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Cathrin Brisken

EPFL SV ISREC UPBRI
SV 2832 (Bâtiment SV)
Station 19
1015 Lausanne

Expertise

Breast Cancer; Mouse Genetics; Mammary Gland Development; Mouse Models; Patient derived Xenografts; Estrogen; Progesterone; Endocrine Disruptors

Mission

Cathrin Brisken obtained MD and PhD in Biophysics from the University of Göttingen, Germany, did postdoctoral work at the Whitehead Institute, MIT, Cambridge, USA, and held appointments at the Whitehead Institute, the Cancer Center of the Massachusetts General Hospital, Harvard Medical School and the Swiss Institute for Experimental Cancer Research. She is Associate Professor in Life Sciences at EPFL and Professor at the Institute of Cancer Research London. She was Dean of the EPFL Doctoral School and cofounded the International Cancer Prevention Institute. She has served on many international committees and advisory boards, including AACR Women in Cancer Research Council, International Breast Cancer Study Group Biological Protocol Working Group, Pezcoller Symposia Scientific Committee. Combining mouse genetics with innovative tissue recombination techniques, her laboratory made major contribution to our understanding of reproductive hormone action in vivo. Specific sex hormones, such as estrogens and progesterone impinge directly on a subset of luminal mammary epithelial cells that express the respective hormone receptors and act as sensor cells translating and amplifying systemic signals into local stimuli. Her lab overcame a major hurdle in ER breast cancer research by developing
clinically relevant xenograft models. These have opened entirely new perspectives on hormone dependent cancer and provided new insights into tumor dormancy.
Cathrin Brisken, MD, PhD, is Associate Professor of Life Sciences at the Swiss Federal Institute of Technology Lausanne (EPFL). Dr. Brisken is internationally recognized for her work on endocrine control of mammary gland development and breast carcinogenesis. Dr. Brisken received her MD and her PhD degree in Biophysics from the Georg August University of Göttingen, Germany. She completed her postdoctoral work in cancer biology with Dr. R.A. Weinberg at the Whitehead Institute of Biomedical Research in Cambridge, MA, USA. She previously held appointments at the Cancer Center of the Massachusetts General Hospital, Harvard Medical School, Boston and the Swiss Institute for Experimental Cancer Research (ISREC). Research in Dr. Brisken's laboratory focuses on the cellular and molecular underpinnings of estrogen and progesterone receptor signaling in the breast and the respective roles of these hormones and hormonally active compounds in carcinogenesis. The aim is to understand how recurrent exposures to endogenous and exogenous hormones contribute to breast carcinogenesis in order to better prevent and treat the disease. The laboratory has pioneered in vivo approaches to genetically dissect the role of the reproductive hormones in driving mouse mammary gland development and shown how they control intercellular communication. Dr. Brisken's group has developed ex vivo and humanized mouse models using patient samples to study hormone action in human tissues in normal settings and during disease progression. Dr. Brisken is member of the International Breast Cancer Study Group (IBCSG) Biological Protocol Working Group. She served as Dean of EPFL Doctoral School (more than 2000 PhD students in 18 PhD programs), as member of the Hinterzartener Kreis, the oncology think-tank associated with the German Science Foundation, and numerous Swiss, European, and AACR committees. She co-founded the International Cancer Prevention Institute.

Doctorants UNIL

Ciarloni Laura, Gass Sandra, Beleut Manfred, Schüpbach Sonia, Yalçin Özuysal Özden

PhD Students

https://people.epfl.ch/367053?lang=en

Past EPFL PhD Students

Renuga Devi Rajaram, Duje Buric, Rachel Marcone, Marie Shamseddin, Valentina Scabia, Dalya Ataca, Patrik Aouad, Céline Berthe Constantin, Fabio De Martino, Yueyun Zhang, Andrea Agnoletto, Carlos Henrique Venturi Ronchi, http://dx.doi.org/10.5075/epfl-thesis-11212

Courses

Molecular endocrinology: health and environment

BIO-450

We will define homeostasis, principles of hormone action and the molecular mechanisms underlying them to illustrate the complexities of physiological regulation. Human interactions with the environment, pertinent public health issues and their causes and preventative strategies will be analyzed.

Practical - Brisken Lab

BIO-608

Breast development and cancer. Learn about experimental approaches to study Breast Development and Breast Cancer.