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Olivier Burri

olivier.burri@epfl.ch https://www.epfl.ch/research/facilities/ptbiop/

Nationalité: Swiss / Venezuelan

2025

Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2

L. Bracq; A. Chuat; B. Kunz; O. Burri; R. Guiet  et al.

EMBO Molecular Medicine. 2025. DOI : 10.1038/s44321-025-00295-3.

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Development of image analysis tool to evaluate Langerhans cell migration after exposure to isothiazolinones

C. Oltramare; O. Burri; N. B. Hopf; S. Jaccoud; A. Seitz  et al.

ARCHIVES OF TOXICOLOGY. 2025. DOI : 10.1007/s00204-025-04013-3.

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2024

Cell density quantification of high resolution Nissl images of the juvenile rat brain

J. Meystre; J. Jacquemier; O. Burri; C. Zsolnai; N. Frank  et al.

Frontiers In Neuroanatomy. 2024. DOI : 10.3389/fnana.2024.1463632.

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Supplementary files for Machine learning for histological annotation and quantification of cortical layers

J. Meystre; O. Burri

2024.

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Cellpose training data and scripts from "Inhibition of CERS1 in aging skeletal muscle exacerbates age-related muscle impairments"

M. Wohlwend; O. Burri; J. Auwerx

2024.

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2023

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

M. Wohlwend; P.-P. U. Laurila; L. Goeminne; T. Imamura de Lima; A. Lalou  et al.

eLife. 2023. DOI : 10.7554/eLife.90522.1.

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Optical imaging of the small intestine immune compartment across scales

A. L. Planchette; C. Schmidt; O. Burri; M. G. de Agueero; A. Radenovic  et al.

Communications Biology. 2023. DOI : 10.1038/s42003-023-04642-3.

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MarrowQuant 2.0: A Digital Pathology Workflow Assisting Bone Marrow Evaluation in Experimental and Clinical Hematology

R. Sarkis; O. Burri; C. Royer-Chardon; F. Schyrr; S. Blum  et al.

Modern Pathology. 2023. DOI : 10.1016/j.modpat.2022.100088.

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2022

Measuring reporter activity domain in EPI aggregates and Gastruloids.ijm

R. Guiet; O. Burri; M. Girgin; M. Lutolf

2022.

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Sphingolipids control dermal fibroblast heterogeneity

L. Capolupo; I. Khven; A. R. Lederer; L. Mazzeo; G. Glousker  et al.

Science. 2022. DOI : 10.1126/science.abh1623.

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An Open-Source Whole Slide Image Registration Workflow at Cellular Precision Using Fiji, QuPath and Elastix

N. Chiaruttini; O. Burri; P. Haub; R. Guiet; J. Sordet-Dessimoz  et al.

Frontiers In Computer Science. 2022. DOI : 10.3389/fcomp.2021.780026.

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2021

Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing

S. Banerjee; S. Vernon; W. Jiao; B. J. Choi; E. Ruchti  et al.

Nature Communications. 2021. DOI : 10.1038/s41467-021-24490-1.

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Cellpose training data and scripts from "Machine learning for histological annotation and quantification of cortical layers"

J. Jacquemier; J. Meystre; O. Burri

2021.

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Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features

Q. Juppet; F. De Martino; E. Marcandalli; M. Weigert; O. Burri  et al.

Journal of Mammary Gland Biology and Neoplasia. 2021. DOI : 10.1007/s10911-021-09485-4.

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Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes

M. Ayer; O. Burri; R. Guiet; A. Seitz; E. Kaba  et al.

Bioconjugate Chemistry. 2021. DOI : 10.1021/acs.bioconjchem.1c00026.

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2020

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier

M. Ayer; M. Schuster; I. Gruber; C. Blatti; E. Kaba  et al.

Advanced Healthcare Materials. 2020. DOI : 10.1002/adhm.202001375.

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MarrowQuant across Aging and Aplasia: A Digital Pathology Tool for Quantification of Bone Marrow Compartments in Histological Sections

J. Tratwal; I. Bekri; C. Boussema; N. Kunz; R. Sarkis  et al.

2020. Annual Meeting of the American-Society-for-Bone-and Mineral Research (ASBMR), ELECTR NETWORK, Sep 11-15, 2020. p. 95 - 95.

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MarrowQuantAcross Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections

J. Tratwal; D. Bekri; C. Boussema; R. Sarkis; N. Kunz  et al.

Frontiers In Endocrinology. 2020. DOI : 10.3389/fendo.2020.00480.

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2019

A Derived Positional Mapping of Inhibitory Subtypes in the Somatosensory Cortex

D. Keller; J. Meystre; R. V. Veettil; O. Burri; R. Guiet  et al.

Frontiers In Neuroanatomy. 2019. DOI : 10.3389/fnana.2019.00078.

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Development of Sample-Adaptable Holders for Lightsheet Microscopy

T. Laroche; O. Burri; L. K. Dubey; A. Seitz

Frontiers In Neuroanatomy. 2019. DOI : 10.3389/fnana.2019.00026.

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Open Source Tools for Biological Image Analysis

R. Guiet; O. Burri; A. Seitz

Computer Optimized Microscopy; Humana Press, 2019.

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An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

A. M. Lima; M. E. Bragina; O. Burri; J. B. Chapalay; F. P. Costa-Fraga  et al.

Platelets. 2019. DOI : 10.1080/09537104.2018.1514106.

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2018

Applying Whole Organ Clearing Techniques To Spinal Cord Injury: A Survey Of Techniques

N. Cho; L. Batti; S. Pages; T. Laroche; O. Burri  et al.

2018. 3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, Toronto, CANADA, Aug 11-16, 2018. p. A51 - A52.

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Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

A. Singh; D. D'Amico; P. A. Andreux; A. M. Fouassier; W. Blanco-Bose  et al.

Cell Reports Medicine. 2022-05-17. DOI : 10.1016/j.xcrm.2022.100633.

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Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast-fatigable motor units in a mouse model of amyotrophic lateral sclerosis

C. Rochat; N. Bernard-Marissal; E. Kaellstig; S. Pradervand; F. E. Perrin  et al.

Glia. 2022-01-03. DOI : 10.1002/glia.24140.

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Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial

S. Liu; D. D'Amico; E. Shankland; S. Bhayana; J. M. Garcia  et al.

Jama Network Open. 2022-01-20. DOI : 10.1001/jamanetworkopen.2021.44279.

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Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

A. Singh; D. D'Amico; P. A. Andreux; G. Dunngalvin; T. Kern  et al.

European Journal Of Clinical Nutrition. 2021-06-11. DOI : 10.1038/s41430-021-00950-1.

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The challenges of impact evaluation: Attempting to measure the effectiveness of community-based disaster risk management

M. Sarabia; A. R. Kägi Trejo; A. Davison; N. M. Banwell; C. Montes  et al.

International Journal of Disaster Risk Reduction. 2020-10-01. DOI : 10.1016/j.ijdrr.2020.101732.

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Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis

H. Lei; E. A. Dirren; C. Poitry-Yamate; B. Schneider; R. Gruetter  et al.

Journal of Cerebral Blood Flow and Metabolism. 2019-07-01. DOI : 10.1177/0271678X18756499.

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The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

P. A. Andreux; W. Blanco-Bose; D. Ryu; F. Burdet; M. Ibberson  et al.

Nature Metabolism. 2019-06-01. DOI : 10.1038/s42255-019-0073-4.

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Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease

V. Laversenne / B. Schneider; P. Aebischer (Dir.)

Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9751.

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A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology

S. M. K. Nazeeruddin / B. Schneider; P. Aebischer (Dir.)

Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.

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Cas9/gRNAs Selective Targeting of the Beethoven Tmc-1 Mutant Allele for Treating Progressive Hearing Loss by AAV-Based Delivery

P. Solanes; B. Pan; P. Aebischer; J. R. Holt; B. Schneider

2018-05-01. 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Chicago, IL, May 16-19, 2018. p. 138-139.

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Cas9/gRNA selective targeting of the Beethoven tmc-1 mutant allele for treating progressive hearing loss by AAV-based delivery

P. Solanes; Y. Asai; B. Pan; C. A. Nist-Lund; P. Aebischer  et al.

2018-12-01. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, Oct 16-19, 2018. p. A107-A108.

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An miRNA-based gene therapy approach to target mutated SOD1 in key cell types in amyotrophic lateral sclerosis (ALS)

V. Vilmont; J. Aebischer; C. Rochat; B. L. Schneider

2018-12-01. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, Oct 16-19, 2018. p. A80-A80.

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AAV based gene therapy for rare diseases

C. C. Rochat / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7888.

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First quantitative survey delineates the distribution of chimpanzees in the Eastern Central African Republic

T. Aebischer; G. Siguindo; E. Rochat; M. Arandjelovic; A. Heilman  et al.

Biological Conservation. 2017. DOI : 10.1016/j.biocon.2017.06.031.

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Bicistronic aav vector for rna interference in als

J. Aebischer; B. Schneider; C. Rochat

US11872290 ; HUE057809 ; EP4008789 ; ES2896181 ; SI3325632 ; PL3325632 ; LT3325632 ; PT3325632 ; DK3325632 ; EP3325632 ; US2021052744 ; US10835621 ; US2018228919 ; EP3325632 ; WO2017013252 ; EP3121284 . 2017.

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Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons

L. Zheng; N. Bernard-Marissal; N. Moullan; D. D'Amico; J. Auwerx  et al.

Human Molecular Genetics. 2017. DOI : 10.1093/hmg/ddw418.

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

D. Ryu; L. Mouchiroud; P. A. Andreux; E. Katsyuba; N. Moullan  et al.

Nat Med. 2016. DOI : 10.1038/nm.4132.

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In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

P. Machler; M. T. Wyss; M. Elsayed; J. Stobart; R. Gutierrez  et al.

Cell Metabolism. 2016. DOI : 10.1016/j.cmet.2015.10.010.

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Use of a Bicistronic Vector to Silence SOD1 in Motoneurons and Astrocytes for the Treatment of Familial Amyotrophic Lateral Sclerosis

J. Bobela-Aebischer; C. Rochat; N. Bernard-Marissal; P. Aebischer; B. L. Schneider

2016. 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington, DC, MAY 04-07, 2016. p. S240-S240.

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A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies

A. Lathuiliere; V. Laversenne; A. Astolfo; E. Kopetzki; H. Jacobsen  et al.

Brain. 2016. DOI : 10.1093/brain/aww036.

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Modulation of AMPK's activity via genetic tools and food-derived compounds as a novel approach to Parkinson's disease treatment

W. J. Bobela / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-6978.

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The effect of the functional interaction between PGC-1α and Parkin on mitochondrial quality control in Parkinson's disease

L. Zheng / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-6868.

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Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

A. Emde; C. Eitan; L.-L. Liou; R. T. Libby; N. Rivkin  et al.

Embo Journal. 2015. DOI : 10.15252/embj.201490493.

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Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

W. Bobela; P. Aebischer; B. L. Schneider

Biomolecules. 2015. DOI : 10.3390/biom5042675.

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SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice

E. Dirren; J. Aebischer; C. Rochat; C. Towne; B. L. Schneider  et al.

Annals Of Clinical And Translational Neurology. 2015. DOI : 10.1002/acn3.162.

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Tmc gene therapy restores auditory function in deaf mice

C. Askew; C. Rochat; B. Pan; Y. Asai; H. Ahmed  et al.

Science Translational Medicine. 2015. DOI : 10.1126/scitranslmed.aab1996.

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Noninvasive assessment of presymptomatic and symptomatic metabolic changes in the brain and brainstem of an ALS mouse model

H. Lei; E. Dirren; B. Schneider; S. Aebischer; R. Gruetter

2015. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, AUG 23-27, 2015. p. 339-340.

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Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

T. Sotelo-Hitschfeld; M. I. Niemeyer; P. Maechler; I. Ruminot; R. Lerchundi  et al.

Journal Of Neuroscience. 2015. DOI : 10.1523/Jneurosci.5036-14.2015.

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Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

S. Yang; M. Cacquevel; L. M. Saksida; T. J. Bussey; B. L. Schneider  et al.

Experimental neurology. 2015. DOI : 10.1016/j.expneurol.2014.11.013.

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A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

J. Dusonchet; H. Li; M. Guillily; M. Liu; K. Stafa  et al.

Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu202.

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Somatic and axonal LIGHT signaling elicit degenerative and regenerative responses in motoneurons, respectively

B. Otsmane; A. Moumen; J. Aebischer; E. Coque; C. Sar  et al.

Embo Reports. 2014. DOI : 10.1002/embr.201337948.

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Intracerebroventricular Injection of Adeno-Associated Virus 6 and 9 Vectors for Cell Type-Specific Transgene Expression in the Spinal Cord

E. Dirren; C. L. Towne; V. Setola; D. E. J. Redmond; B. L. Schneider  et al.

Human Gene Therapy. 2014. DOI : 10.1089/hum.2013.021.

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Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

A. Kaplan; K. J. Spiller; C. Towne; K. C. Kanning; G. T. Choe  et al.

Neuron. 2014. DOI : 10.1016/j.neuron.2013.12.009.

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Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation

A. Lathuiliere; B. Bohrmann; E. Kopetzki; C. Schweitzer; H. Jacobsen  et al.

Biomaterials. 2014. DOI : 10.1016/j.biomaterials.2013.10.026.

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Cerebrospinal fluid-targeted delivery of neutralizing anti-IFN gamma antibody delays motor decline in an ALS mouse model

B. Otsmane; J. Aebischer; A. Moumen; C. Raoul

Neuroreport. 2014. DOI : 10.1097/Wnr.0000000000000043.

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A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells

A. Lathuilière; S. Cosson; M. Lütolf; B. Schneider; P. Aebischer

Biomaterials. 2014. DOI : 10.1016/j.biomaterials.2013.09.071.

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Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model

D. Krakora; P. Mulcrone; M. Meyer; C. Lewis; K. Bernau  et al.

Molecular Therapy. 2013. DOI : 10.1038/mt.2013.108.

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Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles

K. Loew; P. Aebischer; B. L. Schneider

Human Gene Therapy. 2013. DOI : 10.1089/hum.2012.174.

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Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

A. Oueslati; B. L. Schneider; P. Aebischer; H. A. Lashuel

Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1309991110.

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Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

A. Kunze; S. Lengacher; E. Dirren; P. Aebischer; P. J. Magistretti  et al.

Integrative Biology. 2013. DOI : 10.1039/c3ib40022k.

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AAV-mediated gene therapy against motoneuron diseases

E. A. Dirren / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5821.

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A novel encapsulation device for peripheral implantation of antibody-secreting cells

A. Lathuilière / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5796.

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Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

E. Dassie; M. R. Andrews; J.-C. Bensadoun; M. Cacquevel; B. L. Schneider  et al.

Neurobiology Of Aging. 2013. DOI : 10.1016/j.neurobiolaging.2012.11.011.

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An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

P. Coune; M. Craveiro; M. Gaugler; V. Mlynárik; B. Schneider  et al.

NMR in biomedicine. 2013. DOI : 10.1002/nbm.2817.

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Parkinson's Disease: Gene Therapies

P. G. Coune; B. L. Schneider; P. Aebischer

Cold Spring Harbor Perspectives In Medicine. 2012. DOI : 10.1101/cshperspect.a009431.

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How to build science capacity

B. Fanaroff; P. Aebischer; R. Camacho; I. Serageldin; N. Suetin  et al.

Nature. 2012. DOI : 10.1038/490331a.

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Use of viral vectors to create animal models for Parkinson's disease

K. Loew; P. Aebischer

Neurobiology Of Disease. 2012. DOI : 10.1016/j.nbd.2011.12.038.

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Optimizing Millisecond Time Scale Near-Infrared Emission in Polynuclear Chrome(III)–Lanthanide(III) Complexes

L. Aboshyan-Sorgho; H. Nozary; A. Aebischer; J.-C. G. Bünzli; P.-Y. Morgantini  et al.

Journal of the American Chemical Society. 2012. DOI : 10.1021/ja304009b.

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Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease

V. Mlynárik; M. Cacquevel; L. Sun-Reimer; S. Janssens; C. Cudalbu  et al.

Journal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-112072.

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Imaging brain amyloid deposition using grating-based differential phase contrast tomography

B. R. Pinzer; M. Cacquevel; P. Modregger; S. A. McDonald; J. C. Bensadoun  et al.

Neuroimage. 2012. DOI : 10.1016/j.neuroimage.2012.03.029.

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Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

M. N. Gaugler; O. Genc; W. Bobela; S. Mohanna; M. T. Ardah  et al.

Acta Neuropathologica. 2012. DOI : 10.1007/s00401-012-0963-y.

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α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

B. Fauvet; M. K. Mbefo; M.-B. Fares; C. Desobry; S. Michael  et al.

The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M111.318949.

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Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

A. Oueslati; K. E. Paleologou; B. L. Schneider; P. Aebischer; H. A. Lashuel

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012. DOI : 10.1523/JNEUROSCI.3784-11.2012.

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Philanthropy: The price of charity

P. Aebischer

Nature. 2012. DOI : 10.1038/481260a.

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Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function

C. Ciron; S. Lengacher; J. Dusonchet; P. Aebischer; B. Schneider

Human Molecular Genetics. 2012. DOI : 10.1093/hmg/ddr618.

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Role of the FoxO3a Transcription Factor in alpha-synuclein Induced Neurodegeneration

E. Pino / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5245.

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System and Method For In Vivo Delivery of Antibodies and Fragments Thereof

O. Marroquin; P. Aebischer; M. Molinari; N. Bouche

US2011106062 . 2011.

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Proton and phosphorus MRS of a 5xFAD mouse model of Alzheimer's disease

V. Mlynarik; L. Sun-Reimer; S. Janssens; M. Cacquevel; H. Lei  et al.

2011. ISMRM 19th Annual Meeting & Exhibition, Montreal, Canada, May 7-13, 2011.

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Early metabolic changes in the amyotrophic lateral sclerosis SOD1 mouse brain are revealed using 1H MRS rather than CASL and 18FDG PET

H. Lei; E. Dirren; C. Poitry-Yamate; B. Schneider; P. Aebischer  et al.

2011. 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011, Montréal, Québec, Canada.

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Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease

P. G. Coune; J.-C. Bensadoun; P. Aebischer; B. Schneider

Journal of Parkinson's Disease. 2011. DOI : 10.3233/JPD-2011-11058.

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Investigation of the role of PICALM on amyloid metabolism in a transgenic mouse model of Alzheimer’s disease

D. Rubi

2011

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Alpha-Synuclein Effects at the ER-to-Golgi Level and Potential Biomarkers in Rat Models of the Early Phase of Parkinson's Disease

P. G. Coune / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5176.

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Near-infrared→Visible light upconversion in a molecular trinuclear d-f-d complex

L. Aboshyan-Sorgho; C. Besnard; P. Pattison; K. R. Kittilstved; A. Aebischer  et al.

Angewandte Chemie - International Edition. 2011. DOI : 10.1002/anie.201100095.

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Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

O. Marroquin Belaunzaran; M. I. Cordero; V. Setola; S. Bianchi; C. Galli  et al.

Plos One. 2011. DOI : 10.1371/journal.pone.0018268.

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A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2

J. Dusonchet; O. Kochubey; K. Stafa; S. M. Young; R. Zufferey  et al.

Journal of Neuroscience. 2011. DOI : 10.1523/JNEUROSCI.5092-10.2011.

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Use of igf-1 and nt-3 in the treatment of x-linked adrenoleukodystrophy

R. Mastroeni; C. Raoul; P. Aebischer; J.-C. Bensadoun

WO2010089706 . 2010.

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Alpha-Synuclein Animal Models

M. Gaugler; P. G. Coune; S. Mohana; O. Genc; O. El-Agnaf  et al.

2010. 2nd World Parkinson Congress, Glasgow, UK, September 28 - October 1, 2010. p. S606-S606.

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Effective Delivery of the Neuroprotectant to the Brain

P. Aebischer; E. Pino; M. Cacquevel; B. Schneider

2010. 2nd World Parkinson Congress, Glasgow, UK, September 28 - October 1, 2010. p. S602-S602.

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Neuroprotection by Gene Therapy Targeting Mutant SOD1 in Individual Pools of Motor Neurons Does not Translate Into Therapeutic Benefit in fALS Mice

C. Towne; V. Setola; B. L. Schneider; P. Aebischer

Molecular therapy : the journal of the American Society of Gene Therapy. 2010. DOI : 10.1038/mt.2010.260.

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Neurodegenerative Disorders: Gene Therapy on Clinical Trial

P. Aebischer

Frontiers in Neuroscience. 2010.

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AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway

K. Langou; A. Moumen; C. Pellegrino; J. Aebischer; I. Medina  et al.

Journal of Neurochemistry. 2010. DOI : 10.1111/j.1471-4159.2010.06806.x.

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Collapsin response médiator protein 4a(CRMP 4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron death

L. Duplan; N. Bernard; W. Casseron; K. Dudley; E. Thouvenot  et al.

The Journal of Neuroscience. 2010. DOI : 10.1523/JNEUROSCI.5411-09.2010.

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The role of MCT2 in motor neuron function

J. Uldry

2010

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Gene therapy for Parkinson's disease: viral gene delivery to revert a parkinsonian phenotype induced by alpha-synuclein over-expression

S. Mohanna

2010

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Motor Deficits upon Alpha-Synuclein Expression in the Nigrostriatal System Are Due to a Loss of Dopaminergic Vesicles and Reduced Dopamine Release at an early Stage of Neurodegeneration

M. Gaugler / P. Aebischer (Dir.)

Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4765.

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Modeling Parkinson's Disease in Adult Rats Using Viral Vectors as Gene Delivery Tools

J. Dusonchet / P. Aebischer (Dir.)

Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4758.

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Sensitized near-IR luminescence of lanthanide complexes based on push-pull diketone derivatives

N. S. Baek; Y. H. Kim; Y. K. Eom; J. H. Oh; H. K. Kim  et al.

Dalton Transactions. 2010. DOI : 10.1039/b915893f.

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Adeno-Associated Virus-Mediated Gene Delivery for the Treatment of Amyotrophic Lateral Sclerosis and other Motor Neuron Disorders

C. Towne / P. Aebischer (Dir.)

Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4669.

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Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6

C. Towne; B. Schneider; D. Kieran; D. Redmond; P. Aebischer

Gene Therapy. 2010. DOI : 10.1038/gt.2009.119.

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Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

K. E. Paleologou; A. Oueslati; G. Shakked; C. C. Rospigliosi; H.-Y. Kim  et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010. DOI : 10.1523/JNEUROSCI.5922-09.2010.

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Grafts of Dopamine Neurons Can Send Neurites to the Striatum Under GDNF Inducement in a Nonhuman Primate

J. R. Sladek; J. D. Elswonh; R. H. Roth; C. Leranth; T. J. Collier  et al.

2009. 16th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair, Clearwater Beach, FL, Apr 30-May 02, 2009. p. 234-235.

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Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF

D. J. Redmond; J. Elsworth; R. Roth; C. Leranth; T. Collier  et al.

Journal of Comparative Neurology. 2009. DOI : 10.1002/cne.22028.

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Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions

Y. Chu; H. Dodiya; P. Aebischer; C. Olanow; J. Kordower

Neurobiology of Disease. 2009. DOI : 10.1016/j.nbd.2009.05.023.

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Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF

M. Emborg; J. Moirano; J. Raschke; V. Bondarenko; R. Zufferey  et al.

Neurobiology of Disease. 2009. DOI : 10.1016/j.nbd.2009.07.022.

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Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons

A. Ulusoy; G. Shain; T. Björklund; P. Aebischer; D. Kirik

Molecular Therapy. 2009. DOI : 10.1038/mt.2009.142.

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An in vivo culture system for human embryos using an encapsulation technology: a pilot study

C. Blockeel; P. Mock; G. Verheyen; N. Bouche; P. Le Goff  et al.

Human Reproduction. 2009. DOI : 10.1093/humrep/dep005.

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Implication of the JNK pathway in a rat model of Huntington's disease

V. Perrin; N. Dufour; C. Raoul; R. Hassig; E. Brouillet  et al.

Experimental Neurology. 2009. DOI : 10.1016/j.expneurol.2008.10.008.

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Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery

C. Towne; M. Pertin; A. Beggah; P. Aebischer; I. Decosterd

Molecular Pain. 2009. DOI : 10.1186/1744-8069-5-52.

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Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model

R. Mastroeni; J.-C. Bensadoun; D. Charvin; P. Aebischer; A. Pujol  et al.

Annals of Neurology. 2009. DOI : 10.1002/ana.21677.

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A ruthenium-based metallostar: synthesis, sensitized luminescence and 1H relaxivity

L. Moriggi; A. Aebischer; C. Cannizzo; A. Sour; A. Borel  et al.

Dalton Transactions. 2009. DOI : 10.1039/b818599a.

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Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer's mouse model

O. Marroquin Belaunzaran / P. Aebischer (Dir.)

Lausanne, EPFL, 2009. DOI : 10.5075/epfl-thesis-4464.

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Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease Through RNAi

C. Towne; P. Aebischer

Therapeutic Applications of RNAi; 2009. p. 87-108.

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Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

J. Dusonchet; J. Bensadoun; B. Schneider; P. Aebischer

Neurobiology of disease. 2009. DOI : 10.1016/j.nbd.2009.03.013.

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Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

I. Barde; E. Laurenti; S. Verp; A. C. Groner; C. Towne  et al.

Journal of Virology. 2009. DOI : 10.1128/JVI.00001-09.

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Indo-1 derivatives for local calcium sensing

M. Bannwarth; I. Reis Correa Jr.; M. Sztretye; S. Pouvreau; C. Fellay  et al.

ACS Chemical Biology. 2009. DOI : 10.1021/cb800258g.

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Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

S. Azeredo da Silveira; B. Schneider; C. Cifuentes-Diaz; D. Sage; T. Abbas-Terki  et al.

Human Molecular Genetics. 2009. DOI : 10.1093/hmg/ddn417.

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Intrinsic quantum yields and radiative lifetimes of lanthanide tris(dipicolinates)

A. Aebischer; F. Gumy; J.-C. G. Bünzli

Phys. Chem. Chem. Phys.. 2009. DOI : 10.1039/b816131c.

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Intramuscular delivery of GDNF with human mesenchymal stem cells protects dying motor neurons and prolongs survival in a rat model of familial ALS

M. Suzuki; J. McHugh; C. Tork; B. Shelley; A. Hayes  et al.

2008. 15th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair, Clearwater Beach, FL, May 01-03, 2008. p. 482-483.

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Neuropathic pain: Gene therapy as a tool to transduce nociceptors

M. Pertin; C. Towne; T. Berta; A. Beggah; P. Aebischer  et al.

2008. p. 12S-12S.

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Feasibility of gene therapy for the treatment of neuropathic pain: downregulation of GTP cyclohydrolase 1 expression via RNA interference

S. Jean; C. Towne; P. Aebischer; I. Decosterd

2008. p. 3S-3S.

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Development Of A Cell Encapsulation Approach For Human Anti-Tumor Immunotherapy

F. Schwenter; S. Zarei; P. Luy; P. Morel; P. Aebischer  et al.

2008. XXXV Congress of the European Society for Artificial Organs: 'Towards Future Biomedical Technologies. p. 601-601.

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NIR-emitting lanthanide helicates

O. Osetska; M. Albrecht; R. Froehlich; F. Gumy; A. Aebischer  et al.

2008. 235th American-Chemical-Society National Meeting, New Orleans, LA, Apr 06-10, 2008. p. INOR 245.

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Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry

H. Runne; E. Régulier; A. Kuhn; D. Zala; O. Gokce  et al.

The Journal of neuroscience. 2008. DOI : 10.1523/JNEUROSCI.3044-08.2008.

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Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

C. Lo Bianco; J. Shorter; E. Régulier; H. Lashuel; T. Iwatsubo  et al.

The Journal of clinical investigation. 2008. DOI : 10.1172/JCI35781.

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Viral vectors: a potent approach to generate genetic models of Parkinson's disease

B. Schneider; M. Gaugler; P. Aebischer

Parkinson's disease: Molecular and therapeutics insights from model systems; New York: Academic Press, 2008. p. 269-284.

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Viral vectors, animal models and new therapies for Parkinson's disease

B. Schneider; R. Zufferey; P. Aebischer

Parkinsonism Realted Disorders. 2008. DOI : 10.1016/j.parkreldis.2008.04.024.

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Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS

M. Suzuki; J. McHugh; C. Tork; B. Shelley; A. Hayes  et al.

Molecular Therapy. 2008. DOI : 10.1038/mt.2008.197.

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Eco-densité, une intervention durable en milieu urbain, Blackwall Reach East London (Londres, GB)

N. Aebischer; N. Schmied

2008

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Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice

C. Towne; C. Raoul; B. L. Schneider; P. Aebischer

Molecular Therapy. 2008. DOI : 10.1038/mt.2008.73.

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Conditional gene expression and knockdown using lentivirus vectors encoding shRNA

J. Szulc; P. Aebischer

Methods Mol Biol. 2008. DOI : 10.1007/978-1-60327-248-3_18.

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GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys

M. E. Emborg; A. D. Ebert; J. Moirano; S. Peng; M. Suzuki  et al.

Cell Transplant. 2008. DOI : 10.3727/096368908784423300.

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Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons

M. Bauer; J. Szulc; M. Meyer; C. H. Jensen; T. A. Terki  et al.

J Neurochem. 2008. DOI : 10.1111/j.1471-4159.2007.05037.x.

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Impact of phosphorylation of alpha-synuclein in Parkinson's disease

S. Azeredo da Silveira Lajaunias / P. Aebischer (Dir.)

Lausanne, EPFL, 2008. DOI : 10.5075/epfl-thesis-4069.

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From gene to gene therapy and pharmacotherapy, via transgenic animals

P. Aebischer

2007. 11th Congress of the European-Federation-of-Neurological-Societies, Brussels, BELGIUM, Aug 25-28, 2007. p. 2-2.

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Controlling the lateral aggregation of perfluoroalkylated hexa-peri-hexabenzocoronenes

O. F. Aebischer; A. Aebischer; B. Donnio; B. Alameddine; M. Dadras  et al.

Journal of materials chemistry. 2007. DOI : 10.1039/b616057c.

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GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS

M. Suzuki; J. McHugh; C. Tork; B. Shelley; S. M. Klein  et al.

PLoS ONE. 2007. DOI : 10.1371/journal.pone.0000689.

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Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation

B. L. Schneider; C. R. Seehus; E. E. Capowski; P. Aebischer; S. C. Zhang  et al.

Human Molecular Genetics. 2007. DOI : 10.1093/hmg/ddm008.

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Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

V. Perrin; E. Régulier; T. Abbas-Terki; R. Hassig; E. Brouillet  et al.

Molecular Therapy. 2007. DOI : 10.1038/mt.sj.6300141.

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Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

S. Palfi; E. Brouillet; B. Jarraya; J. Bloch; C. Jan  et al.

Molecular Therapy. 2007. DOI : 10.1038/sj.mt.6300185.

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Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts

A. Consiglio; S. Martino; D. Dolcetta; G. Cusella; M. Conese  et al.

J Neurol Sci. 2007. DOI : 10.1016/j.jns.2007.01.010.

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Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy

E. E. Capowski; B. L. Schneider; A. D. Ebert; C. R. Seehus; J. Szulc  et al.

Journal of Neuroscience Methods. 2007. DOI : 10.1016/j.jneumeth.2007.02.022.

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Arts martiaux du Japon: une évolution socio-culturelle

N. Aebischer; J. Clerc; B. Mareine; P. Decaro

2007

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Highly Efficient Near-IR Emitting Yb/Yb and Yb/Al Helicates

M. Albrecht; O. Osetska; R. Fröhlich; J.-C. G. Bünzli; A. Aebischer  et al.

Journal of the American Chemical Society. 2007. DOI : 10.1021/ja0768688.

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Rational Tuning of Melting Entropies for Designing Luminescent Lanthanide-Containing Thermotropic Liquid Crystals at Room Temperature

A. Escande; L. Guénée; H. Nozary; G. Bernardinelli; F. Gumy  et al.

Chemistry, a European Journal. 2007. DOI : 10.1002/chem.200700560.

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Playing Defense Against Lou Gehrig's Disease

P. Aebischer; A. C. Kato

Scientific American. 2007. DOI : 10.1038/scientificamerican1107-86.

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The KRAB repressor domain can trigger de novo promoter methylation during mouse early embryogenesis

M. Wiznerowicz; J. Jakobsson; J. Szulc; S. Liao; A. Quazzola  et al.

Journal of Biological Chemistry. 2007. DOI : 10.1074/jbc.M705898200.

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DJ-1 as a neuroprotective protein in models of Parkinson's disease

K. Piorkowska-Stanco / P. Aebischer (Dir.)

Lausanne, EPFL, 2007. DOI : 10.5075/epfl-thesis-3926.

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Automatic detection of reaction start/endpoints in chemical and biotechnological reaction systems

G. Corminboeuf; M. Amrhein; O. Naef; P. Voirin; E. Vanoli  et al.

Chemometrics and Intelligent Laboratory Systems. 2007. DOI : 10.1016/j.chemolab.2006.06.015.

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A versatile tool for conditional gene expression and knockdown

J. Szulc; M. Wiznerowicz; M.-O. Sauvain; D. Trono; P. Aebischer

Nature Methods. 2006. DOI : 10.1038/nmeth846.

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Cyro SEM: Application in Micro and Nanotechnology

M. Dadras; O. Aebischer; B. Alameddine; T. Jenny; N. F. de Rooij

2006. p. 1822.

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Self-aggregated perfluoroalkylated hexa-peri-hexabenzocoonene fibers observed by cyro-SEM and fluorescence spectroscopy

O. F. Aebischer; A. Aebischer; P. Tondo; B. Alameddine; M. Dadras  et al.

Chemical Communication. 2006. DOI : 10.1039/b609056g.

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The potential of gene therapy for motor neuron diseases

C. Raoul; P. Aebischer

Amyotrophic Lateral Sclerosis; New York, NY: Taylor&Francis, 2006. p. 505-524.

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Viral-based modelling and correction of neurodegenerative diseases by RNA interference

C. Raoul; S. D. Barker; P. Aebischer

Gene therapy. 2006. DOI : 10.1038/sj.gt.3302690.

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Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421

R. Pardo; E. Colin; E. Regulier; P. Aebischer; N. Deglon  et al.

Journal of Neuroscience. 2006. DOI : 10.1523/JNEUROSCI.3706-05.2006.

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Viral vectors as a tool to model and treat Parkinson's disease

J. Bensadoun; P. Aebischer

Wien Klin Wochenschr. 2006. DOI : 10.1007/s00508-006-0736-5.

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CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity

M. Arango; S. Holbert; D. Zala; E. Brouillet; J. Pearson  et al.

Journal of Neuroscience. 2006. DOI : 10.1523/JNEUROSCI.5409-05.2006.

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Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease

A. Sajadi; J. Bensadoun; B. Schneider; C. Lo Bianco; P. Aebischer

Neurobiol Dis. 2006. DOI : 10.1016/j.nbd.2005.10.006.

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Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease

J. L. Ridet; J. Bensadoun; N. Deglon; P. Aebischer; A. D. Zurn

Neurobiol Dis. 2006. DOI : 10.1016/j.nbd.2005.06.003.

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Inducing tolerance to a soluble foreign antigen by encapsulated cell transplants

W. E. Blanco-Bose; B. L. Schneider; P. Aebischer

Molecular Therapy. 2006. DOI : 10.1016/j.ymthe.2005.08.010.

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Kinetic studies on the first dihydrogen aquacomplex, [Ru(H2)(H2O)5]2+: Formation under H2 pressure and catalytic H/D isotope exchange in water

P. V. Grundler; O. V. Yazyev; N. Aebischer; L. Helm; G. Laurenczy  et al.

Inorganica Chimica Acta. 2006. DOI : 10.1016/j.ica.2005.06.056.

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Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates

S. Behrstock; A. Ebert; J. McHugh; S. Vosberg; J. Moore  et al.

Gene Therapy. 2006. DOI : 10.1038/sj.gt.3302679.

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Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL

C. Raoul; E. Buhler; C. Sadeghi; A. Jacquier; P. Aebischer  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2006. DOI : 10.1073/pnas.0508774103.

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GDNF delivery using human neural progenitor cells in a rat model of ALS

S. M. Klein; S. Behrstock; J. McHugh; K. Hoffmann; K. Wallace  et al.

Human Gene Therapy. 2005. DOI : 10.1089/hum.2005.16.509.

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Akt is altered in an animal model of Huntington's disease and in patients

E. Colin; E. Regulier; V. Perrin; A. Durr; A. Brice  et al.

European Journal of Neuroscience. 2005. DOI : 10.1111/j.1460-9568.2005.03985.x.

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Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor

Y. H. Ahn; J. Bensadoun; P. Aebischer; A. D. Zurn; A. Seiger  et al.

Brain Res Bull. 2005. DOI : 10.1016/j.brainresbull.2005.04.009.

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Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

D. Zala; A. Benchoua; E. Brouillet; V. Perrin; M. C. Gaillard  et al.

Neurobiol Dis. 2005. DOI : 10.1016/j.nbd.2005.05.017.

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Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production

A. Sajadi; M. Bauer; B. Thony; P. Aebischer

J Neurochem. 2005. DOI : 10.1111/j.1471-4159.2005.03139.x.

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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS

C. Raoul; T. Abbas-Terki; J. Bensadoun; S. Guillot; G. Haase  et al.

Nature Medicine. 2005. DOI : 10.1038/nm1207.

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Information extraction from the Evolving Factor Analysis

J.-N. Aebischer; M. Amrhein; G. Corminboeuf; S. Crelier; O. Naef  et al.

2005. Swiss Chemical Society – Fall Meeting 2005, Lausanne, Switzerland, October 13, 2005.

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Is it possible to get reliable and easy-to-use information from Evolving Factor Analysis?

P. Voirin; G. Corminboeuf; M. Amrhein; O. Naef; E. Vanoli  et al.

2005. Swiss Statistics Meeting 2005, Zurich, Switzerland, November 9-11, 2005.

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Détermination automatique de fin de réactions à l’aide de méthodes chimiométriques

G. Corminboeuf; M. Amrhein; O. Naef; P. Voirin; E. Vanoli  et al.

2005. Chimiométrie 2005, Lille, France, November 30th to December 1st, 2005.

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Transgenic SOD1 mice as a model for developing amyotrophic lateral sclerosis therapies

S. Guillot / P. Aebischer (Dir.)

Lausanne, EPFL, 2005. DOI : 10.5075/epfl-thesis-3331.

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Dopaminergic fiber protection and regeneration by Wlds protein and GDNF in rodent models of Parkinson disease

A. Etemad-Sajadi / P. Aebischer (Dir.)

Lausanne, EPFL, 2005. DOI : 10.5075/epfl-thesis-3265.

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Use of lentiviral vectors for modelling and treating Parkinson's disease

C. Lo Bianco / P. Aebischer (Dir.)

Lausanne, EPFL, 2005. DOI : 10.5075/epfl-thesis-3167.

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Huntington's disease modeling and treatment

D. Zala / P. Aebischer; N. Déglon (Dir.)

Lausanne, EPFL, 2005. DOI : 10.5075/epfl-thesis-3137.

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ALS, IGF-1 and gene therapy: 'it's never too late to mend'

C. Raoul; P. Aebischer

Gene Therapy. 2004. DOI : 10.1038/sj.gt.3302204.

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Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

H. Kishima; T. Poyot; J. Bloch; J. Dauguet; F. Conde  et al.

Neurobiol Dis. 2004. DOI : 10.1016/j.nbd.2004.03.012.

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Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease

A. Sajadi; B. L. Schneider; P. Aebischer

Current Biology. 2004. DOI : 10.1016/S0960-9822(04)00050-8.

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Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions

F. Schwenter; B. L. Schneider; W. F. Pralong; N. Deglon; P. Aebischer

Human Gene Therapy. 2004. DOI : 10.1089/1043034041361172.

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Salivary glands and gene therapy: the mouth waters

R. Zufferey; P. Aebischer

Gene Therapy. 2004. DOI : 10.1038/sj.gt.3302321.

Detailed record

Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study

J. Bloch; A. C. Bachoud-Levi; N. Deglon; J. P. Lefaucheur; L. Winkel  et al.

Human Gene Therapy. 2004. DOI : 10.1089/hum.2004.15.968.

Detailed record

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

D. Zala; J. Bensadoun; L. Pereira de Almeida; B. R. Leavitt; C. A. Gutekunst  et al.

Exp Neurol. 2004. DOI : 10.1016/j.expneurol.2003.09.002.

Detailed record

Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice

S. Guillot; M. Azzouz; N. Deglon; A. Zurn; P. Aebischer

Neurobiol Dis. 2004. DOI : 10.1016/j.nbd.2004.01.017.

Detailed record

Lentiviral-mediated gene transfer to model triplet repeat disorders

E. Regulier; D. Zala; P. Aebischer; N. Deglon

Methods Mol Biol. 2004. DOI : 10.1385/1-59259-804-8:199.

Detailed record

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

C. Lo Bianco; B. L. Schneider; M. Bauer; A. Sajadi; A. Brice  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2004. DOI : 10.1073/pnas.0405313101.

Detailed record

Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease

C. Lo Bianco; N. Deglon; W. Pralong; P. Aebischer

Neurobiol Dis. 2004. DOI : 10.1016/j.nbd.2004.06.008.

Detailed record

In vivo calcium deposition on polyvinyl alcohol matrix used in hollow fiber cell macroencapsulation devices

F. Schwenter; N. Bouche; W. F. Pralong; P. Aebischer

Biomaterials. 2004. DOI : 10.1016/j.biomaterials.2003.10.030.

Detailed record

Etude chimiométrique sans calibration des données spectrales et analytiques provenant de réactions chimiques

G. Corminboeuf; M. Amrhein; O. Naef; P. Voirin; E. Vanoli  et al.

2004. Chimiométrie'04, Paris, December 2004.

Detailed record

Chemometric optimization of chemical reactions with spectroscopic measurements

J.-N. Aebischer; M. Amrhein; E. Vanoli; G. Corminboeuf; O. Naef

2004. Swiss Chemical Society Fall meeting '04, Zurich, September 2004.

Detailed record

Cell therapy using encapsulated cells producing endostatin

R. Bjerkvig; T. A. Read; P. Vajkoczy; P. Aebischer; W. Pralong  et al.

Local Therapies for Glioma; New York, NY: Springer, 2003. p. 137-141.

Detailed record

Cellular implants: pioneers in xenotransplantation?

B. L. Schneider; P. Aebischer

Xenotransplantation. 2003. DOI : 10.1034/j.1399-3089.2003.02086.x.

Detailed record

Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery

B. L. Schneider; F. Schwenter; W. F. Pralong; P. Aebischer

Molecular Therapy. 2003. DOI : 10.1016/S1525-0016(03)00055-8.

Detailed record

Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology

N. Deglon; V. Aubert; F. Spertini; L. Winkel; P. Aebischer

Xenotransplantation. 2003. DOI : 10.1034/j.1399-3089.2003.00110.x.

Detailed record

Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy

F. Schwenter; N. Deglon; P. Aebischer

J Gene Med. 2003. DOI : 10.1002/jgm.338.

Detailed record

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

E. Regulier; Y. Trottier; V. Perrin; P. Aebischer; N. Deglon

Human Molecular Genetics. 2003. DOI : 10.1093/hmg/ddg305.

Detailed record

Full text

Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

J. Bensadoun; L. Pereira de Almeida; E. G. Fine; J. L. Tseng; N. Deglon  et al.

J Control Release. 2003. DOI : 10.1016/S0168-3659(02)00353-X.

Detailed record

Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina

C. Kostic; F. Chiodini; P. Salmon; M. Wiznerowicz; N. Deglon  et al.

Gene Therapy. 2003. DOI : 10.1038/sj.gt.3301948.

Detailed record

Enhancement of peripheral nerve regeneration by interactive biomaterials

E. G. Fine / P. Aebischer (Dir.)

Lausanne, EPFL, 2003. DOI : 10.5075/epfl-thesis-2423.

Detailed record

Full text

Encapsulation as a strategy for cell xenotransplantation

B. Schneider; P. Aebischer

Future strategies for tissue and organ replacement; London: Imperial College Press, 2002. p. 291-322.

Detailed record

Lentiviruses as vectors for CNS diseases

N. Deglon; P. Aebischer

Current topics in microbiology and immunology. 2002. DOI : 10.1007/978-3-642-56114-6_10.

Detailed record

Allogeneic beta-islet cells correct diabetes and resist immune rejection

M. Pericin; A. Althage; S. Freigang; H. Hengartner; E. Rolland  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2002. DOI : 10.1073/pnas.122241299.

Detailed record

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration

S. Palfi; L. Leventhal; Y. Chu; S. Y. Ma; M. Emborg  et al.

Journal of Neuroscience. 2002. DOI : 10.1523/JNEUROSCI.22-12-04942.2002.

Detailed record

Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons

T. Ostenfeld; Y. T. Tai; P. Martin; N. Deglon; P. Aebischer  et al.

Journal of Neuroscience Res. 2002. DOI : 10.1002/jnr.10396.

Detailed record

Seizure suppression by adenosine-releasing cells is independent of seizure frequency

D. Boison; A. Huber; V. Padrun; N. Deglon; P. Aebischer  et al.

Epilepsia. 2002. DOI : 10.1046/j.1528-1157.2002.33001.x.

Detailed record

Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions

O. C. Aszmann; K. J. Korak; N. Kropf; E. Fine; P. Aebischer  et al.

Plast Reconstr Surg. 2002. DOI : 10.1097/01.PRS.0000020990.82332.43.

Detailed record

Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts

B. Sommer; C. Rinsch; E. Payen; B. Dalle; B. Schneider  et al.

Molecular Therapy. 2002. DOI : 10.1006/mthe.2002.0646.

Detailed record

Lentiviral-mediated RNA interference

T. Abbas-Terki; W. Blanco-Bose; N. Deglon; W. Pralong; P. Aebischer

Human Gene Therapy. 2002. DOI : 10.1089/104303402320987888.

Detailed record

Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length

L. P. de Almeida; C. A. Ross; D. Zala; P. Aebischer; N. Deglon

Journal of Neuroscience. 2002. DOI : 10.1523/JNEUROSCI.22-09-03473.2002.

Detailed record

Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat

F. M. Barras; P. Pasche; N. Bouche; P. Aebischer; A. D. Zurn

Journal of Neuroscience Res. 2002. DOI : 10.1002/jnr.10434.

Detailed record

GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap

E. G. Fine; I. Decosterd; M. Papaloizos; A. D. Zurn; P. Aebischer

European Journal of Neuroscience. 2002. DOI : 10.1046/j.1460-9568.2002.01892.x.

Detailed record

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease

E. Regulier; L. Pereira de Almeida; B. Sommer; P. Aebischer; N. Deglon

Human Gene Therapy. 2002. DOI : 10.1089/10430340260355383.

Detailed record

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia

C. Rinsch; P. Dupraz; B. L. Schneider; N. Deglon; P. H. Maxwell  et al.

Kidney Int. 2002. DOI : 10.1111/j.1523-1755.2002.kid574.x.

Detailed record

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

C. Lo Bianco; J. L. Ridet; B. L. Schneider; N. Deglon; P. Aebischer

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2002. DOI : 10.1073/pnas.152339799.

Detailed record

Encapsulated cell implants as a novel treatment for Parkinson’s disease

J. Tseng; P. Aebischer

Parkinson's disease: Methods and Protocols; Totowa, NJ: Humana Press, 2001. p. 279-288.

Detailed record

Recombinant proteins for neurodegenerative diseases: the delivery issue

P. Aebischer; J. Ridet

Trends in Neurosciences. 2001. DOI : 10.1016/S0166-2236(00)01899-3.

Detailed record

Sustained delivery of GDNF: towards a treatment for Parkinson's disease

A. D. Zurn; H. R. Widmer; P. Aebischer

Brain Res Brain Res Rev. 2001. DOI : 10.1016/S0165-0173(01)00098-4.

Detailed record

Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

A. Huber; V. Padrun; N. Deglon; P. Aebischer; H. Mohler  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2001. DOI : 10.1073/pnas.131102898.

Detailed record

Viral vector-mediated gene therapy for Parkinson's disease

M. Emborg; N. Deglon; L. Leventhal; P. Aebischer; J. Kordower

Clin Neurosci Res. 2001. DOI : 10.1016/S1566-2772(01)00027-5.

Detailed record

Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices

R. Schmidt-Ullrich; T. Aebischer; J. Huelsken; W. Birchmeier; U. Klemm  et al.

Development. 2001.

Detailed record

A self-immunomodulating myoblast cell line for erythropoietin delivery

B. L. Schneider; G. Peduto; P. Aebischer

Gene Therapy. 2001. DOI : 10.1038/sj.gt.3301356.

Detailed record

Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

J. Bensadoun; L. P. de Almeida; M. Dreano; P. Aebischer; N. Deglon

European Journal of Neuroscience. 2001. DOI : 10.1046/j.0953-816x.2001.01802.x.

Detailed record

Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease

L. P. de Almeida; D. Zala; P. Aebischer; N. Deglon

Neurobiol Dis. 2001. DOI : 10.1006/nbdi.2001.0388.

Detailed record

Nerve growth factor- and neurotrophin-3-releasing guidance channels promote regeneration of the transected rat dorsal root

J. Bloch; E. G. Fine; N. Bouche; A. D. Zurn; P. Aebischer

Exp Neurol. 2001. DOI : 10.1006/exnr.2001.7778.

Detailed record

Isolation of multipotent neural precursors residing in the cortex of the adult human brain

Y. Arsenijevic; J. G. Villemure; J. F. Brunet; J. J. Bloch; N. Deglon  et al.

Exp Neurol. 2001. DOI : 10.1006/exnr.2001.7691.

Detailed record

Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2

Y. Arsenijevic; S. Weiss; B. Schneider; P. Aebischer

Journal of Neuroscience. 2001. DOI : 10.1523/JNEUROSCI.21-18-07194.2001.

Detailed record

Inducing host acceptance to encapsulated xenogeneic myoblasts

C. Rinsch; G. Peduto; B. L. Schneider; P. Aebischer

Transplantation. 2001. DOI : 10.1097/00007890-200102150-00002.

Detailed record

Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia

C. Rinsch; P. Quinodoz; B. Pittet; N. Alizadeh; D. Baetens  et al.

Gene Therapy. 2001. DOI : 10.1038/sj.gt.3301436.

Detailed record

Pharmaceutical microencapsulation

O. Jordan; P. Aebischer; J.-F. Clemence

US6080412 ; JPH11509833 ; AU704240 ; MX9707492 ; EP0818993 ; AU5280396 ; CA2216359 ; WO9631199 ; GB9506844 . 2000.

Detailed record

Gene transfer techniques for the delivery of GDNF in Parkinson's disease

J. L. Ridet; N. Deglon; P. Aebischer

Novartis Foundation symposium. 2000.

Detailed record

Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease

V. Mittoux; J. M. Joseph; F. Conde; S. Palfi; C. Dautry  et al.

Human Gene Therapy. 2000. DOI : 10.1089/10430340050015220.

Detailed record

Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors

C. Cisterni; C. E. Henderson; P. Aebischer; B. Pettmann; N. Deglon

J Neurochem. 2000. DOI : 10.1046/j.1471-4159.2000.0741820.x.

Detailed record

Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF

A. C. Bachoud-Levi; N. Deglon; J. P. Nguyen; J. Bloch; C. Bourdet  et al.

Human Gene Therapy. 2000. DOI : 10.1089/10430340050111377.

Detailed record

Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression

G. Peduto; C. Rinsch; B. L. Schneider; E. Rolland; P. Aebischer

Transplantation. 2000.

Detailed record

Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF

J. Bensadoun; N. Deglon; J. L. Tseng; J. L. Ridet; A. D. Zurn  et al.

Exp Neurol. 2000. DOI : 10.1006/exnr.2000.7409.

Detailed record

Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2

M. Azzouz; A. Hottinger; J. C. Paterna; A. D. Zurn; P. Aebischer  et al.

Human Molecular Genetics. 2000. DOI : 10.1093/hmg/9.5.803.

Detailed record

Evaluation of an intrathecal immune response in amyotrophic lateral sclerosis patients implanted with encapsulated genetically engineered xenogeneic cells

A. D. Zurn; H. Henry; M. Schluep; V. Aubert; L. Winkel  et al.

Cell Transplant. 2000. DOI : 10.1177/096368970000900404.

Detailed record

Encapsulated neural transplants

J. L. Tseng; P. Aebischer

Progress in Brain Research. 2000. DOI : 10.1016/S0079-6123(00)27010-6.

Detailed record

Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus

A. F. Hottinger; M. Azzouz; N. Deglon; P. Aebischer; A. D. Zurn

Journal of Neuroscience. 2000. DOI : 10.1523/JNEUROSCI.20-15-05587.2000.

Detailed record

Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension

J. C. Schense; J. Bloch; P. Aebischer; J. A. Hubbell

Nature biotechnology. 2000. DOI : 10.1038/74473.

Detailed record

Complete carbonylation of fac-[Tc(H2O)3(CO)3]+ under CO pressure in aqueous media: a single sample story!

N. Aebischer; R. Schibli; R. Alberto; A. E. Merbach

Angewandte Chemie, International Edition. 2000. DOI : 10.1002/(SICI)1521-3773(20000103)39:1<254::AID-ANIE254>3.0.CO;2-F.

Detailed record

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

N. Déglon; J. L. Tseng; J. Bensadoun; A. D. Zurn; Y. Arsenijevic  et al.

Human Gene Therapy. 2000. DOI : 10.1089/10430340050016256.

Detailed record

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

J. H. Kordower; M. E. Emborg; J. Bloch; S. Y. Ma; Y. Chu  et al.

Science. 2000. DOI : 10.1126/science.290.5492.767.

Detailed record

Treatment of diseases of the central nervous system using encapsulated cells

A. F. Hottinger; P. Aebischer

Advances and Technical Standards in Neurosurgery; 1999. p. 3-20.

Detailed record

Sniff nasal pressure: a sensitive respiratory test to assess progression of amyotrophic lateral sclerosis

J. W. Fitting; R. Paillex; L. Hirt; P. Aebischer; M. Schluep

Annals of Neurology. 1999. DOI : 10.1002/1531-8249(199912)46:6<887::AID-ANA11>3.0.CO;2-L.

Detailed record

Highlights of the cell transplantation meeting at Montreux, March 1999

C. Rinsch; B. L. Schneider; P. Aebischer

Cell Transplant. 1999. DOI : 10.1177/096368979900800601.

Detailed record

Reaction between [Ru(H2O)6]2+ and DMF: a complete volume profile of a monocomplex formation reaction on a d6 low spin aqua ion

N. Aebischer; A. E. Merbach

Inorganic Reaction Mechanisms. 1999. DOI : 10.1515/irm-1999-0307.

Detailed record

Three-dimensional extracellular matrix engineering in the nervous system

M. Borkenhagen; J. F. Clemence; H. Sigrist; P. Aebischer

J Biomed Mater Res. 1998. DOI : 10.1002/(SICI)1097-4636(19980603)40:3<392::AID-JBM8>3.0.CO;2-C.

Detailed record

Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy

J. L. Tseng; S. L. Bruhn; A. D. Zurn; P. Aebischer

Neuroreport. 1998. DOI : 10.1097/00001756-199806010-00027.

Detailed record

Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain

I. Decosterd; E. Buchser; N. Gilliard; J. Saydoff; A. D. Zurn  et al.

Pain. 1998. DOI : 10.1016/S0304-3959(98)00044-X.

Detailed record

In vivo performance of a new biodegradable polyester urethane system used as a nerve guidance channel

M. Borkenhagen; R. C. Stoll; P. Neuenschwander; U. W. Suter; P. Aebischer

Biomaterials. 1998. DOI : 10.1016/S0142-9612(98)00122-7.

Detailed record

A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease

A. D. Zurn; J. L. Tseng; N. Deglon; J. M. Joseph; P. Aebischer

Advances in Pharmacology. 1998. DOI : 10.1016/S1054-3589(08)60899-6.

Detailed record

Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts

E. Regulier; B. L. Schneider; N. Deglon; Y. Beuzard; P. Aebischer

Gene Therapy. 1998. DOI : 10.1038/sj.gt.3300687.

Detailed record

Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice

J. Bensadoun; O. Mirochnitchenko; M. Inouye; P. Aebischer; A. D. Zurn

European Journal of Neuroscience. 1998. DOI : 10.1046/j.1460-9568.1998.00345.x.

Detailed record

Application of Teflon-AF thin films for bio-patterning of neural cell adhesion

S. A. Makohliso; L. Giovangrandi; D. Leonard; H. J. Mathieu; M. Ilegems  et al.

Biosens Bioelectron. 1998. DOI : 10.1016/S0956-5663(98)00036-0.

Detailed record

Formation and in situ characterization of the first dihydrogen aqua complex: [Ru(H2O)5(H2)]2+

N. Aebischer; U. Frey; A. E. Merbach

Chemical Communications. 1998. DOI : 10.1039/A805579C.

Detailed record

Mechanism of Complex Formation of Ruthenium(II) Aquacomplexes with H2C:CH2, MeCN, Me2SO, and CO: Metal-Water Bond Rupture as Rate-Determining Step

N. Aebischer; R. Churlaud; L. Dolci; U. Frey; A. E. Merbach

Inorganic Chemistry. 1998. DOI : 10.1021/ic980628z.

Detailed record

A surface engineering approach towards the development of cell-based biochip sensors

S. Makohliso / P. Aebischer (Dir.)

Lausanne, EPFL, 1998. DOI : 10.5075/epfl-thesis-1848.

Detailed record

Full text

Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization

N. A. Pochon; A. Menoud; J. L. Tseng; A. D. Zurn; P. Aebischer

European Journal of Neuroscience. 1997. DOI : 10.1111/j.1460-9568.1997.tb01623.x.

Detailed record

A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension

C. Rinsch; E. Regulier; N. Deglon; B. Dalle; Y. Beuzard  et al.

Human Gene Therapy. 1997. DOI : 10.1089/hum.1997.8.16-1881.

Detailed record

GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine

J. L. Tseng; E. E. Baetge; A. D. Zurn; P. Aebischer

Journal of Neuroscience. 1997. DOI : 10.1523/JNEUROSCI.17-01-00325.1997.

Detailed record

The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis

A. F. Hottinger; E. G. Fine; M. E. Gurney; A. D. Zurn; P. Aebischer

European Journal of Neuroscience. 1997. DOI : 10.1111/j.1460-9568.1997.tb01511.x.

Detailed record

Trans- and Cis-Water Reactivities in d6 Octahedral Ruthenium(II) Pentaaqua Complexes: Experimental and Density Functional Theory Studies

N. Aebischer; E. Sidorenkova; M. Ravera; G. Laurenczy; D. Osella  et al.

Inorganic Chemistry. 1997. DOI : 10.1021/ic970783y.

Detailed record

Tissue engineering approaches for peripheral nerve regeneration

M. Borkenhagen / P. Aebischer (Dir.)

Lausanne, EPFL, 1997. DOI : 10.5075/epfl-thesis-1688.

Detailed record

Full text

Treatment of Parkinson's disease. Symptomatic cell therapies: cells as biological minipumps

A. D. Zurn; J. Tseng; P. Aebischer

European Neurology. 1996.

Detailed record

Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF

S. A. Tan; N. Deglon; A. D. Zurn; E. E. Baetge; B. Bamber  et al.

Cell Transplant. 1996. DOI : 10.1016/0963-6897(96)00081-4.

Detailed record

The problems of delivering neuroactive molecules to the CNS

S. A. Tan; P. Aebischer

Ciba Found Symp. 1996. DOI : 10.1002/9780470514863.ch14.

Detailed record

Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients

P. Aebischer; M. Schluep; N. Deglon; J. M. Joseph; L. Hirt  et al.

Nature Medicine. 1996. DOI : 10.1038/nm0696-696.

Detailed record

Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience

E. Buchser; M. Goddard; B. Heyd; J. M. Joseph; J. Favre  et al.

Anesthesiology. 1996. DOI : 10.1097/00000542-199611000-00007.

Detailed record

Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF

P. Aebischer; N. A. Pochon; B. Heyd; N. Deglon; J. M. Joseph  et al.

Human Gene Therapy. 1996. DOI : 10.1089/hum.1996.7.7-851.

Detailed record

Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro

A. D. Zurn; L. Winkel; A. Menoud; K. Djabali; P. Aebischer

Journal of Neuroscience Res. 1996. DOI : 10.1002/(SICI)1097-4547(19960415)44:2<133::AID-JNR5>3.0.CO;2-E.

Detailed record

Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts

N. Deglon; B. Heyd; S. A. Tan; J. M. Joseph; A. D. Zurn  et al.

Human Gene Therapy. 1996. DOI : 10.1089/hum.1996.7.17-2135.

Detailed record

Treatment of amyotrophic lateral sclerosis using a gene therapy approach

P. Aebischer; A. C. Kato

European Neurology. 1995.

Detailed record

Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II

J. P. Ranieri; R. Bellamkonda; E. J. Bekos; T. G. Vargo; J. A. Gardella  et al.

J Biomed Mater Res. 1995. DOI : 10.1002/jbm.820290614.

Detailed record

Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro

R. Bellamkonda; J. P. Ranieri; P. Aebischer

Journal of Neuroscience Res. 1995. DOI : 10.1002/jnr.490410409.

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Hydrogel-based three-dimensional matrix for neural cells

R. Bellamkonda; J. P. Ranieri; N. Bouche; P. Aebischer

J Biomed Mater Res. 1995. DOI : 10.1002/jbm.820290514.

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Transplantation in humans of encapsulated xenogeneic cells without immunosuppression. A preliminary report

P. Aebischer; E. Buchser; J. M. Joseph; J. Favre; N. de Tribolet  et al.

Transplantation. 1994.

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Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates

J. P. Ranieri; R. Bellamkonda; E. J. Bekos; J. A. Gardella; H. J. Mathieu  et al.

International Journal of Developmental Neuroscience. 1994. DOI : 10.1016/0736-5748(94)90052-3.

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Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones

A. D. Zurn; E. E. Baetge; J. P. Hammang; S. A. Tan; P. Aebischer

Neuroreport. 1994. DOI : 10.1097/00001756-199412300-00030.

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Monocomplex formation reactions of hexaaquaruthenium(II): a mechanistic study

N. Aebischer; G. Laurenczy; A. Ludi; A. E. Merbach

Inorganic Chemistry. 1993. DOI : 10.1021/ic00065a005.

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Etude par RMN de réactions de formation de complexes en solution aqueuse de Ru(H2O)6²+ avec différents ligands S-donneurs

N. Aebischer

1990

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Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

A. Singh; D. D'Amico; P. A. Andreux; A. M. Fouassier; W. Blanco-Bose  et al.

Cell Reports Medicine. 2022-05-17. DOI : 10.1016/j.xcrm.2022.100633.

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Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast-fatigable motor units in a mouse model of amyotrophic lateral sclerosis

C. Rochat; N. Bernard-Marissal; E. Kaellstig; S. Pradervand; F. E. Perrin  et al.

Glia. 2022-01-03. DOI : 10.1002/glia.24140.

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Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial

S. Liu; D. D'Amico; E. Shankland; S. Bhayana; J. M. Garcia  et al.

Jama Network Open. 2022-01-20. DOI : 10.1001/jamanetworkopen.2021.44279.

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Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

A. Singh; D. D'Amico; P. A. Andreux; G. Dunngalvin; T. Kern  et al.

European Journal Of Clinical Nutrition. 2021-06-11. DOI : 10.1038/s41430-021-00950-1.

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The challenges of impact evaluation: Attempting to measure the effectiveness of community-based disaster risk management

M. Sarabia; A. R. Kägi Trejo; A. Davison; N. M. Banwell; C. Montes  et al.

International Journal of Disaster Risk Reduction. 2020-10-01. DOI : 10.1016/j.ijdrr.2020.101732.

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Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis

H. Lei; E. A. Dirren; C. Poitry-Yamate; B. Schneider; R. Gruetter  et al.

Journal of Cerebral Blood Flow and Metabolism. 2019-07-01. DOI : 10.1177/0271678X18756499.

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The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

P. A. Andreux; W. Blanco-Bose; D. Ryu; F. Burdet; M. Ibberson  et al.

Nature Metabolism. 2019-06-01. DOI : 10.1038/s42255-019-0073-4.

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Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease

V. Laversenne / B. Schneider; P. Aebischer (Dir.)

Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9751.

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A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology

S. M. K. Nazeeruddin / B. Schneider; P. Aebischer (Dir.)

Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.

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Cas9/gRNAs Selective Targeting of the Beethoven Tmc-1 Mutant Allele for Treating Progressive Hearing Loss by AAV-Based Delivery

P. Solanes; B. Pan; P. Aebischer; J. R. Holt; B. Schneider

2018-05-01. 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Chicago, IL, May 16-19, 2018. p. 138-139.

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Cas9/gRNA selective targeting of the Beethoven tmc-1 mutant allele for treating progressive hearing loss by AAV-based delivery

P. Solanes; Y. Asai; B. Pan; C. A. Nist-Lund; P. Aebischer  et al.

2018-12-01. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, Oct 16-19, 2018. p. A107-A108.

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An miRNA-based gene therapy approach to target mutated SOD1 in key cell types in amyotrophic lateral sclerosis (ALS)

V. Vilmont; J. Aebischer; C. Rochat; B. L. Schneider

2018-12-01. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, Oct 16-19, 2018. p. A80-A80.

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AAV based gene therapy for rare diseases

C. C. Rochat / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7888.

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First quantitative survey delineates the distribution of chimpanzees in the Eastern Central African Republic

T. Aebischer; G. Siguindo; E. Rochat; M. Arandjelovic; A. Heilman  et al.

Biological Conservation. 2017. DOI : 10.1016/j.biocon.2017.06.031.

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Bicistronic aav vector for rna interference in als

J. Aebischer; B. Schneider; C. Rochat

US11872290 ; HUE057809 ; EP4008789 ; ES2896181 ; SI3325632 ; PL3325632 ; LT3325632 ; PT3325632 ; DK3325632 ; EP3325632 ; US2021052744 ; US10835621 ; US2018228919 ; EP3325632 ; WO2017013252 ; EP3121284 . 2017.

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Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons

L. Zheng; N. Bernard-Marissal; N. Moullan; D. D'Amico; J. Auwerx  et al.

Human Molecular Genetics. 2017. DOI : 10.1093/hmg/ddw418.

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

D. Ryu; L. Mouchiroud; P. A. Andreux; E. Katsyuba; N. Moullan  et al.

Nat Med. 2016. DOI : 10.1038/nm.4132.

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In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

P. Machler; M. T. Wyss; M. Elsayed; J. Stobart; R. Gutierrez  et al.

Cell Metabolism. 2016. DOI : 10.1016/j.cmet.2015.10.010.

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Use of a Bicistronic Vector to Silence SOD1 in Motoneurons and Astrocytes for the Treatment of Familial Amyotrophic Lateral Sclerosis

J. Bobela-Aebischer; C. Rochat; N. Bernard-Marissal; P. Aebischer; B. L. Schneider

2016. 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington, DC, MAY 04-07, 2016. p. S240-S240.

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A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies

A. Lathuiliere; V. Laversenne; A. Astolfo; E. Kopetzki; H. Jacobsen  et al.

Brain. 2016. DOI : 10.1093/brain/aww036.

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Modulation of AMPK's activity via genetic tools and food-derived compounds as a novel approach to Parkinson's disease treatment

W. J. Bobela / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-6978.

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The effect of the functional interaction between PGC-1α and Parkin on mitochondrial quality control in Parkinson's disease

L. Zheng / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-6868.

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Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

A. Emde; C. Eitan; L.-L. Liou; R. T. Libby; N. Rivkin  et al.

Embo Journal. 2015. DOI : 10.15252/embj.201490493.

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Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

W. Bobela; P. Aebischer; B. L. Schneider

Biomolecules. 2015. DOI : 10.3390/biom5042675.

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SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice

E. Dirren; J. Aebischer; C. Rochat; C. Towne; B. L. Schneider  et al.

Annals Of Clinical And Translational Neurology. 2015. DOI : 10.1002/acn3.162.

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Tmc gene therapy restores auditory function in deaf mice

C. Askew; C. Rochat; B. Pan; Y. Asai; H. Ahmed  et al.

Science Translational Medicine. 2015. DOI : 10.1126/scitranslmed.aab1996.

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Noninvasive assessment of presymptomatic and symptomatic metabolic changes in the brain and brainstem of an ALS mouse model

H. Lei; E. Dirren; B. Schneider; S. Aebischer; R. Gruetter

2015. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, AUG 23-27, 2015. p. 339-340.

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Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

T. Sotelo-Hitschfeld; M. I. Niemeyer; P. Maechler; I. Ruminot; R. Lerchundi  et al.

Journal Of Neuroscience. 2015. DOI : 10.1523/Jneurosci.5036-14.2015.

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Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

S. Yang; M. Cacquevel; L. M. Saksida; T. J. Bussey; B. L. Schneider  et al.

Experimental neurology. 2015. DOI : 10.1016/j.expneurol.2014.11.013.

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A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

J. Dusonchet; H. Li; M. Guillily; M. Liu; K. Stafa  et al.

Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu202.

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Somatic and axonal LIGHT signaling elicit degenerative and regenerative responses in motoneurons, respectively

B. Otsmane; A. Moumen; J. Aebischer; E. Coque; C. Sar  et al.

Embo Reports. 2014. DOI : 10.1002/embr.201337948.

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Intracerebroventricular Injection of Adeno-Associated Virus 6 and 9 Vectors for Cell Type-Specific Transgene Expression in the Spinal Cord

E. Dirren; C. L. Towne; V. Setola; D. E. J. Redmond; B. L. Schneider  et al.

Human Gene Therapy. 2014. DOI : 10.1089/hum.2013.021.

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Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

A. Kaplan; K. J. Spiller; C. Towne; K. C. Kanning; G. T. Choe  et al.

Neuron. 2014. DOI : 10.1016/j.neuron.2013.12.009.

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Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation

A. Lathuiliere; B. Bohrmann; E. Kopetzki; C. Schweitzer; H. Jacobsen  et al.

Biomaterials. 2014. DOI : 10.1016/j.biomaterials.2013.10.026.

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Cerebrospinal fluid-targeted delivery of neutralizing anti-IFN gamma antibody delays motor decline in an ALS mouse model

B. Otsmane; J. Aebischer; A. Moumen; C. Raoul

Neuroreport. 2014. DOI : 10.1097/Wnr.0000000000000043.

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A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells

A. Lathuilière; S. Cosson; M. Lütolf; B. Schneider; P. Aebischer

Biomaterials. 2014. DOI : 10.1016/j.biomaterials.2013.09.071.

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Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model

D. Krakora; P. Mulcrone; M. Meyer; C. Lewis; K. Bernau  et al.

Molecular Therapy. 2013. DOI : 10.1038/mt.2013.108.

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Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles

K. Loew; P. Aebischer; B. L. Schneider

Human Gene Therapy. 2013. DOI : 10.1089/hum.2012.174.

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Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

A. Oueslati; B. L. Schneider; P. Aebischer; H. A. Lashuel

Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1309991110.

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Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

A. Kunze; S. Lengacher; E. Dirren; P. Aebischer; P. J. Magistretti  et al.

Integrative Biology. 2013. DOI : 10.1039/c3ib40022k.

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AAV-mediated gene therapy against motoneuron diseases

E. A. Dirren / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5821.

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A novel encapsulation device for peripheral implantation of antibody-secreting cells

A. Lathuilière / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5796.

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Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

E. Dassie; M. R. Andrews; J.-C. Bensadoun; M. Cacquevel; B. L. Schneider  et al.

Neurobiology Of Aging. 2013. DOI : 10.1016/j.neurobiolaging.2012.11.011.

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An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

P. Coune; M. Craveiro; M. Gaugler; V. Mlynárik; B. Schneider  et al.

NMR in biomedicine. 2013. DOI : 10.1002/nbm.2817.

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Parkinson's Disease: Gene Therapies

P. G. Coune; B. L. Schneider; P. Aebischer

Cold Spring Harbor Perspectives In Medicine. 2012. DOI : 10.1101/cshperspect.a009431.

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How to build science capacity

B. Fanaroff; P. Aebischer; R. Camacho; I. Serageldin; N. Suetin  et al.

Nature. 2012. DOI : 10.1038/490331a.

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Use of viral vectors to create animal models for Parkinson's disease

K. Loew; P. Aebischer

Neurobiology Of Disease. 2012. DOI : 10.1016/j.nbd.2011.12.038.

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Optimizing Millisecond Time Scale Near-Infrared Emission in Polynuclear Chrome(III)–Lanthanide(III) Complexes

L. Aboshyan-Sorgho; H. Nozary; A. Aebischer; J.-C. G. Bünzli; P.-Y. Morgantini  et al.

Journal of the American Chemical Society. 2012. DOI : 10.1021/ja304009b.

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Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease

V. Mlynárik; M. Cacquevel; L. Sun-Reimer; S. Janssens; C. Cudalbu  et al.

Journal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-112072.

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Imaging brain amyloid deposition using grating-based differential phase contrast tomography

B. R. Pinzer; M. Cacquevel; P. Modregger; S. A. McDonald; J. C. Bensadoun  et al.

Neuroimage. 2012. DOI : 10.1016/j.neuroimage.2012.03.029.

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Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

M. N. Gaugler; O. Genc; W. Bobela; S. Mohanna; M. T. Ardah  et al.

Acta Neuropathologica. 2012. DOI : 10.1007/s00401-012-0963-y.

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α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

B. Fauvet; M. K. Mbefo; M.-B. Fares; C. Desobry; S. Michael  et al.

The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M111.318949.

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Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

A. Oueslati; K. E. Paleologou; B. L. Schneider; P. Aebischer; H. A. Lashuel

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012. DOI : 10.1523/JNEUROSCI.3784-11.2012.

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Philanthropy: The price of charity

P. Aebischer

Nature. 2012. DOI : 10.1038/481260a.

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Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function

C. Ciron; S. Lengacher; J. Dusonchet; P. Aebischer; B. Schneider

Human Molecular Genetics. 2012. DOI : 10.1093/hmg/ddr618.

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Role of the FoxO3a Transcription Factor in alpha-synuclein Induced Neurodegeneration

E. Pino / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5245.

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System and Method For In Vivo Delivery of Antibodies and Fragments Thereof

O. Marroquin; P. Aebischer; M. Molinari; N. Bouche

US2011106062 . 2011.

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Proton and phosphorus MRS of a 5xFAD mouse model of Alzheimer's disease

V. Mlynarik; L. Sun-Reimer; S. Janssens; M. Cacquevel; H. Lei  et al.

2011. ISMRM 19th Annual Meeting & Exhibition, Montreal, Canada, May 7-13, 2011.

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Early metabolic changes in the amyotrophic lateral sclerosis SOD1 mouse brain are revealed using 1H MRS rather than CASL and 18FDG PET

H. Lei; E. Dirren; C. Poitry-Yamate; B. Schneider; P. Aebischer  et al.

2011. 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011, Montréal, Québec, Canada.

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Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease

P. G. Coune; J.-C. Bensadoun; P. Aebischer; B. Schneider

Journal of Parkinson's Disease. 2011. DOI : 10.3233/JPD-2011-11058.

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Investigation of the role of PICALM on amyloid metabolism in a transgenic mouse model of Alzheimer’s disease

D. Rubi

2011

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Alpha-Synuclein Effects at the ER-to-Golgi Level and Potential Biomarkers in Rat Models of the Early Phase of Parkinson's Disease

P. G. Coune / P. Aebischer; B. Schneider (Dir.)

Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5176.

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Near-infrared→Visible light upconversion in a molecular trinuclear d-f-d complex

L. Aboshyan-Sorgho; C. Besnard; P. Pattison; K. R. Kittilstved; A. Aebischer  et al.

Angewandte Chemie - International Edition. 2011. DOI : 10.1002/anie.201100095.

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Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

O. Marroquin Belaunzaran; M. I. Cordero; V. Setola; S. Bianchi; C. Galli  et al.

Plos One. 2011. DOI : 10.1371/journal.pone.0018268.

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A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2

J. Dusonchet; O. Kochubey; K. Stafa; S. M. Young; R. Zufferey  et al.

Journal of Neuroscience. 2011. DOI : 10.1523/JNEUROSCI.5092-10.2011.

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Use of igf-1 and nt-3 in the treatment of x-linked adrenoleukodystrophy

R. Mastroeni; C. Raoul; P. Aebischer; J.-C. Bensadoun

WO2010089706 . 2010.

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Alpha-Synuclein Animal Models

M. Gaugler; P. G. Coune; S. Mohana; O. Genc; O. El-Agnaf  et al.

2010. 2nd World Parkinson Congress, Glasgow, UK, September 28 - October 1, 2010. p. S606-S606.

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Effective Delivery of the Neuroprotectant to the Brain

P. Aebischer; E. Pino; M. Cacquevel; B. Schneider

2010. 2nd World Parkinson Congress, Glasgow, UK, September 28 - October 1, 2010. p. S602-S602.

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Neuroprotection by Gene Therapy Targeting Mutant SOD1 in Individual Pools of Motor Neurons Does not Translate Into Therapeutic Benefit in fALS Mice

C. Towne; V. Setola; B. L. Schneider; P. Aebischer

Molecular therapy : the journal of the American Society of Gene Therapy. 2010. DOI : 10.1038/mt.2010.260.

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Neurodegenerative Disorders: Gene Therapy on Clinical Trial

P. Aebischer

Frontiers in Neuroscience. 2010.

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AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway

K. Langou; A. Moumen; C. Pellegrino; J. Aebischer; I. Medina  et al.

Journal of Neurochemistry. 2010. DOI : 10.1111/j.1471-4159.2010.06806.x.

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Collapsin response médiator protein 4a(CRMP 4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron death

L. Duplan; N. Bernard; W. Casseron; K. Dudley; E. Thouvenot  et al.

The Journal of Neuroscience. 2010. DOI : 10.1523/JNEUROSCI.5411-09.2010.

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The role of MCT2 in motor neuron function

J. Uldry

2010

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Gene therapy for Parkinson's disease: viral gene delivery to revert a parkinsonian phenotype induced by alpha-synuclein over-expression

S. Mohanna

2010

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Motor Deficits upon Alpha-Synuclein Expression in the Nigrostriatal System Are Due to a Loss of Dopaminergic Vesicles and Reduced Dopamine Release at an early Stage of Neurodegeneration

M. Gaugler / P. Aebischer (Dir.)

Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4765.

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Modeling Parkinson's Disease in Adult Rats Using Viral Vectors as Gene Delivery Tools

J. Dusonchet / P. Aebischer (Dir.)

Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4758.

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Sensitized near-IR luminescence of lanthanide complexes based on push-pull diketone derivatives

N. S. Baek; Y. H. Kim; Y. K. Eom; J. H. Oh; H. K. Kim  et al.

Dalton Transactions. 2010. DOI : 10.1039/b915893f.

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Adeno-Associated Virus-Mediated Gene Delivery for the Treatment of Amyotrophic Lateral Sclerosis and other Motor Neuron Disorders

C. Towne / P. Aebischer (Dir.)

Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4669.

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Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6

C. Towne; B. Schneider; D. Kieran; D. Redmond; P. Aebischer

Gene Therapy. 2010. DOI : 10.1038/gt.2009.119.

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Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

K. E. Paleologou; A. Oueslati; G. Shakked; C. C. Rospigliosi; H.-Y. Kim  et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010. DOI : 10.1523/JNEUROSCI.5922-09.2010.

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Grafts of Dopamine Neurons Can Send Neurites to the Striatum Under GDNF Inducement in a Nonhuman Primate

J. R. Sladek; J. D. Elswonh; R. H. Roth; C. Leranth; T. J. Collier  et al.

2009. 16th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair, Clearwater Beach, FL, Apr 30-May 02, 2009. p. 234-235.

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Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF

D. J. Redmond; J. Elsworth; R. Roth; C. Leranth; T. Collier  et al.

Journal of Comparative Neurology. 2009. DOI : 10.1002/cne.22028.

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Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions

Y. Chu; H. Dodiya; P. Aebischer; C. Olanow; J. Kordower

Neurobiology of Disease. 2009. DOI : 10.1016/j.nbd.2009.05.023.

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Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF

M. Emborg; J. Moirano; J. Raschke; V. Bondarenko; R. Zufferey  et al.

Neurobiology of Disease. 2009. DOI : 10.1016/j.nbd.2009.07.022.

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Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons

A. Ulusoy; G. Shain; T. Björklund; P. Aebischer; D. Kirik

Molecular Therapy. 2009. DOI : 10.1038/mt.2009.142.

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An in vivo culture system for human embryos using an encapsulation technology: a pilot study

C. Blockeel; P. Mock; G. Verheyen; N. Bouche; P. Le Goff  et al.

Human Reproduction. 2009. DOI : 10.1093/humrep/dep005.

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Implication of the JNK pathway in a rat model of Huntington's disease

V. Perrin; N. Dufour; C. Raoul; R. Hassig; E. Brouillet  et al.

Experimental Neurology. 2009. DOI : 10.1016/j.expneurol.2008.10.008.

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Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery

C. Towne; M. Pertin; A. Beggah; P. Aebischer; I. Decosterd

Molecular Pain. 2009. DOI : 10.1186/1744-8069-5-52.

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Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model

R. Mastroeni; J.-C. Bensadoun; D. Charvin; P. Aebischer; A. Pujol  et al.

Annals of Neurology. 2009. DOI : 10.1002/ana.21677.

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A ruthenium-based metallostar: synthesis, sensitized luminescence and 1H relaxivity

L. Moriggi; A. Aebischer; C. Cannizzo; A. Sour; A. Borel  et al.

Dalton Transactions. 2009. DOI : 10.1039/b818599a.

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Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer's mouse model

O. Marroquin Belaunzaran / P. Aebischer (Dir.)

Lausanne, EPFL, 2009. DOI : 10.5075/epfl-thesis-4464.

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Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease Through RNAi

C. Towne; P. Aebischer

Therapeutic Applications of RNAi; 2009. p. 87-108.

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Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

J. Dusonchet; J. Bensadoun; B. Schneider; P. Aebischer

Neurobiology of disease. 2009. DOI : 10.1016/j.nbd.2009.03.013.

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Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

I. Barde; E. Laurenti; S. Verp; A. C. Groner; C. Towne  et al.

Journal of Virology. 2009. DOI : 10.1128/JVI.00001-09.

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Indo-1 derivatives for local calcium sensing

M. Bannwarth; I. Reis Correa Jr.; M. Sztretye; S. Pouvreau; C. Fellay  et al.

ACS Chemical Biology. 2009. DOI : 10.1021/cb800258g.

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Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

S. Azeredo da Silveira; B. Schneider; C. Cifuentes-Diaz; D. Sage; T. Abbas-Terki  et al.

Human Molecular Genetics. 2009. DOI : 10.1093/hmg/ddn417.

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Intrinsic quantum yields and radiative lifetimes of lanthanide tris(dipicolinates)

A. Aebischer; F. Gumy; J.-C. G. Bünzli

Phys. Chem. Chem. Phys.. 2009. DOI : 10.1039/b816131c.

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Intramuscular delivery of GDNF with human mesenchymal stem cells protects dying motor neurons and prolongs survival in a rat model of familial ALS

M. Suzuki; J. McHugh; C. Tork; B. Shelley; A. Hayes  et al.

2008. 15th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair, Clearwater Beach, FL, May 01-03, 2008. p. 482-483.

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Neuropathic pain: Gene therapy as a tool to transduce nociceptors

M. Pertin; C. Towne; T. Berta; A. Beggah; P. Aebischer  et al.

2008. p. 12S-12S.

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Feasibility of gene therapy for the treatment of neuropathic pain: downregulation of GTP cyclohydrolase 1 expression via RNA interference

S. Jean; C. Towne; P. Aebischer; I. Decosterd

2008. p. 3S-3S.

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Development Of A Cell Encapsulation Approach For Human Anti-Tumor Immunotherapy

F. Schwenter; S. Zarei; P. Luy; P. Morel; P. Aebischer  et al.

2008. XXXV Congress of the European Society for Artificial Organs: 'Towards Future Biomedical Technologies. p. 601-601.

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NIR-emitting lanthanide helicates

O. Osetska; M. Albrecht; R. Froehlich; F. Gumy; A. Aebischer  et al.

2008. 235th American-Chemical-Society National Meeting, New Orleans, LA, Apr 06-10, 2008. p. INOR 245.

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Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry

H. Runne; E. Régulier; A. Kuhn; D. Zala; O. Gokce  et al.

The Journal of neuroscience. 2008. DOI : 10.1523/JNEUROSCI.3044-08.2008.

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Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

C. Lo Bianco; J. Shorter; E. Régulier; H. Lashuel; T. Iwatsubo  et al.

The Journal of clinical investigation. 2008. DOI : 10.1172/JCI35781.

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Viral vectors: a potent approach to generate genetic models of Parkinson's disease

B. Schneider; M. Gaugler; P. Aebischer

Parkinson's disease: Molecular and therapeutics insights from model systems; New York: Academic Press, 2008. p. 269-284.

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Viral vectors, animal models and new therapies for Parkinson's disease

B. Schneider; R. Zufferey; P. Aebischer

Parkinsonism Realted Disorders. 2008. DOI : 10.1016/j.parkreldis.2008.04.024.

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Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS

M. Suzuki; J. McHugh; C. Tork; B. Shelley; A. Hayes  et al.

Molecular Therapy. 2008. DOI : 10.1038/mt.2008.197.

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Eco-densité, une intervention durable en milieu urbain, Blackwall Reach East London (Londres, GB)

N. Aebischer; N. Schmied

2008

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Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice

C. Towne; C. Raoul; B. L. Schneider; P. Aebischer

Molecular Therapy. 2008. DOI : 10.1038/mt.2008.73.

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Conditional gene expression and knockdown using lentivirus vectors encoding shRNA

J. Szulc; P. Aebischer

Methods Mol Biol. 2008. DOI : 10.1007/978-1-60327-248-3_18.

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GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys

M. E. Emborg; A. D. Ebert; J. Moirano; S. Peng; M. Suzuki  et al.

Cell Transplant. 2008. DOI : 10.3727/096368908784423300.

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Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons

M. Bauer; J. Szulc; M. Meyer; C. H. Jensen; T. A. Terki  et al.

J Neurochem. 2008. DOI : 10.1111/j.1471-4159.2007.05037.x.

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Impact of phosphorylation of alpha-synuclein in Parkinson's disease

S. Azeredo da Silveira Lajaunias / P. Aebischer (Dir.)

Lausanne, EPFL, 2008. DOI : 10.5075/epfl-thesis-4069.

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From gene to gene therapy and pharmacotherapy, via transgenic animals

P. Aebischer

2007. 11th Congress of the European-Federation-of-Neurological-Societies, Brussels, BELGIUM, Aug 25-28, 2007. p. 2-2.

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Controlling the lateral aggregation of perfluoroalkylated hexa-peri-hexabenzocoronenes

O. F. Aebischer; A. Aebischer; B. Donnio; B. Alameddine; M. Dadras  et al.

Journal of materials chemistry. 2007. DOI : 10.1039/b616057c.

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GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS

M. Suzuki; J. McHugh; C. Tork; B. Shelley; S. M. Klein  et al.

PLoS ONE. 2007. DOI : 10.1371/journal.pone.0000689.

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Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation

B. L. Schneider; C. R. Seehus; E. E. Capowski; P. Aebischer; S. C. Zhang  et al.

Human Molecular Genetics. 2007. DOI : 10.1093/hmg/ddm008.

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Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

V. Perrin; E. Régulier; T. Abbas-Terki; R. Hassig; E. Brouillet  et al.

Molecular Therapy. 2007. DOI : 10.1038/mt.sj.6300141.

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Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

S. Palfi; E. Brouillet; B. Jarraya; J. Bloch; C. Jan  et al.

Molecular Therapy. 2007. DOI : 10.1038/sj.mt.6300185.

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Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts

A. Consiglio; S. Martino; D. Dolcetta; G. Cusella; M. Conese  et al.

J Neurol Sci. 2007. DOI : 10.1016/j.jns.2007.01.010.

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Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy

E. E. Capowski; B. L. Schneider; A. D. Ebert; C. R. Seehus; J. Szulc  et al.

Journal of Neuroscience Methods. 2007. DOI : 10.1016/j.jneumeth.2007.02.022.

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Arts martiaux du Japon: une évolution socio-culturelle

N. Aebischer; J. Clerc; B. Mareine; P. Decaro

2007

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Highly Efficient Near-IR Emitting Yb/Yb and Yb/Al Helicates

M. Albrecht; O. Osetska; R. Fröhlich; J.-C. G. Bünzli; A. Aebischer  et al.

Journal of the American Chemical Society. 2007. DOI : 10.1021/ja0768688.

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Rational Tuning of Melting Entropies for Designing Luminescent Lanthanide-Containing Thermotropic Liquid Crystals at Room Temperature

A. Escande; L. Guénée; H. Nozary; G. Bernardinelli; F. Gumy  et al.

Chemistry, a European Journal. 2007. DOI : 10.1002/chem.200700560.

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Playing Defense Against Lou Gehrig's Disease

P. Aebischer; A. C. Kato

Scientific American. 2007. DOI : 10.1038/scientificamerican1107-86.

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The KRAB repressor domain can trigger de novo promoter methylation during mouse early embryogenesis

M. Wiznerowicz; J. Jakobsson; J. Szulc; S. Liao; A. Quazzola  et al.

Journal of Biological Chemistry. 2007. DOI : 10.1074/jbc.M705898200.

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DJ-1 as a neuroprotective protein in models of Parkinson's disease

K. Piorkowska-Stanco / P. Aebischer (Dir.)

Lausanne, EPFL, 2007. DOI : 10.5075/epfl-thesis-3926.

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Automatic detection of reaction start/endpoints in chemical and biotechnological reaction systems

G. Corminboeuf; M. Amrhein; O. Naef; P. Voirin; E. Vanoli  et al.

Chemometrics and Intelligent Laboratory Systems. 2007. DOI : 10.1016/j.chemolab.2006.06.015.

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A versatile tool for conditional gene expression and knockdown

J. Szulc; M. Wiznerowicz; M.-O. Sauvain; D. Trono; P. Aebischer

Nature Methods. 2006. DOI : 10.1038/nmeth846.

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Cyro SEM: Application in Micro and Nanotechnology

M. Dadras; O. Aebischer; B. Alameddine; T. Jenny; N. F. de Rooij

2006. p. 1822.

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Self-aggregated perfluoroalkylated hexa-peri-hexabenzocoonene fibers observed by cyro-SEM and fluorescence spectroscopy

O. F. Aebischer; A. Aebischer; P. Tondo; B. Alameddine; M. Dadras  et al.

Chemical Communication. 2006. DOI : 10.1039/b609056g.

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The potential of gene therapy for motor neuron diseases

C. Raoul; P. Aebischer

Amyotrophic Lateral Sclerosis; New York, NY: Taylor&Francis, 2006. p. 505-524.

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Viral-based modelling and correction of neurodegenerative diseases by RNA interference

C. Raoul; S. D. Barker; P. Aebischer

Gene therapy. 2006. DOI : 10.1038/sj.gt.3302690.

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Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421

R. Pardo; E. Colin; E. Regulier; P. Aebischer; N. Deglon  et al.

Journal of Neuroscience. 2006. DOI : 10.1523/JNEUROSCI.3706-05.2006.

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Viral vectors as a tool to model and treat Parkinson's disease

J. Bensadoun; P. Aebischer

Wien Klin Wochenschr. 2006. DOI : 10.1007/s00508-006-0736-5.

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CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity

M. Arango; S. Holbert; D. Zala; E. Brouillet; J. Pearson  et al.

Journal of Neuroscience. 2006. DOI : 10.1523/JNEUROSCI.5409-05.2006.

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Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease

A. Sajadi; J. Bensadoun; B. Schneider; C. Lo Bianco; P. Aebischer

Neurobiol Dis. 2006. DOI : 10.1016/j.nbd.2005.10.006.

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Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease

J. L. Ridet; J. Bensadoun; N. Deglon; P. Aebischer; A. D. Zurn

Neurobiol Dis. 2006. DOI : 10.1016/j.nbd.2005.06.003.

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Inducing tolerance to a soluble foreign antigen by encapsulated cell transplants

W. E. Blanco-Bose; B. L. Schneider; P. Aebischer

Molecular Therapy. 2006. DOI : 10.1016/j.ymthe.2005.08.010.

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Kinetic studies on the first dihydrogen aquacomplex, [Ru(H2)(H2O)5]2+: Formation under H2 pressure and catalytic H/D isotope exchange in water

P. V. Grundler; O. V. Yazyev; N. Aebischer; L. Helm; G. Laurenczy  et al.

Inorganica Chimica Acta. 2006. DOI : 10.1016/j.ica.2005.06.056.

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Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates

S. Behrstock; A. Ebert; J. McHugh; S. Vosberg; J. Moore  et al.

Gene Therapy. 2006. DOI : 10.1038/sj.gt.3302679.

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Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL

C. Raoul; E. Buhler; C. Sadeghi; A. Jacquier; P. Aebischer  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2006. DOI : 10.1073/pnas.0508774103.

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GDNF delivery using human neural progenitor cells in a rat model of ALS

S. M. Klein; S. Behrstock; J. McHugh; K. Hoffmann; K. Wallace  et al.

Human Gene Therapy. 2005. DOI : 10.1089/hum.2005.16.509.

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Akt is altered in an animal model of Huntington's disease and in patients

E. Colin; E. Regulier; V. Perrin; A. Durr; A. Brice  et al.

European Journal of Neuroscience. 2005. DOI : 10.1111/j.1460-9568.2005.03985.x.

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Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor

Y. H. Ahn; J. Bensadoun; P. Aebischer; A. D. Zurn; A. Seiger  et al.

Brain Res Bull. 2005. DOI : 10.1016/j.brainresbull.2005.04.009.

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Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

D. Zala; A. Benchoua; E. Brouillet; V. Perrin; M. C. Gaillard  et al.

Neurobiol Dis. 2005. DOI : 10.1016/j.nbd.2005.05.017.

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Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production

A. Sajadi; M. Bauer; B. Thony; P. Aebischer

J Neurochem. 2005. DOI : 10.1111/j.1471-4159.2005.03139.x.

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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS

C. Raoul; T. Abbas-Terki; J. Bensadoun; S. Guillot; G. Haase  et al.

Nature Medicine. 2005. DOI : 10.1038/nm1207.

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Information extraction from the Evolving Factor Analysis

J.-N. Aebischer; M. Amrhein; G. Corminboeuf; S. Crelier; O. Naef  et al.

2005. Swiss Chemical Society – Fall Meeting 2005, Lausanne, Switzerland, October 13, 2005.

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Is it possible to get reliable and easy-to-use information from Evolving Factor Analysis?

P. Voirin; G. Corminboeuf; M. Amrhein; O. Naef; E. Vanoli  et al.

2005. Swiss Statistics Meeting 2005, Zurich, Switzerland, November 9-11, 2005.

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Détermination automatique de fin de réactions à l’aide de méthodes chimiométriques

G. Corminboeuf; M. Amrhein; O. Naef; P. Voirin; E. Vanoli  et al.

2005. Chimiométrie 2005, Lille, France, November 30th to December 1st, 2005.

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Transgenic SOD1 mice as a model for developing amyotrophic lateral sclerosis therapies

S. Guillot / P. Aebischer (Dir.)

Lausanne, EPFL, 2005. DOI : 10.5075/epfl-thesis-3331.

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Dopaminergic fiber protection and regeneration by Wlds protein and GDNF in rodent models of Parkinson disease

A. Etemad-Sajadi / P. Aebischer (Dir.)

Lausanne, EPFL, 2005. DOI : 10.5075/epfl-thesis-3265.

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Use of lentiviral vectors for modelling and treating Parkinson's disease

C. Lo Bianco / P. Aebischer (Dir.)

Lausanne, EPFL, 2005. DOI : 10.5075/epfl-thesis-3167.

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Huntington's disease modeling and treatment

D. Zala / P. Aebischer; N. Déglon (Dir.)

Lausanne, EPFL, 2005. DOI : 10.5075/epfl-thesis-3137.

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ALS, IGF-1 and gene therapy: 'it's never too late to mend'

C. Raoul; P. Aebischer

Gene Therapy. 2004. DOI : 10.1038/sj.gt.3302204.

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Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

H. Kishima; T. Poyot; J. Bloch; J. Dauguet; F. Conde  et al.

Neurobiol Dis. 2004. DOI : 10.1016/j.nbd.2004.03.012.

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Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease

A. Sajadi; B. L. Schneider; P. Aebischer

Current Biology. 2004. DOI : 10.1016/S0960-9822(04)00050-8.

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Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions

F. Schwenter; B. L. Schneider; W. F. Pralong; N. Deglon; P. Aebischer

Human Gene Therapy. 2004. DOI : 10.1089/1043034041361172.

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Salivary glands and gene therapy: the mouth waters

R. Zufferey; P. Aebischer

Gene Therapy. 2004. DOI : 10.1038/sj.gt.3302321.

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Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study

J. Bloch; A. C. Bachoud-Levi; N. Deglon; J. P. Lefaucheur; L. Winkel  et al.

Human Gene Therapy. 2004. DOI : 10.1089/hum.2004.15.968.

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Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

D. Zala; J. Bensadoun; L. Pereira de Almeida; B. R. Leavitt; C. A. Gutekunst  et al.

Exp Neurol. 2004. DOI : 10.1016/j.expneurol.2003.09.002.

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Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice

S. Guillot; M. Azzouz; N. Deglon; A. Zurn; P. Aebischer

Neurobiol Dis. 2004. DOI : 10.1016/j.nbd.2004.01.017.

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Lentiviral-mediated gene transfer to model triplet repeat disorders

E. Regulier; D. Zala; P. Aebischer; N. Deglon

Methods Mol Biol. 2004. DOI : 10.1385/1-59259-804-8:199.

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Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

C. Lo Bianco; B. L. Schneider; M. Bauer; A. Sajadi; A. Brice  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2004. DOI : 10.1073/pnas.0405313101.

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Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease

C. Lo Bianco; N. Deglon; W. Pralong; P. Aebischer

Neurobiol Dis. 2004. DOI : 10.1016/j.nbd.2004.06.008.

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In vivo calcium deposition on polyvinyl alcohol matrix used in hollow fiber cell macroencapsulation devices

F. Schwenter; N. Bouche; W. F. Pralong; P. Aebischer

Biomaterials. 2004. DOI : 10.1016/j.biomaterials.2003.10.030.

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Etude chimiométrique sans calibration des données spectrales et analytiques provenant de réactions chimiques

G. Corminboeuf; M. Amrhein; O. Naef; P. Voirin; E. Vanoli  et al.

2004. Chimiométrie'04, Paris, December 2004.

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Chemometric optimization of chemical reactions with spectroscopic measurements

J.-N. Aebischer; M. Amrhein; E. Vanoli; G. Corminboeuf; O. Naef

2004. Swiss Chemical Society Fall meeting '04, Zurich, September 2004.

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Cell therapy using encapsulated cells producing endostatin

R. Bjerkvig; T. A. Read; P. Vajkoczy; P. Aebischer; W. Pralong  et al.

Local Therapies for Glioma; New York, NY: Springer, 2003. p. 137-141.

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Cellular implants: pioneers in xenotransplantation?

B. L. Schneider; P. Aebischer

Xenotransplantation. 2003. DOI : 10.1034/j.1399-3089.2003.02086.x.

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Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery

B. L. Schneider; F. Schwenter; W. F. Pralong; P. Aebischer

Molecular Therapy. 2003. DOI : 10.1016/S1525-0016(03)00055-8.

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Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology

N. Deglon; V. Aubert; F. Spertini; L. Winkel; P. Aebischer

Xenotransplantation. 2003. DOI : 10.1034/j.1399-3089.2003.00110.x.

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Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy

F. Schwenter; N. Deglon; P. Aebischer

J Gene Med. 2003. DOI : 10.1002/jgm.338.

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Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

E. Regulier; Y. Trottier; V. Perrin; P. Aebischer; N. Deglon

Human Molecular Genetics. 2003. DOI : 10.1093/hmg/ddg305.

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Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

J. Bensadoun; L. Pereira de Almeida; E. G. Fine; J. L. Tseng; N. Deglon  et al.

J Control Release. 2003. DOI : 10.1016/S0168-3659(02)00353-X.

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Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina

C. Kostic; F. Chiodini; P. Salmon; M. Wiznerowicz; N. Deglon  et al.

Gene Therapy. 2003. DOI : 10.1038/sj.gt.3301948.

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Enhancement of peripheral nerve regeneration by interactive biomaterials

E. G. Fine / P. Aebischer (Dir.)

Lausanne, EPFL, 2003. DOI : 10.5075/epfl-thesis-2423.

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Encapsulation as a strategy for cell xenotransplantation

B. Schneider; P. Aebischer

Future strategies for tissue and organ replacement; London: Imperial College Press, 2002. p. 291-322.

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Lentiviruses as vectors for CNS diseases

N. Deglon; P. Aebischer

Current topics in microbiology and immunology. 2002. DOI : 10.1007/978-3-642-56114-6_10.

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Allogeneic beta-islet cells correct diabetes and resist immune rejection

M. Pericin; A. Althage; S. Freigang; H. Hengartner; E. Rolland  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2002. DOI : 10.1073/pnas.122241299.

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Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration

S. Palfi; L. Leventhal; Y. Chu; S. Y. Ma; M. Emborg  et al.

Journal of Neuroscience. 2002. DOI : 10.1523/JNEUROSCI.22-12-04942.2002.

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Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons

T. Ostenfeld; Y. T. Tai; P. Martin; N. Deglon; P. Aebischer  et al.

Journal of Neuroscience Res. 2002. DOI : 10.1002/jnr.10396.

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Seizure suppression by adenosine-releasing cells is independent of seizure frequency

D. Boison; A. Huber; V. Padrun; N. Deglon; P. Aebischer  et al.

Epilepsia. 2002. DOI : 10.1046/j.1528-1157.2002.33001.x.

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Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions

O. C. Aszmann; K. J. Korak; N. Kropf; E. Fine; P. Aebischer  et al.

Plast Reconstr Surg. 2002. DOI : 10.1097/01.PRS.0000020990.82332.43.

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Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts

B. Sommer; C. Rinsch; E. Payen; B. Dalle; B. Schneider  et al.

Molecular Therapy. 2002. DOI : 10.1006/mthe.2002.0646.

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Lentiviral-mediated RNA interference

T. Abbas-Terki; W. Blanco-Bose; N. Deglon; W. Pralong; P. Aebischer

Human Gene Therapy. 2002. DOI : 10.1089/104303402320987888.

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Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length

L. P. de Almeida; C. A. Ross; D. Zala; P. Aebischer; N. Deglon

Journal of Neuroscience. 2002. DOI : 10.1523/JNEUROSCI.22-09-03473.2002.

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Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat

F. M. Barras; P. Pasche; N. Bouche; P. Aebischer; A. D. Zurn

Journal of Neuroscience Res. 2002. DOI : 10.1002/jnr.10434.

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GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap

E. G. Fine; I. Decosterd; M. Papaloizos; A. D. Zurn; P. Aebischer

European Journal of Neuroscience. 2002. DOI : 10.1046/j.1460-9568.2002.01892.x.

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Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease

E. Regulier; L. Pereira de Almeida; B. Sommer; P. Aebischer; N. Deglon

Human Gene Therapy. 2002. DOI : 10.1089/10430340260355383.

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Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia

C. Rinsch; P. Dupraz; B. L. Schneider; N. Deglon; P. H. Maxwell  et al.

Kidney Int. 2002. DOI : 10.1111/j.1523-1755.2002.kid574.x.

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alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

C. Lo Bianco; J. L. Ridet; B. L. Schneider; N. Deglon; P. Aebischer

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2002. DOI : 10.1073/pnas.152339799.

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Encapsulated cell implants as a novel treatment for Parkinson’s disease

J. Tseng; P. Aebischer

Parkinson's disease: Methods and Protocols; Totowa, NJ: Humana Press, 2001. p. 279-288.

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Recombinant proteins for neurodegenerative diseases: the delivery issue

P. Aebischer; J. Ridet

Trends in Neurosciences. 2001. DOI : 10.1016/S0166-2236(00)01899-3.

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Sustained delivery of GDNF: towards a treatment for Parkinson's disease

A. D. Zurn; H. R. Widmer; P. Aebischer

Brain Res Brain Res Rev. 2001. DOI : 10.1016/S0165-0173(01)00098-4.

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Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

A. Huber; V. Padrun; N. Deglon; P. Aebischer; H. Mohler  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2001. DOI : 10.1073/pnas.131102898.

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Viral vector-mediated gene therapy for Parkinson's disease

M. Emborg; N. Deglon; L. Leventhal; P. Aebischer; J. Kordower

Clin Neurosci Res. 2001. DOI : 10.1016/S1566-2772(01)00027-5.

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Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices

R. Schmidt-Ullrich; T. Aebischer; J. Huelsken; W. Birchmeier; U. Klemm  et al.

Development. 2001.

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A self-immunomodulating myoblast cell line for erythropoietin delivery

B. L. Schneider; G. Peduto; P. Aebischer

Gene Therapy. 2001. DOI : 10.1038/sj.gt.3301356.

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Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

J. Bensadoun; L. P. de Almeida; M. Dreano; P. Aebischer; N. Deglon

European Journal of Neuroscience. 2001. DOI : 10.1046/j.0953-816x.2001.01802.x.

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Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease

L. P. de Almeida; D. Zala; P. Aebischer; N. Deglon

Neurobiol Dis. 2001. DOI : 10.1006/nbdi.2001.0388.

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Nerve growth factor- and neurotrophin-3-releasing guidance channels promote regeneration of the transected rat dorsal root

J. Bloch; E. G. Fine; N. Bouche; A. D. Zurn; P. Aebischer

Exp Neurol. 2001. DOI : 10.1006/exnr.2001.7778.

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Isolation of multipotent neural precursors residing in the cortex of the adult human brain

Y. Arsenijevic; J. G. Villemure; J. F. Brunet; J. J. Bloch; N. Deglon  et al.

Exp Neurol. 2001. DOI : 10.1006/exnr.2001.7691.

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Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2

Y. Arsenijevic; S. Weiss; B. Schneider; P. Aebischer

Journal of Neuroscience. 2001. DOI : 10.1523/JNEUROSCI.21-18-07194.2001.

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Inducing host acceptance to encapsulated xenogeneic myoblasts

C. Rinsch; G. Peduto; B. L. Schneider; P. Aebischer

Transplantation. 2001. DOI : 10.1097/00007890-200102150-00002.

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Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia

C. Rinsch; P. Quinodoz; B. Pittet; N. Alizadeh; D. Baetens  et al.

Gene Therapy. 2001. DOI : 10.1038/sj.gt.3301436.

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Pharmaceutical microencapsulation

O. Jordan; P. Aebischer; J.-F. Clemence

US6080412 ; JPH11509833 ; AU704240 ; MX9707492 ; EP0818993 ; AU5280396 ; CA2216359 ; WO9631199 ; GB9506844 . 2000.

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Gene transfer techniques for the delivery of GDNF in Parkinson's disease

J. L. Ridet; N. Deglon; P. Aebischer

Novartis Foundation symposium. 2000.

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Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease

V. Mittoux; J. M. Joseph; F. Conde; S. Palfi; C. Dautry  et al.

Human Gene Therapy. 2000. DOI : 10.1089/10430340050015220.

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Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors

C. Cisterni; C. E. Henderson; P. Aebischer; B. Pettmann; N. Deglon

J Neurochem. 2000. DOI : 10.1046/j.1471-4159.2000.0741820.x.

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Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF

A. C. Bachoud-Levi; N. Deglon; J. P. Nguyen; J. Bloch; C. Bourdet  et al.

Human Gene Therapy. 2000. DOI : 10.1089/10430340050111377.

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Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression

G. Peduto; C. Rinsch; B. L. Schneider; E. Rolland; P. Aebischer

Transplantation. 2000.

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Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF

J. Bensadoun; N. Deglon; J. L. Tseng; J. L. Ridet; A. D. Zurn  et al.

Exp Neurol. 2000. DOI : 10.1006/exnr.2000.7409.

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Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2

M. Azzouz; A. Hottinger; J. C. Paterna; A. D. Zurn; P. Aebischer  et al.

Human Molecular Genetics. 2000. DOI : 10.1093/hmg/9.5.803.

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Evaluation of an intrathecal immune response in amyotrophic lateral sclerosis patients implanted with encapsulated genetically engineered xenogeneic cells

A. D. Zurn; H. Henry; M. Schluep; V. Aubert; L. Winkel  et al.

Cell Transplant. 2000. DOI : 10.1177/096368970000900404.

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Encapsulated neural transplants

J. L. Tseng; P. Aebischer

Progress in Brain Research. 2000. DOI : 10.1016/S0079-6123(00)27010-6.

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Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus

A. F. Hottinger; M. Azzouz; N. Deglon; P. Aebischer; A. D. Zurn

Journal of Neuroscience. 2000. DOI : 10.1523/JNEUROSCI.20-15-05587.2000.

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Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension

J. C. Schense; J. Bloch; P. Aebischer; J. A. Hubbell

Nature biotechnology. 2000. DOI : 10.1038/74473.

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Complete carbonylation of fac-[Tc(H2O)3(CO)3]+ under CO pressure in aqueous media: a single sample story!

N. Aebischer; R. Schibli; R. Alberto; A. E. Merbach

Angewandte Chemie, International Edition. 2000. DOI : 10.1002/(SICI)1521-3773(20000103)39:1<254::AID-ANIE254>3.0.CO;2-F.

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Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

N. Déglon; J. L. Tseng; J. Bensadoun; A. D. Zurn; Y. Arsenijevic  et al.

Human Gene Therapy. 2000. DOI : 10.1089/10430340050016256.

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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

J. H. Kordower; M. E. Emborg; J. Bloch; S. Y. Ma; Y. Chu  et al.

Science. 2000. DOI : 10.1126/science.290.5492.767.

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Treatment of diseases of the central nervous system using encapsulated cells

A. F. Hottinger; P. Aebischer

Advances and Technical Standards in Neurosurgery; 1999. p. 3-20.

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Sniff nasal pressure: a sensitive respiratory test to assess progression of amyotrophic lateral sclerosis

J. W. Fitting; R. Paillex; L. Hirt; P. Aebischer; M. Schluep

Annals of Neurology. 1999. DOI : 10.1002/1531-8249(199912)46:6<887::AID-ANA11>3.0.CO;2-L.

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Highlights of the cell transplantation meeting at Montreux, March 1999

C. Rinsch; B. L. Schneider; P. Aebischer

Cell Transplant. 1999. DOI : 10.1177/096368979900800601.

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Reaction between [Ru(H2O)6]2+ and DMF: a complete volume profile of a monocomplex formation reaction on a d6 low spin aqua ion

N. Aebischer; A. E. Merbach

Inorganic Reaction Mechanisms. 1999. DOI : 10.1515/irm-1999-0307.

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Three-dimensional extracellular matrix engineering in the nervous system

M. Borkenhagen; J. F. Clemence; H. Sigrist; P. Aebischer

J Biomed Mater Res. 1998. DOI : 10.1002/(SICI)1097-4636(19980603)40:3<392::AID-JBM8>3.0.CO;2-C.

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Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy

J. L. Tseng; S. L. Bruhn; A. D. Zurn; P. Aebischer

Neuroreport. 1998. DOI : 10.1097/00001756-199806010-00027.

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Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain

I. Decosterd; E. Buchser; N. Gilliard; J. Saydoff; A. D. Zurn  et al.

Pain. 1998. DOI : 10.1016/S0304-3959(98)00044-X.

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In vivo performance of a new biodegradable polyester urethane system used as a nerve guidance channel

M. Borkenhagen; R. C. Stoll; P. Neuenschwander; U. W. Suter; P. Aebischer

Biomaterials. 1998. DOI : 10.1016/S0142-9612(98)00122-7.

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A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease

A. D. Zurn; J. L. Tseng; N. Deglon; J. M. Joseph; P. Aebischer

Advances in Pharmacology. 1998. DOI : 10.1016/S1054-3589(08)60899-6.

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Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts

E. Regulier; B. L. Schneider; N. Deglon; Y. Beuzard; P. Aebischer

Gene Therapy. 1998. DOI : 10.1038/sj.gt.3300687.

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Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice

J. Bensadoun; O. Mirochnitchenko; M. Inouye; P. Aebischer; A. D. Zurn

European Journal of Neuroscience. 1998. DOI : 10.1046/j.1460-9568.1998.00345.x.

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Application of Teflon-AF thin films for bio-patterning of neural cell adhesion

S. A. Makohliso; L. Giovangrandi; D. Leonard; H. J. Mathieu; M. Ilegems  et al.

Biosens Bioelectron. 1998. DOI : 10.1016/S0956-5663(98)00036-0.

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Formation and in situ characterization of the first dihydrogen aqua complex: [Ru(H2O)5(H2)]2+

N. Aebischer; U. Frey; A. E. Merbach

Chemical Communications. 1998. DOI : 10.1039/A805579C.

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Mechanism of Complex Formation of Ruthenium(II) Aquacomplexes with H2C:CH2, MeCN, Me2SO, and CO: Metal-Water Bond Rupture as Rate-Determining Step

N. Aebischer; R. Churlaud; L. Dolci; U. Frey; A. E. Merbach

Inorganic Chemistry. 1998. DOI : 10.1021/ic980628z.

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A surface engineering approach towards the development of cell-based biochip sensors

S. Makohliso / P. Aebischer (Dir.)

Lausanne, EPFL, 1998. DOI : 10.5075/epfl-thesis-1848.

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Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization

N. A. Pochon; A. Menoud; J. L. Tseng; A. D. Zurn; P. Aebischer

European Journal of Neuroscience. 1997. DOI : 10.1111/j.1460-9568.1997.tb01623.x.

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A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension

C. Rinsch; E. Regulier; N. Deglon; B. Dalle; Y. Beuzard  et al.

Human Gene Therapy. 1997. DOI : 10.1089/hum.1997.8.16-1881.

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GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine

J. L. Tseng; E. E. Baetge; A. D. Zurn; P. Aebischer

Journal of Neuroscience. 1997. DOI : 10.1523/JNEUROSCI.17-01-00325.1997.

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The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis

A. F. Hottinger; E. G. Fine; M. E. Gurney; A. D. Zurn; P. Aebischer

European Journal of Neuroscience. 1997. DOI : 10.1111/j.1460-9568.1997.tb01511.x.

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Trans- and Cis-Water Reactivities in d6 Octahedral Ruthenium(II) Pentaaqua Complexes: Experimental and Density Functional Theory Studies

N. Aebischer; E. Sidorenkova; M. Ravera; G. Laurenczy; D. Osella  et al.

Inorganic Chemistry. 1997. DOI : 10.1021/ic970783y.

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Tissue engineering approaches for peripheral nerve regeneration

M. Borkenhagen / P. Aebischer (Dir.)

Lausanne, EPFL, 1997. DOI : 10.5075/epfl-thesis-1688.

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Treatment of Parkinson's disease. Symptomatic cell therapies: cells as biological minipumps

A. D. Zurn; J. Tseng; P. Aebischer

European Neurology. 1996.

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Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF

S. A. Tan; N. Deglon; A. D. Zurn; E. E. Baetge; B. Bamber  et al.

Cell Transplant. 1996. DOI : 10.1016/0963-6897(96)00081-4.

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The problems of delivering neuroactive molecules to the CNS

S. A. Tan; P. Aebischer

Ciba Found Symp. 1996. DOI : 10.1002/9780470514863.ch14.

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Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients

P. Aebischer; M. Schluep; N. Deglon; J. M. Joseph; L. Hirt  et al.

Nature Medicine. 1996. DOI : 10.1038/nm0696-696.

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Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience

E. Buchser; M. Goddard; B. Heyd; J. M. Joseph; J. Favre  et al.

Anesthesiology. 1996. DOI : 10.1097/00000542-199611000-00007.

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Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF

P. Aebischer; N. A. Pochon; B. Heyd; N. Deglon; J. M. Joseph  et al.

Human Gene Therapy. 1996. DOI : 10.1089/hum.1996.7.7-851.

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Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro

A. D. Zurn; L. Winkel; A. Menoud; K. Djabali; P. Aebischer

Journal of Neuroscience Res. 1996. DOI : 10.1002/(SICI)1097-4547(19960415)44:2<133::AID-JNR5>3.0.CO;2-E.

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Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts

N. Deglon; B. Heyd; S. A. Tan; J. M. Joseph; A. D. Zurn  et al.

Human Gene Therapy. 1996. DOI : 10.1089/hum.1996.7.17-2135.

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Treatment of amyotrophic lateral sclerosis using a gene therapy approach

P. Aebischer; A. C. Kato

European Neurology. 1995.

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Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II

J. P. Ranieri; R. Bellamkonda; E. J. Bekos; T. G. Vargo; J. A. Gardella  et al.

J Biomed Mater Res. 1995. DOI : 10.1002/jbm.820290614.

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Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro

R. Bellamkonda; J. P. Ranieri; P. Aebischer

Journal of Neuroscience Res. 1995. DOI : 10.1002/jnr.490410409.

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Hydrogel-based three-dimensional matrix for neural cells

R. Bellamkonda; J. P. Ranieri; N. Bouche; P. Aebischer

J Biomed Mater Res. 1995. DOI : 10.1002/jbm.820290514.

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Transplantation in humans of encapsulated xenogeneic cells without immunosuppression. A preliminary report

P. Aebischer; E. Buchser; J. M. Joseph; J. Favre; N. de Tribolet  et al.

Transplantation. 1994.

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Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates

J. P. Ranieri; R. Bellamkonda; E. J. Bekos; J. A. Gardella; H. J. Mathieu  et al.

International Journal of Developmental Neuroscience. 1994. DOI : 10.1016/0736-5748(94)90052-3.

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Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones

A. D. Zurn; E. E. Baetge; J. P. Hammang; S. A. Tan; P. Aebischer

Neuroreport. 1994. DOI : 10.1097/00001756-199412300-00030.

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Monocomplex formation reactions of hexaaquaruthenium(II): a mechanistic study

N. Aebischer; G. Laurenczy; A. Ludi; A. E. Merbach

Inorganic Chemistry. 1993. DOI : 10.1021/ic00065a005.

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Etude par RMN de réactions de formation de complexes en solution aqueuse de Ru(H2O)6²+ avec différents ligands S-donneurs

N. Aebischer

1990

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