Aurélien Bornet

Editer le profil

Collaborateur scientifique

aurelien.bornet@epfl.ch +41 21 69 37161

EPFL SB ISIC-GE
BCH 1538 (Batochime UNIL)
Av. F.-A. Forel 2
CH-1015 Lausanne

+41 21 69 37161
Site web: http://isic.epfl.ch/
Unité: ISIC-GE
Local: BCH 1538

EPFL Valais Wallis
EPFL ISIC-GE-VS
Rue de l'Industrie 17
Case postale 440
CH-1951 Sion

+41 21 69 37161
Site web: http://isic.epfl.ch/valais
Unité: ISIC-GE-VS
Local: BCH 1538

Données administratives

Publications

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Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups

J.-N. Dumez; B. Vuichoud; D. Mammoli; A. Bornet; A. C. Pinon et al.

Journal Of Physical Chemistry Letters. 2017.

DOI : 10.1021/acs.jpclett.7b01512.

Detailed record: https://infoscience.epfl.ch/record/230543?ln=en

Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls

D. L. Silverio; H. A. Van Kalkeren; T.-C. Ong; M. Baudin; M. Yulikov et al.

Helvetica Chimica Acta. 2017.

DOI : 10.1002/hlca.201700101.

Detailed record: https://infoscience.epfl.ch/record/229646?ln=en
Full text: http://infoscience.epfl.ch/record/229646/files/silverio_helv_infoscience.pdf

Hyperpolarization of nitrogen-15 nuclei by cross polarization and dissolution dynamic nuclear polarization

J. Milani; B. Vuichoud; A. Bornet; R. Melzi; S. Jannin et al.

Review Of Scientific Instruments. 2017.

DOI : 10.1063/1.4973777.

Detailed record: https://infoscience.epfl.ch/record/227594?ln=en

Phenylazide Hybrid-Silica - Polarization Platform for Dynamic Nuclear Polarization at Cryogenic Temperatures

W. R. Gruning; H. Bieringer; M. Schwarzwalder; D. Gajan; A. Bornet et al.

Helvetica Chimica Acta. 2017.

DOI : 10.1002/hlca.201600122.

Detailed record: https://infoscience.epfl.ch/record/226986?ln=en

Transportable hyperpolarized metabolites

X. Ji; A. Bornet; B. Vuichoud; J. Milani; D. Gajan et al.

Nature Communications. 2017.

DOI : 10.1038/ncomms13975.

Detailed record: https://infoscience.epfl.ch/record/225829?ln=en

Structured and porous materials particularly suitable as polarizing agents in dissolution dynamic nuclear polarization

C. Thieuleux; L. Veyre; D. Baudouin; C. Coperet; L. Emsley et al.

2016.

Patent number(s) :

WO2016038131

Detailed record: https://infoscience.epfl.ch/record/228152?ln=en

Microwave-gated dynamic nuclear polarization

A. Bornet; A. Pinon; A. Jhajharia; M. Baudin; X. Ji et al.

Physical Chemistry Chemical Physics. 2016.

DOI : 10.1039/c6cp05587g.

Detailed record: https://infoscience.epfl.ch/record/224780?ln=en

Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins

B. Vuichoud; A. Bornet; F. De Nanteuil; J. Milani; E. Canet et al.

Chemistry-A European Journal. 2016.

DOI : 10.1002/chem.201602506.

Detailed record: https://infoscience.epfl.ch/record/223252?ln=en

Hyperpolarization of Frozen Hydrocarbon Gases by Dynamic Nuclear Polarization at 1.2 K

B. Vuichoud; E. Canet; J. Milani; A. Bornet; D. Baudouin et al.

Journal Of Physical Chemistry Letters. 2016.

DOI : 10.1021/acs.jpclett.6b01345.

Detailed record: https://infoscience.epfl.ch/record/222206?ln=en
Full text: http://infoscience.epfl.ch/record/222206/files/Gas-infoscience.pdf

Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics

A. Bornet; M. Maucourt; C. Deborde; D. Jacob; J. Milani et al.

Analytical Chemistry. 2016.

DOI : 10.1021/acs.analchem.6b01094.

Detailed record: https://infoscience.epfl.ch/record/221808?ln=en

Homonuclear decoupling for spectral simplification of carbon-13 enriched molecules in solution-state NMR enhanced by dissolution DNP

S. Chinthalapalli; A. Bornet; D. Carnevale; S. Jannin; G. Bodenhausen

Physical Chemistry Chemical Physics. 2016.

DOI : 10.1039/c5cp07884a.

Detailed record: https://infoscience.epfl.ch/record/219801?ln=en
Full text: http://infoscience.epfl.ch/record/219801/files/P405-Chinthalapalli-Bornet-Carnevale-Jannin-Bodenhausen-Homodecoupling-D-DNP-PCCP-18-11480-2016.pdf

Optimizing dissolution dynamic nuclear polarization

A. Bornet; S. Jannin

Journal Of Magnetic Resonance. 2016.

DOI : 10.1016/j.jmr.2015.12.007.

Detailed record: https://infoscience.epfl.ch/record/217662?ln=en
Full text: http://infoscience.epfl.ch/record/217662/files/Jannin-Bornet-Optimizing%20dissolution%20dynamic%20nuclear%20polarization-%20JMR2016.pdf

Measuring absolute spin polarization in dissolution-DNP by Spin PolarimetrY Magnetic Resonance (SPY-MR)

B. Vuichoud; J. Milani; Q. Chappuis; A. Bornet; G. Bodenhausen et al.

Journal Of Magnetic Resonance. 2015.

DOI : 10.1016/j.jmr.2015.09.006.

Detailed record: https://infoscience.epfl.ch/record/216732?ln=en
Full text: http://infoscience.epfl.ch/record/216732/files/P397-Absolute-Polarization-SPY-MR-Vuichoud-Milani-Chappuis-Bornet-Bodenhausen-Jannin-JMR-260-127-2015%20.pdf

Spin Noise Detection of Nuclear Hyperpolarization at 1.2K

M. T. Poeschko; B. Vuichoud; J. Milani; A. Bornet; M. Bechmann et al.

Chemphyschem. 2015.

DOI : 10.1002/cphc.201500805.

Detailed record: https://infoscience.epfl.ch/record/216403?ln=en
Full text: http://infoscience.epfl.ch/record/216403/files/P399-Poeschko-Vuichoud-Milani-Bornet-Bechmann-Bodenhausen-Jannin-Mueller-Spin-Noise-1.2K-CPC_16_3859_2015_pdf.pdf

Challenges in preparing, preserving and detecting para-water in bulk: overcoming proton exchange and other hurdles

D. Mammoli; N. Salvi; J. Milani; R. Buratto; A. Bornet et al.

Physical Chemistry Chemical Physics. 2015.

DOI : 10.1039/c5cp03350k.

Detailed record: https://infoscience.epfl.ch/record/214264?ln=en
Full text: http://infoscience.epfl.ch/record/214264/files/P395-Challenges-Para-Water-Mammoli-Salvi-Milani-Buratto-Bornet-Sehgal-Canet-Pelupessy-Carnevale-Jannin-Bodenhausen-PCCP-26810-17-2015.pdf

Hyperpolarized Water to Study Protein-Ligand Interactions

Q. Chappuis; J. Milani; B. Vuichoud; A. Bornet; A. D. Gossert et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2015.

DOI : 10.1021/acs.jpclett.5b00403.

Detailed record: https://infoscience.epfl.ch/record/213561?ln=en
Full text: http://infoscience.epfl.ch/record/213561/files

Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

J.-N. Dumez; J. Milani; B. Vuichoud; A. Bornet; J. Lalande-Martin et al.

Analyst. 2015.

DOI : 10.1039/c5an01203a.

Detailed record: https://infoscience.epfl.ch/record/212324?ln=en
Full text: http://infoscience.epfl.ch/record/212324/files/P394-Hyperpolarized-PlantCancer-Cell-Extracts-Dumez-Milani-Vuichoud-Bornet-Lalande-Martin-Tea-Yon-Maucourt-Deborde-Moing-Frydman-Bodenhausen-Jannin-Giraudeau-Analyst-140-5860-2015.pdf

Hyperpolarized para-Ethanol

D. Mammoli; B. Vuichoud; A. Bornet; J. Milani; J.-N. Dumez et al.

Journal Of Physical Chemistry B. 2015.

DOI : 10.1021/jp512128c.

Detailed record: https://infoscience.epfl.ch/record/208355?ln=en
Full text: http://infoscience.epfl.ch/record/208355/files/P392-Hyperpolarized-para-ethanol-Mammoli-Vuichoud-Bornet-Milani-Dumez-Jannin-Bodenhausen-JPhysChemB-119-4048-2015.pdf

De l'usage des protons hyperpolarisés pour augmenter la sensibilité de la RMN

A. Bornet / G. Bodenhausen; S. Jannin (Dir.)

Lausanne, EPFL, 2015.

DOI : 10.5075/epfl-thesis-6581.

Detailed record: https://infoscience.epfl.ch/record/207875?ln=en
Full text: http://infoscience.epfl.ch/record/207875/files/EPFL_TH6581.pdf

A magnetic tunnel to shelter hyperpolarized fluids

J. Milani; B. Vuichoud; A. Bornet; P. Mieville; R. Mottier et al.

Review Of Scientific Instruments. 2015.

DOI : 10.1063/1.4908196.

Detailed record: https://infoscience.epfl.ch/record/207360?ln=en
Full text: http://infoscience.epfl.ch/record/207360/files/P389-Milani-Vuichoud-Bornet-Mieville-Mottier-Jannin-Bodenhausen-Magnetic-Tunnel-Rev-Sci-Instrum-86-024101-2015.pdf

Procédé de spectroscopie RMN avec dégradations d'induction prolongée de cohérences aux temps de vie longs

S. Jannin; A. Bornet; G. Bodenhausen

2014.

Patent number(s) :

EP2523012
US8633697
US2012286782
EP2523012

Detailed record: https://infoscience.epfl.ch/record/211589?ln=en

Toward Quantitative Measurements of Enzyme Kinetics by Dissolution Dynamic Nuclear Polarization

E. Miclet; D. Abergel; A. Bornet; J. Milani; S. Jannin et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2014.

DOI : 10.1021/jz501411d.

Detailed record: https://infoscience.epfl.ch/record/206758?ln=en
Full text: http://infoscience.epfl.ch/record/206758/files/P381-Miclet-Abergel-Bornet-Milani-Jannin-Bodenhausen-Glucose-Phosphorylation-D-DNP-JPhysChemLett-5-3290-2014.pdf

Long-Lived States of Magnetically Equivalent Spins Populated by Dissolution-DNP and Revealed by Enzymatic Reactions

A. Bornet; X. Ji; D. Mammoli; B. Vuichoud; J. Milani et al.

Chemistry-A European Journal. 2014.

DOI : 10.1002/chem.201404967.

Detailed record: https://infoscience.epfl.ch/record/205480?ln=en
Full text: http://infoscience.epfl.ch/record/205480/files/P383-Bornet-Ji-Mammoli-Vuichoud-Milani-Bodenhausen-Jannin-HELLS-Hyperpolarized-Equivalent-Spins-Revealed-Enzymatic-ChemEurJ-20-17113-2014.pdf

Cross polarization from H-1 to quadrupolar Li-6 nuclei for dissolution DNP

A. J. P. Linde; A. Bornet; J. Milani; B. Vuichoud; R. Melzi et al.

Physical Chemistry Chemical Physics. 2014.

DOI : 10.1039/c4cp03592e.

Detailed record: https://infoscience.epfl.ch/record/203931?ln=en
Full text: http://infoscience.epfl.ch/record/203931/files/P386-Perez-Linde-Bornet-Milani-Vuichoud-Melzi-Jannin-Bodenhausen-CP-1H-6Li-D-DNP-PCCP-16-24813-2014.pdf

Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

R. Buratto; A. Bornet; J. Milani; D. Mammoli; B. Vuichoud et al.

CHEMMEDCHEM. 2014.

DOI : 10.1002/cmdc.201402214.

Detailed record: https://infoscience.epfl.ch/record/203894?ln=en
Full text: http://infoscience.epfl.ch/record/203894/files

Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization

D. Gajan; A. Bornet; B. Vuichoud; J. Milani; R. Melzi et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2014.

DOI : 10.1073/pnas.1407730111.

Detailed record: https://infoscience.epfl.ch/record/203185?ln=en
Full text: http://infoscience.epfl.ch/record/203185/files/P376-Gajan-Bornet-Vuichoud-Milani-Melzi-vanKalkeren-Veyre-Thieuleux-Conley-Gruning-Schwarzwalder-Lesage-Coperet-Bodenhausen-Emsley-Jannin-HYPSO-1-0-PNAS-111-14693-2014.pdf

Hyperpolarization of Deuterated Metabolites via Remote Cross-Polarization and Dissolution Dynamic Nuclear Polarization

B. Vuichoud; J. Milani; A. Bornet; R. Melzi; S. Jannin et al.

Journal Of Physical Chemistry B. 2014.

DOI : 10.1021/jp4118776.

Detailed record: https://infoscience.epfl.ch/record/198043?ln=en
Full text: http://infoscience.epfl.ch/record/198043/files/P373-Vuichoud-Milani-Bornet-Melzi-Jannin-Bodenhausen-JPC-118-1411-2014.pdf

Method for the nmr based determination of the affinity of drugs for a target protein

G. Bodenhausen; A. Bornet; N. Salvi; R. Buratto

2013.

Patent number(s) :

EP2786165
EP2786165
WO2013079106

Detailed record: https://infoscience.epfl.ch/record/211807?ln=en

Method and device for rapid dnp

S. Jannin; A. Gianotti; J. Lohman; F. Engelke; R. Melzi et al.

2013.

Patent number(s) :

US9329245
EP2836849
EP2836849
US2013274111
WO2013153101

Detailed record: https://infoscience.epfl.ch/record/211666?ln=en

Boosting Dissolution Dynamic Nuclear Polarization by Cross Polarization

A. Bornet; R. Melzi; P. Linde; J. Angel; P. Hautle et al.

The Journal of Physical Chemistry Letters. 2013.

DOI : 10.1021/jz301781t.

Detailed record: https://infoscience.epfl.ch/record/183017?ln=en

Dynamic Nuclear Polarization and Other Magnetic Ideas at EPFL

A. Bornet; J. Milani; S. Wang; D. Mammoli; R. Buratto et al.

Chimia. 2012.

DOI : 10.2533/chimia.2012.734.

Detailed record: https://infoscience.epfl.ch/record/184638?ln=en
Full text: http://infoscience.epfl.ch/record/184638/files/P360-Bornet-Milani-Wang-Mammoli-Buratto-Salvi-Segawa-Vitzthum-Mieville-Chinthalapalli-Perez-Linde-Carnevale-Jannin-Caporini-Ulzega-Rey-Bodenhausen-DNP-Other-Ideas-Chimia-66-734-2012.pdf

High field dynamic nuclear polarization at 6.7T: Carbon-13 polarization above 70% within 20min

S. Jannin; A. Bornet; R. Melzi; G. Bodenhausen

Chemical Physics Letters. 2012.

DOI : 10.1016/j.cplett.2012.08.017.

Detailed record: https://infoscience.epfl.ch/record/181397?ln=en
Full text: http://infoscience.epfl.ch/record/181397/files/Jannin%206.7%20T%20DNP.pdf

Cross Polarization for Dissolution Dynamic Nuclear Polarization Experiments at Readily Accessible Temperatures 1.2 < T < 4.2 K

A. Bornet; R. Melzi; S. Jannin; G. Bodenhausen

Applied Magnetic Resonance. 2012.

DOI : 10.1007/s00723-012-0358-1.

Detailed record: https://infoscience.epfl.ch/record/180516?ln=en
Full text: http://infoscience.epfl.ch/record/180516/files/P352-Bornet-Melzi-Jannin-Bodenhausen-Cross-Polarization-Accessible-Temperatures-APMR-43-107-2012.pdf

Ultrahigh-Resolution Magnetic Resonance in Inhomogeneous Magnetic Fields: Two-Dimensional Long-Lived-Coherence Correlation Spectroscopy

S. Chinthalapalli; A. Bornet; T. Segawa; R. Sarkar; S. Jannin et al.

Physical Review Letters. 2012.

DOI : 10.1103/PhysRevLett.109.047602.

Detailed record: https://infoscience.epfl.ch/record/180469?ln=en

Boosting the Sensitivity of Ligand-Protein Screening by NMR of Long-Lived States

N. Salvi; R. Buratto; A. Bornet; S. Ulzega; I. R. Rebollo et al.

Journal Of The American Chemical Society. 2012.

DOI : 10.1021/ja303301w.

Detailed record: https://infoscience.epfl.ch/record/180446?ln=en

Long-lived coherences for line-narrowing in high-field NMR

R. Sarkar; P. Ahuja; P. R. Vasos; A. Bornet; O. Wagnieres et al.

Progress In Nuclear Magnetic Resonance Spectroscopy. 2011.

DOI : 10.1016/j.pnmrs.2010.10.002.

Detailed record: https://infoscience.epfl.ch/record/171250?ln=en
Full text: http://infoscience.epfl.ch/record/171250/files/P313-LLC-Review-Sarkar-Ahuja-Vasos-Bornet-Wagnieres-Bodenhausen-Progress-59-83-2011.pdf

Low-temperature cross polarization in view of enhancing dissolution Dynamic Nuclear Polarization in NMR

S. Jannin; A. Bornet; S. Colombo; G. Bodenhausen

Chemical Physics Letters. 2011.

DOI : 10.1016/j.cplett.2011.10.042.

Detailed record: https://infoscience.epfl.ch/record/170410?ln=en

Long-Lived States to Monitor Protein Unfolding by Proton NMR

A. Bornet; P. Ahuja; R. Sarkar; L. Fernandes; S. Hadji et al.

ChemPhysChem. 2011.

DOI : 10.1002/cphc.201100365.

Detailed record: https://infoscience.epfl.ch/record/170326?ln=en

Ultra High-Resolution NMR: Sustained Induction Decays of Long-Lived Coherences

A. Bornet; S. Jannin; J. A. (. Konter; P. Hautle; B. Van Den Brandt et al.

Journal of the American Chemical Society. 2011.

DOI : 10.1021/ja2052792.

Detailed record: https://infoscience.epfl.ch/record/169911?ln=en

Three-field NMR to preserve hyperpolarized proton magnetization as long-lived states in moderate magnetic fields

A. Bornet; S. Jannin; G. Bodenhausen

Chemical Physics Letters. 2011.

DOI : 10.1016/j.cplett.2011.07.015.

Detailed record: https://infoscience.epfl.ch/record/169910?ln=en

Extending Timescales and Narrowing Linewidths in NMR

T. F. Segawa; A. Bornet; N. Salvi; P. Miéville; V. Vitzthum et al.

CHIMIA International Journal for Chemistry. 2011.

DOI : 10.2533/chimia.2011.652.

Detailed record: https://infoscience.epfl.ch/record/169653?ln=en
Full text: http://infoscience.epfl.ch/record/169653/files/2011%20LRMB%20CHIMIA.pdf

Long lived states as a probe of protein stability

A. Bornet

2010.

Detailed record: https://infoscience.epfl.ch/record/161521?ln=en

Life-times of long-lived coherences under different motional regimes

A. Bornet; R. Sarkar; G. Bodenhausen

Journal Of Magnetic Resonance. 2010.

DOI : 10.1016/j.jmr.2010.06.004.

Detailed record: https://infoscience.epfl.ch/record/154938?ln=en

Enseignement & Phd

Enseignement

Chemistry and Chemical Engineering,

Programmes doctoraux

Doctorants

Cours

Basic and advanced NMR - Level 1 (Sion)

Basic theoretical and experimental aspects of NMR. Students will be familarized with modern NMR spectrometers.

Basic and advanced NMR - Level 1 A (EPFL)

Basic and advanced NMR - Level 2 (EPFL)

The goal is to give a sound theoretical and practical foundation in NMR for various applications in research. PhD students and post-docs who have followed the course successfully should be able to perform modern multi-dimensional NMR experiments independe...