Fields of expertise
MissionThe Laboratory of Microsystems 2 of Prof. Martin Gijs was established in 1997 and has as mission the development of new microfabrication technologies and to exploit these for applications of industrial interest. We actively participate in national and international research programs. The research of LMIS2 is centered on four themes: - Novel microfabrication technologies - Magnetic applications - Microfluidics - Bio-Micro-Electro-Mechanical Systems (BioMEMS) Novel microfabrication technologies We have established a sol-gel process for the replication of three-dimensional and thin film glass nanostructures. Moreover, we have discovered a new sol-gel process to synthesize borosilicate nanoparticles. Magnetic applications We are working on miniaturised systems for the handling and magnetic transport of magnetic micro- and nanoparticles in microfluidic devices. Microfluidics Chemists and biologists have recognized the utility of microfabricated devices for transporting and manipulating liquids on a sub-?L scale. We are active in the realisation and use of glass and polymer microfluidic chips. BioMEMS We are developing microfluidic channel- and droplet-based microsystems for the handling of magnetic beads for biomedical and mixing applications. We demonstrated a variety of on-chip immuno- and cell-based- assays using magnetic beads in a microfluidic channel as substrate.
BiographyMartin A.M. Gijs received his degree in physics in 1981 from the Katholieke Universiteit Leuven, Belgium and his Ph.D. degree in physics at the same university in 1986. He joined the Philips Research Laboratories in Eindhoven, The Netherlands, in 1987. Subsequently, he has worked there on micro-and nano-fabrication processes of high critical temperature superconducting Josephson and tunnel junctions, the microfabrication of microstructures in magnetic multilayers showing the giant magnetoresistance effect, the design and realisation of miniaturised motors for hard disk applications and the design and realisation of planar transformers for miniaturised power applications. He joined EPFL in 1997. His present interests are in developing technologies for novel magnetic devices, new microfabrication technologies for microsystems fabrication in general and the development and use of microsystems technologies for microfluidic and biomedical applications in particular.
Difference in Intestine Content of Caenorhabditis elegans When Fed on Non-Pathogenic or Pathogenic BacteriaMicromachines. 2023-07-01. DOI : 10.3390/mi14071386.
Acoustofluidic large-scale mixing for enhanced microfluidic immunostaining for tissue diagnosticsLab On A Chip. 2023-06-27. DOI : 10.1039/d3lc00312d.
High-resolution imaging and analysis of the intestinal bacterial load of Caenorhabditis elegans during early adulthoodRsc Advances. 2023-06-05. DOI : 10.1039/d3ra02934d.
Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscleElife. 2023-04-19. DOI : 10.7554/eLife.83338.
Bubble-enhanced ultrasonic microfluidic chip for rapid DNA fragmentation (vol 22, pg 560, 2022)Lab On A Chip. 2023-03-29. DOI : 10.1039/d3lc90037a.
Efficient AC electrothermal flow (ACET) on-chip for enhanced immunoassaysLab On A Chip. 2023-01-16. DOI : 10.1039/d2lc01147f.
Development of next-generation microfluidic systems for enhanced, faster, and cost-effective immunoassays for tissue diagnostics - Ac electrothermal flow & AcoustofluidicsLausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-10080.
Polydimethylsiloxane microstructure-induced acoustic streaming for enhanced ultrasonic DNA fragmentation on a microfluidic chipLab On A Chip. 2022-09-30. DOI : 10.1039/d2lc00366j.
The enhancement of DNA fragmentation in a bench top ultrasonic water bath with needle-induced air bubbles: Simulation and experimental investigationBiomicrofluidics. 2022-07-01. DOI : 10.1063/5.0101740.
Bubble-enhanced ultrasonic microfluidic chip for rapid DNA fragmentationLab On A Chip. 2022-01-06. DOI : 10.1039/d1lc00933h.
The connectome spectrum as a canonical basis for a sparse representation of fast brain activityNeuroimage. 2021-12-01. DOI : 10.1016/j.neuroimage.2021.118611.
Antimicrobial susceptibility testing by measuring bacterial oxygen consumption on an integrated platformLab On A Chip. 2021-07-16. DOI : 10.1039/d1lc00296a.
Phase calibration of a basic bright-field microscope for 3D metrology of transparent samples at the nanoscale2021-01-01. Conference on Optics and Photonics for Advanced Dimensional Metrology, ELECTR NETWORK, Apr 06-10, 2020. p. 113521N. DOI : 10.1117/12.2559349.
Insight into the Growth of Anisotropic CdSe Nanocrystals: Attachment of Intrinsically Different Building BlocksJournal Of Physical Chemistry C. 2020-12-17. DOI : 10.1021/acs.jpcc.0c07933.
Anin vivomicrofluidic study of bacterial transit inC. elegansnematodesLab On A Chip. 2020-08-07. DOI : 10.1039/d0lc00064g.
Magnetic and Mechanical 3-D Modelling of a 15 T Large Aperture Dipole MagnetIeee Transactions On Applied Superconductivity. 2020-06-01. DOI : 10.1109/TASC.2020.2969639.
PDMS filter structures for size-dependent larval sorting and on-chip egg extraction of C. elegansLab On A Chip. 2020-01-07. DOI : 10.1039/c9lc00949c.
Microfluidic system for Caenorhabditis elegans culture and oxygen consumption rate measurementsLab On A Chip. 2020-01-07. DOI : 10.1039/c9lc00829b.
A power-balance model of the density limit in fusion plasmas: application to the L-mode tokamakNuclear Fusion. 2019-12-01. DOI : 10.1088/1741-4326/ab3b31.
Rapid high-plex staining and simultaneous imaging for immunophenotyping of tissue sections2019-11-06.
Microfluidic-based immunohistochemistry for breast cancer diagnosis: a comparative clinical studyVirchows Archiv. 2019-09-01. DOI : 10.1007/s00428-019-02616-7.
CMOS and 3D Printing for NMR Spectroscopy at the Single Embryo ScaleChimia. 2019-08-01. DOI : 10.2533/chimia.2019.635.
The 16 T Dipole Development Program for FCC and HE-LHCIEEE Transactions on Applied Superconductivity. 2019-08-01. DOI : 10.1109/TASC.2019.2900556.
Geodesic acoustic mode evolution in L-mode approaching the L-H transition on JETPlasma Physics And Controlled Fusion. 2019-07-01. DOI : 10.1088/1361-6587/ab1e73.
On a fusion born triton effect in JET deuterium discharges with H-minority ion cyclotron range of frequencies heatingNuclear Fusion. 2019-06-01. DOI : 10.1088/1741-4326/ab19f5.
COREDIV numerical simulation of high neutron rate JET-ILW DD pulses in view of extension to JET-ILW DT experimentsNuclear Fusion. 2019-05-01. DOI : 10.1088/1741-4326/ab0c47.
Radial variation of heat transport in L-mode JET dischargesNuclear Fusion. 2019-05-01. DOI : 10.1088/1741-4326/ab03e1.
Approximate analytic expressions using Stokes model for tokamak polarimetry and their range of validityPlasma Physics And Controlled Fusion. 2019-05-01. DOI : 10.1088/1361-6587/ab09c2.
Long-lived coupled peeling ballooning modes preceding ELMs on JETNuclear Fusion. 2019-05-01. DOI : 10.1088/1741-4326/ab0031.
High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancerLaboratory Investigation. 2019-05-01. DOI : 10.1038/s41374-018-0172-y.
Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegansLab On A Chip. 2019-01-07. DOI : 10.1039/c8lc00863a.
Automated High-Content Phenotyping Of The Nematode C. Elegans At Single Animal Resolution With A Microfluidic Platform2019-01-01. 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII (TRANSDUCERS and EUROSENSORS), Berlin, GERMANY, Jun 23-27, 2019. p. 2209-2212. DOI : 10.1109/TRANSDUCERS.2019.8808300.
Studying the roundworm Caenorhabditis elegans using microfluidic chips2019-01-01. Conference on Microfluidics, BioMEMS, and Medical Microsystems XVII, San Francisco, CA, Feb 02-04, 2019. p. 1087518. DOI : 10.1117/12.2513194.
Full-orbit and drift calculations of fusion product losses due to explosive fishbones on JETNuclear Fusion. 2019-01-01. DOI : 10.1088/1741-4326/aaea1e.
Measuring fast ions in fusion plasmas with neutron diagnostics at JETPlasma Physics And Controlled Fusion. 2019-01-01. DOI : 10.1088/1361-6587/aad8a6.
Dimensional tailoring of hydrothermally grown zinc oxide nanostructures in a continuous flow micro reactorChemical Communications. 2018-12-04. DOI : 10.1039/c8cc05384g.
Tritium retention characteristics in dust particles in JET with ITER-like wallNuclear Materials And Energy. 2018-12-01. DOI : 10.1016/j.nme.2018.11.001.
Thermal desorption spectrometry of beryllium plasma facing tiles exposed in the JET tokamak (vol 133, pg 135, 2018)Fusion Engineering And Design. 2018-12-01. DOI : 10.1016/j.fusengdes.2018.08.007.
Propagating transport-code input parameter uncertainties with deterministic samplingPlasma Physics And Controlled Fusion. 2018-12-01. DOI : 10.1088/1361-6587/aae80b.
Assessment of the baseline scenario at q(95) similar to 3 for ITERNuclear Fusion. 2018-12-01. DOI : 10.1088/1741-4326/aade57.
Identification of BeO and BeOxDy in melted zones of the JET Be limiter tiles: Raman study using comparison with laboratory samplesNuclear Materials And Energy. 2018-12-01. DOI : 10.1016/j.nme.2018.11.008.
On the role of finite grid extent in SOLPS-ITER edge plasma simulations for JET H-mode discharges with metallic wallNuclear Materials And Energy. 2018-12-01. DOI : 10.1016/j.nme.2018.10.013.
Heat flux analysis of Type-I ELM impact on a sloped, protruding surface in the JET bulk tungsten divertorNuclear Materials And Energy. 2018-12-01. DOI : 10.1016/j.nme.2018.10.009.
3D non-linear MHD simulation of the MHD response and density increase as a result of shattered pellet injectionNuclear Fusion. 2018-12-01. DOI : 10.1088/1741-4326/aae614.
Plasma-wall interaction on the divertor tiles of JET ITER-like wall from the viewpoint of micro/nanoscopic observationsFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.01.051.
Dust generation in tokamaks: Overview of beryllium and tungsten dust characterisation in JET with the ITER-like wallFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.03.027.
Characterisation of neutron generators and monitoring detectors for the in-vessel calibration of JETFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.01.071.
Modelling of the neutron production in a mixed beam DT neutron generatorFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.04.075.
Activation material selection for multiple foil activation detectors in JET TT campaignFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.04.052.
Generation of a plasma neutron source for Monte Carlo neutron transport calculations in the tokamak JETFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.04.065.
Assessment of the strength of kinetic effects of parallel electron transport in the SOL and divertor of JET high radiative H-mode plasmas using EDGE2D-EIRENE and KIPP codesPlasma Physics And Controlled Fusion. 2018-11-01. DOI : 10.1088/1361-6587/aae0a0.
Preparation for commissioning of materials detritiation facility at Culham Science CentreFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.05.019.
Determination of 2D poloidal maps of the intrinsic W density for transport studies in JET-ILWReview Of Scientific Instruments. 2018-11-01. DOI : 10.1063/1.5046562.
Shutdown dose rate measurements after the 2016 Deuterium-Deuterium campaign at JETFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.05.006.
Shutdown dose rate neutronics experiment during high performances DD operations at JETFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.05.053.
Testing of tritium breeder blanket activation foil spectrometer during JET operationsFusion Engineering And Design. 2018-11-01. DOI : 10.1016/j.fusengdes.2018.02.005.
Equilibrium reconstruction at JET using Stokes model for polarimetryNuclear Fusion. 2018-10-01. DOI : 10.1088/1741-4326/aad751.
14 MeV calibration of JET neutron detectors-phase 2: in-vessel calibrationNuclear Fusion. 2018-10-01. DOI : 10.1088/1741-4326/aad4c1.
An improved model for the accurate calculation of parallel heat fluxes at the JET bulk tungsten outer divertorNuclear Fusion. 2018-10-01. DOI : 10.1088/1741-4326/aad83e.
Teaching & PhD