Georges Wagnières

Nationalité: Swiss

EPFL SB IPHYS LIFMET
PH L1 490 (Bâtiment PH)
Station 3
1015 Lausanne

EPFL SB IPHYS LIFMET
PH L1 490 (Bâtiment PH)
Station 3
1015 Lausanne

EPFL SB IPHYS LIFMET
PH L1 490 (Bâtiment PH)
Station 3
1015 Lausanne

EPFL SB IPHYS LIFMET
PH L1 490 (Bâtiment PH)
Station 3
1015 Lausanne

Expertise

- Spectroscopie et imagerie de fluorescence.
- Thérapie photodynamique (PDT).
- Photobiomodulation.
- Spectroscopie et imagerie en optique biomédicale.
- Radiométrie.
- Développement préclinique et clinique de photosensibilisateurs et d'instruments photodiagnostics.
- Optique des tissus biologiques.
- Transfert de technologie et entrepreneurship.

Mission

- Enseignement et recherche en optique biomédicale et en photomédecine.
- Responsable du transfert de technologie du groupe de recherche en photonique biomédicale.
6Georges Wagnières a obtenu son diplôme (MSc) en physique à l'Université de Lausanne, Suisse, en 1986. Il a reçu son doctorat ès science (PhD) en physique (Optique Biomédicale) de l'Ecole Polytechnique Fédérale de Lausanne (EPFL) en 1992, et a effectué un travail de postdoctorat dans les "Wellman Laboratories of Photomedicine" (Harvard Medical School) situés à Boston, MA, USA, en 1993 et 1994. Il a aussi obtenu, en 2001, un "Master in management of technology" délivré par l'Ecole des Hautes Etudes Commerciales (HEC) de l'Université de Lausanne et l'EPFL.
Depuis 1994, il gère un groupe de recherche de l'EPFL actif dans les domaines suivants:
- Caractérisation et détection de lésions cancéreuses par spectroscopie et imagerie de fluorescence ainsi que par imagerie à fort grossissement.
- Traitement du cancer ainsi que d'autres pathologies associées à des désordres immunologiques (maladie de Crohn, Colite ulcéreuse) ou vasculaires par thérapie photodynamique (PDT).
- Développement préclinique et clinique de photosensibilisateurs, de marqueurs fluorescents et d'instruments optiques pour le photodiagnostic.
- Traitement de diverses pathologies, y compris les maladies neuro-dégénératives (Parkinson, Alzheimer), par photobiomodulation.
- Monitorage de la dose optique pour la PDT basée sur l'imagerie de fluorescence de photosensibilisateurs.
- Induction de l'extravasation d'agent chimiothérapeutiques par PDT.
- Mesure in vivo de la concentration d'oxygène dans des tissus biologiques par spectroscopie et imagerie optiques résolues en temps.
- Monitorage d'un traitement au laser de la rétine par imagerie de reflectance.
- Développement de distributeurs de lumière pour des applications biomédicales.
- Dosimétrie de lumière / Radiométrie.
- Spectroscopie et imagerie en optique biomédicale.
Georges Wagnières est aussi co-fondateur et a présidé une société "spin-off" de l'EPFL:
- Medlight SA, fondée en 1997, qui développe, produit et commercialise des distributeurs de lumière pour la thérapie photodynamique.
Georges Wagnières est l'auteur et co-auteur de plus de 250 articles scientifiques dont 165 ont été publiés dans des revues internationales ayant un comité de relecture (review board). De plus, il est inventeur de 18 brevets. Finalement, il supervise ou a supervisé 12 doctorants et enseigne actuellement à l'EPFL l'optique biomédicale et la photomédecine au niveaux "master". Ces cours sont aussi donnés à l'Ecole doctorale (EDCH, EDSV) de l'EPFL.
PUBLICATIONS PRINCIPALES:
SVP visiter: https://www.epfl.ch/labs/lifmet/wagnieres/publications/

Boite aux lettres pour fichier

Vous pouvez me transmettre des fichiers avec le formulaire ci-dessous (max. 300MB)

HOMEPAGE DU GROUPE

https://lifmet.epfl.ch/wagnieres/

START-UPs

Medlight SA
http://www.medlight.com/

2023

[222] Effect of Photobiomodulation on Protein Kinase C delta, Cytochrome C, and Mitochondria in U87 MG Cells

V. PevnaG. WagnieresD. JancuraV. Huntosova

Cells

2023-05-22

DOI : 10.3390/cells12101441

[221] Porphyrin metalla-assemblies coupled to cellulose nanocrystals for PDT and imaging applications

J. C. S. SimoesG. WagnieresS. SarpakiV. SolB. Therrien

Journal Of Porphyrins And Phthalocyanines

2023-05-05

DOI : 10.1142/S1088424623500499

2022

[220] Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

D. MacabreyJ. JoniovaQ. GasserC. BechelliA. Longchamp  et al.

Frontiers In Cardiovascular Medicine

2022-10-03

DOI : 10.3389/fcvm.2022.965965

[219] Optimization of the Distance between Cylindrical Light Distributors Used for Interstitial Light Delivery in Biological Tissues

A. GregorS. SaseG. Wagnieres

Photonics

2022-09-01

DOI : 10.3390/photonics9090597

[218] Photobiomodulation and photodynamic therapy-induced switching of autophagy and apoptosis in human dermal fibroblasts

V. PevnaD. HorvathG. WagnieresV. Huntosova

Journal Of Photochemistry And Photobiology B-Biology

2022-09-01

DOI : 10.1016/j.jphotobiol.2022.112539

[217] Cathepsin B-Cleavable Polymeric Photosensitizer Prodrug for Selective Photodynamic Therapy: In Vitro Studies

M. JainJ. BouillouxI. BorregoS. CookH. van den Bergh  et al.

Pharmaceuticals

2022-05-01

DOI : 10.3390/ph15050564

[216] Identification of excimer delayed fluorescence by Protoporphyrin IX: A novel access to local chromophore concentration?

G. CroizatA. GregorJ. JoniovaE. GerelliG. Wagnieres

Journal Of Photochemistry And Photobiology B-Biology

2022-04-01

DOI : 10.1016/j.jphotobiol.2022.112408

2021

[215] Stimulation and homogenization of the protoporphyrin IX endogenous production by photobiomodulation to increase the potency of photodynamic therapy

J. JoniovaC. KazemiraadE. GerelliG. Wagnieres

Journal Of Photochemistry And Photobiology B-Biology

2021-12-01

DOI : 10.1016/j.jphotobiol.2021.112347

[214] Autophagy and Apoptosis Induced in U87 MG Glioblastoma Cells by Hypericin-Mediated Photodynamic Therapy Can Be Photobiomodulated with 808 nm Light

V. PevnaG. WagnieresV. Huntosova

Biomedicines

2021-11-01

DOI : 10.3390/biomedicines9111703

[213] Understanding delayed fluorescence and triplet decays of Protoporphyrin IX under hypoxic conditions

M. ScholzG. CroizatJ. PsencikR. DedicS. Nonell  et al.

Photochemical & Photobiological Sciences

2021-07-03

DOI : 10.1007/s43630-021-00044-8

[212] Intraocular Lens Refractive Index and Its Impact on External Surface Reflections

G. D. KymionisJ. KimM. PetrelliM. A. GrentzelosK. Hashemi  et al.

Journal Of Refractive Surgery

2021-06-01

DOI : 10.3928/1081597X-20210310-01

[211] Influence of Oxidative Stress on Time-Resolved Oxygen Detection by [Ru(Phen)3]2+ In Vivo and In Vitro

V. HuntosovaD. HorvathR. SeligaG. Wagnières

Molecules

2021-01-18

DOI : 10.3390/molecules26020485

[210] Sodium Thiosulfate, a Source of Hydrogen Sulfide, Promotes Angiogenesis via Metabolic Reprogramming of Endothelial Cells

D. MacabreyJ. JoniovaA. LongchampJ.-M. CorpatauxG. Wagnieres  et al.

2021-01-01. p. 18-18.

2020

[209] Grid-aware distributed control of electric vehicle charging stations in active distribution grids

S. A. S. FahmyR. K. GuptaM. Paolone

Electric Power Systems Research

2020-08-15

DOI : 10.1016/j.epsr.2020.106697

[208] A general framework for non-exponential delayed fluorescence and phosphorescence decay analysis, illustrated on Protoporphyrin IX

G. CroizatA. GregorE. GerelliJ. JoniovaM. Scholz  et al.

Journal of Photochemistry and Photobiology B-Biology

2020-08-01

DOI : 10.1016/j.jphotobiol.2020.111887

[207] Catechin reduces phototoxic effects induced by protoporphyrin IX-based photodynamic therapy in the chick embryo chorioallantoic membrane

J. JoniovaG. Wagnieres

Journal Of Biomedical Optics

2020-06-01

DOI : 10.1117/1.JBO.25.6.063807

[206] Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

M. ZellwegerY. XiaoM. JainM.-N. GiraudA. Pitzschke  et al.

Applied Sciences-Basel

2020-06-01

DOI : 10.3390/app10124304

[205] An objective comparison of detection and segmentation algorithms for artefacts in clinical endoscopy

S. AliF. ZhouB. BradenA. BaileyS. Yang  et al.

Scientific Reports

2020-02-17

DOI : 10.1038/s41598-020-59413-5

[204] Comparison of autofluorescence and white-light bronchoscopies performed with the Evis Lucera Spectrum for the detection of bronchial cancers: a meta-analysis

S. SunY. YangM. ChenL. WangH. Pan  et al.

Translational Lung Cancer Research

2020-02-01

DOI : 10.21037/tlcr.2020.01.04

2019

[203] Vascular-targeted low dose photodynamic therapy stabilizes tumor vessels by modulating pericyte contractility

S. CavinT. RiedelP. RosskopfovaM. GonzalezG. Baldini  et al.

Lasers In Surgery And Medicine

2019-08-01

DOI : 10.1002/lsm.23069

[202] Increase and homogenization of the endogenous production of protoporphyrin IX by photobiomodulation

J. JoniovaE. GerelliG. Wagnieres

2019-01-01. Conference on Medical Laser Applications and Laser-Tissue Interactions IX , Munich, GERMANY , Jun 23-24, 2019. p. 110790Q.

DOI : 10.1117/12.2527082.

[201] Photoprotective effect of catechin during ALA-PDT

J. JoniovaG. Wagnieres

2019-01-01. 17th World Congress of the International-Photodynamic-Association (IPA) , Cambridge, MA , Jun 28-Jul 04, 2019. p. 11070BZ.

DOI : 10.1117/12.2527278.

2018

[200] Hypericin can cross barriers in the chicken's chorioallantoic membrane model when delivered in low-density lipoproteins

L. BlascakovaD. HorvathD. BelejG. WagnieresP. Miskovsky  et al.

Photodiagnosis And Photodynamic Therapy

2018-09-01

DOI : 10.1016/j.pdpdt.2018.07.009

2017

[199] Time-resolved imaging of oxidative stress and cell/tissue oxygenation

V. HuntosovaS. SokolovaM. MisuthD. HorvathG. Wagnieres  et al.

2017. 19th IUPAB Congress / 11th EBSA Congress , British Biophys Soc, Edinburgh, SCOTLAND , JUL 16-20, 2017. p. S367-S367.

[198] Modulation of the endogenous production of protoporphyrin IX in a yeast - based model organism

J. JoniovaE. GerelliG. Wagnieres

2017. Conference on Optical Biopsy XV - Toward Real-Time Spectroscopic Imaging and Diagnosis , San Francisco, CA , JAN 31-FEB 01, 2017. p. 1006018.

DOI : 10.1117/12.2256504.

[197] In vivo measurement of the tissue oxygenation by time-resolved luminescence spectroscopy of protoporphyrin IX: Strategies to minimize artefacts associated with photoproducts

E. GerelliV. HuntosovaD. HorvathG. Wagnieres

2017. Conference on Optical Biopsy XV - Toward Real-Time Spectroscopic Imaging and Diagnosis , San Francisco, CA , JAN 31-FEB 01, 2017. p. 1006016.

DOI : 10.1117/12.2256669.

[196] Negligible interaction of [Ru(Phen) 3 ] 2+ with human serum albumin makes it promising for a reliable in vivo assessment of the tissue oxygenation

D. BelejZ. JurasekovaM. NemergutG. WagnieresD. Jancura  et al.

Journal of Inorganic Biochemistry

2017

DOI : 10.1016/j.jinorgbio.2017.05.016

[195] Interstitial fluid pressure: A novel biomarker to monitor photo-induced drug uptake in tumor and normal tissues.

S. CavinX. WangM. ZellwegerM. GonzalezM. Bensimon  et al.

Lasers Surg. Med.

2017

DOI : 10.1002/lsm.22687

[194] Determination of the radiance of cylindrical light diffusers: design of a one-axis charge-coupled device camera-based goniometer setup

A. PitzschkeJ. BertholetB. LovisaM. ZellwegerG. Wagnieres

Journal Of Biomedical Optics

2017

DOI : 10.1117/1.Jbo.22.3.035004

[193] Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

M. JainM. ZellwegerG. WagnieresH. Van Den BerghS. Cook  et al.

Cardiovascular Therapeutics

2017

DOI : 10.1111/1755-5922.12238

2016

[192] Measurement of pO2 by luminescence lifetime spectroscopy: A comparative study of the phototoxicity and sensitivity of [Ru(Phen)3]2+ and PdTCPP in vivo

V. HuntosovaE. GerelliD. HorvathG. Wagnieres

Journal of Biophotonics

2016

DOI : 10.1002/jbio.201600127

[191] Optimization and characterization of the endogenous production of protoporphyrin IX in a yeast model

J. JoniováE. GerelliM. ZellwegerG. Wagnières

Journal of biomedical optics

2016

DOI : 10.1117/1.JBO.21.12.125008

[190] Effect of PpIX photoproducts formation on pO2 measurement by time-resolved delayed fluorescence spectroscopy of PpIX in solution and in vivo

V. HuntosovaE. GerelliM. ZellwegerG. Wagnières

Journal of photochemistry and photobiology. B, Biology

2016

DOI : 10.1016/j.jphotobiol.2016.09.022

[189] Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment

M. JainM. ZellwegerA. FrobertJ. ValentinH. Van Den Bergh  et al.

Frontiers In Physiology

2016

DOI : 10.3389/fphys.2016.00400

[188] Use of Water-Soluble Oxygen Sensors to Study the Oxygen Consumption during Photosensitization with Hypericin in Vitro and in Vivo

V. HuntosovaD. BelejE. GerelliP. MiskovskyG. Wagnieres

2016. 60th Annual Meeting of the Biophysical-Society , Los Angeles, USA , February 27 - March 2, 2016. p. 507A-508A.

DOI : 10.1016/j.bpj.2015.11.2712.

[187] Study of the NIR Light Induced Effects on Neuroblastoma N2A Cells with Parkinson's-Like Features

L. KoptasikovaV. HuntosovaE. GerelliP. MiskovskyG. Wagnieres  et al.

2016. 60th Annual Meeting of the Biophysical-Society , Los Angeles, USA , February 27 - March 2, 2016. p. 470A-471A.

DOI : 10.1016/j.bpj.2015.11.2519.

[186] Review of the role played by the photosensitizer's photobleaching during photodynamic therapy

M. AtifM. ZellwegerG. Wagnieres

Journal Of Optoelectronics And Advanced Materials

2016

2015

[185] Treatment of pleural malignancies by photo-induction combined to systemic chemotherapy: Proof of concept on rodent lung tumors and feasibility study on porcine chest cavities

X. WangF. GronchiM. BensimonT. MercierL. A. Decosterd  et al.

Lasers In Surgery And Medicine

2015

DOI : 10.1002/lsm.22422

[184] Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease

A. OueslatiB. LovisaJ. PerrinG. WagnièresH. van den Bergh  et al.

PloS One

2015

DOI : 10.1371/journal.pone.0140880

[183] Study of the influence of over-the-counter vitamin supplement intake on urine fluorescence to optimize cancer detection by fluorescence cystoscopy

M. ZellwegerC. MartocciaM. MenginC. IselinH. Van Den Bergh  et al.

Journal Of Biomedical Optics

2015

DOI : 10.1117/1.Jbo.20.6.066011

[182] Optical properties of the deep brain in the red and NIR: changes observed under in-vivo, post-mortem, frozen and formalin-fixated conditions

A. PitzschkeB. LovisaO. SeydouxM. ZellwegerM. Pfleiderer  et al.

2015. Conference on Medical Laser Applications and Laser-Tissue Interactions VII , Munich, GERMANY , JUN 21-23, 2015. p. 954207.

DOI : 10.1117/12.2183687.

[181] Red and NIR light dosimetry in the human deep brain

A. PitzschkeB. LovisaO. SeydouxM. ZellwegerM. Pfleiderer  et al.

Physics in Medicine and Biology

2015

DOI : 10.1088/0031-9155/60/7/2921

[180] Fluence plays a critical role on the subsequent distribution of chemotherapy and tumor growth delay in murine mesothelioma xenografts pre-treated by photodynamic therapy

Y. WangX. WangM.-A. Le BitouxG. WagnieresH. Vandenbergh  et al.

Lasers in Surgery and Medicine

2015

DOI : 10.1002/lsm.22329

[179] Optical properties of rabbit brain in the red and near-infrared: changes observed under in vivo, postmortem, frozen, and formalin-fixated conditions

A. PitzschkeB. LovisaO. SeydouxM. HaenggiM. F. Oertel  et al.

Journal Of Biomedical Optics

2015

DOI : 10.1117/1.Jbo.20.2.025006

2014

[178] Endosomes: Guardians Against [Ru(Phen)3]2+ Photo-action In Endothelial Cells During In Vivo pO2 Detection?

V. HuntosovaK. StroffekovaG. WagnieresM. NovotovaZ. Nichtova  et al.

Metallomics

2014

DOI : 10.1039/C4MT00190G

[177] Temperature and oxygen-concentration dependence of singlet oxygen production by RuPhen as induced by quasi-continuous excitation

J. VarcholaV. HuntosovaD. JancuraG. WagnieresP. Miskovsky  et al.

Photochemical & Photobiological Sciences

2014

DOI : 10.1039/C4PP00202D

[176] Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model

J. Y. PerentesY. WangX. WangE. AbdelnourM. Gonzalez  et al.

Translational oncology

2014

DOI : 10.1016/j.tranon.2014.04.010

[175] In vivo measurement of tissue oxygenation by time-resolved luminescence spectroscopy: advantageous properties of dichlorotris(1, 10-phenanthroline)-ruthenium(II) hydrate

V. HuntosovaS. GayP. Nowak-SliwinskaS. K. RajendranM. Zellweger  et al.

Journal of Biomedical Optics

2014

DOI : 10.1117/1.JBO.19.7.077004

[174] Optical spectroscopy of the bladder washout fluid to optimize fluorescence cystoscopy with Hexvix

C. MartocciaM. ZellwegerB. LovisaP. JichlinskiH. Van Den Bergh  et al.

Journal of Biomedical Optics

2014

DOI : 10.1117/1.JBO.19.9.097002

[173] Light dose plays a critical role for the distribution of chemotherapy and tumor response in mesothelioma xenografts pre-treated by photodynamic therapy

J. Y. PerentesX. WangY. WangM.-A. Le BitouxG. Wagnieres  et al.

2014. 101st Annual Congress of the Swiss-Society-of-Surgery . p. 23-23.

[172] Detection of Bladder Cancer by Fluorescence Cystoscopy: From Bench to Bedside - the Hexvix Story

G. WagnièresP. JichlinskiN. LangeP. KuceraH. van den Bergh

Handbook of Photomedicine; Taylor & Francis,

2014.

p. 411-426.

DOI : 10.1201/b15582-41.

[171] Study of the stability of the 5-aminolevulinic acid tyrosine ester in aqueous solution

S. GayC. MartocciaM. ZellwegerQ. WangG. Wagnières

ARKIVOC - Online Journal of Organic Chemistry

2014

DOI : 10.3998/ark.5550190.p008.469

2013

[170] Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic Therapy

F. PiffarettiM. ZellwegerB. KasraeeJ. BargeD. Salomon  et al.

Dermatology

2013

DOI : 10.1159/000353775

[169] Correlations between photoactivable porphyrins’ fluorescence, erythema and the pain induced by PDT on normal skin using ALA-derivatives

J. BargeT. GlanzmannM. ZellwegerD. SalomonH. Van Den Bergh  et al.

Photodiagnosis and Photodynamic Therapy

2013

DOI : 10.1016/j.pdpdt.2013.08.005

[168] Near-Infrared 808 nm Light Boosts Complex IV-Dependent Respiration and Rescues a Parkinson-Related pink1 Model

M. VosB. LovisaA. GeensV. A. MoraisG. Wagnières  et al.

PLoS ONE

2013

DOI : 10.1371/journal.pone.0078562

2012

[167] Etude préclinique des effets vasculaires induits par la thérapie photodynamique de nouveaux dérivés d’acide 5-aminolevulinique

S. GayC. MartocciaJ. BargeP. Nowak-SliwinskaG. Wagnières

MRCT CNRS; Biophotonique, optique et diagnostic

2012

[166] Reflectance imaging of the human retina at 810 nm does not suffice to optimize the parameters of hydrodynamic rebalancing laser treatment

F. PiffarettiJ.-P. BalliniR. PerottiM. ZellwegerE. Vezzola  et al.

Journal Of Biomedical Optics

2012

DOI : 10.1117/1.Jbo.17.11.116027

[165] Real-time, in vivo measurement of tissular pO(2) through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy

F. PiffarettiA. M. NovelloR. S. KumarE. ForteC. Paulou  et al.

Journal Of Biomedical Optics

2012

DOI : 10.1117/1.Jbo.17.11.115007

[164] Photoactive sawhorse-type diruthenium tetracarbonyl complexes

J. P. JohnpeterF. SchmittE. Denoyelle-Di-MuroG. WagnieresL. Juillerat-Jeanneret  et al.

Inorganica Chimica Acta

2012

DOI : 10.1016/j.ica.2012.05.026

[163] Probing the Interaction Between a Surfactant-Cobalt(III) Complex and Bovine Serum Albumin

R. Senthil KumarH. van den BerghG. Wagnières

Journal of Solution Chemistry

2012

DOI : 10.1007/s10953-012-9800-0

[162] Angiogenesis inhibition by the maleimide-based small molecule GNX-686

P. Nowak-SliwinskaM. StortoT. CataudellaJ.-P. BalliniR. Gatz  et al.

Microvascular Research

2012

DOI : 10.1016/j.mvr.2011.10.004

2011

[161] Study of the pO2-sensitivity of the dendrimeric and free forms of Pd-meso-tetra(4-carboxyphenyl)porphyrin, incorporated or not in chitosan-based nanoparticles

P. Nowak-SliwinskaP. KäuperH. van den BerghG. Wagnières

Chimia

2011

DOI : 10.2533/chimia.2011.691

[160] Organometallic Ruthenium(II) Arene Compounds with Antiangiogenic Activity

P. Nowak-SliwinskaV. BeijnumR. JudyA. CasiniA. A. Nazarov  et al.

Journal of Medicinal Chemistry

2011

DOI : 10.1021/jm2002074

[159] Human serum albumin binding and cytotoxicity studies of surfactant–cobalt(III) complex containing 1,10-phenanthroline ligand

R. S. KumarP. PaulA. RiyasdeenG. WagnièresH. van den Bergh  et al.

Colloids and Surfaces B: Biointerfaces

2011

DOI : 10.1016/j.colsurfb.2011.03.012

[158] Low dose endoluminal photodynamic therapy improves murine T cell-mediated colitis

L. FavreF. BorleD. VelinD. BachmannH. Bouzourene  et al.

Endoscopy

2011

DOI : 10.1055/s-0030-1256382

2010

[157] Errata: Processing of Fluorescence Angiograms for the Quantification of Vascular Effects Induced by Anti-angiogenic Agents in the CAM model (vol 79, pg 21, 2010)

P. Nowak-SliwinskaJ.-P. BalliniG. WagnièresH. van den Bergh

Microvascular Research

2010

DOI : 10.1016/j.mvr.2010.01.009

[156] Early stirrings of landscape genomics: Awaiting next-next generation sequencing platforms before take-off

S. JoostR. Negrini

Sustainable Improvement of Animal Production and Health; Rome: Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture,

2010.

p. 185-189.

[155] Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints

F. SchmittL. LagopoulosP. KaeuperN. RossiN. Busso  et al.

Journal Of Controlled Release

2010

DOI : 10.1016/j.jconrel.2010.02.008

[154] In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy

S. H. LimC. ThiviergeP. Nowak-SliwinskaJ. HanH. van den Bergh  et al.

Journal of Medicinal Chemistry

2010

DOI : 10.1021/jm901823u

[153] The Neovessel Occlusion Efficacy of 15(1)-hydroxypurpurin-7-lactone dimethyl ester induced with photodynamic therapy

S. H. LimP. Nowak-SliwinskaF. A. KamarulzamanH. Van Den BerghG. Wagnières  et al.

Photochemistry and Photobiology

2010

DOI : 10.1111/j.1751-1097.2009.00684.x

[152] Angiostasis-induced vascular normalization can improve photodynamic therapy

P. Nowak-SliwinskaG. WagnièresH. van den BerghA. W. Griffioen

Cellular and Molecular Life Sciences

2010

DOI : 10.1007/s00018-010-0294-x

[151] Processing of fluorescence angiograms for the quantification of vascular effects induced by anti-angiogenic agents in the CAM model

P. Nowak-SliwinskaJ.-P. BalliniG. WagnièresH. Van Den Bergh

Microvascular Research

2010

DOI : 10.1016/j.mvr.2009.10.004

[150] Photodynamic Therapy Selectively Enhances Liposomal Doxorubicin Uptake in Sarcoma Tumors to Rodent Lungs

C. ChengE. DebefveA. HaoualaS. Andrejevic-BlantT. Krueger  et al.

Lasers In Surgery And Medicine

2010

DOI : 10.1002/lsm.20912

[149] Fluorescence of the bladder washout fluid following cystoscopy: a preliminary study

B. LovisaA. M. NovelloP. JichlinskiH. van den BerghG. Wagnieres

2010. Conference on Photonic Therapeutics and Diagnostics VI , San Francisco, CA , Jan 23-25, 2010. p. 75481J.

DOI : 10.1117/12.842100.

[148] Pioneers in biomedical optics: Special section honoring professor Tayyaba Hasan

B. W. PogueG. A. WagnieresL. D. Lilge

Journal of Biomedical Optics

2010

DOI : 10.1117/1.3492580

[147] High-magnification vascular imaging to reject false-positive sites in situ during Hexvix® fluorescence cystoscopy

B. LovisaP. JichlinskiB.-C. WeberD. AymonH. van den Bergh  et al.

Journal of Biomedical Optics

2010

DOI : 10.1117/1.3484257

[146] Development of Minimally-Invasive Optical Methods to Individualize the Doses Used for Therapeutic Applications of Light

F. Piffaretti / G. Wagnières (Dir.)

Lausanne, EPFL, 2010.

DOI : 10.5075/epfl-thesis-4831.

[145] Endoscopic Fluorescence Imaging

B. Lovisa / G. Wagnières (Dir.)

Lausanne, EPFL, 2010.

DOI : 10.5075/epfl-thesis-4797.

2009

[144] In vitro and in vivo studies of new photoluminescent oxygen sensors for non-invasive intravascular pO 2 measurements

P. Nowak-SliwinskaE. ForteH. Van Den BerghG. Wagnières

2009. p. 73806N.

DOI : 10.1117/12.822989.

[143] Vascular effects induced by anti-VEGF agents in the CAM model: Effect of the DMSO

P. Nowak-SliwinskaJ.-P. BalliniH. Van Den BerghG. Wagnières

2009.

DOI : 10.1117/12.822967.

[142] In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence

P. UehlingerT. GabrechtT. GlanzmannJ.-P. BalliniA. Radu  et al.

Journal of biomedical optics

2009

DOI : 10.1117/1.3088100

[141] Detection of early bladder carcinoma by fluorescence cystoscopy with Hexvix: optical characterization of a high magnification cystoscope

B. LovisaP. JichlinskiD. AymonB.-C. WeberH. Van Den Bergh  et al.

2009. Photonic Therapeutics and Diagnostics V , San Jose, CA, USA . p. 716118-716118-6.

DOI : 10.1117/12.809195.

[140] Bladder cancer detection by fluorescence imaging with Hexvix®: Analysis and processing of images obtained during high magnification cystoscopy

B. LovisaP. JichlinskiD. AymonB.-C. WeberH. van den Bergh  et al.

2009. Conference on Clinical and Biomedical Spectroscopy , Munich, GERMANY , JUN 16-18, 2009.

DOI : 10.1117/12.822971.

[139] Photodynamic Hair Re-Growth Inhibition With Ala Derivatives

J. BargeT. GlanzmannD. SalomonH. van den BerghG. Wagnières

2009. 29th Annual Conference of the American-Society-for-Laser-Medicine and Surgery , National Harbor, MD , Apr 01-05, 2009. p. 38-38.

[138] Autofluorescence bronchoscopy: quantification of inter-patient variations of fluorescence intensity

T. GabrechtB. LovisaH. van den BerghG. Wagnières

Lasers in medical science

2009

DOI : 10.1007/s10103-007-0518-y

[137] Assessment of a sheep animal model to optimize photodynamic therapy with Foscan in the esophague

T. GlanzmannM. ZellwegerF. BorleR. CondeA. Radu  et al.

Lasers In Surgery And Medicine

2009

DOI : 10.1002/lsm.20844

2008

[136] Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light

T. GabrechtA. RaduP. GrosjeanB. WeberG. Reichle  et al.

Photodiagnosis and photodynamic therapy

2008

DOI : 10.1016/j.pdpdt.2008.01.005

[135] Autofluorescence detection of tumors in the human lung - spectroscopical measurements in situ, in an in vivo model and in vitro

D. HüttenbergerT. GabrechtG. WagnièresB. WeberA. Linder  et al.

Photodiagnosis and photodynamic therapy

2008

DOI : 10.1016/j.pdpdt.2008.05.002

[134] Fluorescence cystoscopy: Perspective in clinical practice and research

P. JichlinskiB. LovisaC. ErlingD. AymonH. van den Bergh  et al.

Der Urologe. Ausg. A

2008

DOI : 10.1007/s00120-008-1778-2

[133] Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne(r)), in the CAM model

E. DebefveB. PegazH. van den BerghG. WagnièresN. Lange  et al.

Angiogenesis

2008

DOI : 10.1007/s10456-008-9106-4

[132] Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma

N. DögnitzD. SalomonM. ZellwegerJ.-P. BalliniT. Gabrecht  et al.

Journal of photochemistry and photobiology.B.Biology

2008

DOI : 10.1016/j.jphotobiol.2008.07.012

[131] Glycoside esters of 5-aminolevulinic acid for photodynamic therapy of cancer

R. VallinayagamF. SchmittJ. BargeG. WagnièresV. Wenger  et al.

Bioconjugate Chemistry

2008

DOI : 10.1021/bc700324r

[130] Detection of early bladder carcinoma by fluorescence cystoscopy with Hexvix(R): Improvement of the specificity by microcystoscopy

B. LovisaP. JichlinskiD. AymonH. Van Den BerghG. Wagnières

2008. p. 684218.

DOI : 10.1117/12.763353.

2007

[129] Detection of early bronchial cancer by autofluorescence: Results in patients with H&N cancer

T. GabrechtA. RaduM. ZellwegerB. LovisaD. Goujon  et al.

2007. p. OC1-OC8.

DOI : 10.1364/ECBO.2007.6628_12.

[128] Correlations between tissular effects, PPIX fluorescence and the pain induced by PDT on normal skin

D. SalomonJ. BargesT. GlanzmannG. Wagnieres

2007. 37th Annual Meeting of the European-Society-for-Dermatological-Research , Zurich, SWITZERLAND , Sep 05-08, 2007. p. S47-S47.

[127] Design of an endoscopic optical reference to be used for autofluorescence bronchoscopy with a commercially available diagnostic autofluorescence endoscopy (DAFE) system

T. GabrechtB. LovisaF. BorleG. Wagnières

Physics in medicine and biology

2007

DOI : 10.1088/0031-9155/52/8/N02

[126] Blue-violet excited autofluorescence spectroscopy and imaging of normal and cancerous human bronchial tissue after formalin fixation

T. GabrechtS. Andrejevic-BlantG. Wagnières

Photochemistry and photobiology

2007

DOI : 10.1562/2006-03-20-RA-852

[125] Design of a light delivery system for the photodynamic treatment of the Crohn's disease

T. GabrechtF. BorleH. Van Den BerghP. MichettiM.-A. Ortner  et al.

2007.

DOI : 10.1117/12.728477.

[124] Autofluorescence bronchoscopy: Clinical experience with an optimized system in head and neck cancer patients

T. GabrechtA. RaduM. ZellwegerB. LovisaD. Goujon  et al.

Medical Laser Application

2007

DOI : 10.1016/j.mla.2007.09.003

[123] Optimized autofluorescence bronchoscopy using additional backscattered red light

T. GabrechtT. GlanzmannL. FreitagB.-C. WeberH. van den Bergh  et al.

Journal of biomedical optics

2007

DOI : 10.1117/1.2811952

[122] Improvement of the Contrast in Cancer Detection by Autofluorescence Bronchoscopy using a narrow spectral violet Excitation: A preliminary study

B. LovisaT. GabrechtS. AndrejevicP. GrosjeanA. Radu  et al.

Biomedical Signal Processing and Control

2007

DOI : 10.1016/j.bspc.2007.07.004

[121] Detection of early bronchial cancer by autofluorescence: first clinical results with an improved system

M. ZellwegerD. GoujonA. RaduP. GrosjeanT. Stepinac  et al.

2007

2006

[120] Photodynamic therapy as a novel therapeutic approach for the treatment of Crohn's disease

L. FavreD. VelinF. BorleD. BachmannS. Schreiber  et al.

Gastroenterology

2006

[119] Improvement of the contrast in cancer detection by autofluorescence bronchoscopy using a narrow spectral violet excitation: A preliminary study

B. LovisaT. GabrechtS. AndrejevicP. GrosjeanA. Radu  et al.

2006. p. 17-21.

DOI : 10.3182/20060920-3-FR-2912.00008.

[118] Preclinical comparison of mTHPC and verteporfin for intracavitary photodynamic therapy of malignant pleural mesothelioma

I. OpitzT. KruegerY. PanH.-J. AltermattG. Wagnières  et al.

European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes

2006

DOI : 10.1159/000094028

[117] Photothrombic activity of m-THPC-loaded liposomal formulations: pre-clinical assessment on chick chorioallantoic membrane model

B. PegazE. DebefveJ.-P. BalliniG. WagnièresS. Spaniol  et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2006

DOI : 10.1016/j.ejps.2006.01.008

[116] On the role of iron and one of its chelating agents in the production of protoporphyrin IX generated by 5-aminolevulinic acid and its hexyl ester derivative tested on an epidermal equivalent of human skin

P. UehlingerJ. P. BalliniH. van den BerghG. Wagnieres

Photochemistry and Photobiology

2006

DOI : 10.1562/2005-12-04-RA-745

[115] Clinical fluorescence spectroscopy and imaging for the detection of early carcinoma by autofluorescence bronchoscopy and the study of the protoporphyrin IX pharmacokinetics in the endometrium

T. Gabrecht / G. Wagnières (Dir.)

Lausanne, EPFL, 2006.

DOI : 10.5075/epfl-thesis-3537.

2005

[114] Influence of the excitation wavelength on the Tumor-to-Healthy Contrast in Autofluorescence Bronchoscopy - A Comprehensive Study

T. GabrechtP. UehlingerS. AndrejevicP. GrosjeanA. Radu  et al.

2005. p. 586207.

DOI : 10.1117/12.633009.

[113] Autofluorescence detection of tumors in the human lung: comparison between in-vivo and in vitro measurements

D. HüttenbergerT. GabrechtG. WagnièresB. WeberA. Linder  et al.

2005. p. 1-9.

DOI : 10.1117/12.633011.

[112] Influence of the menstrual cycle on aminolevulinic acid induced protoporphyrin IX fluorescence in the endometrium: in vivo study

A. DegenT. GabrechtG. WagnieresR. CaduffB. Imthurn  et al.

Lasers in Surgery and Medicine

2005

DOI : 10.1002/lsm.20139

[111] Preclinical evaluation of a novel water-soluble chlorin E-6 derivative (BLC 1010) as photosensitizer for the closure of the neovessels

B. PegazE. DebefveF. BorleJ. P. BalliniG. Wagnieres  et al.

Photochemistry and Photobiology

2005

DOI : 10.1562/2005-02-23-RA-448

[110] Photodynamic therapy and endoscopic mucosal resection as minimally invasive approaches for the treatment of early esophageal tumors: Pre-clinical and clinical experience in Lausanne

A. RaduP. GrosjeanY. JaquetR. PilloudG. Wagnières  et al.

Photodiagnosis and Photodynamic Therapy

2005

DOI : 10.1016/S1572-1000(05)00035-9

[109] Light-induced retinal vascular damage by Pd-porphyrin luminescent oxygen probes

T. K. StepinacS. K. ChamotE. Rungger-BrandleP. FerrezJ. L. Munoz  et al.

Investigative Ophthalmology & Visual Science

2005

DOI : 10.1167/iovs.04-0500

2004

[108] Méthodes optiques de mesure de la concentration d'oxygène tissulaire pour la photothérapie dynamique

G. Wagnières

Photoniques

2004

[107] Time-dependent hexaminolaevulinate induced protoporphyrin IX distribution after topical application in patients with cervical intraepithelial neoplasia: A fluorescence microscopy study

S. Andrejevic-BlantA. MajorF. LudickeJ. P. BalliniG. Wagnieres  et al.

Lasers in Surgery and Medicine

2004

DOI : 10.1002/lsm.20095

[106] Photodynamic endometrial ablation for the treatment of dysfunctional uterine bleeding: A preliminary report

A. F. DegenT. A. GabrechtL. MosimannM. K. FehrR. Hornung  et al.

Lasers in Surgery and Medicine

2004

DOI : 10.1002/lsm.10244

[105] Optimalisation de la photothérapie dynamique et de la photodétection de cancers précoces par spectroscopie résolue en temps de luminophores endogènes et exogènes

P. Uehlinger / G. Wagnières (Dir.)

Lausanne, EPFL, 2004.

DOI : 10.5075/epfl-thesis-3149.

2003

[104] Method for hair removal

H. van den BerghG. WagnieresN. LangeN. DoegnitzD. Salomon

2003.

Patent number(s) :
CA2463345
US8235974
ES2324651
DK1443891
PT1443891
DE60231734
AT426394
EP1443891
AU2002340698
US2005124984
EP1443891
WO03041673
CA2463345
WO03041673
EP1312353

[103] Optimization of the spectral design used to detect early carcinoma in the human tracheo-bronchial tree by autofluorescence imaging

T. GabrechtT. GlanzmannL. FreitagP. GrosjeanB. Weber  et al.

2003. p. 1-7.

DOI : 10.1364/ECBO.2003.5141_1.

[102] On the influence of the instillation time on the results of HAL (Hexvix®) fluorescence detection of superficial bladder cancer

P. JichlinskiD. AymonG. WagnièresA. MartiN. Lange  et al.

2003. p. 272-277.

DOI : 10.1117/12.502218.

[101] Photodynamic endometrial ablation: Morphological study

P. WyssR. CaduffY. TadirA. DegenG. Wagnières  et al.

Lasers in Surgery and Medicine

2003

DOI : 10.1002/lsm.10163

[100] Lung cancer Imaging by autofluorescence bronchoscopy

G. WagnièresA. Mc WilliamsS. Lam

Handbook of Biomedical Fluorescence; Marcel Dekker Inc.,

2003.

p. 361-396.

[99] In vivo autofluorescence imaging of early cancers in the human tracheobronchial tree with a spectrally optimized system

D. GoujonM. ZellwegerA. RaduP. GrosjeanB.-C. Weber  et al.

Journal of biomedical optics

2003

DOI : 10.1117/1.1528594

[98] Selectivity of the photosensitiser Tookad((R)) for photodynamic therapy evaluated in the Syrian golden hamster cheek pouch tumour model

F. BorleA. RaduC. FontollietH. van den BerghP. Monnier  et al.

British Journal of Cancer

2003

DOI : 10.1038/sj.bjc.6601428

[97] Evaluation of the photosensitizer Tookad (R) for photodynamic therapy on the Syrian golden hamster cheek pouch model: Light dose, drug dose and drug-light interval effects

F. BorleA. RaduP. MonnierH. van den BerghG. Wagnieres

Photochemistry and Photobiology

2003

DOI : 10.1562/0031-8655(2003)078<0377:EOTPTF>2.0.CO;2

[96] Photodynamic diagnosis of ovarian cancer using hexaminolaevulinate: a preclinical study

F. LudickeT. GabrechtN. LangeG. WagnieresH. van den Bergh  et al.

British Journal of Cancer

2003

DOI : 10.1038/sj.bjc.6600958

[95] Mucosal ablation with photodynamic therapy in the esophagus: optimization of light dosimetry in the sheep model

A. RaduR. CondeC. FontollietG. WagnieresH. Van den Bergh  et al.

Gastrointestinal Endoscopy

2003

DOI : 10.1016/S0016-5107(03)70027-3

[94] Endoscopic fluorescence detection of intraepithelial neoplasia in Barrett's esophagus after oral administration of aminolevulinic acid

T. StepinacC. FelleyP. JornodN. LangeT. Gabrecht  et al.

Endoscopy

2003

DOI : 10.1055/s-2003-41514

[93] Caractérisation de tissus biologiques in vivo par imagerie de l'intensité ou du temps de vie de luminescence

T. Stepinac / G. Wagnières (Dir.)

Lausanne, EPFL, 2003.

DOI : 10.5075/epfl-thesis-2645.

2002

[92] In vivo fluorescence spectroscopy to optimize the detection of early bronchial carcinoma by autofluorescence imaging

G. WagnièresM. ZellwegerP. GrosjeanD. GoujonR. Conde  et al.

2002. p. 1-12.

DOI : 10.1117/12.466647.

[91] Uptake and localisation of mTHPC (Foscan (R)) and its C-14-labelled form in normal and tumour tissues of the hamster squamous cell carcinoma model: a comparative study

S. A. BlantT. M. GlanzmannJ. P. BalliniG. WagnieresH. van den Bergh  et al.

British Journal of Cancer

2002

DOI : 10.1038/sj.bjc.6600651

[90] Optimization of the diameter of a radial irradiation device for photodynamic therapy in the esophagus

T. StepinacP. GrosjeanA. WoodtliP. MonnierH. van den Bergh  et al.

Endoscopy

2002

DOI : 10.1055/s-2002-25280

[89] Photoeradication of Helicobacter pylori using 5-aminolevulinic acid: Preliminary human studies

C. H. Wilder-SmithP. Wilder-SmithP. GrosjeanH. van den BerghA. Woodtli  et al.

Lasers in Surgery and Medicine

2002

DOI : 10.1002/lsm.10066

2001

[88] Time-resolved autofluorescence spectroscopy of the bronchial mucosa for the detection of early cancer: Clinical results

T. M. GlanzmannP. UehlingerJ.-P. BalliniA. RaduT. Gabrecht  et al.

2001. p. 199-209.

DOI : 10.1117/12.447136.

[87] First report on hexyl-ester aminolevulinic acid (h-ALA) induced fluorescence cystoscopy in superficial bladder cancer

P. JichlinskiA. MartiL. GuillouN. LangeG. Wagnières

European Urology

2001

[86] Detection of early bronchial carcinoma by imaging of the tissue autofluorescence

D. GoujonT. GlanzmannT. GabrechtM. ZellwegerA. Radu  et al.

2001. p. 131-138.

DOI : 10.1117/12.447129.

[85] A new drug-screening procedure for photosensitizing agents used in photodynamic therapy for CNV

N. LangeJ. P. BalliniG. WagnieresH. van den Bergh

Investigative Ophthalmology & Visual Science

2001

[84] Localization of tetra(m-hydroxyphenyl)chlorin (Foscan) in human healthy tissues and squamous cell carcinomas of the upper aero-digestive tract, the esophagus and the bronchi: a fluorescence microscopy study

S. A. BlantP. GrosjeanJ. P. BalliniG. WagnieresH. van den Bergh  et al.

Journal of Photochemistry and Photobiology B-Biology

2001

DOI : 10.1016/S1011-1344(01)00148-8

[83] Absolute autofluorescence spectra of human healthy, metaplastic, and early cancerous bronchial tissue in vivo

M. ZellwegerD. GoujonR. CondeM. ForrerH. van den Bergh  et al.

Applied optics

2001

DOI : 10.1364/AO.40.003784

[82] In vivo autofluorescence spectroscopy of human bronchial tissue to optimize the detection and imaging of early cancers

M. ZellwegerP. GrosjeanD. GoujonP. MonnierH. van den Bergh  et al.

Journal of biomedical optics

2001

DOI : 10.1117/1.1332774

2000

[81] 5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells

P. UehlingerM. ZellwegerG. WagnièresL. Juillerat-JeanneretH. van den Bergh  et al.

Journal of photochemistry and photobiology. B, Biology

2000

DOI : 10.1016/S1011-1344(99)00159-1

[80] Photodynamic therapy of early squamous cell cancers of the esophagus

A. RaduG. WagnièresH. van den BerghP. Monnier

Gastrointestinal endoscopy clinics of North America

2000

[79] Time-dependent biodistribution of tetra(m-hydroxyphenyl)chlorin and benzoporphyrin derivative monoacid ring A in the hamster model: comparative fluorescence microscopy study

S. Andrejevic BlantJ. P. BalliniH. van den BerghC. FontollietG. Wagnières  et al.

Photochemistry and photobiology

2000

DOI : 10.1562/0031-8655(2000)0710333TDBOTM2.0.CO2

[78] A light distributor for photodynamic endometrial ablation

R. BaysA. WoodtliL. MosimannP. WyssG. Wagnières  et al.

Photomedicine in Gynecology and Reproduction; Basel: Karger,

2000.

p. 243-245.

DOI : 10.1159/000062772.

[77] Pharmacokinetics and pharmacodynamics of tetra(m-hydroxyphenyl)chlorin in the hamster cheek pouch tumor model: comparison with clinical measurements

T. GlanzmannM. ForrerS. Andrejevic BlantA. WoodtliP. Grosjean  et al.

Journal of Photochemistry and Photobiology B-Biology

2000

DOI : 10.1016/S1011-1344(00)00069-5

[76] Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa

M. ZellwegerA. RaduP. MonnierH. van den BerghG. Wagnières

Journal of Photochemistry and Photobiology B: Biology

2000

DOI : 10.1016/S1011-1344(00)00027-0

[75] Fluorescence spectroscopy of exogenous, exogenously-induced and endogenous fluorophores for the photodetection and photodynamic therapy of cancer

M. Zellweger / G. Wagnières (Dir.)

Lausanne, EPFL, 2000.

DOI : 10.5075/epfl-thesis-2126.

1999

[74] Solution for diagnosing or treating tissue pathology

A. MartiN. LangeM. ZellwegerG. WagnieresH. Van Den Bergh  et al.

1999.

Patent number(s) :
JP4630395
JP2010163445
US7348361
CA2327393
DE69904033
US2003158258
ES2188146
DE69904033
AT228018
EP1073472
JP2002512205
FR2777782
EP1073472
FR2777782
CA2327393
WO9953962

[73] Noninvasive determination of the optical properties of two-layered turbid media from time-resolved reflectance measurements

A. KienleT. GlanzmannG. WagnieresH. van den Bergh

1999. p. 20-27.

DOI : 10.1117/12.336945.

[72] Frequency-Domain Fluorescence Lifetime Imaging (FLIM) For Real-Time Endoscopic Tissue Characterization

G. WagnièresT. StepinacJ. MiseretH. van den Bergh

1999. Biomedical Topical Meeting , Munich, Germany , June 14, 1999. p. 477-479.

DOI : 10.1364/BIO.1999.JTuA2.

[71] Stability of the fluorescence measurement of Foscan in the normal human oral cavity as an indicator of its content in early cancers of the esophagus and the bronchi

M. ZellwegerP. GrosjeanP. MonnierH. Van Den BerghG. Wagnieres

Photochemistry and Photobiology

1999

DOI : 10.1111/j.1751-1097.1999.tb03335.x

[70] Photoeradication of Helicobacter pylori in humans: Phase 1 study

C. H. Wilder-SmithP. GrosjeanG. WagnieresP. Wilder-SmithG. Dorta  et al.

American Gastroenterology Association Annual meeting

1999

[69] Time-resolved spectrofluorometer for clinical tissue characterization during endoscopy

T. GlanzmannJ.-P. BalliniH. van den BerghG. Wagnieres

Review of Scientific Instruments

1999

DOI : 10.1063/1.1150038

[68] In vivo fluence rate and fractionation effects on tumor response and photobleaching: Photodynamic therapy with two photosensitizers in an orthotopic rat tumor model

S. IinumaK. T. SchomackerG. WagnieresM. RajadhyakshaM. Bamberg  et al.

Cancer Research

1999

[67] Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study

N. LangeP. JichlinskiM. ZellwegerM. ForrerA. Marti  et al.

British Journal of Cancer

1999

DOI : 10.1038/sj.bjc.6690338

[66] Instrumentation for real-time fluorescence lifetime imaging in endoscopy

J. MizeretT. StepinacM. HansroulA. StudzinskiH. van den Bergh  et al.

Review of Scientific Instruments

1999

DOI : 10.1063/1.1150132

[65] Photodynamic therapy for 101 early cancers of the upper aerodigestive tract, the esophagus, and the bronchi: a single-institution experience

A. RaduP. GrosjeanC. FontollietG. WagnièresA. Woodtli  et al.

Diagnostic and therapeutic endoscopy

1999

DOI : 10.1155/DTE.5.145

1998

[64] Dependence of time and space resolved reflectance on the anisotropy factor g and on the shape of the phase function

S. AvrillierB. GelebartJ.-M. TualleE. TinetG. Wagnieres

1998. Advances in Optical Imaging and Photon Migration , Orlando, Florida, USA , March 8, 1998.

DOI : 10.1364/AOIPM.1998.ATuB8.

[63] Long circulating half-life and high tumor selectivity of the photosensitizer meta-tetrahydroxyphenylchlorin conjugated to polyethylene glycol in nude mice grafted with a human colon carcinoma

P. WestermannT. GianzmannS. AndrejevicD. R. BraichotteM. Forrer  et al.

International Journal of Cancer

1998

DOI : 10.1002/(SICI)1097-0215(19980610)76:6<842::AID-IJC13>3.0.CO;2-4

[62] Clinical evaluation of the cutaneous phototoxicity of 5, 10, 15, 20-tetra (m-hydroxyphenyl)chlorin

G. WagnieresC. HadjurP. GrosjeanD. BraichotteJ.-F. Savary  et al.

Journal of Photochemistry and Photobiology a

1998

DOI : 10.1111/j.1751-1097.1998.tb09696.x

[61] Noninvasive determination of the optical properties of two-layered turbid media

A. KienleM. S. PattersonN. DognitzR. BaysG. Wagnieres  et al.

Applied Optics

1998

DOI : 10.1364/AO.37.000779

[60] Investigation of two-layered turbid media with time-resolved reflectance

A. KienleT. GlanzmannG. WagnieresH. van den Bergh

Applied Optics

1998

DOI : 10.1364/AO.37.006852

[59] Clinical photodynamic therapy for superficial cancer in the esophagus and the bronchi: 514 nm compared with 630 nm light irradiation after sensitization with Photofrin II

P. GrosjeanG. WagnieresC. FontollietH. Van Den BerghP. Monnier

British Journal of Cancer

1998

DOI : 10.1038/bjc.1998.330

[58] Pharmacokinetics of tetra(m-hydroxyphenyl)chlorin in human plasma and individualized light dosimetry in photodynamic therapy

T. GlanzmannC. HadjurM. ZellwegerP. GrosjeanM. Forrer  et al.

Photochemistry and Photobiology

1998

DOI : 10.1111/j.1751-1097.1998.tb09099.x

[57] Interstitial photodynamic therapy with tetra(m-hydroxyphenyl)chlorin: tumor versus striated muscle damage

S. Andrejevic-BlantA. WoodtliG. WagnieresC. FontollietH. Van Den Bergh  et al.

International Journal of Radiation Oncology Biology Physics

1998

DOI : 10.1016/S0360-3016(98)00221-1

[56] Determination of tissue optical properties by steady-state spatial frequency-domain reflectometry

N. DognitzG. Wagnières

Lasers in Medical Science

1998

DOI : 10.1007/BF00592960

[55] Spectroscopic studies of photobleaching and photoproduct formation of meta(tetrahydroxyphenyl)chlorin (m-THPC) used in photodynamic therapy. The production of singlet oxygen by m-THPC

C. HadjurN. LangeJ. RebsteinP. MonnierH. van den Bergh  et al.

Journal of Photochemistry and Photobiology B: Biology

1998

DOI : 10.1016/S1011-1344(98)00177-8

[54] Photodynamic therapy of early squamous cell carcinomas of the esophagus: A review of 31 cases

J. F. SavaryP. GrosjeanP. MonnierC. FontollietG. Wagnieres  et al.

Endoscopy

1998

DOI : 10.1055/s-2007-1001252

[53] In vivo fluorescence spectroscopy and imaging for oncological applications

G. WagnièresW. M. StarB. C. Wilson

Photochemistry and Photobiology

1998

DOI : 10.1111/j.1751-1097.1998.tb02521.x

1997

[52] Fluorescence photodetection of urothelial neoplastic foci in superficial bladder cancer

P. JichlinskiM. ForrerJ. C. MizeretD. BraichotteG. Zimmer  et al.

1997. p. 470-474.

DOI : 10.1117/12.275078.

[51] Determination of the absorption and reduced scattering coefficients of human skin and bladder by spatial frequency domain reflectometry

N. DögnitzG. WagnièresA. KienleH. Van den Bergh

1997. p. 102-109.

DOI : 10.1117/12.297883.

[50] An endoscopic fluorescence imaging system for simultaneous visual examination and photodetection of cancers

G. WagnièresA. StudzinskiH. van den BerghE. Hubert

Review of Scientific Instruments

1997

DOI : 10.1063/1.1147811

[49] Photodynamic therapy for early squamous cell carcinomas of the esophagus, bronchi, and mouth with m-tetra(hydroxyphenyl) chlorin

J.-F. SavaryP. MonnierC. FontollietJ. MizeretG. Wagnières  et al.

Archives of Otolaryngology - Head and Neck Surgery

1997

DOI : 10.1001/archotol.1997.01900020042006

[48] EPR and spectrophotometric studies of free radicals (O2.-, .OH, BPD-MA.-) and singlet oxygen (1O2) generated by irradiation of benzoporphyrin derivative monoacid ring A

C. HadjurG. WagnieresP. MonnierH. Van Den Bergh

Photochemistry and Photobiology

1997

DOI : 10.1111/j.1751-1097.1997.tb01929.x

[47] Photodynamic therapy of early squamous cell carcinoma with tetra(m-hydroxyphenyl)chlorin: optimal drug-light interval

S. Andrejevic-BlantC. HadjurJ. P. BalliniG. WagnièresC. Fontolliet  et al.

British journal of cancer

1997

DOI : 10.1038/bjc.1997.502

[46] Light dosimetry for photodynamic therapy in the esophagus

R. BaysG. WagnieresD. RobertD. BraichotteJ. F. Savary  et al.

Lasers in Surgery and Medicine

1997

DOI : 10.1002/(SICI)1096-9101(1997)20:3<290::AID-LSM8>3.0.CO;2-L

[45] Three-dimensional optical phantom and its application in photodynamic therapy

R. BaysG. WagnieresD. RobertJ. F. TheumannA. Vitkin  et al.

Lasers in Surgery and Medicine

1997

DOI : 10.1002/(SICI)1096-9101(1997)21:3<227::AID-LSM2>3.0.CO;2-S

[44] Wavelength-dependent effect of tetra(m-hydroxyphenyl)chlorin for photodynamic therapy in an 'early' squamous cell carcinoma model

S. A. BlantJ. F. TheumannM. ForrerG. WagnieresH. Van den Bergh  et al.

Lasers in Medical Science

1997

DOI : 10.1007/BF02765108

[43] Production of the free radicals O-2(.-) and OH by irradiation of the photosensitizer zinc(II) phthalocyanine

C. HadjurG. WagnièresF. IhringerP. MonnierH. van den Bergh

Journal of Photochemistry and Photobiology B-Biology

1997

DOI : 10.1016/S1011-1344(96)07440-4

[42] Photoinduction of fluorophores in the retina using a 514-nm argon ion laser

J. InderfurthG. Wagnieres

German Journal of Ophthalmology

1997

[41] Clinical evaluation of a method for detecting superficial transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following topical application of 5-aminolevulinic acid: Preliminary results

P. JichlinskiM. ForrerJ. MizeretT. GlanzmannD. Braichotte  et al.

Lasers in Surgery and Medicine

1997

DOI : 10.1002/(SICI)1096-9101(1997)20:4<402::AID-LSM5>3.0.CO;2-U

[40] Clinical value of fluorescence cystoscopy in the detection of superficial transitional cell carcinomas of the bladder

P. JichlinskiG. WagnièresM. ForrerJ. MizeretL. Guillou  et al.

Annales d'Urologie

1997

[39] An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy

G. WagnièresS. ChengM. ZellwegerN. UtkeD. Braichotte  et al.

Physics in Medicine and Biology

1997

DOI : 10.1088/0031-9155/42/7/014

[38] Frequency-domain fluorescence lifetime imaging for endoscopic clinical cancer photodetection: Apparatus design and preliminary results

G. WagnièresJ. MizeretA. StudzinskiH. Bergh

Journal of Fluorescence

1997

DOI : 10.1007/BF02764580

[37] Clinical imaging fluorescence apparatus for the endoscopic photodetection of early cancers by use of Photofrin II

G. WagnièresA. StudzinskiD. R. BraichotteP. MonnierC. Depeursinge  et al.

Applied Optics

1997

DOI : 10.1364/AO.36.005608

[36] Clinical assessment of fluorescence cystoscopy during transurethral bladder resection in superficial bladder cancer

P. JichlinskiG. WagnieresM. ForrerJ. MizeretL. Guillou  et al.

Urological Research

1997

DOI : 10.1007/BF00942040

1996

[35] Light distributors for photodynamic therapy | Les distributeurs de lumiere pour le traitement photodynamique

R. BaysG. WagnieresJ. MizeretA. WoodtliM. Forrer  et al.

1996. p. 407-409.

[34] Usefulness of fluorescence photodetection of neoplastic urothelial foci in bladder cancer following intravesical instillation of delta-aminolevulinic acid (5-ALA)

P. M. D. JichlinskiM. ForrerJ. C. MizeretD. BraichotteG. Wagnieres  et al.

1996. p. 340-347.

DOI : 10.1117/12.240028.

[33] Design and characterization of a phantom that simultaneously simulates tissue optical properties between 400 and 650 nm

G. WagnieresS. ChengM. ZellwegerN. UtkeD. Braichotte  et al.

1996. p. 94-103.

DOI : 10.1117/12.260824.

[32] Tissue characterization by time-resolved fluorescence spectroscopy of endogenous and exogenous fluorochromes: apparatus design and preliminary results

T. GlanzmannJ.-P. BalliniP. M. D. JichlinskiH. Van den BerghG. Wagnieres

1996. p. 41-50.

DOI : 10.1117/12.260818.

[31] Measurements by fluorescence microscopy of the time-dependent distribution of meso-tetra-hydroxyphenylchlorin in healthy tissues and chemically induced ''early'' squamous cell carcinoma of the Syrian hamster cheek pouch

S. AndrejevicJ. F. SavaryP. MonnierC. FontollietD. Braichotte  et al.

Journal of Photochemistry and Photobiology B-Biology

1996

DOI : 10.1016/S1011-1344(96)07362-9

[30] Clinical determination of tissue optical properties by endoscopic spatially resolved reflectometry

R. BaysG. WagnieresD. RobertD. BraichotteJ. F. Savary  et al.

Applied Optics

1996

DOI : 10.1364/AO.35.001756

[29] In-vivo fluence rate effect in photodynamic therapy of early cancers with tetra(m-hydroxyphenyl)chlorin

S. A. BlantA. WoodtliG. WagnièresC. FontollietH. van den Bergh  et al.

Photochemistry and Photobiology

1996

DOI : 10.1111/j.1751-1097.1996.tb01862.x

[28] Optimizing light dosimetry in photodynamic therapy of the bronchi by fluorescence spectroscopy

D. BraichotteJ. F. SavaryT. GlanzmannP. MonnierG. Wagnieres  et al.

Lasers in Medical Science

1996

DOI : 10.1007/BF02134915

[27] Photodynamic Therapy for Cancer of the Upper Aerodigestive Tract Using Tetra(m-hydroxyphenyl)chlorin

P. GrosjeanJ. F. SavaryJ. MizeretG. WagnièresA. Woodtli  et al.

Journal of Clinical Laser Medicine & Surgery

1996

DOI : 10.1089/clm.1996.14.281

[26] Tetra(m-hydroxyphenyl)chlorin clinical photodynamic therapy of early bronchial and oesophageal cancers

P. GrosjeanJ. F. SavaryG. WagnieresJ. MizeretA. Woodtli  et al.

Lasers in Medical Science

1996

DOI : 10.1007/BF02134913

[25] Les indications et performances du laser en urologie

F. SchmidlinP. JichlinskiG. DelacrétazG. WagnièresH. Leisinger  et al.

Médecine et Hygiène

1996

1995

[24] Fluorescence excitation and emission spectra of ALA-induced protoporphyrin IX in normal and tumoral tissue of the human bladder

M. ForrerT. GlanzmannJ. MizeretD. BraichotteG. Wagnieres  et al.

1995. p. 84-88.

DOI : 10.1117/12.198705.

[23] Fluorescence imaging photodetection of early cancer in the bronchi with mTHPC and in the bladder with ALA-induced protoporphyrin IX: preliminary clinical results

M. ForrerJ. MizeretD. BraichotteG. WagnieresJ.-F. Savary  et al.

1995. p. 109-114.

DOI : 10.1117/12.203434.

[22] Evaluation with mTHPC of early squamous cell carcinomas of the cheek pouch mucosa of Golden Syrian hamsters as a model for clinical PDT of early cancers in the upper aerodigestive tract, the esophagus

T. GlanzmannJ.-F. TheumannM. ForrerD. BraichotteG. Wagnieres  et al.

1995. p. 51-58.

DOI : 10.1117/12.203366.

[21] Clinical measurements of tissue optical properties in the esophagus and in the oral cavity

R. BaysG. WagnieresD. RobertJ. MizeretD. Braichotte  et al.

1995. p. 388-395.

DOI : 10.1117/12.203382.

[20] Superficial bladder tumors | LES TUMEURS SUPERFICIELLES DE LA VESSIE

P. JichlinskiJ. MizeretM. ForrerH. Van Den BerghF. Schmidlin  et al.

Revue Medicale de la Suisse Romande

1995

[19] Endoscopic frequency-domain fluorescence lifetime imaging for clinical cancer photodetection: apparatus design

G. WagnieresJ. MizeretA. StudzinskiH. Bergh

1995. p. 42-54.

DOI : 10.1117/12.208173.

[18] Importance of fluence rate in photodynamic therapy with ALA-induced PpIX and BPD-MA in a rat bladder tumor model

S. IinumaG. WagnieresK. T. SchomackerM. BambergT. Hasan

1995. p. 136-140.

DOI : 10.1117/12.208182.

[17] In-vivo measurement of fluorescence bleaching of meso-tetra hydroxy phenyl chlorin (mTHPC) in the esophagus and the oral cavity

M. ForrerT. GlanzmannD. BraichotteG. WagnieresH. Bergh  et al.

1995. p. 33-39.

DOI : 10.1117/12.228901.

[16] Endoscopic tissue fluorescence life-time imaging by frequency domain light-induced fluorescence

J. MizeretG. WagnieresA. StudzinskiC. ShangguanH. Bergh

1995. p. 40-48.

DOI : 10.1117/12.228902.

[15] Clinical pharmacokinetic studies of photofrin by fluorescence spectroscopy in the oral cavity, the esophagus, and the bronchi

D. R. BraichotteG. A. WagnièresR. BaysP. MonnierV. Bergh  et al.

Cancer

1995

DOI : 10.1002/1097-0142(19950601)75:11<2768::AID-CNCR2820751122>3.0.CO;2-I

[14] Clinical pharmacokinetic studies of tetra(meta-hydroxyphenyl)chlorin in squamous cell carcinoma by fluorescence spectroscopy at 2 wavelengths

D. BraichotteJ.-F. SavaryT. GlanzmannP. WestermannS. Folli  et al.

International Journal of Cancer

1995

DOI : 10.1002/ijc.2910630209

[13] Pharmacokinetics of meso-(tetrahydroxyphenyl)chlorin (mTHPC) studied by fluorescence spectroscopy on early cancer of the cheek pouch mucosa of Golden Syrian hamsters

T. GlanzmannJ.-F. TheumannD. BraichotteM. ForrerG. Wagnieres  et al.

1995. International Symposium on Biomedical Optics Europe '94 , Lille, France . p. 89.

DOI : 10.1117/12.198706.

1994

[12] Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice

S. FolliP. WestermannD. BraichotteA. PelegrinG. Wagnieres  et al.

Cancer Research

1994

[11] A clinical comparison of the pharmacokinetics of m-THPC and photofrin II as observed by light induced fluorescence

D. BraichotteJ.-F. SavaryG. WagnièresA. MudryC. Fontolliet  et al.

1994. Europto Biomedical Optics '93 , Budapest, Hungary . p. 62-73.

DOI : 10.1117/12.166811.

1992

[10] Clinical LIF pharmacokinetic measurements with Photofrin II for optimizing the photodetection of early cancer

D. BraichotteG. WagnieresJ. M. PhilippozR. BaysH.-B. Ris  et al.

1992. p. 229-240.

DOI : 10.1117/12.60952.

[9] Preliminary clinical results on a second generation photosensitizer: mTHPC

D. BraichotteG. WagnièresJ. M. D. PhilippozR. BaysH. B. Ris  et al.

1992. International Conference on Photodynamic Therapy and Medical Laser Applications , Milan, Italy , 24-27 June 1992. p. 461-465.

[8] Photoimmunodiagnosis with antibody-fluorescein conjugates: In vitro and in vivo preclinical studies

A. PelegrinS. FolliG. WagnieresD. BraichotteF. Buchegger  et al.

Journal of cellular pharmacology

1992

[7] Further appraisal of PDI and PDT of early squamous cell carcinomas of the pharynx, oesophagus and bronchi

P. MonnierC. FontollietG. WagnièresD. BraichotteH. van den Berg

1992. International Conference on Photodynamic Therapy and Medical Laser Applications , Milan, Italy , 24-27 June 1992.

[6] Clinical pharmacokinetic studies of Photofrin II by fluorescence spectroscopy

D. BraichotteG. WagnièresP. MonnierR. BaysH. van den Bergh

1992. International Conference on Photodynamic Therapy and Medical Laser Applications , Milan , 24-27 June 1992.

[5] Immunophotodiagnosis of Colon Carcinomas in Patients Injected with Fluoresceinated Chimeric Antibodies against Carcinoembryonic Antigen

S. FolliG. WagnièresA. PelegrinJ. M. CalmesD. Braichotte  et al.

Proceedings of the National Academy of Sciences of the United States of America

1992

DOI : 10.1073/pnas.89.17.7973

1991

[4] Photofrin II pharmacokinetics and optical dosing in tissue: apparatus and clinical measurements for the pharynx, esophagus, and tracheobronchial tree

D. BraichotteR. BaysG. WagnieresA. ChatelainC. W. Burckhardt  et al.

Photodynamic Therapy : Basic Principles and Clinical Applications

1991

[3] Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice

A. PelegrinS. FolliF. BucheggerJ. P. MachG. Wagnières  et al.

Cancer

1991

DOI : 10.1002/1097-0142(19910515)67:10<2529::AID-CNCR2820671024>3.0.CO;2-B

1990

[2] Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye: apparatus design and realization

G. WagnieresC. DepeursingeP. MonnierM. SavaryP. Cornaz  et al.

1990. OE/LASE '90 , Los Angeles, CA, United States . p. 43-52.

DOI : 10.1117/12.17649.

[1] Photodetection and photodynamic therapy of "early" squamous cell carcinomas of the pharynx, oesophagus and tracheo-bronchial tree

P. MonnierM. SavaryC. FontollietG. WagnièresA. Châtelain  et al.

Lasers in Medical Science

1990

DOI : 10.1007/BF02031377

Enseignement et PhD

Past Phd As Director

Matthieu Philippe Emmanuel Zellweger, Thomas Stepinac, Pascal Uehlinger, Tanja Gabrecht, Filippo Piffaretti, Blaise Lovisa, Cyrus Kazemiraad

Courses

Biomedical optics

BIOENG-445

Les mécanismes jouant un rôle dans les effets induits par la lumière sur les tissus biologiques, leurs propriétés optiques ainsi que des notions de radiométrie sont abordés dans ce cours. De plus, des applications diagnostiques et thérapeutiques de la lumière les plus illustratives y sont abordées.

Photomedicine

CH-448

Les applications diagnostiques et thérapeutiques de la lumière en clinique seront présentées. De plus, les mécanismes impliqués dans les interactions lumière-tissus biologiques, les propriétés optiques de ces tissus ainsi que des éléments de photobiologie et photochimie seront abordés.