Vamsi Krishna Polavarapu
EPFL SV ISREC UPORICCHIO
SV 2824 (Bâtiment SV)
Station 19
1015 Lausanne
+41 21 693 68 16
EPFL › SV › ISREC › UPORICCHIO
Website: https://oricchiolab.epfl.ch
Expertise
I work extensively with patient derived samples to generate clinical insights across genetics, epigenetics, and transcriptomics. My focus is on developing and applying robust next-generation sequencing workflows that translate molecular data from real-world clinical specimens into meaningful biological and clinical interpretation.
I am co-inventor of FFPE-ATAC-seq and FACT-seq (FFPE tissue with antibody-guided chromatin tagmentation with sequencing) to enable chromatin accessibility and histone modification profiling directly from formalin-fixed paraffin-embedded (FFPE) tissues, unlocking the potential of archived patient samples for high-resolution epigenetic analysis.
I am co-inventor of FFPE-ATAC-seq and FACT-seq (FFPE tissue with antibody-guided chromatin tagmentation with sequencing) to enable chromatin accessibility and histone modification profiling directly from formalin-fixed paraffin-embedded (FFPE) tissues, unlocking the potential of archived patient samples for high-resolution epigenetic analysis.
Mission
My goal is to advance precision medicine by building scalable, clinically adaptable multi-omic sequencing solutions that transform patient data into diagnostic and therapeutic insights.
Current Work
Currently, I investigate cancer cell plasticity in human samples acquired from patients, using both bulk and single-cell multimodal sequencing approaches. I aim to uncover regulatory mechanisms and clinically relevant biomarkers.
Education
Master of science Applied Biotechnology
|2018 – 2020 Uppsala University