Cristina Ramona Cudalbu

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Position
Managing Director of 9.4T MRI Animal imaging and technology core - CIBM http://www.cibm.ch/9-Tesla

EPFL ENT-R CIBM-AIT
CH F0 628 (Bâtiment CH)
Station 6
CH-1015 Lausanne

Données administratives

Publications

Enseignement & Phd

Enseignement

Programmes doctoraux

  • Doctoral Program in Physics

Doctorants

Teaching

- Regular teaching during the Doctoral course “Advanced biomedical imaging methods and instrumentation”, EPFL, Lausanne (2009-2016) - “Cause or effect of Hepatic Encephalopathy”, 17th International Society for Hepatic Encephalopathy and Nitrogen Metabolism Symposium, 2017 - “Challenges for push-button processing and quantification of MR spectra”, ESMRMB 2016 Meeting in Viena -“In vivo and ex vivo edema measurements in Hepatic Encephalopathy”, 16th International Society for Hepatic Encephalopathy and Nitrogen Metabolism Symposium, 2014 -“MRS of Rodents at Ultra-High Fields” within “MR Spectroscopy & Spectroscopic Imaging–sunrise course”, held at the ISMRM 2012 Meeting in Melbourne, Australia, 5-11 May, 2012. - “Metabolite quantification” within “Potentials and challenges of high-field MRS –sunrise course”, held at the ISMRM-ESMRMB 2009 Meeting in Stockholm, Sweden, 1-7 May, 2010. - “Magnetic Resonance Imaging and Spectroscopy: application to animal models of Hepatic Encephalopathy”, held during “Alternative models and classical approaches in animal experimentation”, 5th of June 2012, CHUV, Lausanne - “Bioimaging“ held during the course“ Bioimaging and Lab animal science: Importance of hygiene, anesthesia and stress” 25th of April 2012, CHUV, Lausanne - “Image à résonance magnétique nucléaire et son application en expérimentation animale “ held during « Cours d’Introduction à l’Expérimentation Animale (Module 1) » 19 March 2010, Lausanne. PhD § Master students: - PhD thesis: “Development and implementation of 1H magnetic resonance techniques for an improved in vivo assessment of cerebral metabolic disorders”, Melanie Craveiro, EPFL, 2009-2013 – - Master Thesis of André Rocha Morais, Universidade Nova de Lisboa, Portugal, 2013 - Master Thesis: Treatments in Chronic Hepatic Encephalopathy: an in vivo and longitudinal MRS study on a rat model of Biliary Cirrhosis,Ana da Silva Santos, University of Coimbra, Portugal, 2013 - Master Thesis: “Brain metabolism and brain edema in a rat model of chronic liver disease: in vivo longitudinal 1H MRS, 31P MRS, Water mapping and Diffusion Tensor Imaging studies at 9.4T”, Arjun Jayaswal - Imperial College, London, UK, EPFL, 2012-2013 -Master Thesis: “Brain metabolism and brain edema in chronic liver failure during brain development measured using 1H Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging”, Hend Koubaji, EPFL, 2012-2013. - Master Thesis: “MR Imaging and MR Spectroscopy in preclinical models of Parkinson disease: application to the Haloperidol model”, Eleanor Berry - Imperial College, London, UK, EPFL, 2010-2011 winner of "The Gloucester Research Prize for Academic Excellence in Physics", 2010-2011 - Master Thesis: “Creatine kinase reaction rates in rat brain measured by localized phosphorus saturation transfer spectroscopy”. project 2010 EPFL: Sharon Janssens - University of Ghent - Master Thesis: "Short-echo-time 1H MRS of ischemic evolution in mice lacking PPAR beta at 14.1T". Melanie Craveiro, EPFL, 2009 - TP IV Project: « Diffusion Weighted Spectrosopy of brain glutamine ». Heiva Le Blay, EPFL 2016 - TP-IV Project: "Methodological aspects of 15N-1H-NMR in vitro and in vivo". Melanie Craveiro, EPFL, 2008 - TP-IV Project: "Short-echo-time 1H MRS of mice lacking PPAR beta at 14.1T". Melanie Craveiro, EPFL, 2008

Recherche

Current work

- In vivo studies of brain metabolism and edema in Hepatic Encephalopathy
- Hepatic Encephalopathy due to acute liver failure, chronic liver disease and hyperammonemia
- Chronic hepatic encephalopathy during brain development
- Animal models of Hepatic Encephalopathy and neuroprotection strategies
- Brain metabolites and macromlecules quantification
- Brain tumors
- In vivo proton, carbon and nitrogen MR Spectroscopy in small animals

Grants

2013-2017: Co-applicant in FP7-PEOPLE Marie Curie Initial Training Network project (Transforming Magnetic Resonance Spectroscopy into a Clinical Tool (TRANSACT))

2014: PI for the Industrial grant VSL Pharmaceuticals Inc.

2014-2016: Co-applicant in the Swiss Bridge Foundation application "Towards patient-specific treatments in glioblastoma: Comparison and validation of high-resolution imaging and molecular profiles of human glioblastoma and respective paired orthotopic xenografts in the mouse" (PI Andreas Hottinger)

2017-2018: Co-applicant in the Swiss Cancer League application “Characterizing invasiveness of patient derived brain tumor transplants in mice by gene expression profiling in association with metabolite profiles obtained by magnetic resonance spectroscopy (MRS). A pilot project”, (PI Monika Hegi)

2017-2021: Swiss National Science Foundation; grants n° 310030_173222/1 to Cudalbu&Braissant&McLin. “Translational Non-Invasive Metabolic Studies towards Novel Treatments of Chronic Hepatic Encephalopathy in Developing Brain, from 3D Organotypic Brain Cell Cultures to the In vivo Rat and Human Brain.”

2017-2021: Swiss National Science Foundation; grants n° 31003A-175778/1 to Braissant&Cudalbu. “Cerebral creatine deficiency syndromes: New in vivo AAV approaches to treat SLC6A8 deficiency.”