Christian Depeursinge
Professeur honoraire
christian.depeursinge@epfl.ch +41 21 693 61 77 http://apl.epfl.ch/muvision
Biography
Christian Depeursinge is the leader of the Microvision and Micro-Diagnostics (MVD) group at the Advanced Photonics Laboratory of the Institute of Microengineering at EPFL (Ecole Polytechnique Fédérale de Lausanne), Switzerland (http://apl.epfl.ch/muvision). His research and expertise in biomedical engineering and optics is internationally acknowledged. His current research topics include coherent and incoherent Imaging applied to diagnostics in biology, His research group pioneered in the development of DHM technology. He worked on several projects developed in cooperation with European and international partners. He is author and co-author of over 100 papers published in peer reviewed journals, several book chapters and more than 30 patents. He has given more than 20 invited lectures and plenaries in the last five years. He developed many projects in cooperation with national and international industries. He is co-founder of a start-up company (Lyncée Tec SA: www.Lynceetec.com). He is currently teaching at EPFL and occasionally in foreign universities and institutes.
ALUMNI
PhD StudentsYves Delacrétaz (2009)
Florian Charrière (2007)
Tristan Colomb (2006)
Anca Marian (2005)
Frédéric Montfort (2005)
Pia Massatsch (2003)
Daniel Salzmann (2002)
Philippe Thueler (2001)
Laure Montandon-Varoda (2000)
Etienne Cuche (2000)
Frédéric Bevilacqua (1998)
Laurent Thybaud (1997)
Ramiro Conde (1995)
Olivier Coquoz (1994)
Julio Soruco (1993)
Emmanuel B. de Haller (1993)
Patrick Poscio (1992)
Lionel Desponds (1991)
Etienne Bornand (1986)
Abdel Kader Boutaleb (1984)
Yvan Pochon (1983)
Master Students
Christophe Pache (2008)
Daniel Boss (2008)
Mathieu Grossenbacher (2006)
Nicolas Pavillon (2006)
Yves Delacrétaz (2004)
Florian Charrière (2003)
Jonas Kühn (2003)
Tristan Colomb (2000)
Frédéric Montfort (2000)
Pierre Marquet
RESEARCH INTERESTS
Optics plays an increasing role in nanotechnologies, life sciences, biophysical research, and biomedical engineering. Optical imaging, in particular, presents a renewal of interest, based on the development of new concepts in coherent imaging. Exploitation of light coherence appears as a cornerstone in the development of new imaging technology in microscopy and the analysis of mutually coherent fields generated by the sources of radiation (specially engineered or generated by the observed molecules themselves) will provide access to the intimate organization of biological matter, at the ultimate limit of single molecules. The development, in my research group, of digital holographic microscopy (DHM) appears as a generalization of optical coherence imaging approach, in that it collects the data simultaneously for many directions of the impinging optical beam and appears therefore as a unique tool to restore the pieces of information coherently delivered by the irradiated matter. Further on, the recourse to spectroscopy, more particularly to nonlinear optical properties of matter, biological matter in particular, will provide a unique access to the molecular structure and biochemical composition of living cells and tissues, thus offering probably one of the most attractive tools in the field of optical microscopy.
The main research axis can be outlined as follows:
1) Tomography of cells and tissues
2) Super-resolution (nanometer range)
3) Extension of the coherent imaging technology to fluorescence imaging
4) Multi-modality imaging combining DHM and atomic force microscopy (AFM)
5) Functional imaging by coherent nonlinear microscopy
6) Imaging in turbid media
SELECTED RECENT PUBLICATIONS
For a full list of publications, please go here
B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, P. Marquet, "Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy and impedance volume analyser", Cytometry A 73A, 895-903 (2008).
J. Kühn, F. Charrière, T. Colomb, E. Cuche, F. Montfort, Y. Emery, P. Marquet, and C. Depeursinge, "Axial sub-nanometer accuracy in digital holographic microscopy", Measurement Science & Technology 19, 074007 (2008).
B. Rappaz, F. Charrière, C. Depeursinge, P.J. Magistretti, and P. Marquet, "Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium", Opt. Lett. 33(7), 744-746 (2008).
F. Charrière, A. Marian, T. Colomb, P. Marquet, and C. Depeursinge, "Amplitude point spread function measurement of high NA microscope objectives by digital holographic microscopy", Opt. Lett. 32(16), 2456-2458 (2007).
F. Montfort, T. Colomb, F. Charrière, J. Kühn, P. Marquet, E. Cuche, S. Herminjard, and C. Depeursinge, "Submicrometer optical tomography by multiple-wavelength digital holographic microscopy", Appl. Opt. 45(32), 8209-8217 (2006).
F. Charrière, N. Pavillon, T. Colomb, C. Depeursinge, T.J. Heger, E.A.D. Mitchell, P. Marquet, and B. Rappaz, "Living specimen tomography by digital holographic microscopy: morphometry of testate amoeba", Opt. Express 14(16), 7005-7013 (2006).
F. Charrière, A. Marian, F. Montfort, J. Kühn, T. Colomb, E. Cuche, P. Marquet, and C. Depeursinge, "Cell refractive index tomography by digital holographic microscopy", Opt. Lett. 31(2), 178-180 (2006).
P. Marquet, B. Rappaz, P.J. Magistretti, E. Cuche, Y. Emery, T. Colomb, C. Depeursinge, "Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy", Opt. Lett. 30(5), 468-470 (2005).
E. Cuche, P. Marquet, and C. Depeursinge, "Simultaneous amplitude-contrast and quantitative phase-contrast microscopy by numerical reconstruction of Fresnel off-axis holograms", Appl. Opt. 38(34), 6994-7001 (1999).
E. Cuche, F. Bevilacqua, and C. Depeursinge, "Digital holography for quantitative phase-contrast imaging", Opt. Lett. 24(5), 291-293 (1999).
RECENT INVITED LECTURES
"Digital Holographic Microscopy (DHM): A versatile tool for micro- and nano- technology as well as biomedical applications", International Topical Meeting on Photonics, 2008, Hyogo, Japan.
"Digital Holographic Microscopy: a new perspective in 3D imaging at the nanoscale", Biophotonics ASIA Optics Within Life Sciences (OWLS-10) conference, 2008, Singapore. (plenary)
"Digital Holographic Microscopy (DHM) applied to metrology and biomedical applications", OFD'08 6th international conference on optics design and fabrication, 2008, Taipei, Taïwan.
"Innovative aspects of Digital Holographic Microscopy", ELMI 8th European Light Microscopy Initiative, 2008, Davos, Switzerland.
"Full numerical processing of optical data in microscopy: a perspective offered by digital holography", Photonics Ireland, 2007, Galway, Ireland.
"Recent progress and perspectives in Digital Holographic Microscopy", OSA: Digital Holography and Three dimensional imaging, 2007, Vancouver, Canada.
"Performance and limitations of Digital Holographic Microscopy: theory and practice", 3rd Asian and Pacific Rim Symposium on Biophotonics, 2007, Cairn, Australia.
"DHM (Digital Holographic Microscopy): one step further towards full numerical optics in microscopy. Application to full tomography.", Workshop on Digital Holographic Reconstruction & Optical Tomography, 2007, Loughborough University, United Kingdom.
Publications
Publications Infoscience
Texture-driven parametric snakes for semi-automatic image segmentation
Computer Vision And Image Understanding. 2019-11-01. DOI : 10.1016/j.cviu.2019.102793.Simultaneous dual-contrast three-dimensional imaging in live cells via optical diffraction tomography and fluorescence
Photonics Research. 2019-09-01. DOI : 10.1364/PRJ.7.001042.Neural network training for cross-protocol radiomic feature standardization in computed tomography
Journal Of Medical Imaging. 2019-04-01. DOI : 10.1117/1.JMI.6.2.024008.Revealing Tumor Habitats from Texture Heterogeneity Analysis for Classification of Lung Cancer Malignancy and Aggressiveness
Scientific Reports. 2019-03-14. DOI : 10.1038/s41598-019-38831-0.PET-based prognostic survival model after radiotherapy for head and neck cancer
European Journal Of Nuclear Medicine And Molecular Imaging. 2019-03-01. DOI : 10.1007/s00259-018-4134-9.The use of texture-based radiomics CT analysis to predict outcomes in early-stage non-small cell lung cancer treated with stereotactic ablative radiotherapy
British Journal Of Radiology. 2019-01-01. DOI : 10.1259/bjr.20180228.Quantitative phase imaging in biomedicine
Nature Photonics. 2018-10-01. DOI : 10.1038/s41566-018-0253-x.Rotation Invariance and Directional Sensitivity: Spherical Harmonics versus Radiomics Features
2018-01-01. 9th International Workshop on Machine Learning in Medical Imaging (MLMI), Granada, SPAIN, Sep 16, 2018. p. 107-115. DOI : 10.1007/978-3-030-00919-9_13.Holographic Visualisation and Interaction of Fused CT, PET and MRI Volumetric Medical Imaging Data Using Dedicated Remote GPGPU Ray Casting
2018-01-01. Int Workshop on Point-of-Care Ultrasound / Int Workshop on Bio-Imaging and Visualizat for Patient-Customized Simulat / Int Workshop on Correct of Brainshift with Intra-Operat Ultrasound / Int Workshop on Computat Precis Med, Granada, SPAIN, Sep 16-20, 2018. p. 102-110. DOI : 10.1007/978-3-030-01045-4_12.Rotation-covariant tissue analysis for interstitial lung diseases using learned steerable filters: Performance evaluation and relevance for diagnostic aid
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS. 2018. DOI : 10.1016/j.compmedimag.2018.01.005.(F-18)-FDG PET/CT parameters to predict survival and recurrence in patients with locally advanced cervical cancer treated with chemoradiotherapy
CANCER RADIOTHERAPIE. 2018. DOI : 10.1016/j.canrad.2017.10.003.Metabolic Tumor Volume and Total Lesion Glycolysis in Oropharyngeal Cancer Treated With Definitive Radiotherapy: Which Threshold Is the Best Predictor of Local Control?
Clinical Nuclear Medicine. 2017. DOI : 10.1097/Rlu.0000000000001614.3D Solid Texture Classification Using Locally-Oriented Wavelet Transforms
IEEE Transactions on Image Processing. 2017. DOI : 10.1109/TIP.2017.2665041.A PET-Based Nomogram for Oropharyngeal Cancers
European Journal of Cancer. 2017. DOI : 10.1016/j.ejca.2017.01.018.Automated Classification of Brain Tumor Type in Whole-Slide Digital Pathology Images Using Local Representative Tiles
Medical Image Analysis. 2016. DOI : 10.1016/j.media.2015.12.002.A 3-D Riesz-Covariance Texture Model for Prediction of Nodule Recurrence in Lung CT
IEEE Transactions on Medical Imaging. 2016. DOI : 10.1109/TMI.2016.2591921.Multidimensional Texture Analysis for Improved Prediction of Ultrasound Liver Tumor Response to Chemotherapy Treatment
2016. p. 619-626. DOI : 10.1007/978-3-319-46720-7_72.Optimized Distributed Hyperparameter Search and Simulation for Lung Texture Classification in CT Using Hadoop
Journal of Imaging. 2016. DOI : 10.3390/jimaging2020019.Overview of the Predictive Value of Quantitative 18 FDG PET in Head and Neck Cancer Treated with Chemoradiotherapy
Critical Reviews in Oncology/Hematology. 2016. DOI : 10.1016/j.critrevonc.2016.10.009.Quantitative phase-digital holographic microscopy: a new imaging modality to identify original cellular biomarkers of diseases
2016. 2nd Confernce on Quantitative Phase Imaging ((QPI II), San Francisco, CA, FEB 14-17, 2016. p. 97180K. DOI : 10.1117/12.2213454.Combining Unsupervised Feature Learning and Riesz Wavelets for Histopathology Image Representation: Application to Identifying Anaplastic Medulloblastoma
2015. 18th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Munich, GERMANY, OCT 05-09, 2015. p. 581-588. DOI : 10.1007/978-3-319-24553-9_71.Towards an incoherent off-axis digital holographic microscope
2015. 1st Conference on Quantitative Phase Imaging (QPI), San Francisco, CA, FEB 07-10, 2015. p. 93360E. DOI : 10.1117/12.2078793.Optimized Steerable Wavelets for Texture Analysis of Lung Tissue In 3-D CT: Classification of Usual Interstitial Pneumonia
2015. p. 403-406. DOI : 10.1109/ISBI.2015.7163897.Off-axis digital holographic camera for quantitative phase microscopy
Biomedical Optics Express. 2014. DOI : 10.1364/Boe.5.001721.Portable advanced off-axis camera for quantitative phase microscopy
2014. Conference on Three-Dimensional and Multidimensional Microscopy - Image Acquisition and Processing XXI, San Francisco, CA, FEB 03-06, 2014. DOI : 10.1117/12.2037799.Rotation-Covariant Texture Learning Using Steerable Riesz Wavelets
IEEE Transactions on Image Processing. 2014. DOI : 10.1109/Tip.2013.2295755.Three-dimensional solid texture analysis in biomedical imaging: Review and opportunities
Medical Image Analysis. 2014. DOI : 10.1016/j.media.2013.10.005.Apparatus and method for quantitative phase tomography through linear scanning with coherent and non-coherent detection
US10113961 ; US2017023472 ; US2014347672 ; EP2736403 ; WO2013018024 . 2013.A Practical Inverse-Problem Approach to Digital Holographic Reconstruction
Optics Express. 2013. DOI : 10.1364/OE.21.003417.Optical reconstruction of transparent objects with phase-only SLMs
Optics Express. 2013. DOI : 10.1364/Oe.21.028246.Exploring Neural Cell Dynamics with Digital Holographic Microscopy
Annual Review Of Biomedical Engineering; Palo Alto: Annual Reviews, 2013. p. 407-431.Quantitative phase noise in a two-color low coherence Digital Holographic Microscope
2013. Conference on Practical Holography XXVII - Materials and Applications, San Francisco, CA, FEB 03-04, 2013. DOI : 10.1117/12.2002413.Full field vertical scanning in short coherence digital holographic microscope
Optics Express. 2013. DOI : 10.1364/Oe.21.012643.Measurement of absolute cell volume, osmotic membrane water permeability, and refractive index of transmembrane water and solute flux by digital holographic microscopy
Journal Of Biomedical Optics. 2013. DOI : 10.1117/1.Jbo.18.3.036007.Marker-free phase nanoscopy
Nature Photonics. 2013. DOI : 10.1038/Nphoton.2012.329.3D Optical Imaging of Living Cells in Microgravity
Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5624.Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy
ASSAY and Drug Development Technologies. 2013. DOI : 10.1089/adt.2012.476.Simultaneous Optical Recording in Multiple Cells by Digital Holographic Microscopy of Chloride Current Associated to Activation of the Ligand-Gated Chloride Channel GABA(A) Receptor
Plos One. 2012. DOI : 10.1371/journal.pone.0051041.Spatially-Resolved Eigenmode Decomposition of Red Blood Cells Membrane Fluctuations Questions the Role of ATP in Flickering
Plos One. 2012. DOI : 10.1371/journal.pone.0040667.Local demodulation of holograms using the Riesz transform with application to microscopy
Journal Of The Optical Society Of America A-Optics Image Science And Vision. 2012. DOI : 10.1364/JOSAA.29.002118.Accelerated autofocusing of off-axis holograms using critical sampling
Optics Letters. 2012. DOI : 10.1364/OL.37.005094.Near-Affine-Invariant Texture Learning for Lung Tissue Analysis Using Isotropic Wavelet Frames
IEEE Transactions On Information Technology In Biomedicine. 2012. DOI : 10.1109/TITB.2012.2198829.Quantitative Measurement of absolute cell volume and intracellular integral refractive index (RI) with Dual-wavelength Digital Holographic Microscopy (DHM)
2012. Conference on Biophotonics - Photonic Solutions for Better Health Care III, Brussels, BELGIUM, Apr 16-19, 2012. p. -. DOI : 10.1117/12.922598.Digital holographic microscopy for the cytomorphological imaging of cells under zero gravity
2012. Conference on Three-Dimensional and Multidimensional Microscopy - Image Acquisition and Processing XIX, San Francisco, CA, Jan 24-26, 2012. p. -. DOI : 10.1117/12.908413.Single shot dual wavelength full field imaging in low coherence digital holographic microscopy
2012. Conference on Practical Holography XXVI - Materials and Applications, San Francisco, CA, Jan 22-25, 2012. p. -. DOI : 10.1117/12.906390.Early Cell Death Detection with Digital Holographic Microscopy
Plos One. 2012. DOI : 10.1371/journal.pone.0030912.Monte Carlo simulation of the field back-scattered from rough surfaces
Journal Of The Optical Society Of America A-Optics Image Science And Vision. 2012. DOI : 10.1364/JOSAA.29.000270.Reconstruction in interferometric synthetic aperture microscopy: comparison with optical coherence tomography and digital holographic microscopy
Journal Of The Optical Society Of America A-Optics Image Science And Vision. 2012. DOI : 10.1364/JOSAA.29.000244.Enhanced robustness digital holographic microscopy for demanding environment of space biology
Biomedical Optics Express. 2012. DOI : 10.1364/BOE.3.000313.Resolution and Complex Deconvolution in Holographic Microscopy
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5281.Holographic second harmonic generation imaging
Second harmonic generation imaging; Boca Raton: CRC Press/Taylor and Francis, 2012.Single-shot, simultaneous incoherent and holographic microscopy
Journal of Microscopy. 2012. DOI : 10.1111/j.1365-2818.2011.03543.x.Complex index refraction tomography with sub ?/6-resolution
EP2553513 ; US8937722 ; US2013057869 ; EP2553513 ; WO2011121523 ; WO2011121523 . 2011.Dual wavelength full field imaging in low coherence digital holographic microscopy
Optics Express. 2011. DOI : 10.1364/OE.19.024005.Beyond the lateral resolution limit by phase imaging
Journal of Biomedical Optics. 2011. DOI : 10.1117/1.3640812.Realistic 3D coherent transfer function inverse filtering of complex fields
Optics Express. 2011. DOI : 10.1364/BOE.2.002216.Determination of Transmembrane Water Fluxes in Neurons Elicited by Glutamate Ionotropic Receptors and by the Co-transporters KCC2 and NKCC1: A Digital Holographic Microscopy Study
Journal of Neuroscience. 2011. DOI : 10.1523/JNEUROSCI.0286-11.2011.Quantitative phase restoration by direct inversion using the optical transfer function
Optics Letters. 2011. DOI : 10.1364/OL.36.002671.Holographic Second Harmonic Generation Microscopy
Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5141.Dual-wavelength Digital Holography for quantification of cell volume and integral refractive index (RI)
2011. European Conferences on Biomedical Optics, Munich, May 22-26, 2011. p. 808608. DOI : 10.1117/12.889767.Cell death detection and ionic homeostasis monitoring with digital holographic microscopy
2011. European Conferences on Biomedical Optics, Munich, May 22-26, 2011. p. 809004. DOI : 10.1117/12.889246.Holographic Second Harmonic Generation Imaging
2011. Digital Holography and Three-Dimensional Imaging (DH), Tokyo, Japan, May 9-11, 2011. p. DWC16.Three-dimensional deconvolution of complex fields
2011. Digital Holography and Three-Dimensional Imaging (DH), Tokyo, Japan, May 9-11, 2011. p. DMB4.Cell Death and Ionic Regulation Detection with Digital Holographic Microscopy
2011. Digital Holography and Three-Dimensional Imaging (DH), Tokyo, Japan, May 9-11, 2011. p. DTuC25. DOI : 10.1364/DH.2011.DTuC25.Cellular Dynamics and Three-Dimensional Refractive Index Distribution Studied with Quantitative Phase Imaging
Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5100.Holographic second harmonic generation (SHG) microscopy
2011. Focus on Microscopy, Konstanz, GE, April 17-20, 2011.Complex field imaging for diffraction tomography
2011. Novel Techniques in Microscopy (NTM), Monterey, CA, USA, April 4-6, 2011. p. NTuC7. DOI : 10.1364/NTM.2011.NTuC7.Quantitative phase from defocus
2011. Novel Techniques in Microscopy (NTM), Monterey, CA, USA, April 4-6, 2011. p. NTuC6. DOI : 10.1364/NTM.2011.NTuC6.Holographic Second Harmonic Generation Microscopy
2011. Novel Techniques in Microscopy (NTM), Monterey, CA, USA, April 4-6, 2011. p. NTuC2. DOI : 10.1364/NTM.2011.NTuC2.Early Glutamate-mediated Cell Death Detection with Digital Holographic Microscopy
2011. Novel Techniques in Microscopy (NTM), Monterey, CA, USA, April 4-6, 2011. p. JTuA13. DOI : 10.1364/BODA.2011.JTuA13.Beyond the lateral resolution limit by phase imaging
2011. Biomedical Optics (BiOS), San Fransisco, CA, January, 22-28, 2011. p. 79040S. DOI : 10.1117/12.874945.Second harmonic phase microscopy of collagen fibers
2011. Biomedical Optics (BiOS), San Fransisco, CA, January, 22-28, 2011. p. 79030G. DOI : 10.1117/12.874538.Exact Complex-Wave Reconstruction in Digital Holography
Journal of the Optical Society of America A. 2011. DOI : 10.1364/JOSAA.28.000983.A method and apparatus for enhanced spatial bandwidth wavefronts reconstructed from digital interferograms or holograms
US2012116703 ; EP2422242 ; WO2010122530 . 2010.Method and apparatus for retrieval of amplitude and phase of nonlinear electromagnetic waves
US9134242 ; US2012069345 ; WO2010125508 . 2010.Method and apparatus for 3d object shape and surface topology measurements by contour depth extraction acquired in a single shot
WO2010092533 . 2010.Label-free second harmonic phase imaging of biological specimen by digital holographic microscopy
Optics Letters. 2010. DOI : 10.1364/OL.35.004102.Extension de profondeur de champ pour l'étude des microfluides en microscopie par holographie numérique
2010. 1re rencontre francophone d'holographie numérique appliquée à la métrologie des fluides, Rouen, France, October, 21-22, 2010.Réflectométrie holographique numérique appliquée à la métrologie des fluides
2010. 1re rencontre francophone d’holographie numérique appliquée à la métrologie des fluides, Rouen, France, October, 21-22, 2010.Off-Axis Low Coherence Interferometry for Surface Topology Measurement
2010. Speckle 2010, Florianopolis, Brazil, September, 13-15, 2010. p. -. DOI : 10.1117/12.870742.Signification of the phase function parameter gamma explored with a fractal distribution of scatterers
Optics Express. 2010. DOI : 10.1364/OE.18.023664.Endoscopic low coherence topography measurement for upper airways and hollow samples
Journal of Biomedical Optics. 2010. DOI : 10.1117/1.3512218.Diffraction tomography for biological cells imaging using digital holographic microscopy
2010. Laser Applications in Life Sciences, Oulu, Finland, June 9-11, 2010. p. 737613. DOI : 10.1117/12.871061.Microscopy image resolution improvement by deconvolution of complex fields
Optics Express. 2010. DOI : 10.1364/OE.18.019462.Real time, nanometric 3D-tracking of nanoparticles made possible by second harmonic generation digital holographic microscopy
Optics Express. 2010. DOI : 10.1364/OE.18.017392.Iterative method for zero-order suppression in off-axis digital holography
Optics Express. 2010. DOI : 10.1364/OE.18.015318.Sub-Rayleigh resolution by phase imaging
Optics Letters. 2010. DOI : 10.1364/OL.35.002176.Extended depth-of-focus by digital holographic microscopy
Optics Letters. 2010. DOI : 10.1364/OL.35.001840.Study of Intracellular Ion Dynamics with a Multimodality Approach Combining Epifluorescence and Digital Holographic Microscopy
2010. Digital Holography and Three-Dimensional Imaging, Miami, FL, USA, April 12-14, 2010. p. JMA26. DOI : 10.1364/BIOMED.2010.JMA26.Holographic Microscopy: From the Idea to the Market
2010. Digital Holography and Three-Dimensional Imaging, Miami, FL, USA, April 12-14, 2010. p. DWC3.Real Time 3-D Cytomorphological Imaging Using Digital Holographic Microscopy and Fluorescence Microscopy for Space Biology
2010. Digital Holography and Three-Dimensional Imaging, Miami, FL, USA, April 12-14, 2010. p. DTuA5. DOI : 10.1364/DH.2010.DTuA5.Artifact-free reconstruction from off-axis digital holograms through nonlinear filtering
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 77231U--9. DOI : 10.1117/12.854178.Digital holographic microscopy for silicon microsystems metrology
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 77191M. DOI : 10.1117/12.854297.Fast non-contact surface roughness measurements up to the micrometer range by dual-wavelength digital holographic microscopy
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 771805. DOI : 10.1117/12.854550.Exploring red blood cell membrane dynamics with digital holographic microscopy
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 77153I. DOI : 10.1117/12.854717.Determination of local optical properties of the rat barrel cortex during neural activation: Monte-Carlo approach to light propagation
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 771531. DOI : 10.1117/12.854136.Digital holography for second harmonic microscopy: application to 3D-tracking of nanoparticles
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 771505. DOI : 10.1117/12.854289.Studies on synthetic deconvolution of complex fields with digital holographic microscopy
2010. Focus on Microscopy 2010, Shanghai, China, March 28-31, 2010. p. MO-MO-PAR-C.Digital holographic microscopy real-time monitoring of cytoarchitectural alterations during simulated microgravity
Journal of Biomedical Optics. 2010. DOI : 10.1117/1.3377960.Cell Morphology and Intracellular Ionic Homeostasis explored with a Multimodal Approach combining Epifluorescence and Digital Holographic Microscopy
Journal of Biophotonics. 2010. DOI : 10.1002/jbio.201000018.Infoscience
Texture-driven parametric snakes for semi-automatic image segmentation
Computer Vision And Image Understanding. 2019-11-01. DOI : 10.1016/j.cviu.2019.102793.Simultaneous dual-contrast three-dimensional imaging in live cells via optical diffraction tomography and fluorescence
Photonics Research. 2019-09-01. DOI : 10.1364/PRJ.7.001042.Neural network training for cross-protocol radiomic feature standardization in computed tomography
Journal Of Medical Imaging. 2019-04-01. DOI : 10.1117/1.JMI.6.2.024008.Revealing Tumor Habitats from Texture Heterogeneity Analysis for Classification of Lung Cancer Malignancy and Aggressiveness
Scientific Reports. 2019-03-14. DOI : 10.1038/s41598-019-38831-0.PET-based prognostic survival model after radiotherapy for head and neck cancer
European Journal Of Nuclear Medicine And Molecular Imaging. 2019-03-01. DOI : 10.1007/s00259-018-4134-9.The use of texture-based radiomics CT analysis to predict outcomes in early-stage non-small cell lung cancer treated with stereotactic ablative radiotherapy
British Journal Of Radiology. 2019-01-01. DOI : 10.1259/bjr.20180228.Quantitative phase imaging in biomedicine
Nature Photonics. 2018-10-01. DOI : 10.1038/s41566-018-0253-x.Rotation Invariance and Directional Sensitivity: Spherical Harmonics versus Radiomics Features
2018-01-01. 9th International Workshop on Machine Learning in Medical Imaging (MLMI), Granada, SPAIN, Sep 16, 2018. p. 107-115. DOI : 10.1007/978-3-030-00919-9_13.Holographic Visualisation and Interaction of Fused CT, PET and MRI Volumetric Medical Imaging Data Using Dedicated Remote GPGPU Ray Casting
2018-01-01. Int Workshop on Point-of-Care Ultrasound / Int Workshop on Bio-Imaging and Visualizat for Patient-Customized Simulat / Int Workshop on Correct of Brainshift with Intra-Operat Ultrasound / Int Workshop on Computat Precis Med, Granada, SPAIN, Sep 16-20, 2018. p. 102-110. DOI : 10.1007/978-3-030-01045-4_12.Rotation-covariant tissue analysis for interstitial lung diseases using learned steerable filters: Performance evaluation and relevance for diagnostic aid
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS. 2018. DOI : 10.1016/j.compmedimag.2018.01.005.(F-18)-FDG PET/CT parameters to predict survival and recurrence in patients with locally advanced cervical cancer treated with chemoradiotherapy
CANCER RADIOTHERAPIE. 2018. DOI : 10.1016/j.canrad.2017.10.003.Metabolic Tumor Volume and Total Lesion Glycolysis in Oropharyngeal Cancer Treated With Definitive Radiotherapy: Which Threshold Is the Best Predictor of Local Control?
Clinical Nuclear Medicine. 2017. DOI : 10.1097/Rlu.0000000000001614.3D Solid Texture Classification Using Locally-Oriented Wavelet Transforms
IEEE Transactions on Image Processing. 2017. DOI : 10.1109/TIP.2017.2665041.A PET-Based Nomogram for Oropharyngeal Cancers
European Journal of Cancer. 2017. DOI : 10.1016/j.ejca.2017.01.018.Automated Classification of Brain Tumor Type in Whole-Slide Digital Pathology Images Using Local Representative Tiles
Medical Image Analysis. 2016. DOI : 10.1016/j.media.2015.12.002.A 3-D Riesz-Covariance Texture Model for Prediction of Nodule Recurrence in Lung CT
IEEE Transactions on Medical Imaging. 2016. DOI : 10.1109/TMI.2016.2591921.Multidimensional Texture Analysis for Improved Prediction of Ultrasound Liver Tumor Response to Chemotherapy Treatment
2016. p. 619-626. DOI : 10.1007/978-3-319-46720-7_72.Optimized Distributed Hyperparameter Search and Simulation for Lung Texture Classification in CT Using Hadoop
Journal of Imaging. 2016. DOI : 10.3390/jimaging2020019.Overview of the Predictive Value of Quantitative 18 FDG PET in Head and Neck Cancer Treated with Chemoradiotherapy
Critical Reviews in Oncology/Hematology. 2016. DOI : 10.1016/j.critrevonc.2016.10.009.Quantitative phase-digital holographic microscopy: a new imaging modality to identify original cellular biomarkers of diseases
2016. 2nd Confernce on Quantitative Phase Imaging ((QPI II), San Francisco, CA, FEB 14-17, 2016. p. 97180K. DOI : 10.1117/12.2213454.Combining Unsupervised Feature Learning and Riesz Wavelets for Histopathology Image Representation: Application to Identifying Anaplastic Medulloblastoma
2015. 18th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Munich, GERMANY, OCT 05-09, 2015. p. 581-588. DOI : 10.1007/978-3-319-24553-9_71.Towards an incoherent off-axis digital holographic microscope
2015. 1st Conference on Quantitative Phase Imaging (QPI), San Francisco, CA, FEB 07-10, 2015. p. 93360E. DOI : 10.1117/12.2078793.Optimized Steerable Wavelets for Texture Analysis of Lung Tissue In 3-D CT: Classification of Usual Interstitial Pneumonia
2015. p. 403-406. DOI : 10.1109/ISBI.2015.7163897.Off-axis digital holographic camera for quantitative phase microscopy
Biomedical Optics Express. 2014. DOI : 10.1364/Boe.5.001721.Portable advanced off-axis camera for quantitative phase microscopy
2014. Conference on Three-Dimensional and Multidimensional Microscopy - Image Acquisition and Processing XXI, San Francisco, CA, FEB 03-06, 2014. DOI : 10.1117/12.2037799.Rotation-Covariant Texture Learning Using Steerable Riesz Wavelets
IEEE Transactions on Image Processing. 2014. DOI : 10.1109/Tip.2013.2295755.Three-dimensional solid texture analysis in biomedical imaging: Review and opportunities
Medical Image Analysis. 2014. DOI : 10.1016/j.media.2013.10.005.Apparatus and method for quantitative phase tomography through linear scanning with coherent and non-coherent detection
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Optics Express. 2013. DOI : 10.1364/OE.21.003417.Optical reconstruction of transparent objects with phase-only SLMs
Optics Express. 2013. DOI : 10.1364/Oe.21.028246.Exploring Neural Cell Dynamics with Digital Holographic Microscopy
Annual Review Of Biomedical Engineering; Palo Alto: Annual Reviews, 2013. p. 407-431.Quantitative phase noise in a two-color low coherence Digital Holographic Microscope
2013. Conference on Practical Holography XXVII - Materials and Applications, San Francisco, CA, FEB 03-04, 2013. DOI : 10.1117/12.2002413.Full field vertical scanning in short coherence digital holographic microscope
Optics Express. 2013. DOI : 10.1364/Oe.21.012643.Measurement of absolute cell volume, osmotic membrane water permeability, and refractive index of transmembrane water and solute flux by digital holographic microscopy
Journal Of Biomedical Optics. 2013. DOI : 10.1117/1.Jbo.18.3.036007.Marker-free phase nanoscopy
Nature Photonics. 2013. DOI : 10.1038/Nphoton.2012.329.3D Optical Imaging of Living Cells in Microgravity
Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5624.Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy
ASSAY and Drug Development Technologies. 2013. DOI : 10.1089/adt.2012.476.Simultaneous Optical Recording in Multiple Cells by Digital Holographic Microscopy of Chloride Current Associated to Activation of the Ligand-Gated Chloride Channel GABA(A) Receptor
Plos One. 2012. DOI : 10.1371/journal.pone.0051041.Spatially-Resolved Eigenmode Decomposition of Red Blood Cells Membrane Fluctuations Questions the Role of ATP in Flickering
Plos One. 2012. DOI : 10.1371/journal.pone.0040667.Local demodulation of holograms using the Riesz transform with application to microscopy
Journal Of The Optical Society Of America A-Optics Image Science And Vision. 2012. DOI : 10.1364/JOSAA.29.002118.Accelerated autofocusing of off-axis holograms using critical sampling
Optics Letters. 2012. DOI : 10.1364/OL.37.005094.Near-Affine-Invariant Texture Learning for Lung Tissue Analysis Using Isotropic Wavelet Frames
IEEE Transactions On Information Technology In Biomedicine. 2012. DOI : 10.1109/TITB.2012.2198829.Quantitative Measurement of absolute cell volume and intracellular integral refractive index (RI) with Dual-wavelength Digital Holographic Microscopy (DHM)
2012. Conference on Biophotonics - Photonic Solutions for Better Health Care III, Brussels, BELGIUM, Apr 16-19, 2012. p. -. DOI : 10.1117/12.922598.Digital holographic microscopy for the cytomorphological imaging of cells under zero gravity
2012. Conference on Three-Dimensional and Multidimensional Microscopy - Image Acquisition and Processing XIX, San Francisco, CA, Jan 24-26, 2012. p. -. DOI : 10.1117/12.908413.Single shot dual wavelength full field imaging in low coherence digital holographic microscopy
2012. Conference on Practical Holography XXVI - Materials and Applications, San Francisco, CA, Jan 22-25, 2012. p. -. DOI : 10.1117/12.906390.Early Cell Death Detection with Digital Holographic Microscopy
Plos One. 2012. DOI : 10.1371/journal.pone.0030912.Monte Carlo simulation of the field back-scattered from rough surfaces
Journal Of The Optical Society Of America A-Optics Image Science And Vision. 2012. DOI : 10.1364/JOSAA.29.000270.Reconstruction in interferometric synthetic aperture microscopy: comparison with optical coherence tomography and digital holographic microscopy
Journal Of The Optical Society Of America A-Optics Image Science And Vision. 2012. DOI : 10.1364/JOSAA.29.000244.Enhanced robustness digital holographic microscopy for demanding environment of space biology
Biomedical Optics Express. 2012. DOI : 10.1364/BOE.3.000313.Resolution and Complex Deconvolution in Holographic Microscopy
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5281.Holographic second harmonic generation imaging
Second harmonic generation imaging; Boca Raton: CRC Press/Taylor and Francis, 2012.Single-shot, simultaneous incoherent and holographic microscopy
Journal of Microscopy. 2012. DOI : 10.1111/j.1365-2818.2011.03543.x.Complex index refraction tomography with sub ?/6-resolution
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Optics Express. 2011. DOI : 10.1364/OE.19.024005.Beyond the lateral resolution limit by phase imaging
Journal of Biomedical Optics. 2011. DOI : 10.1117/1.3640812.Realistic 3D coherent transfer function inverse filtering of complex fields
Optics Express. 2011. DOI : 10.1364/BOE.2.002216.Determination of Transmembrane Water Fluxes in Neurons Elicited by Glutamate Ionotropic Receptors and by the Co-transporters KCC2 and NKCC1: A Digital Holographic Microscopy Study
Journal of Neuroscience. 2011. DOI : 10.1523/JNEUROSCI.0286-11.2011.Quantitative phase restoration by direct inversion using the optical transfer function
Optics Letters. 2011. DOI : 10.1364/OL.36.002671.Holographic Second Harmonic Generation Microscopy
Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5141.Dual-wavelength Digital Holography for quantification of cell volume and integral refractive index (RI)
2011. European Conferences on Biomedical Optics, Munich, May 22-26, 2011. p. 808608. DOI : 10.1117/12.889767.Cell death detection and ionic homeostasis monitoring with digital holographic microscopy
2011. European Conferences on Biomedical Optics, Munich, May 22-26, 2011. p. 809004. DOI : 10.1117/12.889246.Holographic Second Harmonic Generation Imaging
2011. Digital Holography and Three-Dimensional Imaging (DH), Tokyo, Japan, May 9-11, 2011. p. DWC16.Three-dimensional deconvolution of complex fields
2011. Digital Holography and Three-Dimensional Imaging (DH), Tokyo, Japan, May 9-11, 2011. p. DMB4.Cell Death and Ionic Regulation Detection with Digital Holographic Microscopy
2011. Digital Holography and Three-Dimensional Imaging (DH), Tokyo, Japan, May 9-11, 2011. p. DTuC25. DOI : 10.1364/DH.2011.DTuC25.Cellular Dynamics and Three-Dimensional Refractive Index Distribution Studied with Quantitative Phase Imaging
Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5100.Holographic second harmonic generation (SHG) microscopy
2011. Focus on Microscopy, Konstanz, GE, April 17-20, 2011.Complex field imaging for diffraction tomography
2011. Novel Techniques in Microscopy (NTM), Monterey, CA, USA, April 4-6, 2011. p. NTuC7. DOI : 10.1364/NTM.2011.NTuC7.Quantitative phase from defocus
2011. Novel Techniques in Microscopy (NTM), Monterey, CA, USA, April 4-6, 2011. p. NTuC6. DOI : 10.1364/NTM.2011.NTuC6.Holographic Second Harmonic Generation Microscopy
2011. Novel Techniques in Microscopy (NTM), Monterey, CA, USA, April 4-6, 2011. p. NTuC2. DOI : 10.1364/NTM.2011.NTuC2.Early Glutamate-mediated Cell Death Detection with Digital Holographic Microscopy
2011. Novel Techniques in Microscopy (NTM), Monterey, CA, USA, April 4-6, 2011. p. JTuA13. DOI : 10.1364/BODA.2011.JTuA13.Beyond the lateral resolution limit by phase imaging
2011. Biomedical Optics (BiOS), San Fransisco, CA, January, 22-28, 2011. p. 79040S. DOI : 10.1117/12.874945.Second harmonic phase microscopy of collagen fibers
2011. Biomedical Optics (BiOS), San Fransisco, CA, January, 22-28, 2011. p. 79030G. DOI : 10.1117/12.874538.Exact Complex-Wave Reconstruction in Digital Holography
Journal of the Optical Society of America A. 2011. DOI : 10.1364/JOSAA.28.000983.A method and apparatus for enhanced spatial bandwidth wavefronts reconstructed from digital interferograms or holograms
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WO2010092533 . 2010.Label-free second harmonic phase imaging of biological specimen by digital holographic microscopy
Optics Letters. 2010. DOI : 10.1364/OL.35.004102.Extension de profondeur de champ pour l'étude des microfluides en microscopie par holographie numérique
2010. 1re rencontre francophone d'holographie numérique appliquée à la métrologie des fluides, Rouen, France, October, 21-22, 2010.Réflectométrie holographique numérique appliquée à la métrologie des fluides
2010. 1re rencontre francophone d’holographie numérique appliquée à la métrologie des fluides, Rouen, France, October, 21-22, 2010.Off-Axis Low Coherence Interferometry for Surface Topology Measurement
2010. Speckle 2010, Florianopolis, Brazil, September, 13-15, 2010. p. -. DOI : 10.1117/12.870742.Signification of the phase function parameter gamma explored with a fractal distribution of scatterers
Optics Express. 2010. DOI : 10.1364/OE.18.023664.Endoscopic low coherence topography measurement for upper airways and hollow samples
Journal of Biomedical Optics. 2010. DOI : 10.1117/1.3512218.Diffraction tomography for biological cells imaging using digital holographic microscopy
2010. Laser Applications in Life Sciences, Oulu, Finland, June 9-11, 2010. p. 737613. DOI : 10.1117/12.871061.Microscopy image resolution improvement by deconvolution of complex fields
Optics Express. 2010. DOI : 10.1364/OE.18.019462.Real time, nanometric 3D-tracking of nanoparticles made possible by second harmonic generation digital holographic microscopy
Optics Express. 2010. DOI : 10.1364/OE.18.017392.Iterative method for zero-order suppression in off-axis digital holography
Optics Express. 2010. DOI : 10.1364/OE.18.015318.Sub-Rayleigh resolution by phase imaging
Optics Letters. 2010. DOI : 10.1364/OL.35.002176.Extended depth-of-focus by digital holographic microscopy
Optics Letters. 2010. DOI : 10.1364/OL.35.001840.Study of Intracellular Ion Dynamics with a Multimodality Approach Combining Epifluorescence and Digital Holographic Microscopy
2010. Digital Holography and Three-Dimensional Imaging, Miami, FL, USA, April 12-14, 2010. p. JMA26. DOI : 10.1364/BIOMED.2010.JMA26.Holographic Microscopy: From the Idea to the Market
2010. Digital Holography and Three-Dimensional Imaging, Miami, FL, USA, April 12-14, 2010. p. DWC3.Real Time 3-D Cytomorphological Imaging Using Digital Holographic Microscopy and Fluorescence Microscopy for Space Biology
2010. Digital Holography and Three-Dimensional Imaging, Miami, FL, USA, April 12-14, 2010. p. DTuA5. DOI : 10.1364/DH.2010.DTuA5.Artifact-free reconstruction from off-axis digital holograms through nonlinear filtering
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 77231U--9. DOI : 10.1117/12.854178.Digital holographic microscopy for silicon microsystems metrology
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 77191M. DOI : 10.1117/12.854297.Fast non-contact surface roughness measurements up to the micrometer range by dual-wavelength digital holographic microscopy
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 771805. DOI : 10.1117/12.854550.Exploring red blood cell membrane dynamics with digital holographic microscopy
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 77153I. DOI : 10.1117/12.854717.Determination of local optical properties of the rat barrel cortex during neural activation: Monte-Carlo approach to light propagation
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 771531. DOI : 10.1117/12.854136.Digital holography for second harmonic microscopy: application to 3D-tracking of nanoparticles
2010. Photonics Europe 2010, Bruxelles, Belgium, April 13-15, 2010. p. 771505. DOI : 10.1117/12.854289.Studies on synthetic deconvolution of complex fields with digital holographic microscopy
2010. Focus on Microscopy 2010, Shanghai, China, March 28-31, 2010. p. MO-MO-PAR-C.Digital holographic microscopy real-time monitoring of cytoarchitectural alterations during simulated microgravity
Journal of Biomedical Optics. 2010. DOI : 10.1117/1.3377960.Cell Morphology and Intracellular Ionic Homeostasis explored with a Multimodal Approach combining Epifluorescence and Digital Holographic Microscopy
Journal of Biophotonics. 2010. DOI : 10.1002/jbio.201000018.Enseignement & Phd
Enseignement
Microengineering