Jérôme Waser

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Full Professor

jerome.waser@epfl.ch +41 21 693 93 88 http://lcso.epfl.ch/

https://orcid.org/0000-0002-4570-914X

EPFL SB ISIC LCSO
BCH 1402 (Batochime UNIL)
Av. F.-A. Forel 2
1015 Lausanne

+41 21 693 93 88
Office: BCH 4306
EPFL > SB > ISIC > LCSO

Web site: Web site: https://lcso.epfl.ch

+41 21 693 93 88
Office: BCH 4306
EPFL > SB > SB-SCGC > SCGC-ENS

Web site: Web site: https://www.epfl.ch/schools/sb/scgc/

+41 21 693 93 88
Office: BCH 4306
EPFL > VPA-AVP-DLE > AVP-DLE-EDOC > EDCH-ENS

+41 21 693 93 88
Office: BCH 4306
EPFL > VPA > VPA-FAC > OSSC

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Mission

To learn more about our mission, please have a look at the LCSO website: http://lcso.epfl.ch/

Biography

Jérôme Waser biography and CV: https://www.epfl.ch/labs/lcso/waser/

Publications

Infoscience publications

Infoscience

Silyl Ethynyl Benziodoxolone Reagents

D. F. González; S. Nicolai; J. Waser

Encyclopedia of Reagents for Organic Synthesis; Wiley, 2012.

Detailed record

Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1 lambda(3),2-benziodoxol-3(1H)-one and Alkynylation of Indoles, Thiophenes, and Anilines

J. P. Brand; J. Waser

Synthesis-Stuttgart. 2012. DOI : 10.1055/s-0031-1290589.

Detailed record

Ethynyl Benziodoxolones for the Direct Alkynylation of Heterocycles: Structural Requirement, Improved Procedure for Pyrroles, and Insights into the Mechanism

J. P. Brand; C. Chevalley; R. Scopelliti; J. Waser

Chemistry - A European Journal. 2012. DOI : 10.1002/chem.201200200.

Detailed record

Development of Catalytic Umpolung : Part 1: Direct Alkynylation of Heterocycles and Electron-Rich Aromatics using Alkynyl-Benziodoxolones - Part 2: Synthesis of New Bifunctional (Thio)urea-Carbene Catalysts

J. Brand / J. Waser (Dir.)

Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5397.

Detailed record

Catalytic Formal Homo-Nazarov Reaction and Other Cyclizations of Cyclopropanes : from Methodology to Total Synthesis

F. De Simone / J. Waser (Dir.)

Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5269.

Detailed record

Indole Alkaloids Synthesis via a Selective Cyclization of Aminocyclopropanes

F. De Simone; J. Waser

CHIMIA. 2012. DOI : 10.2533/chimia.2012.233.

Detailed record

Catalytic Enantiospecific [3+2] Annulation of Aminocyclopropanes with Ketones

F. Benfatti; F. de Nanteuil; J. Waser

Chemistry - A European Journal. 2012. DOI : 10.1002/chem.201103971.

Detailed record

Asymmetric Organocatalysis Meets Hypervalent Iodine Chemistry for the alpha-Functionalization of Carbonyl Compounds

D. Gonzalez Fernandez; F. Benfatti; J. Waser

Chemcatchem. 2012. DOI : 10.1002/cctc.201200116.

Detailed record

Para-Selective Gold-Catalyzed Direct Alkynylation of Anilines

J. P. Brand; J. Waser

Organic Letters. 2012. DOI : 10.1021/ol203289v.

Detailed record

Iron-Catalyzed [3+2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

F. Benfatti; F. de Nanteuil; J. Waser

Organic Letters. 2012. DOI : 10.1021/ol203144v.

Detailed record

Electrophilic alkynylation: the dark side of acetylene chemistry

J. P. Brand; J. Waser

Chemical Society Reviews. 2012. DOI : 10.1039/c2cs35034c.

Detailed record

Benziodoxole-based hypervalent iodine reagents for atom-transfer reactions

J. P. Brand; D. Fernandez Gonzalez; S. Nicolai; J. Waser

Chemical Communications (ChemComm). 2011. DOI : 10.1039/C0CC02265A.

Detailed record

Formal Homo-Nazarov and Other Cyclization Reactions of Activated Cyclopropanes

F. De Simone; T. Saget; F. Benfatti; S. Almeida; J. Waser

Chemistry - A European Journal. 2011. DOI : 10.1002/chem.201102583.

Detailed record

Benziodoxole-based hypervalent iodine reagents for atom-transfer reactions

J. P. Brand; D. Gonzalez Fernandez; S. Nicolai; J. Waser

Chemical Communications (ChemComm). 2011. DOI : 10.1039/c0cc02265a.

Detailed record

One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

J. P. Brand; C. Chevalley; J. Waser

Beilstein Journal Of Organic Chemistry. 2011. DOI : 10.3762/bjoc.7.65.

Detailed record

Cyclopropanes and Hypervalent Iodine Reagents: High Energy Compounds for Applications in Synthesis and Catalysis

D. Gonzalez Fernandez; F. De Simone; J. P. Brand; S. Nicolai; J. Waser

CHIMIA. 2011. DOI : 10.2533/chimia.2011.649.

Detailed record

A Palladium-Catalyzed Aminoalkynylation Strategy towards Bicyclic Heterocycles: Synthesis of (±)-Trachelanthamidine

S. Nicolai; C. Piemontesi; J. Waser

Angewandte Chemie International Edition. 2011. DOI : 10.1002/anie.201100718.

Detailed record

New Acetylene Chemistry : Direct [alpha]-Alkynylation of Carbonyls with Ethynyl Benziodoxolones (EBX)

D. Fernández González / J. Waser (Dir.)

Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5214.

Detailed record

Catalytic [3+2] Annulation of Aminocyclopropanes for the Enantiospecific Synthesis of Cyclopentylamines

F. de Nanteuil; J. Waser

Angewandte Chemie International Edition. 2011. DOI : 10.1002/anie.201106255.

Detailed record

Cyclization of Aminocyclopropanes in Indole Alkaloids Synthesis

F. De Simone; J. Waser

Synlett. 2011. DOI : 10.1055/s-0030-1259553.

Detailed record

Pd(0)-Catalyzed Oxy- and Aminoalkynylation of Olefins for the Synthesis of Tetrahydrofurans and Pyrrolidines

S. Nicolai; J. Waser

Organic Letters. 2011. DOI : 10.1021/ol2029383.

Detailed record

Direct Alkynylation of Thiophenes: Cooperative Activation of TIPS–EBX with Gold and Brønsted Acids

J. P. Brand; J. Waser

Angewandte Chemie International Edition. 2010. DOI : 10.1002/anie.201003179.

Detailed record

Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine

F. De Simone; J. Gertsch; J. Waser

Angewandte Chemie International Edition. 2010. DOI : 10.1002/anie.201001853.

Detailed record

Ethynyl-1,2-benziodoxol-3(1 H)-one (EBX): An Exceptional Reagent for the Ethynylation of Keto, Cyano, and Nitro Esters

D. Fernández González; J. P. Brand; J. Waser

Chemistry - A European Journal. 2010. DOI : 10.1002/chem.201001539.

Detailed record

Synthesis of Chiral Bifunctional (Thio)Urea N-Heterocyclic Carbenes

J. P. Brand; J. I. Osuna-Siles; J. Waser

Synlett. 2010. DOI : 10.1055/s-0029-1219543.

Detailed record

Pd-Catalyzed Intramolecular Oxyalkynylation of Alkenes with Hypervalent Iodine

S. Nicolai; S. Erard; D. Fernandez Gonzalez; J. Waser

Organic Letters. 2010. DOI : 10.1021/ol9027286.

Detailed record

Azides by Olefin Hydroazidation Reactions

J. Waser; E. M. Carreira

Organic Azides: Syntheses and Applications; Wiley, 2010. p. 95 - 112.

Detailed record

Cyclization and Cycloaddition Reactions of Cyclopropyl Carbonyls and Imines

F. De Simone; J. Waser

Synthesis: Journal of Synthetic Organic Chemistry. 2009. DOI : 10.1055/s-0029-1216998.

Detailed record

Cyclization of Cyclopropyl Carbonyls and the Homo-Nazarov Reaction

F. De Simone; J. Waser

CHIMIA. 2009. DOI : 10.2533/chimia.2009.162.

Detailed record

Catalytic Formal Homo-Nazarov Cyclization

F. De Simone; J. Andrès; R. Torosantucci; J. Waser

Organic Letters. 2009. DOI : 10.1021/ol802970g.

Detailed record

Direct Alkynylation of Indole and Pyrrole Heterocycles

J. P. Brand; J. Charpentier; J. Waser

Angewandte Chemie International Edition. 2009. DOI : 10.1002/anie.200905419.

Detailed record

Other publications

Full publication list

A full publication list of LCSO with graphical abstracts is available on the following website: http://lcso.epfl.ch/Publications

Research

Link to our resarch

A regularly updated description of our research program is available on the following website: http://lcso.epfl.ch/Research

Teaching & PhD

Teaching

Chemistry and Chemical Engineering

PhD Students

Aregger Nina, Baldassari Carlo, Göbel Felix, Kamei Yuji, Lee Najung, Lucidarme Daphne, Marty Christine Alice Jacqueline, Olikauskas Valentas, Orain Lucie Sophie Christel, Schöpfer Alexandre Alain, Solé Àvila Helena, Tanguy Clément Gabriel Baptiste, Wu Wei,

Past EPFL PhD Students

Amos Stephanie Grace Elizabeth , Borrel Julien Aymeric , Brand Jonathan , Caramenti Paola , Cavalli Diana , Das Ashis Kumar , De Simone Filippo , De la Barre De Nanteuil Florian Patrick Marie Daniel , Declas Nina , Fernández González Davinia , Garreau Marion Marie-Agnès , Greenwood Phillip Gulliver Dominic , Grinhagena Elija , Le Du Eliott Hugo Joran , Le Vaillant Franck , Li Yifan , Liu Xingyu , Muriel Bastian Antoine Rodolphe Claude , Nguyen Vu Trung Tin , Nicolai Stefano , Orcel Ugo Jonathan , Palamini Pierre Gérard Joseph , Perrotta Daniele , Pisella Guillaume Dominique , Purins Mikus , Racine Sophie Lucie , Robert Emma Gabrielle Louise , Simonet-Davin Raphaël Michel Henri , Smyrnov Vladyslav , Tessier Romain Gaëtan , Vita Maria Victoria , Wang Mingming ,

Jérôme Waser

Full Professor

Mission

Biography

Publications

Infoscience publications

Infoscience

Silyl Ethynyl Benziodoxolone Reagents

Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1 lambda(3),2-benziodoxol-3(1H)-one and Alkynylation of Indoles, Thiophenes, and Anilines

Ethynyl Benziodoxolones for the Direct Alkynylation of Heterocycles: Structural Requirement, Improved Procedure for Pyrroles, and Insights into the Mechanism

Development of Catalytic Umpolung : Part 1: Direct Alkynylation of Heterocycles and Electron-Rich Aromatics using Alkynyl-Benziodoxolones - Part 2: Synthesis of New Bifunctional (Thio)urea-Carbene Catalysts

Catalytic Formal Homo-Nazarov Reaction and Other Cyclizations of Cyclopropanes : from Methodology to Total Synthesis

Indole Alkaloids Synthesis via a Selective Cyclization of Aminocyclopropanes

Catalytic Enantiospecific [3+2] Annulation of Aminocyclopropanes with Ketones

Asymmetric Organocatalysis Meets Hypervalent Iodine Chemistry for the alpha-Functionalization of Carbonyl Compounds

Para-Selective Gold-Catalyzed Direct Alkynylation of Anilines

Iron-Catalyzed [3+2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

Electrophilic alkynylation: the dark side of acetylene chemistry

Benziodoxole-based hypervalent iodine reagents for atom-transfer reactions

Formal Homo-Nazarov and Other Cyclization Reactions of Activated Cyclopropanes

Benziodoxole-based hypervalent iodine reagents for atom-transfer reactions

One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

Cyclopropanes and Hypervalent Iodine Reagents: High Energy Compounds for Applications in Synthesis and Catalysis

A Palladium-Catalyzed Aminoalkynylation Strategy towards Bicyclic Heterocycles: Synthesis of (±)-Trachelanthamidine

New Acetylene Chemistry : Direct [alpha]-Alkynylation of Carbonyls with Ethynyl Benziodoxolones (EBX)

Catalytic [3+2] Annulation of Aminocyclopropanes for the Enantiospecific Synthesis of Cyclopentylamines

Cyclization of Aminocyclopropanes in Indole Alkaloids Synthesis

Pd(0)-Catalyzed Oxy- and Aminoalkynylation of Olefins for the Synthesis of Tetrahydrofurans and Pyrrolidines

Direct Alkynylation of Thiophenes: Cooperative Activation of TIPS–EBX with Gold and Brønsted Acids

Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine

Ethynyl-1,2-benziodoxol-3(1 H)-one (EBX): An Exceptional Reagent for the Ethynylation of Keto, Cyano, and Nitro Esters

Synthesis of Chiral Bifunctional (Thio)Urea N-Heterocyclic Carbenes

Pd-Catalyzed Intramolecular Oxyalkynylation of Alkenes with Hypervalent Iodine

Azides by Olefin Hydroazidation Reactions

Cyclization and Cycloaddition Reactions of Cyclopropyl Carbonyls and Imines

Cyclization of Cyclopropyl Carbonyls and the Homo-Nazarov Reaction

Catalytic Formal Homo-Nazarov Cyclization

Direct Alkynylation of Indole and Pyrrole Heterocycles

Other publications

Full publication list

Research

Link to our resarch

Teaching & PhD

Teaching

PhD Students

Past EPFL PhD Students

All postal addresses and positions