Amanda Lewis
EPFL SB IPHYS LBEM
BSP 419 (Cubotron UNIL)
Rte de la Sorge
1015 Lausanne
+41 21 693 88 78
Office: BSP 419
EPFL › SB › IPHYS › LBEM
Website: https://www.epfl.ch/labs/lbem/
Awards
A rare window into genetic Synucleinopathies: A correlative EM study of the E83Q DLB brain
Parkinson Schweiz
2026
Identifying novel biomarkers in skin biopsies for the diagnosis of synuclein diseases
Parkinson Schweiz
2023
Synapsis Foundation
Career development award
2021
Selected publications
Ultrastructural diversity of α-synuclein pathology in the post-mortem brain of Parkinson patients: implications for Lewy body formation.
Amanda J Lewis, Lukas van den Heuvel, Marta di Fabrizio, Domenic Burger, Evelien Huisman, John GJM Bol, Wilma DJ van de Berg & Henning Stahlberg
Published in In review. Preprint available on BioRxiv. in 2026
Myelin damage in donor skin differentiates between synucleinopathies.
Marta Di Fabrizio, Bram L. van der Gaag, Mara Terzi, Eve Aaron, Noa B. C. Steerenberg, John G. J. M. Bol, Wilma D. J. Van de Berg, Henning Stahlberg & Amanda J. Lewis
Published in In review. Preprint available on BioRxiv. in 2026
Correlative ultrastructural mapping of Lewy pathology reveals regional diversity in Parkinson’s disease and Dementia with Lewy bodies.
Notash Shafiei, Daniel Stӓhli, Domenic Burger, Marta Di Fabrizio, Lukas van den Heuvel, Jean Daraspe, Carolin Böing, Sarah H. Shahmoradian, Wilma D. J. van de Berg, Christel Genoud, Henning Stahlberg & Amanda J. Lewis
Published in In review. Preprint available on BioRxiv in 2026
Cryo-EM structure of α-synuclein fibrils harbouring the Dementia with Lewy Bodies-associated E83Q mutation.
Notash Shafiei, Inayatullah Mohammed, Senthil T. Kumar, Anne-Laure Mahul-Mellier, Babatunde Ekundayo, Daniel Stähli, Amanda J. Lewis & Henning Stahlberg
Published in In review. Preprint available on BioRxiv in 2026
Synthetic α-synuclein fibrils replicate in mice causing MSA neuropathology.
Domenic Burger, Marianna Kashyrina, Lukas van den Heuvel, Hortense de La Seiglière, Amanda J. Lewis, Francesco De Nuccio, Inayathulla Mohammed, Jérémy Verchère, Cécile Feuillie, Mélanie Berbon, Marie-Laure Arotcarena, Aude Retailleau, Erwan Bezard, Marie-Hélène Canron, Wassilios G. Meissner, Antoine Loquet, Luc Bousset, Christel Poujol, K. Peter R. Nilsson, Florent Laferrière, Thierry Baron, Dario Domenico Lofrumento, Francesca De Giorgi, Henning Stahlberg & François Ichas
Published in Nature in 2025
A correlative light and electron microscopy protocol for human brain and other biological models.
Notash Shafiei; Daniel Stӓhli; Domenic Burger; Marta Di Fabrizio; Lukas van den Heuvel; Jean Daraspe; Carolin Böing; Sarah H. Shahmoradian; Wilma D. J. van de Berg; Christel Genoud, Henning Stahlberg & Amanda Lewis
Published in Nature Protocols in 2025
Distinct ultrastructural phenotypes of glial and neuronal α-synuclein inclusions in Multiple System Atrophy.
Carolin Böing; Marta Di Fabrizio; Domenic Burger; John G J M Bol; Evelien Huisman; Annemieke J M Rozemuller; Wilma D J van de Berg; Henning Stahlberg & Amanda J Lewis
Published in Brain in 2024
Lewy Pathology in Parkinson’s disease consists of crowded organelles and lipid membranes.
Sarah H. Shahmoradian, Amanda J. Lewis, Christel Genoud, Jürgen Hench, Tim E. Moors, Paula P. Navarro, Daniel Castaño-Díez, Gabriel Schweighauser, Alexandra Graff-Meyer, Kenneth N. Goldie, Rosmarie Sütterlin, Evelien Huisman, Angela Ingrassia, Yvonne de Gier, Annemieke J. M. Rozemuller, Jing Wang, Anne De Paepe, Johannes Erny, Andreas Staempfli, Joerg Hoernschemeyer, Frederik Großerüschkamp, Daniel Niedieker, Samir F. El-Mashtoly, Marialuisa Quadri, Wilfred F. J. Van IJcken, Vincenzo Bonifati, Klaus Gerwert, Bernd Bohrmann, Stephan Frank, Markus Britschgi, Henning Stahlberg, Wilma D. J. Van de Berg & Matthias E. Lauer
Published in Nature Neuroscience in 2019
Imaging of post-mortem human brain tissue using electron and X-ray microscopy.
Amanda J Lewis, Christel Genoud, Mélissa Pont, Wilma DJ van de Berg, Stephan Fran, Henning Stahlberg, Sarah H Shahmoradian, Ashraf Al-Amoudi
Published in Current Opinion in Structural Biology in 2019