different patterns of receptor-activated cytoplasmic Ca2+ oscillations in single pancreatic acinar cells: dependence on receptor type, agonist concentration and intracellular Ca2+ buffering. EMBO J 10: 527-533.
Review articles:
16R. Aronoff R, Matyas F, Mateo C, Ciron C, Schneider B, Petersen CCH (2010) Long-range connectivity of mouse primary somatosensory barrel cortex. Eur J Neurosci 31: 2221-2233.
15R. Crochet S, Petersen CCH (2009) Cortical dynamics by layers. Neuron 64: 298-300.
14R. Petersen CCH (2009) Genetic determinants of barrel cortex map formation. Eur J Neurosci 29: 1378.
13R. Petersen CCH (2009) Genetic manipulation, whole-cell recordings and functional imaging of the sensorimotor cortex of behaving mice. Acta Physiol 195: 91-99.
12R. Helmchen F, Petersen CCH (2008) New views into the brain of mice on the move. Nat Methods 5: 925-926.
11R. Aronoff R, Petersen CCH (2008) Layer, column and cell-type specific genetic manipulation in mouse barrel cortex. Front Neurosci 2: 64-71
10R. Ascoli GA, Alonso-Nanclares L, Anderson SA, Barrionuevo G, Benavides-Piccione R, Burkhalter A, Buzsáki G, Cauli B, DeFelipe J, Fairén A, Feldmeyer D, Fishell G, Fregnac Y, Freund TF, Gardner D, Gardner EP, Goldberg JH, Helmstaedter M, Hestrin S, Karube F, Kisvárday ZF, Lambolez B, Lewis DA, Marin O, Markram H, Muńoz A, Packer A, Petersen CCH, Rockland KS, Rossier J, Rudy B, Somogyi P, Staiger JF, Tamas G, Thomson AM, Toledo-Rodriguez M, Wang Y, West DC, Yuste R (2008) Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nature Rev Neurosci 9: 557-568.
9R. Petersen CCH (2007) The functional organization of the barrel cortex. Neuron 56: 339-355.
8R. Aronoff R, Petersen CCH (2006) Controlled and localized genetic manipulation in the brain. J Cell Mol Med 10: 333-352.
7R. Petersen CCH (2005) Evoking spontaneous activity. Neuron 48: 710-711.
6R. Petersen CCH (2003) The barrel cortex - integrating molecular, cellular and systems physiology. Pflügers Arch 447: 126-134.
5R. Petersen CCH (1996) Store operated calcium entry. Seminars in the Neurosciences 8: 293-300.
4R. Bennett DL, Petersen CCH, Cheek TR (1995) Cracking ICRAC in the eye. Curr Biol 5: 1225-1228.
3R. Petersen OH, Petersen CCH, Kasai H (1994) Calcium and hormone action. Annu Rev Physiol 56: 297-319.
2R. Petersen OH, Thorn P, Toescu EC, Lawrie A M, Smith P, Petersen CCH, Tepikin AV, Gallacher DV (1993) Local and global cytosolic Ca2+ oscillations evoked by agonists and inositol trisphosphate. Biomedical Research 14: 43-46.
1R. Petersen OH, Gallacher DV, Wakui M, Yule DI, Petersen CCH, Toescu EC (1991) Receptor-activated cytoplasmic Ca2+ oscillations in pancreatic acinar cells: generation and spreading of Ca2+ signals. Cell Calcium 12: 135-144.
Book Chapters:
9B. Petersen CCH (2011) Voltage-sensitive dye imaging of cortical spatiotemporal dynamics in awake behaving mice. Chapter in 'Imaging in neuroscience'. Edited by Fritjof Helmchen and Arthur Konnerth. Published by Cold Spring Harbor Laboratory Press.
8B. Grinvald A, Petersen CCH (2010) Imaging the dynamics of neocortical population activity in behaving and freely moving mammals. Chapter in 'Membrane potential imaging in the nervous system'. Edited by Marco Canepari and Dejan Zecevic. Published by Springer.
7B. Ferezou I, Matyas F, Petersen CCH (2009) Imaging the brain in action - real-time voltage-sensitive dye imaging of sensorimotor cortex of awake behaving mice. Chapter in 'In vivo optical imaging of brain function'. Edited by Ron Frostig. Published by CRC Press.
6B. Petersen CCH (2009) Barrel Cortex Circuits. Chapter in 'Encyclopedia of Neuroscience'. Volume 2, pp. 41-45. Edited by Larry Squire. Published by Academic Press, Oxford, UK.
5B. Crochet S, Ferezou I, Petersen CCH (2007) Spontaneous activity of the somatosensory barrel cortex. Chapter 6 in 'Mechanisms of Spontaneous Active States in the Neocortex'. Edited by Igor Timofeev. Published by Research Signpost.
4B. Petersen CCH (2007) Higher Nervous Functions. Chapter 9 in 'Lecture Notes on Human Physiology'. Edited by Ole Petersen. Published by Blackwell.
3B. Petersen CCH (2007) Sensory Systems. Chapter 6 in 'Lecture Notes on Human Physiology'. Edited by Ole Petersen. Published by Blackwell.
2B. Petersen CCH (2006) Advances in understanding cortical function through combined voltage-sensitive dye imaging, whole-cell recordings and analysis of cellular morphology. Chapter 14 in 'Neuroanatomical Tract-Tracing 3: molecular, neurons, and systems'. Edited by Laszlo Zaborszky. Floris Wouterlood and Jose Lanciego. Published by Springer.
1B. Petersen CCH (2005) A practical guide: whole-cell recording and voltage-sensitive dye imaging in vivo. Chapter 91 in 'Imaging in neuroscience and development: a laboratory manual'. Edited by Rafael Yuste and Arthur Konnerth. Cold Spring Harbor Laboratory Press.
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Associate Professor