Christophe Roussel

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Research and Teaching Associate

christophe.roussel@epfl.ch +41 21 693 76 75

EPFL SB SCGC-GE
CH B0 391 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 76 75
Office: CH B0 391
EPFL > SB > SB-SCGC > SCGC-GE

Web site: Web site: https://www.epfl.ch/schools/sb/scgc/

+41 21 693 76 75
EPFL > SB > SB-SCGC > SCGC-ENS

Web site: Web site: https://www.epfl.ch/schools/sb/scgc/

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Administrative data

Fields of expertise

Electrochemistry
Analytical Sciences
Material Sciences

Biography

2015: Habilitation à Diriger les Recherches (HDR) in chemistry at the Ecole Normale Supérieure Paris-Saclay (Cachan, France).

2000: PhD Thesis in physical organic chemistry at the University of Bourgogne Franche-Comté (Besançon, France) / Ecole Normale Supérieure Paris-Saclay (Cachan, France).

1997: DEA de chimie-physique des interfaces at the University of Bourgogne Franche-Comté (Besançon, France).

1996: Maîtrise de chimie-physique at the University of Bourgogne Franche-Comté (Besançon, France).

1995: Licence de chimie at the University of Bourgogne Franche-Comté (Besançon, France).

1994: DEUG sciences de la nature et de la vie at the University of Bourgogne Franche-Comté (Besançon, France).

1992: Baacalauréat mathématiques et sciences de la nature (académie de Besançon, France).

Publications

Selected publications

Other publications

Articles

Heterogeneous Overhauser-DNP on 1H dominated by scalar coupling in aqueous solution
J. Milani, F. Saenz, C. Roussel, and J.-P. Ansermet, Magnetic Resonnance in Chemistry, 2023, 61, 180

Blatter-type radicals as polarizing agents for electrochemical overhauser dynamic nuclear polarization
F. Saenz, M. Tamski, J. Milani, C. Roussel, H. Frauenrath and J.-P. Ansermet, Chemical communication, 2022, 58, 689

Stabilization of p-GaAs electrode surfaces in organic solvent by bi-phenyl rings for spin dependent electron transfer studies
M. Tamski, J.-P. Ansermet and C. Roussel , Journal of Photochemistry and Photobiology A: Chemistry, 2021, 404, 112853

Electrochemical Overhauser Dynamic Nuclear Polarization
M. A. Tamski, J. Milani, C. Roussel and J.-P. Ansermet, Physical Chemistry Chemical Physics, 2020, 22, 17769

Optimization of a Py-GC/MS method for silicone-Based lubricants analysis
F. Maurer, K. Buffaz , G. Massonnet, C. Roussel and C.Burnier, Journal of Analytical and Applied Pyrolysis, 2020, 149, 104861

Spin-dependent charge transfer at chiral electrodes probed by magnetic resonance
F. Blumenschein, M. A. Tamski, C. Roussel, E. Z. B. Smolinsky, F. Tassinari, R. Naaman and J.-P. Ansermet, Physical Chemistry Chemical Physics, 2020, 22, 997

Probing charge transfer processes at p-GaAs electrodes under weak optical excitation
M. A. Tamski, F. Blumenschein, C. Roussel and J.-P. Ansermet, Journal of Photochemistry and Photobiology A: Chemistry, 2019, 382, 111894

Quantification of THC in cannabis plants by Fast-HPLC-DAD: a promising method for routine analyses
C. Burnier, P. Esseiva, C. Roussel, Talanta, 2019, 192, 135

Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized13C-substrates
A. Capozzi, T. Cheng, G. Boero, C. Roussel, A. Comment, Nature Communications, 2017, 8, 15757

Experimental and theoretical studies on electropolymerization of polar amino acids on platinum electrode
T. Alhedabi, H. Cattey, C. Roussel, V. Blondeau-Patissier, T. Gharbi, G. Herlem, Material Chemistry and Physics, 2017, 185, 183-194

Preparation, kinetics, mechanism and properties of semi-transparent photocatalytic stable films active in dye degradation
L. Suarez, C. Pulgarin, C. Roussel, J. Kiwi, Applied Catalysis A, 2016, 516, 70-80

Photo-Induced non-Persistent Radicals as Polarizing Agents for X-Nuclei Dissolution-DNP
A. Capozzi, J.-N. Hyacinthe, T. Cheng, T. Eichhorn, G. Boero, C. Roussel, J. Van der Klink, A. Comment, Journal of Physical Chemistry C, 2015, 119, 22632-22639

Optimal glass-forming solvent brings sublimation dynamic nuclear polarization to 129Xe hyperpolarization biomedical imaging standards
A. Capozzi, C. Roussel, A. Comment, J.-N. Hyacinthe, Journal of Physical Chemistry C, 2015, 119, 5020-5025

Standard addition strip for quantitative electrostatic spray ionization mass spectrometry analysis: Determination of caffeine in drinks
E. Tobolkina, L. Qiao, C. Roussel, H. H. Girault, Talanta, 2014, 130, 377-381

Hyperpolarized 13C MRI contrast agent generated by shining light on a pure glucose metabolic product for probing metabolism in vivo in real time
T.R. Eichhorn, Y. Takado, N. Salameh, A. Capozzi, T. Cheng, J.-N. Hyacinthe, M. Mishkovsky, C. Roussel, A. Comment, Proceedings of the national academy of sciences of the united states of America, 2013, 110, 18064-18069

RF-plasma pretreatment of surfaces leading to TiO2 coatings with improved optical absorption and OH radical-production
O. Baghriche, S. Rtimi, C. Pulgarin, C. Roussel, J. Kiwi, Applied Catalysis B, 2013, 130-131, 65-72

Photocatalytic discoloration of aqueous malachite green solutions by UV-illuminated TiO2 nano-particles under air and nitrogen atmospheres: effects of counter-ions and pH
J.A. Rengifo-Herrera, L.R. Pizzo, M.N. Blanco, C. Roussel, C. Pulgarin, Photochemical and photobiological sciences, 2011, 10, 29-34

Reactivity of arynitriloxides and C-aroyl-N-phenylnitrones with 3-methylenedihydro-(3H)-furan-2-one and itaconic anhydride
C. Roussel, K. Ciamala, J. Vebrel , C. Riche, Heterocycles, 2009, 78, 1977-1991

About the electrospray ionization source in Mass Spectrometry: electrochemistry and on-chip reactions
M. Prudent, M. A. Méndez, C. Roussel, B. Su, N. Lion, J. S. Rossier, H. H. Girault, Chimia, 2009, 63, 283-287

Protoporphyrin IX sensitized titanium oxide gel electrode
S. X. Tan, B. Su, C. Roussel, H. H. Girault, Inorganica Chimica Acta, 2008, 361, 746-760

MALDI in-source photo-oxidation reactions for on-line peptide tagging
L. Qiao, C. Roussel, J. J. Wan, J. L. Kong, P. Y. Yang, H. H. Girault, B. H. Liu, Angewandte Chemie, International Edition, 2008, 47, 2646-2648

Reaction of 3-methylenedihydro-(3H)-furan-2-one with diazoalkanes. Syntheses and crystal structures of spiranic cyclopropyl compounds
C. Roussel, K. Ciamala, J. Vebrel, M. Knorr, M. M. Kubicki, Heterocycles, 2007, 71, 1517-1528,

Specific on-plate enrichment of phosphorylated peptides for direct MALDI-TOF MS analysis
L. Qiao, C. Roussel, J. J. Wan, P. Y. Yang, H. H. Girault, B. H. Liu, Journal of Proteome Research, 2007, 6, 4763-4769

Electrochemical generation of Cu(I) complexes in aqueous solutions studied by on-line mass spectrometry
M. Prudent, C. Roussel, H. H. Girault, Electrochemistry Communications, 2007, 9, 2067-2074

2,3-diphenyl-2,3-dihydrospiro[1,3-oxazole-5(4H),1'(3'H)-2-benzofuran]-3'-one
J.-C. Daran, R. Fihi, C. Roussel, N. Laghrib, M. Azrour, K. Ciamala, J. Vebrel, Acta Crystallographica E, 2006, 62, o329-o331

Immobilized pH gradient gel cell to study the pH dependence of drug lipophilicity
H.-T. Lam, C. M. Pereira, C. Roussel, P.-A. Carrupt, H. H. Girault, Analytical Chemistry, 2006, 78, 1503-1508

Probing cysteine reactivity in proteins by Mass Spectrometric EC-tagging
L. Dayon, C. Roussel, and H. H. Girault, Journal of Proteome Research, 2006, 5, 793-800

Salt removal during off-gel electrophoresis of protein samples
I. L. Arnaud, J. Josserand, H. Jensen, N. Lion, C. Roussel, H. H. Girault, Electrophoresis, 2005, 26, 1650-1658

Size-selective separation of Gold nanoparticles using isoelectric focusing electrophoresis (IEF)
I. L. Arnaud, J.-P. Abid, C. Roussel, H. H. Girault, Chemical Communications, 2005, 787-788

Antioxidant sensors based on DNA-modified electrodes
J. F. Liu, C. Roussel, G. Lagger, P. Tacchini, and H. H. Girault, Analytical Chemistry, 2005, 77, 7687-7694

On-Line counting of cysteine residues in peptides during electrospray ionization by electrogenerated tags and their application to protein identification
L. Dayon, C. Roussel, M. Prudent, N. Lion, H. H. Girault, Electrophoresis, 2005, 26, 238-247

On-line electrochemical tagging of free cysteines in peptides during nanospray ionisation mass spectrometry: An Overview
L. Dayon, C. Roussel, H. H. Girault, Chimia, 2004, 58, 204-207

On-line electrochemical tagging of free cysteine during nanospray ionisation for mass spectrometry analysis
C. Roussel, L. Dayon, T. C. Rohner, N. Lion, H. H. Girault, Biophotonics New Frontier: From Genome to Proteome, Proceedings of Spie, 2004, 5461, 30-37

Generation of mass tags by the inherent electrochemistry of electrospray for protein mass spectrometry
C. Roussel, L. Dayon, N. Lion, T. C. Rohner, J. Josserand, J. S. Rossier, H. Jensen, H. H. Girault, Journal of the American Society for Mass Spectrometry, 2004, 15, 1767-1779

On-line cysteine modification for protein analysis: new probes for electrochemical tagging nanospray mass spectrometry
C. Roussel, L. Dayon, H. Jensen, and H. H. Girault, Journal of Electroanalytical Chemistry, 2004, 570, 187-199

Microfluidic systems in proteomics
N. Lion, T. C. Rohner, L. Dayon, I. L. Arnaud, E. Damoc, N. Youhnovski, Z.-Y. Wu, C. Roussel, J. Josserand, H. Jensen, J. S. Rossier, M. Przybylski, H. H. Girault, Electrophoresis, 2003, 24, 3533-3562

Mechanistic aspect of on-line electrochemical tagging of free L-cysteine residues during electrospray ionisation for mass spectrometry in protein analysis
C. Roussel, T. C. Rohner, H. Jensen, H. H. Girault, ChemPhysChem, 2003, 4, 200-206

Spiroheterocycles from reaction of nitrones with methylene-gamma-butyrolactones and some of their rearrangements
C. Roussel, R. Fihi, K. Ciamala, J. Vebrel, T. Zair, C. Riche, Organic and Biomolecular Chemistry, 2003, 1, 2689-2698

The [3 2] cycloaddition of diphenyldiazomethane and ethyl diazoacetate with itaconic anhydride. A new access to spiranic cyclopropane derivatives
C. Roussel, K. Ciamala, J-M. Melot, J. Vebrel, C. Riche, Journal of Chemical research (s), 2002, 9, 449-451

Revisiting the addition of nitriloxides on protoanemonine. A new access to (2E)-3-(3'-arylisoxazol-5'-yl)propenoic acids
C. Roussel, R. Fihi, K. Ciamala, P. Audebert, J. Vebrel, New Journal of Chemistry, 2000, 24, 471-476

Contribution of microwaves in organic synthesis: statement of a methodology for the microwave-induced preparation of benzofuran-2(3H)-one and its comparison with classical heating
P. Concalo, C. Roussel, J-M. Melot, J. Vebrel, Journal of the Chemical Society Perking Trans. 2, 1999, 2111-2115

Cycloaddition of some arylnitriloxides with 3-methylenephtalide: electrocatalytic openning of the adduct
C. Roussel, K. Ciamala, P. Audebert, J. Vebrel, New Journal of Chemistry, 1999, 23, 989-992

Patents

Method for the preparation of a sample comprising highly polarized nuclear spins and uses and devices for such a method
J. Milani, M. Tamski, J.-P. Ansermet, and C. Roussel, PCT/EP2020/053161, WO2021/156063, 2021

Method for the generation of radicals for Dynamic Nuclear Polarization and uses thereof for NMR, MRS and MRI
T.R. Eichhorn, C. Roussel, A. Comment, PCT/EP2013/709430, WO2014/139573, 2014

Solid-phase extraction and ionisation device
B. Liu, L. Qiao, N. Lion, J.J. Wan, M. Prudent, C. Roussel, P.Y. Yang, H.H. Girault, PCT/EP2008/5347, WO2009/003673, 2009

Ionisation device
L. Qiao, P.Y. Yang, B. Liu, N. Lion, C. Roussel, H.H. Girault, PCT/EP2008/000140, WO2008/083966, 2008

Chemical wall-plug product comprises separate components which, when mixed, undergo simultaneous expansion and polymerization-crosslinking reactions to form an expanded 3-dimensional thermoset structure
J. Vebrel, P. Goncalo, C. Roussel, J. Vuillermoz, PCT/FR2000/01132, WO2000/66673-A, 2000

Teaching & PhD

Teaching

Chemistry and Chemical Engineering

Past EPFL PhD Students

Blumenschein Felix , Capozzi Andrea ,

Courses

Electrochemistry of solutions

Students integrate the concepts of electric potentials, the Fermi level of the electron and apply the Nernst equation. They understand the structure of an electrified interface. Electrochemical generators, electrolysis and the basics of amperometry are presented.

Analytical separation methods

Students understand the physico-chemical principles of chromatographic and electrophoretic separation methods

Experimental analytical chemistry

This laboratory work aims to illustrate the analytical separation methods course as well as to accustom the students with the qualitative and quantitative aspects of analytical chemistry. The number of proposed experiments depend on the number of incoming students.

Physical and chemical analyses of materials

The course relates on the use of electromagnetic (X-Ray) and corpuscular (electrons) radiations for physical and chemical analysis of solid materials.

Advanced general chemistry (for SFU)

The aim of this course is to acquire the essential concepts relating to the structure of matter and chemical reactivity. The course and the series of exercises provide the methodology for solving typical general chemistry problems by reasoning and calculation.