Ute Koch

ute.koch@epfl.ch

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Nationality: German

EPFL SV ISREC UPRAD
SV 2533 (Bâtiment SV)
Station 19
1015 Lausanne

+41 21 693 07 75
Office: SV 2533
EPFL › SV › ISREC › UPRAD

Website: https://radtke-lab.epfl.ch

+41 21 693 07 75
EPFL › VPA › VPA-AVP-DLE › AVP-DLE-EDOC › EDMS-ENS

Website: https://go.epfl.ch/edms

+41 21 693 07 75
EPFL › SV › SV-SSV › SSV-ENS

Website: https://sv.epfl.ch/education

Expertise

SCIENTIFIC EXPERTISES
Current Molecular Biology and Cloning, Developmental Biology, Cellular and Molecular Immunology, Lymphocyte Maturation and Lineage Commitment, Thymic Selection, Hematopoietic Stem Cell Biology, Bone Marrow Transplantation, Graft-versus-Host Disease, Skin Transplantation, T Lymphocyte Subset Induction (Th1 - Th2, Cytokine Regulation), Extensive Knowledge in Flow Cytometry
IT SKILLS
Microsoft-Office: Word, Excel, PowerPoint.
File Maker Pro: Database design and management.
Flow cytometry Analysis: CellQuest, FlowJo.

Expertise

Publications Teaching & PhD

Infoscience

Early Notch signals from fibroblastic reticular cells program effector CD8<SUP>+</SUP> T cell differentiation

D. Maurice De Sousa; E. Perkey; L. Le Corre; S. Boulet; D. Gomez Atria et al.

JOURNAL OF EXPERIMENTAL MEDICINE. 2025. DOI : 10.1084/jem.20231758.

Ute Koch

Expertise

Expertise

Infoscience

Early Notch signals from fibroblastic reticular cells program effector CD8<SUP>+</SUP> T cell differentiation

Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs

Stroma-Driven Notch2 Signaling Controls Naive B Cell Fate By Regulating Microenvironmental Positioning within the Spleen

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation

Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia

Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors

A third Notch in colorectal cancer progression and metastasis

Pharmacological disruption of the Notch transcription factor complex

Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelia lineage in fetal thymus development

Notch Signaling - a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

Signalling strength determines proapoptotic functions of STING

Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Derivation of Traceable and Transplantable Photoreceptors from Mouse Embryonic Stem Cells

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Specific Notch receptor-ligand interactions control human TCR-alpha beta/gamma delta development by inducing differential Notch signal strength

Stem cells living with a Notch

DL4-mediated Notch signaling is required for the development of fetal alpha beta and gamma delta T cells

Redundant Notch1 and Notch2 Signaling Is Necessary for IFNγ Secretion by T Helper 1 Cells During Infection with Leishmania major

Activation of a glioma-specific immune response by oncolytic parvovirus Minute Virus of Mice infection

Transcription factor ROR alpha is critical for nuocyte development

Loss of Cutaneous TSLP-Dependent Immune Responses Skews the Balance of Inflammation from Tumor Protective to Tumor Promoting

Notch Signaling In Normal And Malignant T-Cells

Factors determining the spontaneous activation of splenic dendritic cells in culture

Dll1- and Dll4-mediated Notch signaling is required for homeostasis of intestinal stem cells

Notch signaling is dispensable for mature melanocytes but essential for melanocyte stem cells

Mechanisms of T Cell Development and Transformation

Notch signaling regulates follicular helper T Cell differentiation

Notch in T-ALL: new players in a complex disease

BCL6 and BCoR gang up on Notch to regulate left-right patterning

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin

Notch Signaling In Solid Tumors

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

Additive and global functions of HoxA cluster genes in mesoderm derivatives

Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies

Hedgehog signaling is dispensable for adult hematopoietic stem cell function

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis

Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells

Haematopoietic stem cell niche in Drosophila

Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation

Early Notch signals from fibroblastic reticular cells program effector CD8<SUP>+</SUP> T cell differentiation

Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs

Stroma-Driven Notch2 Signaling Controls Naive B Cell Fate By Regulating Microenvironmental Positioning within the Spleen

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation

Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia

Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors

A third Notch in colorectal cancer progression and metastasis

Pharmacological disruption of the Notch transcription factor complex

Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelia lineage in fetal thymus development

Notch Signaling - a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

Signalling strength determines proapoptotic functions of STING

Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Derivation of Traceable and Transplantable Photoreceptors from Mouse Embryonic Stem Cells

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Specific Notch receptor-ligand interactions control human TCR-alpha beta/gamma delta development by inducing differential Notch signal strength

Stem cells living with a Notch

DL4-mediated Notch signaling is required for the development of fetal alpha beta and gamma delta T cells

Redundant Notch1 and Notch2 Signaling Is Necessary for IFNγ Secretion by T Helper 1 Cells During Infection with Leishmania major

Activation of a glioma-specific immune response by oncolytic parvovirus Minute Virus of Mice infection

Transcription factor ROR alpha is critical for nuocyte development