Daniel Constam
Web site: Web site: https://go.epfl.ch/edms
+41 21 693 07 41
EPFL
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SV
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SV-SSV
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SSV-ENS
Web site: Web site: https://sv.epfl.ch/education
EPFL SV ISREC UPCDA
SV 2837 (Bâtiment SV)
Station 19
1015 Lausanne
+41 21 693 07 41
+41 21 693 07 43
Office:
SV 2837
EPFL
>
SV
>
ISREC
>
UPCDA
Web site: Web site: https://constam-lab.epfl.ch
Web site: Web site: https://go.epfl.ch/phd-edms
Fields of expertise
Biography
Daniel Constam received his doctoral degree in Natural Sciences from ETH Zürich in the neuroimmunology group of Adriano Fontana (1993). For postdoctoral studies, he joined the laboratory of Elizabeth Robertson as an EMBO fellow at Harvard University to characterize proprotein convertase (PC) functions in mouse models of early embryogenesis (1994-1999). As an ISREC group leader (>2000) and Associate Professor at EPFL (>2007), he initially continued to study pluripotency and lineage differentiation during development and found that several secreted PCs jointly regulate cell-cell adhesion and TGFβ signaling pathways at the cross-roads of stem cell and cancer biology. To map the proteolytic activity of PCs and their relative distribution in exocytic or endocytic vesicles, his lab developed PC-specific FRET sensors for high resolution live imaging in normal cells and in tumour-host interactions. His studies on TGFβ signaling also identified the RNA-binding protein Bicc1 and its self-polymerization in membrane-less organelles as regulators of mRNA translation and cell metabolism that cooperate with primary cilia to prevent cystic growth in renal tubules and in pancreatic and bile ducts.Teaching & PhD
Teaching
Life Sciences Engineering