Cristina Ramona Cudalbu

Editer le profil

cristina.cudalbu@epfl.ch +41 21 693 76 85 https://www.epfl.ch/labs/mrs4brain/

Linkedin ID

https://orcid.org/0000-0003-4582-2465

Google Scholar ID

EPFL CIBM-AIT
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 76 85
Local: CH F0 582
EPFL > VPA-AVP-CP > CIBM > CIBM-AIT

Web site: Site web: https://www.cibm.ch/

EPFL CIBM-AIT
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 76 85
Local: CH F0 582
EPFL > VPA-AVP-PGE > AVP-PGE-EDOC > EDPY-ENS

EPFL CIBM-AIT
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 76 85
Local: CH F0 582
EPFL > SB > SB-SPH > SPH-ENS

Web site: Site web: https://sph.epfl.ch/

vCard
Données administratives

Parcours professionnel

Maître d'enseignement et de recherche (MER)

School of Basic Sciences

EPFL

2024-now

Deputy

Centre d’Imagerie Biomedicale (CIBM), Animal Imaging and Technology (AIT) section

EPFL

2023-now

Research and Teaching Associate

School of Basic Sciences

EPFL

2022-2024

Senior Research Staff Scientist and 9.4T MRI Operational Manager

Centre d’Imagerie Biomedicale (CIBM), Animal Imaging and Technology (AIT) section

EPFL

2012-now

Postdoctoral researcher

Laboratory for Functional and Metabolic Imaging (LIFMET)

EPFL

2007-2012

Formation

PhD

RMN Laboratory MIB

University Claude-Bernard Lyon 1, France

2003-2006

Master of Science

Biophysics and Medical Physics

University Babes-Bolyai, Cluj Napoca, Romania

2002-2003

Publications

Publications Infoscience

Infoscience

2024

[1] Rescue of myocytes and locomotion through AAV2/9-2YF intracisternal gene therapy in a rat model of creatine transporter deficiency

G. Fernandes-Pires; M. D. Azevedo; M. Lanzillo; C. Roux-Petronelli; P.-A. Binz et al.

Molecular Therapy Methods & Clinical Development. 2024-06-13. DOI : 10.1016/j.omtm.2024.101251.

Detailed record: https://infoscience.epfl.ch/record/311724?ln=en

[2] Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

J. Mosso; G. Briand; K. Pierzchala; D. Simicic; A. Sierra et al.

Frontiers In Neuroscience. 2024-03-20. DOI : 10.3389/fnins.2024.1344076.

Detailed record: https://infoscience.epfl.ch/record/310566?ln=en
Full text: https://infoscience.epfl.ch/record/310566/files/fnins-18-1344076.pdf

[3] Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

D. Evstafeva; F. Ilievski; Y. Bao; Z. Luo; B. Abramovic et al.

Nature Communications. 2024-03-12. DOI : 10.1038/s41467-024-46481-8.

Detailed record: https://infoscience.epfl.ch/record/310471?ln=en
Full text: https://infoscience.epfl.ch/record/310471/files/document.pdf

2023

[4] Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field

J. Mosso; D. Simicic; B. Lanz; R. Gruetter; C. Cudalbu

Magnetic Resonance In Medicine. 2023-09-28. DOI : 10.1002/mrm.29805.

Detailed record: https://infoscience.epfl.ch/record/306053?ln=en
Full text: https://infoscience.epfl.ch/record/306053/files/Magnetic%20Resonance%20in%20Med%20-%202023%20-%20Mosso%20-%20Diffusion%E2%80%90weighted%20SPECIAL%20improves%20the%20detection%20of%20J%E2%80%90coupled%20metabolites%20at.pdf

[5] New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual 18F-FDG PET and 9.4T 1H MRS Preclinical Study

J. Mosso; T. Yin; C. Poitry-Yamate; D. Simicic; M. Lepore et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S12-S12. DOI : 10.14309/01.ajg.0000948348.20966.21.

Detailed record: https://infoscience.epfl.ch/record/307750?ln=en

[6] Automated segmentation and labeling of subcutaneous mouse implants at 14.1T

J. Adda; G. Bioley; D. van de Ville; C. Cudalbu; M. G. Preti et al.

Frontiers In Signal Processing. 2023-08-21. DOI : 10.3389/frsip.2023.1155618.

Detailed record: https://infoscience.epfl.ch/record/305880?ln=en

[7] Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset

D. Evstafeva; J.-C. Leroux; C. R. Cudalbu; D. Simicic

2023.

Detailed record: https://infoscience.epfl.ch/record/309960?ln=en

[8] Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling

C. Ligneul; C. Najac; A. Doring; C. Beaulieu; F. Branzoli et al.

Magnetic Resonance In Medicine. 2023-11-09. DOI : 10.1002/mrm.29877.

Detailed record: https://infoscience.epfl.ch/record/308192?ln=en

[9] Evaluation of a Hydroxamate-Based Urease Inhibitor in a Rodent Model of Hepatic Encephalopathy

D. Evstafeva; F. Ilievski; Y. Bao; Z. Luo; B. Abramovic et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S30-S31. DOI : 10.14309/01.ajg.0000948468.55577.45.

Detailed record: https://infoscience.epfl.ch/record/307754?ln=en

[10] Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy

D. Simicic; K. Pierzchala; O. Braissant; C. Toso; G. Oldani et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S24-S25. DOI : 10.14309/01.ajg.0000948428.52697.c3.

Detailed record: https://infoscience.epfl.ch/record/307753?ln=en

[11] Age Dependence of Neurometabolic Changes in a Rat Pup Model of Type C Hepatic Encephalopathy

D. Simicic; V. Rackayova; O. Braissant; C. Toso; G. Oldani et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S24-S24. DOI : 10.14309/01.ajg.0000948424.84976.19.

Detailed record: https://infoscience.epfl.ch/record/307752?ln=en

[12] The Beneficial Effect of Oral Cr Supplementation in an Early Childhood Rat Model of Chronic Hepatic Encephalopathy: In Vivo Longitudinal 1H and 31P Magnetic Resonance Spectroscopy Study

D. Simicic; O. Braissant; K. Pierzchala; S. Mitrea; D. Sessa et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. P17. DOI : 10.14309/01.ajg.0000948352.71525.d3.

Detailed record: https://infoscience.epfl.ch/record/307751?ln=en

[13] New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

J. J. Mosso

Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-10502.

Detailed record: https://infoscience.epfl.ch/record/306779?ln=en
Full text: https://infoscience.epfl.ch/record/306779/files/EPFL_TH10502.pdf

[14] Lessons on brain edema in HE: from cellular to animal models and clinical studies

K. Pierzchala; A. Hadjihambi; J. Mosso; R. Jalan; C. F. F. Rose et al.

Metabolic Brain Disease. 2023-08-22. DOI : 10.1007/s11011-023-01269-5.

Detailed record: https://infoscience.epfl.ch/record/304908?ln=en
Full text: https://infoscience.epfl.ch/record/304908/files/document.pdf

[15] Editorial for the special issue on Brain Biochemistry in Liver Disease

C. Cudalbu; A. J. L. Cooper

Analytical Biochemistry. 2023-09-15. DOI : 10.1016/j.ab.2023.115248.

Detailed record: https://infoscience.epfl.ch/record/304876?ln=en

[16] High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study

C. Cudalbu; L. Xin; B. Marechal; S. Lachat; F. Zangas-Gheri et al.

Analytical Biochemistry. 2023-07-04. DOI : 10.1016/j.ab.2023.115212.

Detailed record: https://infoscience.epfl.ch/record/304161?ln=en
Full text: https://infoscience.epfl.ch/record/304161/files/1-s2.0-S000326972300177X-main.pdf

[17] Central Nervous System Oxidative Stress interplay with inflammation in a rat model of Type C Hepatic Encephalopathy - brothers in arms?

K. Pierzchala; D. Simicic; A. Sienkiewicz; D. Sessa; S. Mitrea et al.

2023-03-01. 1st international conference on the Future of Redox Biology, ITALY, Jun 17-19, 2022. p. S15-S15. DOI : 10.1016/j.freeradbiomed.2022.12.056.

Detailed record: https://infoscience.epfl.ch/record/303114?ln=en

[18] Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

D. Simicic; V. Rackayova; O. Braissant; C. Toso; G. Oldani et al.

Metabolic Brain Disease. 2023-05-06. DOI : 10.1007/s11011-023-01210-w.

Detailed record: https://infoscience.epfl.ch/record/302792?ln=en

[19] Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations

A. D. Harris; H. Amiri; M. Bento; R. Cohen; C. R. K. Ching et al.

Frontiers In Neurology. 2023-01-04. DOI : 10.3389/fneur.2022.1045678.

Detailed record: https://infoscience.epfl.ch/record/300533?ln=en
Full text: https://infoscience.epfl.ch/record/300533/files/fneur_2022_1045678.pdf

2022

[20] Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy (vol 178, pg 295, 2022)

K. Pierzchala; D. Simicic; A. Sienkiewicz; D. Sessa; S. Mitrea et al.

Free Radical Biology And Medicine. 2022-03-01. DOI : 10.1016/j.freeradbiomed.2022.01.016.

Detailed record: https://infoscience.epfl.ch/record/294217?ln=en

[21] MP-PCA denoising for diffusion MRS data: promises and pitfalls

J. Mosso; D. Simicic; K. Simsek; R. Kreis; C. Cudalbu et al.

Neuroimage. 2022-11-01. DOI : 10.1016/j.neuroimage.2022.119634.

Detailed record: https://infoscience.epfl.ch/record/298715?ln=en

[22] Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

D. Simicic; C. Cudalbu; K. Pierzchala

Analytical Biochemistry. 2022-10-01. DOI : 10.1016/j.ab.2022.114795.

Detailed record: https://infoscience.epfl.ch/record/297214?ln=en

[23] Central Nervous System Oxidative Stress Interplay With Inflammation In A Rat Model Of Type C Hepatic Encephalopathy - Brothers In Arms?

P. Katarzyna; S. Dunja; S. Dario; M. Stefanita; B. Olivier et al.

2022-08-20. p. 40-40.

Detailed record: https://infoscience.epfl.ch/record/296871?ln=en

[24] Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy

D. Simicic

Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9422.

Detailed record: https://infoscience.epfl.ch/record/296066?ln=en
Full text: https://infoscience.epfl.ch/record/296066/files/EPFL_TH9422.pdf

[25] Abnormal brain oxygen homeostasis in an animal model of liver disease

A. Hadjihambi; C. Cudalbu; K. Pierzchala; D. Simicic; C. Donnelly et al.

Jhep Reports. 2022-08-01. DOI : 10.1016/j.jhepr.2022.100509.

Detailed record: https://infoscience.epfl.ch/record/295962?ln=en

[26] PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

J. Mosso; T. Yin; C. Poitry-Yamate; D. Simicic; M. Lepore et al.

Analytical Biochemistry. 2022-06-15. DOI : 10.1016/j.ab.2022.114606.

Detailed record: https://infoscience.epfl.ch/record/295944?ln=en

[27] Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats

J. Mosso; T. Yin; C. Poitry-Yamate; D. Simicic; M. Lepore et al.

2022-06-01. p. 57-58.

Detailed record: https://infoscience.epfl.ch/record/294990?ln=en

[28] Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy

K. Pierzchala; D. Simicic; A. Sienkiewicz; D. Sessa; S. Mitrea et al.

Free Radical Biology And Medicine. 2022-01-01. DOI : 10.1016/j.freeradbiomed.2021.12.011.

Detailed record: https://infoscience.epfl.ch/record/291657?ln=en

[29] Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy

L. Duran-Trio; G. Fernandes-Pires; J. Grosse; I. Soro-Arnaiz; C. Roux-Petronelli et al.

Journal Of Inherited Metabolic Disease. 2022. DOI : 10.1002/jimd.12470.

Detailed record: https://infoscience.epfl.ch/record/291317?ln=en

2021

[30] Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE

E. Flatt; V. A. McLin; O. Braissant; K. Pierzchala; P. Mastromarino et al.

Scientific Reports. 2021-09-09. DOI : 10.1038/s41598-021-97018-8.

Detailed record: https://infoscience.epfl.ch/record/288857?ln=en
Full text: https://infoscience.epfl.ch/record/288857/files/s41598-021-97018-8.pdf

[31] Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

M. Mishkovsky; O. Gusyatiner; B. Lanz; C. Cudalbu; I. Vassallo et al.

Scientific Reports. 2021-03-11. DOI : 10.1038/s41598-021-85339-7.

Detailed record: https://infoscience.epfl.ch/record/285246?ln=en
Full text: https://infoscience.epfl.ch/record/285246/files/Mishkovsky_HPGlucGliom_SciRep_2021.pdf

[32] Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

V. Rackayova; E. Flatt; O. Braissant; J. Grosse; D. Capobianco et al.

Scientific Reports. 2021-01-26. DOI : 10.1038/s41598-021-81871-8.

Detailed record: https://infoscience.epfl.ch/record/287400?ln=en
Full text: https://infoscience.epfl.ch/record/287400/files/articles-s41598-021-81871-8.pdf

[33] Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

C. Cudalbu; P. Bady; M. Lai; L. Xin; O. Gusyatiner et al.

Acta Neuropathologica Communications. 2021-08-04. DOI : 10.1186/s40478-021-01232-4.

Detailed record: https://infoscience.epfl.ch/record/287868?ln=en
Full text: https://infoscience.epfl.ch/record/287868/files/s40478-021-01232-4.pdf

[34] In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times

D. Simicic; V. Rackayová; L. Xin; I. Tkáč; T. Borbath et al.

Magnetic Resonance in Medicine. 2021-07-15. DOI : 10.1002/mrm.28910.

Detailed record: https://infoscience.epfl.ch/record/287462?ln=en
Full text: https://infoscience.epfl.ch/record/287462/files/mrm.28910.pdf

[35] The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery

M. G. Melo; N. Remacle; H.-P. Cudre-Cung; C. Roux; M. Poms et al.

Molecular Genetics And Metabolism. 2021-06-01. DOI : 10.1016/j.ymgme.2021.03.017.

Detailed record: https://infoscience.epfl.ch/record/287041?ln=en

[36] 2021 ISHEN guidelines on animal models of hepatic encephalopathy

S. DeMorrow; C. Cudalbu; N. Davies; A. R. Jayakumar; C. F. Rose

Liver International. 2021-05-11. DOI : 10.1111/liv.14911.

Detailed record: https://infoscience.epfl.ch/record/285853?ln=en

[37] Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations

A. Lin; O. Andronesi; W. Bogner; I.-Y. Choi; E. Coello et al.

Nmr In Biomedicine. 2021-02-09. DOI : 10.1002/nbm.4484.

Detailed record: https://infoscience.epfl.ch/record/284600?ln=en

[38] A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism

L. Duran-Trio; G. Fernandes-Pires; D. Simicic; J. Grosse; C. Roux-Petronelli et al.

Scientific Reports. 2021. DOI : 10.1038/s41598-020-80824-x.

Detailed record: https://infoscience.epfl.ch/record/283911?ln=en
Full text: https://infoscience.epfl.ch/record/283911/files/s41598-020-80824-x.pdf

[39] Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy

V. Račkayová; D. Simicic; G. Donati; O. Braissant; R. Gruetter et al.

Journal of Neurochemistry. 2021. DOI : 10.1111/jnc.15294.

Detailed record: https://infoscience.epfl.ch/record/282869?ln=en

2020

[40] Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

C. Cudalbu; K. L. Behar; P. K. Bhattacharyya; W. Bogner; T. Borbath et al.

Nmr In Biomedicine. 2020-11-25. DOI : 10.1002/nbm.4393.

Detailed record: https://infoscience.epfl.ch/record/282171?ln=en

[41] Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

B. Lanz; A. Abaei; O. Braissant; I.-Y. Choi; C. Cudalbu et al.

Nmr In Biomedicine. 2020-08-26. DOI : 10.1002/nbm.4325.

Detailed record: https://infoscience.epfl.ch/record/279961?ln=en

[42] B(0)shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

C. Juchem; C. Cudalbu; R. A. de Graaf; R. Gruetter; A. Henning et al.

Nmr In Biomedicine. 2020-06-28. DOI : 10.1002/nbm.4350.

Detailed record: https://infoscience.epfl.ch/record/278608?ln=en

[43] Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations

R. Kreis; V. Boer; I.-Y. Choi; C. Cudalbu; R. A. de Graaf et al.

Nmr In Biomedicine. 2020-08-17. DOI : 10.1002/nbm.4347.

Detailed record: https://infoscience.epfl.ch/record/279668?ln=en

[44] Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

V. Rackayova; O. Braissant; A.-L. Rougemont; C. Cudalbu; V. A. McLin

Scientific Reports. 2020. DOI : 10.1038/s41598-020-64416-3.

Detailed record: https://infoscience.epfl.ch/record/277495?ln=en
Full text: https://infoscience.epfl.ch/record/277495/files/s41598-020-64416-3.pdf

[45] MP-PCA denoising dramatically improves SNR in large-sized MRS data: an illustration in diffusion-weighted MRS

I. Jelescu; J. Veraart; C. R. Cudalbu

ISMRM 28th Annual Meeting & Exhibition, Paris, France, August 8-13, 2020.

Detailed record: https://infoscience.epfl.ch/record/277018?ln=en
Full text: https://infoscience.epfl.ch/record/277018/files/https_submissions2.mirasmart.com_ISMRM2020_ViewSubmissionPublic.aspx_sei%3DSjjxlmRCQ.pdf

2019

[46] Probiotics Combined With Rifaximin for the Treatment of Chronic Hepatic Encephalopathy: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism Using BDL Rats

E. Flatt; O. Braissant; S. Mitrea; D. Sessa; P. Mastromarino et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S19-S19. DOI : 10.14309/01.ajg.0000582124.67482.93.

Detailed record: https://infoscience.epfl.ch/record/274297?ln=en

[47] Brain Regional Susceptibility to Oxidative Stress in a Rat Model of Chronic Hepatic Encephalopathy: In-Vivo 1H MRS, Ex-Vivo ESR Spectroscopy and Histology Findings

K. Pierzchala; D. Simicic; V. Rackayova; D. Sessa; A. Sienkiewicz et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S33-S36. DOI : 10.14309/01.ajg.0000582248.03815.eb.

Detailed record: https://infoscience.epfl.ch/record/274296?ln=en

[48] Antibiotic Rifaximin for Treatment of Chronic Liver Disease-Induced HE: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism on BDL Rats

E. Flatt; O. Braissant; S. Mitrea; D. Sessa; R. Gruetter et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S18-S19. DOI : 10.14309/01.ajg.0000582120.59858.08.

Detailed record: https://infoscience.epfl.ch/record/274294?ln=en

[49] In Vivo Longitudinal 1H MRS Study of Hippocampal, Cereberal and Striatal Metabolic Changes in the Adult Brain Using an Animal Model of Chronic Hepatic Encephalopathy

D. Simicic; K. Pierzchala; V. Rackayova; O. Braissant; S.-O. Mitrea et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S17-S17. DOI : 10.14309/01.ajg.0000582108.29364.13.

Detailed record: https://infoscience.epfl.ch/record/274295?ln=en

[50] Cholestasis Decreases Dendritic Spine Density in a Rat Hippocampal Organotypic Culture

L. Giovannoni; M. De Roo; O. Braissant; H. Henry; C. Cudalbu et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S37-S38. DOI : 10.14309/01.ajg.0000582272.41932.fe.

Detailed record: https://infoscience.epfl.ch/record/274293?ln=en

[51] Hippocampal and Cerebellar Astrocytes Morphological Alterations in a Rat Model of Chronic Hepatic Encephalopathy

K. Pierzchala; D. Simicic; O. Braissant; V. A. McLin; C. Cudalbu

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S33-S33.

Detailed record: https://infoscience.epfl.ch/record/274292?ln=en

[52] Neurometabolism in Grey Matter of Children With Chronic Liver Disease or Portosystemic Shunting: A 1H-MRS Study at 7T

C. Cudalbu; L. Xin; S. Lachat; N. Valenza; F. Zangas-Gehri et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S31-S32. DOI : 10.14309/01.ajg.0000582224.88567.2a.

Detailed record: https://infoscience.epfl.ch/record/274290?ln=en

[53] Reply to: "Magnetic resonance spectroscopy: A surrogate marker of hepatic encephalopathy?''

V. A. Mclin; O. Braissant; C. Cudalbu

Journal of Hepatology. 2019-11-01. DOI : 10.1016/j.jhep.2019.08.003.

Detailed record: https://infoscience.epfl.ch/record/271622?ln=en

[54] Bile Acids And Ammonium Contribute To Changes In Dendritic Spine Distribution In An Organotypic Culture Of Rat Hippocampus

L. Giovannoni; M. Deroo; O. Braissant; H. Henry; C. R. Cudalbu et al.

2019-10-01. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Boston, MA, Nov 08-12, 2019. p. 471A-472A.

Detailed record: https://infoscience.epfl.ch/record/271553?ln=en

[55] Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

O. Braissant; V. Rackayova; K. Pierzchala; J. Grosse; V. A. McLin et al.

Journal Of Hepatology. 2019-09-01. DOI : 10.1016/j.jhep.2019.05.022.

Detailed record: https://infoscience.epfl.ch/record/269843?ln=en
Full text: https://infoscience.epfl.ch/record/269843/files/1-s2.0-S0168827819303083-main.pdf

[56] Brain Edema in Chronic Hepatic Encephalopathy

C. Cudalbu; S. D. Taylor-Robinson

Journal Of Clinical And Experimental Hepatology. 2019-05-01. DOI : 10.1016/j.jceh.2019.02.003.

Detailed record: https://infoscience.epfl.ch/record/268492?ln=en

[57] Methodological consensus on clinical proton MRS of the brain: Review and recommendations

M. Wilson; O. Andronesi; P. B. Barker; R. Bartha; A. Bizzi et al.

Magnetic Resonance in Medicine. 2019. DOI : 10.1002/mrm.27742.

Detailed record: https://infoscience.epfl.ch/record/265150?ln=en
Full text: https://infoscience.epfl.ch/record/265150/files/Wilson_consensusPaper_MRM_2019.pdf

2018

[58] Metabolic And Transcriptional Profiles Of Gbm Invasion: Comparison Of Patients And Paired Patient Derived Xenografts Using1H Magnetic Resonance Spectroscopy And Imaging (7T And 14T) And Rna-Sequencing

M. Hegi; C. Cudalbu; P. Bady; M. Lai; L. Xin et al.

2018-11-01. 23rd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO) / 3rd CNS Anticancer Drug Discovery and Development Conference, New Orleans, LA, Nov 14-18, 2018. p. 35-35.

Detailed record: https://infoscience.epfl.ch/record/266707?ln=en

[59] Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine

H. A. I. Yoshihara; D. Firsov; C. R. Cudalbu; R. Gruetter

ISMRM 2018, Paris, France, June16-21, 2018.

Detailed record: https://infoscience.epfl.ch/record/279675?ln=en

[60] Brain metabolism during Chronic Hepatic Encephalopathy studied by in vivo 1H and 31P MRS

V. Rackayová

Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8612.

Detailed record: https://infoscience.epfl.ch/record/256956?ln=en
Full text: https://infoscience.epfl.ch/record/256956/files/EPFL_TH8612.pdf

[61] In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

M. Lai; I. Vassallo; B. Lanz; C. Poitry-Yamate; M.-F. Hamou et al.

International Journal of Cancer. 2018. DOI : 10.1002/ijc.31299.

Detailed record: https://infoscience.epfl.ch/record/255355?ln=en
Full text: https://infoscience.epfl.ch/record/255355/files/Lai_Glioma_IntlJCanc_2018.pdf

[62] In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose

M. Lai; B. Lanz; C. Poitry-Yamate; J. F. Romero; C. M. Berset et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2018. DOI : 10.1177/0271678X17734101.

Detailed record: https://infoscience.epfl.ch/record/231906?ln=en
Full text: https://infoscience.epfl.ch/record/231906/files/Lai_13Cmouse_JCBFM_2018.pdf

2017

[63] Editorial for the special issue on introduction to in vivo Magnetic Resonance Spectroscopy (MRS): A method to non-invasively study metabolism

C. Cudalbu; A. J. L. Cooper

Analytical Biochemistry. 2017. DOI : 10.1016/j.ab.2017.05.014.

Detailed record: https://infoscience.epfl.ch/record/229510?ln=en

[64] Metabolic changes in developing brain due to chronic liver disease: an in vivo longitudinal and multiparametric study using P-31-MRS (magnetic resonance spectroscopy), P-31-Magnetization transfer and H-1-MRS

V. Rackayova; V. Mlynarik; C. Cudalbu

2017. 28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET, Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY, APR 01-04, 2017. p. 496-497.

Detailed record: https://infoscience.epfl.ch/record/228760?ln=en

[65] MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models

B. Lanz; V. Rackayova; O. Braissant; C. Cudalbu

Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.021.

Detailed record: https://infoscience.epfl.ch/record/224080?ln=en

[66] Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficiencies

V. Rackayova; C. Cudalbu; P. J. W. Pouwels; O. Braissant

Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.007.

Detailed record: https://infoscience.epfl.ch/record/222972?ln=en

2016

[67] Brain edema: a valid endpoint for measuring hepatic encephalopathy?

C. Bémeur; C. Cudalbu; G. Dam; A. S. Thrane; A. J. L. Cooper et al.

Metabolic brain disease. 2016. DOI : 10.1007/s11011-016-9843-9.

Detailed record: https://infoscience.epfl.ch/record/218756?ln=en

[68] (1)H and (31)P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism

V. Rackayova; O. Braissant; V. A. McLin; C. Berset; B. Lanz et al.

Metabolic brain disease. 2016. DOI : 10.1007/s11011-015-9715-8.

Detailed record: https://infoscience.epfl.ch/record/210870?ln=en

2015

[69] In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T

C. Cudalbu; M. Craveiro; V. Mlynárik; J. Bremer; A. Aguzzi et al.

Neurochemical research. 2015. DOI : 10.1007/s11064-015-1643-9.

Detailed record: https://infoscience.epfl.ch/record/210871?ln=en
Full text: https://infoscience.epfl.ch/record/210871/files/Cudalbu_NChemRes_Prion_2015.pdf

2014

[70] Neurochemical profile differentiation of glioma induced by cancer stem cells expressing WIF1: a 1H-MRS longitudinal study at 14.1T

M. Lai; C. R. Cudalbu; B. Lanz; I. Vassallo; M.-F. Hamou et al.

2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.

Detailed record: https://infoscience.epfl.ch/record/203435?ln=en
Full text: https://infoscience.epfl.ch/record/203435/files/LongitudinalStudy_ISMRMabstract_Final.pdf

[71] In vivo 13C MRS in the mouse brain at 14.1 T and metabolic flux quantification during infusion of [1,6-13C2] Glucose

M. Lai; B. Lanz; C. J. d. C. Romero; C. R. Cudalbu; R. Gruetter

2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.

Detailed record: https://infoscience.epfl.ch/record/203434?ln=en
Full text: https://infoscience.epfl.ch/record/203434/files/13CMRS_abstractISMRM2014.pdf

[72] Optimized MEGA-SPECIAL for in vivo glutamine detection in the rat brain at 14.1 T

M. Craveiro; C. Cudalbu; V. Mlynárik; R. Gruetter

NMR in Biomedicine. 2014. DOI : 10.1002/nbm.3168.

Detailed record: https://infoscience.epfl.ch/record/200499?ln=en
Full text: https://infoscience.epfl.ch/record/200499/files/Craveiro_MEGA_SPECIAL_2014.pdf

[73] Studying glioblastoma progression in a rat model of human glioma initiating cells using 1H MRS and DTI

M. Mishkovsky; C. R. Cudalbu; E. Can; D. Mario; I. Radovanovic et al.

2014. International Society for Magnetic Resonance in Medicine, Milano, Italy, 2014.

Detailed record: https://infoscience.epfl.ch/record/198965?ln=en

[74] Clinical Proton MR Spectroscopy in Central Nervous System Disorders

G. Öz; J. R. Alger; P. B. Barker; R. Bartha; A. Bizzi et al.

Radiology. 2014. DOI : 10.1148/radiol.13130531.

Detailed record: https://infoscience.epfl.ch/record/197156?ln=en
Full text: https://infoscience.epfl.ch/record/197156/files

[75] In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T

M. Craveiro; V. Clément-Schatlo; D. Marino; R. Gruetter; C. Cudalbu

Journal of Neurochemistry. 2014. DOI : 10.1111/jnc.12673.

Detailed record: https://infoscience.epfl.ch/record/196648?ln=en
Full text: https://infoscience.epfl.ch/record/196648/files/MC_MM_JNeurochem_2014.pdf

2013

[76] Differences in CNS metabolism between pups and adults in an animal model of biliary cirrhosis: longitudinal, non-invasive in vivo study

C. Cudalbu; O. Braissant; V. A. Mclin

2013. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases. p. 803A-803A.

Detailed record: https://infoscience.epfl.ch/record/199195?ln=en

[77] In vivo brain energy metabolism in a rat model of chronic Hepatic Encephalopathy using 31P MRS

C. Cudalbu; O. Braissant; A. Jayaswal; R. Gruetter; V. A. Mclin

2013. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases', u'64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases'. p. 393A-393A.

Detailed record: https://infoscience.epfl.ch/record/199194?ln=en

[78] In vivo brain energy metabolism in a rat model of chronic Hepatic Encephalopathy using 31P MRS

C. Cudalbu; O. Braissant; A. Jayaswal; R. Gruetter; V. A. McLin

2013. The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013, Washington, DC, November 1 - 5, 2013. p. 379.

Detailed record: https://infoscience.epfl.ch/record/189926?ln=en

[79] Differences in CNS metabolism between pups and adults in an animal model of biliary cirrhosis: longitudinal, non-invasive in vivo study

C. Cudalbu; O. Braissant; V. A. Mclin

2013. The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013, Washington, DC, November 1 - 5, 2013. p. 1219.

Detailed record: https://infoscience.epfl.ch/record/189925?ln=en

[80] The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts

C. Cudalbu; V. A. Mclin; H. Lei; J. M. N. Duarte; A.-L. Rougemont et al.

PLoS ONE. 2013. DOI : 10.1371/journal.pone.0069782.

Detailed record: https://infoscience.epfl.ch/record/187954?ln=en
Full text: https://infoscience.epfl.ch/record/187954/files/cudalbu_C57%202013.pdf

[81] Brain metabolism in rat model of human glioma initiating cells

M. Mishkovsky; C. R. Cudalbu; A. Comment; D. Mario; I. Radovanovic et al.

2013. International Society for Magnetic Resonance in Medicine, Salt Lake City, USA, April 2013.

Detailed record: https://infoscience.epfl.ch/record/187399?ln=en

[82] The C57BL/6 mouse exhibits sporadic congenital portosystemic shunts

C. R. Cudalbu; V. McLin; H. Lei; J. das Neves Duarte; A.-L. Rougemont et al.

ISMRM.

Detailed record: https://infoscience.epfl.ch/record/186417?ln=en
Full text: https://infoscience.epfl.ch/record/186417/files/The%20C57BL6%20mouse%20exhibits%20sporadic%20congenital%20portosystemic%20shunts_0111.pdf

[83] In vivo and longitudinal assessment of brain metabolism in Hepatic Encephalopathy using 1H MRS

C. R. Cudalbu; V. McLin; O. Braissant; R. Gruetter

ISMRM.

Detailed record: https://infoscience.epfl.ch/record/186416?ln=en
Full text: https://infoscience.epfl.ch/record/186416/files/In%20vivo%20and%20longitudinal%20assessment%20of%20brain%20metabolism%20in%20Hepatic%20Encephalopathy%20using%201H%20MRS_3993.pdf

[84] Hepatic encephalopathy and brain metabolism: a longitudinal in vivo study

C. Cudalbu; V. McLin; O. Braissant

2013. 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Cancun, MEXICO, APR 20-24, 2013. p. 178-179.

Detailed record: https://infoscience.epfl.ch/record/186361?ln=en

[85] The C57BL/6 mouse exhibits sporadic congenital portosystemic shunts

C. Cudalbu; V. McLin; H. Lei; J. Duarte; A. Rougemont et al.

2013. 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Cancun, MEXICO, APR 20-24, 2013. p. 107-108.

Detailed record: https://infoscience.epfl.ch/record/186351?ln=en

[86] In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using (1)H Magnetic Resonance Spectroscopy

C. Cudalbu

Metabolic brain disease. 2013. DOI : 10.1007/s11011-012-9368-9.

Detailed record: https://infoscience.epfl.ch/record/186170?ln=en
Full text: https://infoscience.epfl.ch/record/186170/files/11011_2012_Article_9368.pdf

[87] Ammonia toxicity to the brain

O. Braissant; V. A. McLin; C. Cudalbu

Journal of inherited metabolic disease. 2013. DOI : 10.1007/s10545-012-9546-2.

Detailed record: https://infoscience.epfl.ch/record/186169?ln=en

[88] Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

L. Xin; G. Gambarota; C. Cudalbu; V. Mlynárik; R. Gruetter

Magma (New York, N.Y.). 2013. DOI : 10.1007/s10334-013-0378-3.

Detailed record: https://infoscience.epfl.ch/record/186164?ln=en
Full text: https://infoscience.epfl.ch/record/186164/files/Xin_Magma_14T_T2_2013.pdf

[89] Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T

B. Schaller; L. Xin; C. Cudalbu; R. Gruetter

NMR in biomedicine. 2013. DOI : 10.1002/nbm.2896.

Detailed record: https://infoscience.epfl.ch/record/183890?ln=en
Full text: https://infoscience.epfl.ch/record/183890/files/Schaller_MM3T_NBM_2013.pdf

[90] Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES

B. Lanz; J. M. N. Duarte; N. Kunz; V. Mlynárik; R. Gruetter et al.

Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2013. DOI : 10.1002/mrm.24406.

Detailed record: https://infoscience.epfl.ch/record/180912?ln=en
Full text: https://infoscience.epfl.ch/record/180912/files/Lanz_Amares_2013.pdf

2012

[91] In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failure

C. R. Cudalbu; V. McLin; O. Braissant; N. Kunz; Y. Van de Looij et al.

ISMRM 20th Annual Scientific Meeting, 5-11 May 2012, Melbourne, Australia.

Detailed record: https://infoscience.epfl.ch/record/186419?ln=en

[92] Brain osmolytes and brain edema in a rat model of chronic liver failure: in vivo longitudinal 1H Spectroscopic imaging and Diffusion tensor imaging studies at 9.4T

C. R. Cudalbu; O. Braissant; M. Lepore; R. Gruetter; V. McLin

The 15th International Society of Hepatic Encephalopathy and Nitrogen Metabolism, Symposium May 29 - June 2, 2012, Denmark.

Detailed record: https://infoscience.epfl.ch/record/186418?ln=en

[93] Handling macromolecule signals in the quantification of the neurochemical profile

C. Cudalbu; V. Mlynárik; R. Gruetter

Journal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-120100.

Detailed record: https://infoscience.epfl.ch/record/181513?ln=en
Full text: https://infoscience.epfl.ch/record/181513/files/Cudalbu_MM_JAD.pdf

[94] Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease

V. Mlynárik; M. Cacquevel; L. Sun-Reimer; S. Janssens; C. Cudalbu et al.

Journal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-112072.

Detailed record: https://infoscience.epfl.ch/record/181512?ln=en
Full text: https://infoscience.epfl.ch/record/181512/files/Mlynarik_JAD.pdf

[95] Phosphorus MRS Study of a Murine Model of Peripheral Arterial Disease

V. Mlynárik; M. Pellegrin; C. R. Cudalbu; L. Mazzolai; R. Gruetter

2012. ISMRM 20th Annual Scientific Meeting, Melbourne, Australia, 5-11 May 2012.

Detailed record: https://infoscience.epfl.ch/record/178177?ln=en

[96] In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failure

C. R. Cudalbu; V. McLin; O. Braissant; N. Kunz; Y. van de Looij et al.

2012. ISMRM 20th Annual Scientific Meeting, Melbourne, Australia, 5-11 May 2012.

Detailed record: https://infoscience.epfl.ch/record/177993?ln=en
Full text: https://infoscience.epfl.ch/record/177993/files/CLD_ISMRM2012.pdf

[97] Assessment Of Cerebral Osmotic Regulation In A Rat Model Of Biliary Cirrhosis Using MR Spectroscopy

V. A. McLin; O. Braissant; Y. van de Looij; N. Kunz; R. Gruetter et al.

2012. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona, SPAIN, Apr 18-22, 2012. p. S231-S232.

Detailed record: https://infoscience.epfl.ch/record/177240?ln=en

[98] Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy

C. R. Cudalbu; B. Lanz; J. M. N. Duarte; F. D. Morgenthaler; Y. Pilloud et al.

Journal Of Cerebral Blood Flow And Metabolism. 2012. DOI : 10.1038/jcbfm.2011.173.

Detailed record: https://infoscience.epfl.ch/record/176834?ln=en

[99] In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla

V. Mlynarik; C. R. Cudalbu; V. Clement; D. Marino; I. Radovanovic et al.

Nmr In Biomedicine. 2012. DOI : 10.1002/nbm.1763.

Detailed record: https://infoscience.epfl.ch/record/176445?ln=en

2011

[100] In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla

V. Clement-Schatlo; V. Mlynarik; C. Cudalbu; D. Marino; I. Radovanovic et al.

2011. p. S15-S15.

Detailed record: https://infoscience.epfl.ch/record/186253?ln=en

[101] In vivo longitudinal 1H MRS study of transgenic mouse models of prion disease in the hippocampus and cerebellum at 14.1T

C. R. Cudalbu; M. Craveiro; V. Mlynárik; J. Bremer; A. Aguzzi et al.

2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.

Detailed record: https://infoscience.epfl.ch/record/177997?ln=en
Full text: https://infoscience.epfl.ch/record/177997/files/696_final%20abstract_prion_cudalbu.pdf

[102] In vivo localized 15N MRS detection of hyperpolarized 15N labeled choline in the rat brain

C. R. Cudalbu; A. Comment; T. Cheng; M. Mishkovsky; R. Gruetter

2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.

Detailed record: https://infoscience.epfl.ch/record/177996?ln=en
Full text: https://infoscience.epfl.ch/record/177996/files/Cudalbu_choline_ISMRM2011.pdf

[103] Impact of the prior knowledge on the quantification of in vivo 13C spectra using two different algorithms: LCModel and AMARES

C. R. Cudalbu; B. Lanz; J. M. Duarte; N. Kunz; R. Gruetter

2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.

Detailed record: https://infoscience.epfl.ch/record/177995?ln=en
Full text: https://infoscience.epfl.ch/record/177995/files/Cudalbu_ISMRM-2011_1388.pdf

[104] Imaging the in vivo effect of hyperammonemia in the rat brain: a Spectroscopic Imaging and Diffusion Tensor Imaging study

C. R. Cudalbu; N. Kunz; B. Lanz; Y. van de Looij; V. Mlynárik et al.

2011. BRAIN’11 & BRAINPET’11, Barcelona, Spain, 24-28 May 2011.

Detailed record: https://infoscience.epfl.ch/record/177994?ln=en
Full text: https://infoscience.epfl.ch/record/177994/files/Cudalbu_Brain2011.pdf

[105] Effect of manganese chloride on the neurochemical profile of the rat hypothalamus

N. Just; C. R. Cudalbu; H. Lei; R. Gruetter

Journal of Cerebral Blood Flow and Metabolism. 2011. DOI : 10.1038/jcbfm.2011.92.

Detailed record: https://infoscience.epfl.ch/record/177439?ln=en
Full text: https://infoscience.epfl.ch/record/177439/files/Just_Mn_JCBFM_2011.pdf

[106] Assessing The Importance Of An Astrocyte Specific Anaplerotic Enzyme In The Central Nervous System Of Rat

S. Lengacher; C. R. Cudalbu; N. Aznavour; R. Gruetter; P. Magistretti

2011. 10th European Meeting on Glial Cells in Health and Disease, Prague, CZECH REPUBLIC, Sep 13-17, 2011. p. S109-S110.

Detailed record: https://infoscience.epfl.ch/record/171014?ln=en

2010

[107] Investigation of spatial distribution of metabolites in rat brain at elevated plasma glucose levels

V. Mlynarik; C. R. Cudalbu; H. Frenkel; N. Costers; R. Gruetter

2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.

Detailed record: https://infoscience.epfl.ch/record/178176?ln=en

[108] Localized 31P saturation transfer in rat brain

V. Mlynarik; C. R. Cudalbu; Y. Pilloud; R. Gruetter

2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.

Detailed record: https://infoscience.epfl.ch/record/178174?ln=en

[109] In vivo simultaneous measurement of glutamine synthetase and glutamate dehydrogenase activity in the hyperammonemic rat brain using localized 1H and 15N MRS

C. R. Cudalbu; B. Lanz; P. R. Vasos; Y. Pilloud; V. Mlynárik et al.

2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.

Detailed record: https://infoscience.epfl.ch/record/178001?ln=en
Full text: https://infoscience.epfl.ch/record/178001/files/radC6175_15N.pdf

[110] Imaging glutamine synthesis rates in the hyperammonemic rat brain

C. R. Cudalbu; V. Mlynárik; B. Lanz; H. Frenkel; N. Costers et al.

2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.

Detailed record: https://infoscience.epfl.ch/record/177999?ln=en
Full text: https://infoscience.epfl.ch/record/177999/files/radC3AE9_csi_ammonia.pdf

[111] In vivo Magnetic Resonance Spectroscopy (MRS) studies of brain metabolism during ammonia infusion

C. R. Cudalbu; B. Lanz; H. Frenkel; V. Mlynárik; R. Gruetter

2010. 9th International Conference on Brain Energy Metabolism, Budapest, 7-10 July 2010.

Detailed record: https://infoscience.epfl.ch/record/177998?ln=en
Full text: https://infoscience.epfl.ch/record/177998/files/Cudalbu_abstract.pdf

[112] Marker-independent identification of glioma-initiating cells

V. Clement; D. Marino; C. R. Cudalbu; M.-F. Hamou; V. Mlynarik et al.

Nature Methods. 2010. DOI : 10.1038/NMETH.1430.

Detailed record: https://infoscience.epfl.ch/record/172836?ln=en
Full text: https://infoscience.epfl.ch/record/172836/files/Nature%20Methods%202010.pdf

[113] Diffusion-Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances in Short-Echo Time H-1-MRS

N. Kunz; C. R. Cudalbu; V. Mlynarik; P. S. Hueppi; S. V. Sizonenko et al.

Magnetic Resonance In Medicine. 2010. DOI : 10.1002/mrm.22490.

Detailed record: https://infoscience.epfl.ch/record/172318?ln=en
Full text: https://infoscience.epfl.ch/record/172318/files/Kunz_DW_MM.pdf

[114] Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats

C. R. Cudalbu; A. Comment; F. Kurdzesau; R. van Heeswijk; K. Uffmann et al.

Physical Chemistry Chemical Physics. 2010. DOI : 10.1039/c002309b.

Detailed record: https://infoscience.epfl.ch/record/166970?ln=en
Full text: https://infoscience.epfl.ch/record/166970/files/cudalbu_15N_DNP.pdf

2009

[115] Proton MRS investigation of human glioma models in nude mice at 14.1 T

V. Mlynarik; C. R. Cudalbu; V. Clément; D. Marino; I. Radovanovic et al.

2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.

Detailed record: https://infoscience.epfl.ch/record/178173?ln=en
Full text: https://infoscience.epfl.ch/record/178173/files/Mlyn_1969gliomas.pdf

[116] Mapping glucose and lactate concentrations with microliter resolution in rat brain using short-echo-time spectroscopic imaging

V. Mlynarik; C. R. Cudalbu; H. Frenkel; R. Gruetter

2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.

Detailed record: https://infoscience.epfl.ch/record/178172?ln=en
Full text: https://infoscience.epfl.ch/record/178172/files/Mlyn_1962CSI.pdf

[117] Simultaneous Localized in vivo 1H and 15N MRS of Glutamine Synthesis in the hyperammonaemic rat brain

C. R. Cudalbu; B. Lanz; F. D. Morgenthaler; Y. Pilloud; V. Mlynárik et al.

2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April.

Detailed record: https://infoscience.epfl.ch/record/178164?ln=en
Full text: https://infoscience.epfl.ch/record/178164/files/15N_ammonia_cudalbu.pdf

[118] Short-echo-time 1H MRS of the mouse lacking prion protein (Prnp-/-) at 14.1T

C. R. Cudalbu; V. Mlynárik; J. Bremer; A. Aguzzi; R. Gruetter

2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.

Detailed record: https://infoscience.epfl.ch/record/178163?ln=en
Full text: https://infoscience.epfl.ch/record/178163/files/prion%20abstract_ISMRM2009.pdf

[119] In vivo localized 15N and 1H MRS in the hyperammonaemic rat brain at 9.4T

C. R. Cudalbu; B. Lanz; F. Morgenthaler; Y. Pilloud; V. Mlynarik et al.

2009. ESMRMB, Antalya, TR, October 1-3.

Detailed record: https://infoscience.epfl.ch/record/178161?ln=en
Full text: https://infoscience.epfl.ch/record/178161/files/ESMRMB2009-115%5B1%5D_eposter.pdf

[120] MEASUREMENT OF GLUTAMINE SYNTHESIS RATE IN THE HYPERAMMONAEMIC RAT BRAIN USING IN VIVO 1H AND 15N MRS

C. R. Cudalbu; B. Lanz; F. Morgenthaler; V. Mlynárik; R. Gruetter

2009. INTERNATIONAL SYMPOSIUM ON HEPATIC ENCEPHALOPATHY, Valencia, Spain, September 17-19.

Detailed record: https://infoscience.epfl.ch/record/178160?ln=en
Full text: https://infoscience.epfl.ch/record/178160/files/HE_cudalbu.pdf

[121] Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

R. van Heeswijk; K. Uffmann; A. Comment; F. Kurdzesau; C. Perazzolo et al.

Magnetic Resonance In Medicine. 2009. DOI : 10.1002/mrm.21952.

Detailed record: https://infoscience.epfl.ch/record/159787?ln=en
Full text: https://infoscience.epfl.ch/record/159787/files/6Li.pdf

[122] Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum

C. R. Cudalbu; V. Mlynarik; L. Xin; R. Gruetter

Measurement Science & Technology. 2009. DOI : 10.1088/0957-0233/20/10/104034.

Detailed record: https://infoscience.epfl.ch/record/159432?ln=en
Full text: https://infoscience.epfl.ch/record/159432/files/cudalbu_measscitechn_2009.pdf

[123] Comparison of T-1 Relaxation Times of the Neurochemical Profile in Rat Brain at 9.4 Tesla and 14.1 Tesla

C. R. Cudalbu; V. Mlynarik; L. Xin; R. Gruetter

Magnetic Resonance In Medicine. 2009. DOI : 10.1002/mrm.22022.

Detailed record: https://infoscience.epfl.ch/record/159323?ln=en
Full text: https://infoscience.epfl.ch/record/159323/files/cudalbu_T1.pdf

[124] Glutamine synthesis rate in the hyperammonaemic rat brain using simultaneous localized in vivo H-1 and N-15 MRS

C. R. Cudalbu; B. Lanz; F. Morgenthaler; Y. Pilloud; V. Mlynarik et al.

2009. 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, Jun 29-Jul 03, 2009. p. S609-S610.

Detailed record: https://infoscience.epfl.ch/record/159181?ln=en
Full text: https://infoscience.epfl.ch/record/159181/files/cudalbu_brain%26brainpet2009.pdf

2008

[125] In Vivo Detection of Hyperpolarized 15N Choline in the Rat

C. R. Cudalbu; A. Comment; K. Uffmann; R. van Heeswijk; C. Perazzolo et al.

2008. 16th Annual ISMRM Meeting, Toronto, May 2008.

Detailed record: https://infoscience.epfl.ch/record/178170?ln=en
Full text: https://infoscience.epfl.ch/record/178170/files/In%20vivo%20detection%20of%20hyperpolarized%2015N%20Choline%20in%20the%20rat_ISMRM2008_Cudalbu_3195.pdf

[126] Improved Spectral Dispersion in Proton MR Spectroscopy of the Neurochemical Profile in the Rat Brain at 14.1 Tesla

V. Mlynárik; C. R. Cudalbu; L. Xin; R. Gruetter

2008. 16th Annual ISMRM Meeting, Toronto, May 2008.

Detailed record: https://infoscience.epfl.ch/record/178169?ln=en
Full text: https://infoscience.epfl.ch/record/178169/files/1461_14T.pdf

[127] Comparison of Two Approaches to Model the Macromolecule Spectrum for the Quantification of Short TE 1H MRS Spectra at 14.1T

C. R. Cudalbu; V. Mlynárik; L. Xin; R. Gruetter

2008. 16th Annual ISMRM Meeting, Toronto, May 2008.

Detailed record: https://infoscience.epfl.ch/record/178168?ln=en
Full text: https://infoscience.epfl.ch/record/178168/files/Comparison%20of%20two%20approaches%20to%20model%20the%20macromolecule%20spectrum%20for%20the%20quantification%20of%20short%20TE%201H%20MRS%20spectra%20at%2014T_Cudalbu_ismrm08_3174.pdf

[128] 1H NMR T1 Relaxation Times of the Neurochemical Profiles in Rat Brain at 14.1T

C. R. Cudalbu; V. Mlynárik; L. Xin; R. Gruetter

2008. 16th Annual ISMRM Meeting, Toronto, May 2008.

Detailed record: https://infoscience.epfl.ch/record/178167?ln=en
Full text: https://infoscience.epfl.ch/record/178167/files/1H%20NMR%20T1%20relaxation%20times%20of%20the%20neurochemical%20profiles%20in%20rat%20brain%20at%2014.1T_cudalbu_ismrm08_1594.pdf

[129] Comparison of the T1 of the neurochemical profile in rat brain at 9.4T and 14.1T

C. R. Cudalbu; V. Mlynárik; L. Xin; R. Gruetter

2008. 25th Annual Scientific Meeting of ESMRMB, Valencia, Spain, 2008.

Detailed record: https://infoscience.epfl.ch/record/178166?ln=en
Full text: https://infoscience.epfl.ch/record/178166/files/SubmitPrinterFriendlyVers_T1_emsrmb2008.pdf

[130] MRS study of human glioma-initiating cells grown in the brain of nude Mice

V. Mlynarik; C. R. Cudalbu; V. Clément; I. Radovanovic; R. Gruetter

2008. 25th Annual Scientific Meeting of ESMRMB, Valencia, Spain.

Detailed record: https://infoscience.epfl.ch/record/178165?ln=en
Full text: https://infoscience.epfl.ch/record/178165/files/SubmitPrinterFriendlyVers_glioma%20esmrmb%202008.pdf

[131] Hahn T2 Relaxation Times of the Neurochemical Profile at 14.1T in the in vivo Rat Brain

L. Xin; G. Gambarota; C. R. Cudalbu; V. Mlynarik; R. Gruetter

2008. ISMRM 16th Scientific Meeting & Exhibition, Toronto, Ontario, Canada, May 3-9, 2008.

Detailed record: https://infoscience.epfl.ch/record/177663?ln=en
Full text: https://infoscience.epfl.ch/record/177663/files/00694.pdf

[132] H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile

V. Mlynarik; C. R. Cudalbu; L. Xin; R. Gruetter

Journal Of Magnetic Resonance. 2008. DOI : 10.1016/j.jmr.2008.06.019.

Detailed record: https://infoscience.epfl.ch/record/160558?ln=en
Full text: https://infoscience.epfl.ch/record/160558/files/14T_MRS.pdf

[133] Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE H-1 MRS spectra

C. R. Cudalbu; V. Mlynarik; L. Xin; R. Gruetter

2008. IEEE International Workshop on Imaging Systems and Techniques, Chania, GREECE, Sep 10-12, 2008. p. 309-312. DOI : 10.1109/IST.2008.4659991.

Detailed record: https://infoscience.epfl.ch/record/160247?ln=en

2007

[134] MR study of a mouse model of implanted human glioma cells at 14.1T

C. R. Cudalbu; V. Mlynárik; V. Clement; I. Radovanovic; R. Gruetter

2007. Changins “Neuroscience” meeting, Switzerland, 21 November 2007.

Detailed record: https://infoscience.epfl.ch/record/178171?ln=en

Enseignement & Phd

Enseignement

Physics

Doctorants

Alves Brayan,

A dirigé les thèses EPFL de

Mosso Jessie Julie , Rackayová Veronika , Simicic Dunja ,

Cours

MRI Practicals on CIBM preclinical imaging systems

L'objectif de ce cours est d'enseigner aux étudiants comment réaliser des expériences d'IRM et de MRS (SRM) de base in-vivo et ex-vivo directement sur des systèmes d'IRM précliniques horizontaux à ultra-haut champ.

Cristina Ramona Cudalbu

Parcours professionnel

Formation

Publications

Publications Infoscience

Infoscience

2024

[1] Rescue of myocytes and locomotion through AAV2/9-2YF intracisternal gene therapy in a rat model of creatine transporter deficiency

[2] Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

[3] Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

2023

[4] Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field

[5] New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual <SUP>18</SUP>F-FDG PET and 9.4T <SUP>1</SUP>H MRS Preclinical Study

[6] Automated segmentation and labeling of subcutaneous mouse implants at 14.1T

[7] Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset

[8] Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling

[9] Evaluation of a Hydroxamate-Based Urease Inhibitor in a Rodent Model of Hepatic Encephalopathy

[10] Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy

[11] Age Dependence of Neurometabolic Changes in a Rat Pup Model of Type C Hepatic Encephalopathy

[12] The Beneficial Effect of Oral Cr Supplementation in an Early Childhood Rat Model of Chronic Hepatic Encephalopathy: <i>In Vivo</i> Longitudinal <SUP>1</SUP>H and <SUP>31</SUP>P Magnetic Resonance Spectroscopy Study

[13] New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

[14] Lessons on brain edema in HE: from cellular to animal models and clinical studies

[15] Editorial for the special issue on Brain Biochemistry in Liver Disease

[16] High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study

[17] Central Nervous System Oxidative Stress interplay with inflammation in a rat model of Type C Hepatic Encephalopathy - brothers in arms?

[18] Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

[19] Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations

2022

[20] Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy (vol 178, pg 295, 2022)

[21] MP-PCA denoising for diffusion MRS data: promises and pitfalls

[22] Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

[23] Central Nervous System Oxidative Stress Interplay With Inflammation In A Rat Model Of Type C Hepatic Encephalopathy - Brothers In Arms?

[24] Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy

[25] Abnormal brain oxygen homeostasis in an animal model of liver disease

[26] PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

[27] Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats

[28] Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy

[29] Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy

2021

[30] Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE

[31] Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

[32] Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

[33] Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

[34] In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times

[35] The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery

[36] 2021 ISHEN guidelines on animal models of hepatic encephalopathy

[37] Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations

[38] A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism

[39] Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy

2020

[40] Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

[41] Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

[42] B(0)shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

[43] Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations

[44] Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

[45] MP-PCA denoising dramatically improves SNR in large-sized MRS data: an illustration in diffusion-weighted MRS

2019

[46] Probiotics Combined With Rifaximin for the Treatment of Chronic Hepatic Encephalopathy: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism Using BDL Rats

[47] Brain Regional Susceptibility to Oxidative Stress in a Rat Model of Chronic Hepatic Encephalopathy: In-Vivo 1H MRS, Ex-Vivo ESR Spectroscopy and Histology Findings

[48] Antibiotic Rifaximin for Treatment of Chronic Liver Disease-Induced HE: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism on BDL Rats

[49] In Vivo Longitudinal 1H MRS Study of Hippocampal, Cereberal and Striatal Metabolic Changes in the Adult Brain Using an Animal Model of Chronic Hepatic Encephalopathy

[50] Cholestasis Decreases Dendritic Spine Density in a Rat Hippocampal Organotypic Culture

[51] Hippocampal and Cerebellar Astrocytes Morphological Alterations in a Rat Model of Chronic Hepatic Encephalopathy

[52] Neurometabolism in Grey Matter of Children With Chronic Liver Disease or Portosystemic Shunting: A 1H-MRS Study at 7T

[53] Reply to: "Magnetic resonance spectroscopy: A surrogate marker of hepatic encephalopathy?''

[54] Bile Acids And Ammonium Contribute To Changes In Dendritic Spine Distribution In An Organotypic Culture Of Rat Hippocampus

[55] Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

[56] Brain Edema in Chronic Hepatic Encephalopathy

[57] Methodological consensus on clinical proton MRS of the brain: Review and recommendations

2018

[58] Metabolic And Transcriptional Profiles Of Gbm Invasion: Comparison Of Patients And Paired Patient Derived Xenografts Using1H Magnetic Resonance Spectroscopy And Imaging (7T And 14T) And Rna-Sequencing

[59] Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine

[60] Brain metabolism during Chronic Hepatic Encephalopathy studied by in vivo 1H and 31P MRS

[61] In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

[62] In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose

2017

[63] Editorial for the special issue on introduction to in vivo Magnetic Resonance Spectroscopy (MRS): A method to non-invasively study metabolism

[64] Metabolic changes in developing brain due to chronic liver disease: an in vivo longitudinal and multiparametric study using P-31-MRS (magnetic resonance spectroscopy), P-31-Magnetization transfer and H-1-MRS

[65] MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models

[66] Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficiencies