Sebastian Maerkl
Nationalité: German
EPFL STI IBI-STI LBNC
BM 1141 (Bâtiment BM)
Station 17
1015 Lausanne
+41 21 693 78 35
+41 21 693 11 61
Office:
BM 1141
EPFL › STI › IBI-STI › LBNC
Site web: https://lbnc.epfl.ch/
EPFL STI IBI-STI LBNC
BM 1141 (Bâtiment BM)
Station 17
1015 Lausanne
+41 21 693 78 35
Office:
BM 1141
EPFL › VPA › VPA-AVP-DLE › AVP-DLE-EDOC › EDBB-GE
Site web: https://go.epfl.ch/phd-edbb
Formation
2008 – 2008 California Institute of Technology
2001 – 2001 Fairleigh-Dickinson University
2001 – 2001 Fairleigh-Dickinson University
Prix et distinctions
Category: Biotechnology
2005
The prize honors annually the best Caltech Ph.D. thesis in the given category.
2008
EPFL prize for dedication to teaching and promotion of EPFL students and the school at large.
2012
2015
European Research Council
2016
2019
2025
PURE system optimization and exploration of self-regeneration for synthetic cell applications
Lausanne, EPFL, 2025. DOI : 10.5075/epfl-thesis-11059.2024
Nature-inspired recycling of a protein mixture into a green fluorescent protein-based hydrogel
RSC Sustainability. 2024. DOI : 10.1039/d4su00212a.Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network
Lausanne, EPFL, 2024. DOI : 10.5075/epfl-thesis-10077.2021
A high-throughput microfluidic nanoimmunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultralow-volume blood samples
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2021. DOI : 10.1073/pnas.2025289118.Towards an artificial cell: Development of a system which self-regenerates the protein components of the PURE system in microfluidic reactors
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8286.2020
A partially self-regenerating synthetic cell
Nature Communications. 2020. DOI : 10.1038/s41467-020-20180-6.Bottom-Up Construction of Complex Biomolecular Systems With Cell-Free Synthetic Biology
Frontiers in Bioengineering and Biotechnology. 2020. DOI : 10.3389/fbioe.2020.00213.2018
Microfluidic Transfection for High-Throughput Mammalian Protein Expression
Methods in Molecular Biology. 2018. DOI : 10.1007/978-1-4939-8730-6_13.Microfluidic device for real-time formulation of reagents and their subsequent encapsulation into double emulsions
Scientific Reports. 2018. DOI : 10.1038/s41598-018-26542-x.2017
Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7889.A Microfluidic Biodisplay
Acs Synthetic Biology. 2017. DOI : 10.1021/acssynbio.7b00088.A system, device and method for multiplexed biomarker diagnostics of ultra-low volume whole blood samples
WO2017102593 . 2017.2016
A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing
Scientific Reports. 2016. DOI : 10.1038/srep23937.Integrating Gene Synthesis and MITOMI for Rapid Protein Engineering
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-6796.2015
Rapid cell-free forward engineering of novel genetic ring oscillators
eLife. 2015. DOI : 10.7554/eLife.09771.2014
A 1024-sample serum analyzer chip for cancer diagnostics
Lab On A Chip. 2014. DOI : 10.1039/c31c51153g.Long-Term Single Cell Analysis of S. pombe on a Microfluidic Microchemostat Array
Plos One. 2014. DOI : 10.1371/journal.pone.0093466.2013
A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening
Integrative Biology. 2013. DOI : 10.1039/c3ib20263a.iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks
Nucleic Acids Research. 2013. DOI : 10.1093/nar/gks1323.2011
Does Positive Selection Drive Transcription Factor Binding Site Turnover? A Test with Drosophila Cis-Regulatory Modules
PLoS Genetics. 2011. DOI : 10.1371/journal.pgen.1002053.2010
Experimental strategies for studying transcription factor-DNA binding specificities
Briefings in Functional Genomics. 2010. DOI : 10.1093/bfgp/elq023.2009
An in vitro microfluidic approach to generating protein-interaction networks
Nature Methods. 2009. DOI : 10.1038/nmeth.1289.2008
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
Nature Biotechnology. 2008. DOI : 10.1038/nbt.1490.Enseignement et PhD
Doctorant·es actuel·les
Amogh Kumar Baranwal, Pao-Wan Lee, Seyed Saeed Mottaghi, Onur Burak Özdemir
A dirigé les thèses EPFL de
Nicolas Dénervaud, Sylvie Rockel, Jean-Bernard Nobs, Arun Stephen Rajkumar, Henrike Marie Niederholtmeyer, Matthew Christopher Blackburn, Kristina Pan Woodruff, Francesca Volpetti, Ekaterina Emilova Petrova, Zoe Newell Swank, Ivan Istomin, Grégoire Michielin, Fabien Jammes, Barbora Lavickova, Hon Ming Andrew Yip, Amir Shahein, Shiyu Cheng, Laura Grasemann, Ragunathan Bava Ganesh
A co-dirigé les thèses EPFL de
Meltem Elitas, Johannes Becker, Zuzana Tatárová, Amanda Verpoorte, Simone Giaveri
Cours
Introduction to bioengineering
EE-526
Ce cours offre aux étudiants en ingénierie une compréhension fondamentale de la bio-ingénierie, un domaine multidisciplinaire qui intègre les principes de la biologie, de la chimie et de l'ingénierie.
Lab on cell-free synthetic biology
EE-490(j)
Le cours de biologie synthétique acellulaire présente aux ingénieurs les techniques les plus couramment utilisées pour mener des travaux en biotechnologie et en bio-ingénierie. De plus, ce cours est une expérience de démocratisation de l'éducation et de la science ouverte en générant des ressources