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Alexander Mathis

EPFL SV BMI UPAMATHIS
Campus Biotech
B1 3 274.040
Chemin des mines 9
1202 Genève

EPFL SV BMI UPAMATHIS
Campus Biotech
B1 3 274.040
Chemin des mines 9

EPFL SV BMI UPAMATHIS
Campus Biotech
B1 3 274.040
Chemin des mines 9

EPFL SV BMI UPAMATHIS
Campus Biotech
B1 3 274.040
Chemin des mines 9

Expertise

measuring behavior, modeling sensorimotor control, skill learning, machine learning, computational neuroscience, phenotyping, proprioception
Alexander Mathis is an assistant professor at the Brain Mind Institute. He is working at the intersection of computational neuroscience, and machine learning, focusing on trying to understand the statistics of behavior and how the brain creates behavior. He studied pure Mathematics at the Ludwig-Maximilians-Universität München, where he also obtained his PhD in computational neuroscience (with Andreas V.M. Herz). During his PhD he developed a theory on how space is represented in the brain. He then was a postdoctoral fellow at Harvard University (with Venkatesh N. Murthy) and the University of Tübingen (with Matthias Bethge) working on a broad range of topics from the sense of smell to computer vision.

Since 2020 he is an assistant professor at EPFL, where his group currently works on theories of proprioception and motor control. Additionally, they develop machine learning tools for behavioral analysis (e.g. DeepLabCut, DLC2action, hBehaveMAE, WildCLIP, AmadeusGPT) and conversely try to learn from the brain to solve challenging machine learning problems such as learning motor skills. Indeed with his students, he won competitions based on brain-inspired reinforcement learning algorithms for skill learning (MyoChallenge at NeurIPS 2022 and 2023). He received numerous prizes and fellowships, incl. the 2024 Robert Bing Prize, 2023 Eric Kandel Young Neuroscientists Prize, 2023 Frontiers of Science Award, a Marie Sklodowska-Curie Postdoctoral Fellowship, and a scholarship from the Studienstiftung des deutschen Volkes.

Selected publications

DeepLabCut: Markerless tracking of user-defined features with deep learning

Alexander Mathis, Pranav Mamidanna, Kevin M. Cury, Taiga Abe, Venkatesh N. Murthy, Mackenzie Weygandt Mathis* & Matthias Bethge*
Published in Nature Neuroscience in

Task-driven neural network models predict neural dynamics of proprioception

Alessandro Marin Vargas, Axel Bisi, Alberto Silvio Chiappa, Christopher Versteeg, Lee E Miller, Alexander Mathis
Published in Cell in

Rethinking pose estimation in crowds: overcoming the detection information-bottleneck and ambiguity

Mu Zhou*, Lucas Stoffl*, Mackenzie W. Mathis, Alexander Mathis
Published in International Conference on Computer Vision in

Multi-animal pose estimation, identification and tracking with DeepLabCut

Jessy Lauer, Mu Zhou, Shaokai Ye, William Menegas, Steffen Schneider, Tanmay Nath, Mohammed Mostafizur Rahman, Valentina Di Santo, Daniel Soberanes, Guoping Feng, Venkatesh N Murthy, George Lauder, Catherine Dulac, Mackenzie Weygandt Mathis, Alexander Mathis
Published in Nature Methods in

DMAP: a Distributed Morphological Attention Policy for Learning to Locomote with a Changing Body

Alberto Chiappa, Alessandro Marin Vargas, Alexander Mathis
Published in NeurIPS in

Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice

Ying Li, Alexander Mathis, Benjamin Grewe, Jessica A. Osterhout, Biafra Ahanonu, Mark J. Schnitzer, Venkatesh N. Murthy, Catherine Dulac
Published in Cell in

Optimal Population Codes for Space: Grid Cells Outperform Place Cells

Alexander Mathis, Andreas V.M. Herz, Martin Stemmler
Published in Neural Computation in

Teaching & PhD

Current Phd

Sepideh Mamooler, Merkourios Simos, Andy Bonnetto, Michal Stanislaw Grudzien, Chengkun Li, Haozhe Qi, Valentin Alexandre Guy Gabeff, Bianca Ziliotto

Past Phd As Director

Alessandro Marin Vargas, Alberto Chiappa, Stoffl Lucas, Mu Zhou

Courses

Applied software engineering for life sciences

BIO-210

We learn and apply software engineering principles to develop Python projects addressing life science problems. Projects will be expanded iteratively throughout the semester.

Brain-like computation and intelligence

NX-414

Recent advances in machine learning have contributed to the emergence of powerful models of animal perception and behavior. In this course we will compare the behavior and underlying mechanisms in these models as well as brains.

Lecture series on scientific machine learning

PHYS-754

This lecture presents ongoing work on how scientific questions can be tackled using machine learning. Machine learning enables extracting knowledge from data computationally and in an automatized way. We will learn on examples how this is influencing the very scientific method.