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Christian Iseli

christian.iseli@epfl.ch https://bix.epfl.ch

EPFL SV PTECH BICC
AAB 1 19 (Bâtiment AAB)
Station 19
1015 Lausanne

EPFL SV PTECH BICC
AAB 1 19 (Bâtiment AAB)
Station 19
1015 Lausanne

EPFL SV PTECH BICC
AAB 1 19 (Bâtiment AAB)
Station 19
1015 Lausanne

- Melanin and Neurotransmitter Signalling Genes Are Differentially Co-Expressed in Growing Feathers of White and Rufous Barn Owls

A.-L. Ducrest; L. S.-J. Garcia; S. Neuenschwander; E. Schmid-Siegert; C. Simon  et al.

PIGMENT CELL & MELANOMA RESEARCH. 2025. DOI : 10.1111/pcmr.70001.

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- Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and herald the birth of molecular immunity

M. Pirovino; C. Iseli; J. A. Curran; B. Conrad

PLOS COMPUTATIONAL BIOLOGY. 2025. DOI : 10.1371/journal.pcbi.1012162.

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- Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing

A. N. Glaus; M. Brechet; G. Swinnen; L. Lebeigle; J. Iwaszkiewicz  et al.

Nature Genetics. 2025. DOI : 10.1038/s41588-024-02026-9.

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- DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen

S. Martin; F. Fournes; G. Ambrosini; C. Iseli; K. Bojkowska  et al.

NUCLEIC ACIDS RESEARCH. 2024. DOI : 10.1093/nar/gkae757.

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- tRNA-derived fragments in T lymphocyte-beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice

F. Brozzi; C. Jacovetti; C. Cosentino; V. Menoud; K. Wu  et al.

DIABETOLOGIA. 2024. DOI : 10.1007/s00125-024-06207-3.

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- Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles

S. Bassani; J. Chrast; G. Ambrosini; N. Voisin; F. Schuetz  et al.

Genome Medicine. 2024. DOI : 10.1186/s13073-024-01339-y.

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- Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

K. Pinjusic; G. Ambrosini; J. Lourenco; N. Fournier; C. Iseli  et al.

Frontiers In Immunology. 2024. DOI : 10.3389/fimmu.2023.1335207.

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- A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer

S. Bobisse; V. Bianchi; J. Tanyi; A. Sarivalasis; E. Missiaglia  et al.

Nature Cancer. 2023. DOI : 10.1038/s43018-023-00623-x.

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- Chromosome-level organization of the regulatory genome in the Drosophila nervous system

G. Mohana; J. Dorier; X. Li; M. Mouginot; R. C. Smith  et al.

Cell. 2023. DOI : 10.1016/j.cell.2023.07.008.

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- Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy

A. Seifinejad; M. Ramosaj; L. Shan; S. Li; M.-L. Possovre  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2023. DOI : 10.1073/pnas.2220911120.

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- Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles

J. Villà-Freixa; B. Conrad; C. Iseli; M. Pirovino

PLOS ONE. 2023. DOI : 10.1371/journal.pone.0281661.

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- DNA modifications impact natural transformation of Acinetobacter baumannii

N. Vesel; C. Iseli; N. Guex; A. Lemopoulos; M. Blokesch

Nucleic Acids Research. 2023. DOI : 10.1093/nar/gkad377.

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- Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

H. A. Lashuel; A.-L. Mahul-Mellier; S. Novello; R. N. Hegde; Y. Jasiqi  et al.

Npj Parkinsons Disease. 2022. DOI : 10.1038/s41531-022-00388-7.

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- SPICA: Swiss portal for immune cell analysis

M. Andreatta; F. P. A. David; C. Iseli; N. Guex; S. J. Carmona

Nucleic Acids Research. 2022. DOI : 10.1093/nar/gkab1055.

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- Essential role of Cp190 in physical and regulatory boundary formation

A. Kaushal; J. Dorier; B. Wang; G. Mohana; M. Taschner  et al.

Science Advances. 2022. DOI : 10.1126/sciadv.abl8834.

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- Blood virosphere in febrile Tanzanian children

S. Cordey; F. Laubscher; M.-A. Hartley; T. Junier; K. Keitel  et al.

Emerging Microbes & Infections. 2021. DOI : 10.1080/22221751.2021.1925161.

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- Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

M. Bruand; D. Barras; M. Mina; E. Ghisoni; M. Morotti  et al.

Cell Reports. 2021. DOI : 10.1016/j.celrep.2021.109412.

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- CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

A. Kaushal; G. Mohana; J. Dorier; I. Özdemir; A. Omer  et al.

Nature Communications. 2021. DOI : 10.1038/s41467-021-21366-2.

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Teaching & PhD

Courses

Bioinformatic Analysis of RNA-sequencing (Fall)

BIO-693(a)

Bioinformatic Analysis of RNA-sequencing (Spring)

BIO-693(b)

This course will take place at EPFL in June 2026, from 8th to 12th, in room AAC 137. It introduces the workflows and techniques that are used for the analysis of bulk and single-cell RNA-seq data. It empowers students to understand and analyze their own data.

Methods: omics in biomedical research

BIOENG-519

High-throughput methodologies broadly called Omics allow to characterize the complexity and dynamics of any biological system. This course will provide a general description of different methods related to the Omics field followed by hands-on rotations in participating technological platforms.