Cristina Ramona Cudalbu

CH F0 628 (Bâtiment CH)
Station 6
CH-1015 Lausanne

Administrative data

Fields of expertise

  •  In vivo proton, phosphorus, carbon and nitrogen MR Spectroscopy 
  • Chronic  Hepatic Encephalopathy, Hyperammonemia
  • Brain metabolites quantification and macromolecules
  • In vivo proton Spectroscopic Imaging 
  • Magnetic Resonance Imaging, Diffusion Weighted Imaging 
  •  Brain tumors 
  • Dynamic nuclear polarization 




Just N, Cudalbu C, Lei H, Gruetter R.
J Cereb Blood Flow Metab. 2011 Dec;31(12):2324-33.
Effect of manganese chloride on the neurochemical profile of the rat hypothalamus.
Xin L, Gambarota G, Cudalbu C, Mlyn�rik V, Gruetter R.
MAGMA. 2013 Dec;26(6):549-54.
Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.
H. Rabeson, H. Ratiney, F. Fauvelle, C. Cudalbu, S. Cavassila, A. Bernard, P. Giraudon, D. van Ormondt, D. Graveron-Demilly.
Journal of Optoelectronics and Advanced Materials, 2007, 9 (3): 505-511.
Quantitation for in vivo and ex vivo NMR Spectroscopy
RB. van Heeswijk, K Uffmann, A Comment, F Kurdzesau, C Perazzolo, C Cudalbu, S Jannin, JA. Konter, P Hautle, B van den Brandt, G Navon, JJ. van der Klink and R Gruetter.
Magn Reson Med. 2009 Jun;61(6):1489-93
Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents
Schaller B, Xin L, Cudalbu C, Gruetter R.
NMR Biomed. 2013 May;26(5):593-9.
Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T.
V Mlynarik, C Cudalbu, L Xin, R Gruetter.
J Magn Reson. 2008 Oct;194(2):163-8
1H NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile
Vladim�r Mlyn�rik, Cristina Cudalbu, Virginie Cl�ment, Denis Marino, Ivan Radovanovic, Rolf Gruetter
NMR Biomed. 2012 Apr;25(4):506-13.
In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla
C Cudalbu, V. Mlyn�rik, R. Gruetter
J Alzheimers Dis. 2012;31 Suppl 3:S101-15. Review.
Handling macromolecule signals in the quantification of the neurochemical profile
Cl�ment V, Marino D, Cudalbu C, Hamou MF, Mlynarik V, de Tribolet N, Dietrich PY, Gruetter R, Hegi ME, Radovanovic I.
Nat Methods, 2010 Mar;7(3):224-8.
Marker-independent identification of glioma-initiating cells
C. Cudalbu, V Mlynarik, L Xin, R Gruetter.
Meas. Sci. Technol. 20:104034 (2009)
Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE 1H MRS spectra.
Craveiro M, Cl�ment-Schatlo V, Marino D, Gruetter R, Cudalbu C.
J Neurochem. 2014 Feb 7. doi: 10.1111/jnc.12673. [Epub ahead of print]
In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1 H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T.
C. Cudalbu, A. Rengle, O. Beuf, S. Cavassila.
C.R. Chimie, Volume 11, Issues 4-5, April-May 2008, Pages 442-447
Rat brain metabolite relaxation time estimates using Magnetic Resonance Spectroscopy at two different field strengths
C. Cudalbu, S. Cavassila, H. Rabeson, D. van Ormondt, D. Graveron-Demilly.
NMR Biomed, 2008, 21: 627-636.
Influence of Measured and Simulated Basis-Sets on the Metabolite Concentration Estimates
C. Cudalbu, B. Lanz, J.M.N. Duarte, FD Morgenthaler, Y. Pilloud, V. Mlyn�rik and R. Gruetter.
J Cereb Blood Flow Metab. 2012 Apr;32(4):696-708
Cerebral Glutamine metabolism under hyperamonemia determined in vivo by localized 1H and 15N NMR spectroscopy
C. Cudalbu, A. Montavont, P. Ryvlin, S. Cavassila.
CR Chimie, Volume 11, Issues 4-5, April-May 2008, Pages 434-441.
Brain metabolite concentration estimates using MRS in a chronic model of temporal lobe epilepsy
Cudalbu C
Metab Brain Dis. 2013 Jun;28(2):167-74.
In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using (1)H Magnetic Resonance Spectroscopy
C. Cudalbu, O. Beuf, S. Cavassilla.
Journal of VLSI Signal Processing Systems, 55 (1-3) , pp. 25-34, DOI: 10.1007/s11265-008-0187-5.
In vivo short echo time localized 1H MRS of the rat brain at 7T: influence of two strategies of background-accommodation on the metabolite concentration estimation using QUEST
Kunz N, Cudalbu C, Mlynarik V, H�ppi PS, Sizonenko SV, Gruetter R.
Magn Reson Med. 2010 Oct;64(4):939-46.
Diffusion-weighted spectroscopy: a novel approach to determine macromolecule resonances in short-echo time 1H-MRS
Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Din�er A, Dydak U, Emir UE, Frahm J, Gonz�lez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, H�ppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marja?ska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tk�? I, Vigneron DB, Kauppinen RA; MRS Consensus Group.
Radiology. 2014 Mar;270(3):658-79. doi: 10.1148/radiol.13130531.
Clinical proton MR spectroscopy in central nervous system disorders.
Braissant O, McLin VA, Cudalbu C.
J Inherit Metab Dis. 2013 Jul;36(4):595-612
Ammonia toxicity to the brain
C Cudalbu, A Stan, O. Cozar.
Studia UBB, Physica, 2003, 48(2), pp 3-11
Dose distribution in the irradiation of medulloblastoma with two adjacent fields,
Lanz B, Duarte JM, Kunz N, Mlyn�rik V, Gruetter R, Cudalbu C.
Magn Reson Med. 2013 Jun;69(6):1512-22.
Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES.
C. Cudalbu, S. Cavassila, H. Ratiney, D. Grenier, A. Briguet, D. Graveron-Demilly.
C. R. Chimie, 9, 2006, pp 534-538.
Estimation of metabolite concentrations of healthy mouse brain by Magnetic Resonance Spectroscopy at 7 Tesla
Cudalbu C, McLin VA, Lei H, Duarte JM, Rougemont AL, Oldani G, Terraz S, Toso C, Gruetter R
PLoS One. 2013 Jul 23;8(7):e69782.
The C57BL/6J mouse exhibits sporadic congenital portosystemic shunts.
Cudalbu C, Comment A, Kurdzesau F, van Heeswijk RB, Uffmann K, Jannin S, Denisov V, Kirik D, Gruetter R.
Phys Chem Chem Phys. 2010 Jun 14;12(22):5818-23
Feasibility of in vivo(15)N MRS detection of hyperpolarized (15)N labeled choline in rats
Mlyn�rik V, Cacquevel M, Sun-Reimer L, Janssens S, Cudalbu C, Lei H, Schneider BL, Aebischer P, Gruetter R.
J Alzheimers Dis. 2012;31 Suppl 3:S87-99.
Proton and Phosphorus Magnetic Resonance Spectroscopy of a Mouse Model of Alzheimer's Disease.
C. Cudalbu, V Mlynarik, L Xin, R Gruetter.
Magn Reson Med. 2009 Oct;62(4):862-7
Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4T and 14.1T


Current work

Development: implement/validate new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS
-        Implement new acquisition techniques for fast spectroscopic imaging and diffusion spectroscopy
-        Implement new techniques for brain macromolecules quantification

Animal models: chronic liver failure/chronic hepatic encephalopathy, Brain tumors, creatine deficiencies, etc



2013-2017: Co-applicant in FP7-PEOPLE Marie Curie Initial Training Network project (Transforming Magnetic Resonance Spectroscopy into a Clinical Tool (TRANSACT))
 2014: PI for the Industrial grant VSL Pharmaceuticals Inc. 
 2014-2016: Co-applicant in the Swiss Bridge Foundation application "Towards patient-specific treatments in glioblastoma: Comparison and validation of high-resolution imaging and molecular profiles of human glioblastoma and respective paired orthotopic xenografts in the mouse" (PI Andreas Hottinger)
 2017-2018: Co-applicant in the Swiss Cancer League application “Characterizing invasiveness of patient derived brain tumor transplants in mice by gene expression profiling in association with metabolite profiles obtained by magnetic resonance spectroscopy (MRS). A pilot project”, (PI Monika Hegi)
 2017-2021: Swiss National Science Foundation; grants n° 310030_173222/1 to Cudalbu&Braissant&McLin. “Translational Non-Invasive Metabolic Studies towards Novel Treatments of Chronic Hepatic Encephalopathy in Developing Brain, from 3D Organotypic Brain Cell Cultures to the In vivo Rat and Human Brain.”
 2017-2021: Swiss National Science Foundation; grants n° 31003A-175778/1 to Braissant&Cudalbu. “Cerebral creatine deficiency syndromes: New in vivo AAV approaches to treat SLC6A8 deficiency.”