Georgios Sflomos
Fields of expertise
Pre-clinical Models, Invasive Lobular Carcinoma, Extracellular Matrix, Metastasis
Biography
Having dedicated over two decades to conducting fundamental and translational research, specifically on solid tumor malignancies, I possess extensive expertise as a molecular oncology researcher. Over the past 8 years, my focus has been on the most common special histological subtype, a highly hormone-sensitive form of breast cancer known as invasive Lobular Breast Carcinoma (ILC).My drive stems from a deep passion for uncovering hidden biological phenomena in translational oncology research. My expertise lies in pioneering preclinical cancer models, particularly ER-positive breast cancers, addressing this subtype's lack of clinically relevant preclinical models. I have achieved significant breakthroughs, including developing a game-changing in vivo intraductal model that closely mimics patient responses to treatments and metastasis as well as cutting-edge experimental methods and tools that have expanded the horizons of preclinical and translational ILC research.
Current work
I currently lead Working Group 4 for ILC Model Systems. This initiative is a crucial part of the EU-funded COST Action LOBSTERPOT (CA19138), orchestrated by the European Lobular Breast Cancer Consortium (ELBCC). Our goal is to enhance the understanding, diagnosis, and treatment of ILC, thereby making significant strides in the fight against this disease. As a member of the scientific advisory board subcommittee of the Lobular Breast Cancer Alliance (LBCA), I am actively involved in promoting the development of innovative research models for ILC.Publications
Selected publications
George Sflomos, Laura Battista, Patrick Aouad, Fabio De Martino, Valentina Scabia, Athina Stravodimou, Ayyakkannu Ayyanan, Assia Ifticene-Treboux, RLS; Philipp Bucher, Maryse Fiche, Giovanna Ambrosini , Cathrin Brisken |
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1 |
George Sflomos, Valerian Dormoy, Tauno Metsalu, Rachel Jeitziner, Laura Battista, Valentina Scabia, Wassim Raffoul, Jean-Francois Delaloye, Assya Treboux, Maryse Fiche, Jaak Vilo, Ayyakkannu Ayyanan, Cathrin Brisken |
A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response |
Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André & Catarina Brito |
A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures |
Stéphanie Cagnet#, Dalya Ataca#, George Sflomos#, Patrick Aouad, Sonia Schuepbach-Mallepell, Henry Hugues, Andrée Krust, Ayyakkannu Ayyanan, Valentina Scabia, and Cathrin Brisken |
Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium |
George Sflomos, Marie Shamsheddin, Cathrin Brisken |
An ex vivo model to study hormone action in the human breast |
George Sflomos and Cathrin Brisken |
Breast Cancer Microenvironment and the Metastatic Process |
Marie Shamseddin, Fabio De Martino, Céline Constantin, Valentina Scabia, Anne-Sophie Lancelot, Csaba Laszlo, Ayyakkannu Ayyannan, Laura Battista, Wassim Raffoul, Marie-Christine Gailloud-Matthieu, Philipp Bucher, Maryse Fiche, Giovanna Ambrosini, George Sflomos, Cathrin Brisken |
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation |
N Tasdemir, J Scott, J Laotche, W Hou, EA Bossart, J Atkinson, G Sflomos, S Sreekumar, C Castro, C Anderson, AV Lee, C Brisken, PC Lucas, NE Davidson and S Oesterreich |
Novel human cell line xenograft models of ERα-positive metastatic invasive lobular breast carcinoma as pre-clinical platforms for validating candidate genetic drivers |
Berna C Özdemir, George Sflomos, Cathrin Brisken |
The challenges of modeling hormone receptor-positive breast cancer in mice |
George Sflomos, Cathrin Brisken |
A new Achilles Heel in breast cancer? |