Vamsi Krishna Polavarapu

EPFL SV ISREC UPORICCHIO
SV 2824 (Bâtiment SV)
Station 19
1015 Lausanne

EPFL SV ISREC UPORICCHIO
SV 2824 (Bâtiment SV)
Station 19
1015 Lausanne

EPFLETUEDOCEDMS

Expertise

I work extensively with patient derived samples to generate clinical insights across genetics, epigenetics, and transcriptomics. My focus is on developing and applying robust next-generation sequencing workflows that translate molecular data from real-world clinical specimens into meaningful biological and clinical interpretation.

I am co-inventor of FFPE-ATAC-seq and FACT-seq (FFPE tissue with antibody-guided chromatin tagmentation with sequencing) to enable chromatin accessibility and histone modification profiling directly from formalin-fixed paraffin-embedded (FFPE) tissues, unlocking the potential of archived patient samples for high-resolution epigenetic analysis.

Mission

My goal is to advance precision medicine by building scalable, clinically adaptable multi-omic sequencing solutions that transform patient data into diagnostic and therapeutic insights.

Current Work

Currently, I investigate cancer cell plasticity in human  samples acquired from patients, using both bulk and single-cell multimodal sequencing approaches. I aim to uncover regulatory mechanisms and clinically relevant biomarkers.

Education

Master of science Applied Biotechnology

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2018 – 2020 Uppsala University