Andrea Capozzi
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Open PhD positions
Open PhD position on the Physics of Xenon hyperpolarizationA PhD student position is available on the Physics of Xenon hyperpolarization: Spin Exchange Optical Pumping (SEOP) and Dynamic Nuclear Polarization (DNP)
The project builds on a well-established and long-standing collaboration between the Laboratory for Functional and Metabolic Imaging at EPFL (Lausanne, Switzerland) and the School of Health Science (Geneva, Switzerland).
The involved research lays across nuclear spin dynamics and biomedical imaging. The main goal of the project is to answer fundamental questions on the spin order transfer mechanisms to enhance the Xenon polarization.
The successful candidate will have a strong interest in nuclear spin Physics and Chemical Physics, be able to work independently in a multidisciplinary team and get acquainted quickly with new methods. We expect him/her to be comfortable in an experimental environment as well as for theoretical developments.
The candidate will have access to a top-notch hyperpolarization laboratory equipped with two DNP polarizers/ESR spectrometers (3.35 T and 5 T), one SEOP polarizer, a multi-nuclei 1 T benchtop NMR spectrometer, a low-field MRI scanner and a 400 MHz NMR spectrometer. Active external collaborations also provide access to clinical and pre-clinical MRI platforms.
With a master degree preferably in Physics or Chemical Physics, the candidate should have good communication skills, experience with programming (MATLAB, Python, C/C ) and experimental Physics.
French speaking proficiency and experience with NMR/ESR is a plus.
The project involves regular travels between Lausanne and Geneva.
Applicants should send by email a CV, cover letter, master final marks, publications on scientific journals if any and three references (with email address) to:
andrea.capozzi@epfl.ch
jean-noel.hyacinthe@hesge.ch
EPFL SB IPHYS LIFMET
CH F1 633 (Bâtiment CH)
Station 6
1015 Lausanne
Web site: Web site: https://lifmet.epfl.ch/
Fields of expertise
Nuclear Magnetic Resonance (NMR)
Electron Spin Resonance (ESR)
Dynamic Nuclear Polarization (DNP)
Hyperpolarization Techniques
Cryogenics
Electron Spin Resonance (ESR)
Dynamic Nuclear Polarization (DNP)
Hyperpolarization Techniques
Cryogenics
Education
PhD
Physics
EPFL
Mar 2016
MSc
Physics
University of Pavia
Dec 2011
BSc
Physics
University of Pavia
Dec 2009
Awards
Publications
Selected publications
Radaelli A., Yoshihara H. A. I., Nonaki H., Sando S., Ardenkjær-Larsen J.H., Gruetter R., Capozzi A.# The Journal of Physical Chemistry Letters |
13C Dynamic Nuclear Polarization using SA-BDPA at 6.7 T and 1.1 K: Coexistence of Pure Thermal Mixing and Well-Resolved Solid-Effect |
Patel S.#, Pinon A. C., Lerche M. H., Karlsson M., Capozzi A., Ardenkjær-Larsen J. H.; The Journal of Physical Chemistry C |
UV-Irradiated 2-Keto-(1-13C)Isocaproic Acid for High-Performance 13C Hyperpolarized MR |
Pinon A. C., Capozzi A., Ardenkjær-Larsen J.H.# Magnetic Resonance Matererials in Physics, Biology and Medicine |
Hyperpolarization via dissolution dynamic nuclear polarization: new technological and methodological advances |
Pinon A. C., Capozzi A., Ardenkjær-Larsen J.H.# Communication Chemistry |
Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals |
Capozzi A.#, Patel S, Wenckebach W.T., Karlsson M., Lerche M.H, Ardenkjær-Larsen J.H. The Journal of Physical Chemistry Letters |
Gadolinium Effect at High-Magnetic-Field DNP: 70% 13C Polarization of [U-13C] Glucose Using Trityl |
Capozzi A.#, Patel S., Gunnarsson C.P., Marco-Rius I., Comment A., Karlsson M., Lerche M.H., Ouari O., Ardenkjær-Larsen J.H. Angewandte Chemie International Edition |
Efficient Hyperpolarization of U-13C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals |
Albannay M.M., Vinther J.M.O., Capozzi A., Zhurbenko V., Ardenkjaer-Larsen J.H.# The Journal of Magnetic Resonance |
Optimized microwave delivery in dDNP |
Marco-Rius I.#, Cheng T., Gaunt A.P., Patel S., Kreis F., Capozzi A., Wright A.J., Brindle K.M., Ouari O., Comment A. Journal of the American Chemical Society (JACS) |
Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates |
Capozzi A.#, Karlsson M., Petersen J. R., Lerche M. H., Ardenkjær-Larsen J. H. The Journal of Physical Chemistry C |
Liquid-State 13C Polarization of 30% through Photoinduced Nonpersistent Radicals |
Bastiaansen J.A.M.#, Yoshihara H.A.I., Capozzi A., Schwitter J., Gruetter R., Merritt M.E., Comment A. Magnetic Resonance in Medicine (MRM) |
Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced non-persistent radicals |
Capozzi A., Cheng T., Boero G., Roussel C., Comment A. Nature Communications |
Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized C-13-substrates |
Capozzi A.#, Hyacinthe J.-N., Cheng T., Eichhorn T.R., Boero G., Roussel C., van der Klink J.J., Comment A.# The Journal of Physical Chemistry C |
Photo-Induced non-Persistent Radicals as Polarizing Agents for X-Nuclei dissolution-DNP |
Capozzi A.#, Roussel C., Comment A.#, Hyacinthe J.-N. The Journal of Physical Chemistry C |
Optimal glass-forming solvent brings sublimation dynamic nuclear polarization to 129Xe hyperpolarization biomedical imaging standards |
Breukels V.#, Jansen K.C., van Heijster F.H., Capozzi A., van Bentum P.J.M., Schalken J.A., Comment A., Scheenen T.W.J. NMR in Biomedicine |
Direct dynamic measurement of intracellular and extracellular lactate in small-volume cell suspensions with 13C hyperpolarized NMR |
Orlando T.#, Capozzi A., Umut E., Bordonali L., Mariani M., Galinetto P., Pineider F., Innocenti C., Masala P., Tabak F., Scavini M., Santini P., Corti M., Sangregorio C., Ghigna P.l, Lascialfari A. The Journal of Physical Chemistry C |
Spin dynamics in hybrid iron oxide-gold nanostructures |
Eichhorn T.R., Takado, Y., Salameh N., Capozzi A., Cheng T., Hyacinthe J.-N., Mishkovsky M., Roussel C., Comment A.# Proceedings of the National Academy of Science (PNAS) |
Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging |
Cheng T.#, Capozzi A., Takado Y., Balzan R., Comment A. Physical Chemistry Chemical Physics (PCCP) |
Over 35% liquid-state 13C polarization obtained via dissolution dynamic nuclear polarization at 7 T and 1 K using ubiquitous nitroxyl radicals |