Georgios Sflomos
EPFL SV ISREC UPBRI
SV 2830 (Bâtiment SV)
Station 19
CH-1015 Lausanne
Web site: Web site: https://brisken-lab.epfl.ch
Current work
- Invasive Lobular Breast Carcinoma (ILC) is the second most frequently occurring histological breast cancer (BC) subtype. It is hard to detect through conventional diagnostic screenings (mammography and/or ultrasound.
- It exhibits widespread and peculiar metastatic colonization in ovaries, GI tract, peritoneum, skin, meninges, central nervous system, and bone. ILCs are slowly progressive breast tumors and are exquisitely hormone-sensitive. Unfortunately, ILCs are poorly characterized due to the lack of in vivo models that faithfully recapitulate the disease progression and metastases (Sflomos G. and Brisken C., 2017).
- A recently described intraductal transplantation methodology that faithfully mimics estrogen receptor-positive BCs is currently further exploited for metastatic ILCs (Sflomos G. et al., 2016, 2021).
Publications
Selected publications
| George Sflomos, Valerian Dormoy, Tauno Metsalu, Rachel Jeitziner, Laura Battista, Valentina Scabia, Wassim Raffoul, Jean-Francois Delaloye, Assya Treboux, Maryse Fiche, Jaak Vilo, Ayyakkannu Ayyanan, Cathrin Brisken |
A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response |
| George Sflomos, Laura Battista, Patrick Aouad, Fabio De Martino, Valentina Scabia, Athina Stravodimou, Ayyakkannu Ayyanan, Assia Ifticene-Treboux, RLS; Philipp Bucher, Maryse Fiche, Giovanna Ambrosini , Cathrin Brisken |
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1 |
| Stéphanie Cagnet#, Dalya Ataca#, George Sflomos#, Patrick Aouad, Sonia Schuepbach-Mallepell, Henry Hugues, Andrée Krust, Ayyakkannu Ayyanan, Valentina Scabia, and Cathrin Brisken |
Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium |
| George Sflomos, Marie Shamsheddin, Cathrin Brisken |
An ex vivo model to study hormone action in the human breast |
| George Sflomos and Cathrin Brisken |
Breast Cancer Microenvironment and the Metastatic Process |
| Marie Shamseddin, Fabio De Martino, Céline Constantin, Valentina Scabia, Anne-Sophie Lancelot, Csaba Laszlo, Ayyakkannu Ayyannan, Laura Battista, Wassim Raffoul, Marie-Christine Gailloud-Matthieu, Philipp Bucher, Maryse Fiche, Giovanna Ambrosini, George Sflomos, Cathrin Brisken |
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation |
| N Tasdemir, J Scott, J Laotche, W Hou, EA Bossart, J Atkinson, G Sflomos, S Sreekumar, C Castro, C Anderson, AV Lee, C Brisken, PC Lucas, NE Davidson and S Oesterreich |
Novel human cell line xenograft models of ERα-positive metastatic invasive lobular breast carcinoma as pre-clinical platforms for validating candidate genetic drivers |
| Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André & Catarina Brito |
A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures |
| Berna C Özdemir, George Sflomos, Cathrin Brisken |
The challenges of modeling hormone receptor-positive breast cancer in mice |
| George Sflomos, Cathrin Brisken |
A new Achilles Heel in breast cancer? |