Gerardo Turcatti
+41 21 693 96 66
EPFL
>
SV
>
SV-SSV
>
SSV-ENS
Web site: Site web: https://sv.epfl.ch/education
EPFL SV PTECH PTCB
AAB 0 03 (Bâtiment AAB)
Station 15
1015 Lausanne
Web site: Site web: https://bsf.epfl.ch/
Domaines de compétences
Senior scientific level (R&D) with extensive experience in the management of multidisciplinary technological projects. Long industrial experience in Biotechnology and Pharmaceutical-oriented companies with increasing responsibilities in challenging environments. Broad experience in evaluation of technologies, scientific projects and transfer of technological know-how. Expertise in several fields such as Bio-analytical Chemistry, Receptor Biochemistry, DNA and Protein Chemistry and periodically acting as an advisor for academic institutions and as a consultant for biotechnological and pharmaceutical companies.
Publications
Publications Infoscience
Infoscience
Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor
Blood Advances. 2023-12-29. DOI : 10.1182/bloodadvances.2023009964.In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit
Blood Transfusion. 2023-07-01. DOI : 10.2450/2022.0086-22.Automated Dual-Mode Cell Monitoring To Simultaneously Explore Calcium Dynamics and Contraction-Relaxation Kinetics within Drug-Treated Stem Cell-Derived Cardiomyocytes
Acs Sensors. 2023-06-19. DOI : 10.1021/acssensors.3c00073.Repurposing drug screen of patient-derived malignant pleural mesothelioma cells reveals potential anti-cancer activity
2023-04-01. p. S117-S118.High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Scientific Data. 2022-10-08. DOI : 10.1038/s41597-022-01733-4.Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
Nature Communications. 2022-07-02. DOI : 10.1038/s41467-022-31428-8.Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway
Pharmaceuticals. 2022-05-27. DOI : 10.3390/ph15060669.Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening
Cancers. 2022-03-01. DOI : 10.3390/cancers14061575.A Label-Free, High-Throughput Phenotypic Screen Of Adipocytic Differentiation Modulators To Accelerate Hematopoietic Recovery
2022-01-01. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S38-S38.Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern
Current Research in Virological Science. 2022. DOI : 10.1016/j.crviro.2022.100019.Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier
Mbio. 2021-11-01. DOI : 10.1128/mBio.02621-21.Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer
Angewandte Chemie-International Edition. 2021-08-25. DOI : 10.1002/anie.202107815.Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules
International Journal of Molecular Sciences. 2021-04-20. DOI : 10.3390/ijms22084293.Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity
Viruses. 2021-01-18. DOI : 10.3390/v13010128.The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus
Antimicrobial Agents and Chemotherapy. 2020-08-20. DOI : 10.1128/AAC.01002-20.A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus
Scientific Data. 2020-08-12. DOI : 10.1038/s41597-020-00604-0.Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries
Chemical Science. 2020-06-26. DOI : 10.1039/D0SC01944E.High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays
Nature Biomedical Engineering. 2020-06-08. DOI : 10.1038/s41551-020-0565-2.Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics
mBio. 2020-05-05. DOI : 10.1128/mBio.00538-20.Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging
Acs Photonics. 2020-01-01. DOI : 10.1021/acsphotonics.9b01152.Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators
Slas Discovery. 2019-11-28. DOI : 10.1177/2472555219887142.Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands
Science Advances. 2019-08-21. DOI : 10.1126/sciadv.aaw2851.Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis
Plos One. 2019-01-29. DOI : 10.1371/journal.pone.0211268.A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery
Analytical Chemistry. 2019-01-01. DOI : 10.1021/acs.analchem.8b04672.Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging
Biomedical Optics Express. 2018-10-01. DOI : 10.1364/BOE.9.004714.Targeting STING with covalent small-molecule inhibitors
Nature. 2018. DOI : 10.1038/s41586-018-0287-8.High-throughput, nonperturbing quantification of lipid droplets with digital holographic microscopy
JOURNAL OF LIPID RESEARCH. 2018. DOI : 10.1194/jlr.D085217.Red blood cells ageing markers: a multi-parametric analysis
Blood Transfusion. 2017. DOI : 10.2450/2017.0318-16.Repositioning approved drugs for the treatment of problematic cancers using a screening approach
Plos One. 2017. DOI : 10.1371/journal.pone.0171052.Screening out irrelevant cell-based models of disease
Nature Reviews Drug Discovery. 2016. DOI : 10.1038/nrd.2016.175.Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway
2016. 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, JUN 09-12, 2016. p. 29-29.Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus
Nature Microbiology. 2016. DOI : 10.1038/nmicrobiol.2016.8.Identification of CDC-48 inhibitors in C. elegans
2015. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Berlin, GERMANY, JUL 04-09, 2015. p. 389-389.Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
Embo Reports. 2015. DOI : 10.15252/embr.201540081.Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy
Optics Express. 2015. DOI : 10.1364/OE.23.013333.Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening
Label-Free Biosensor Methods in Drug Discovery; New York: Springer, 2015. p. 307-325.Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology
2014. AABB Annual Meeting, Philadelphia, PA, OCT 25-28, 2014. p. 49A-50A.Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
European Journal Of Medicinal Chemistry. 2014. DOI : 10.1016/j.ejmech.2014.06.078.Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland
Combinatorial Chemistry & High Throughput Screening. 2014. DOI : 10.2174/1386207317666140323194716.Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening
Combinatorial chemistry & high throughput screening. 2014. DOI : 10.2174/13862073113166660062.Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from
Chemistry - A European Journal. 2013. DOI : 10.1002/chem.201203296.Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy
ASSAY and Drug Development Technologies. 2013. DOI : 10.1089/adt.2012.476.Chemical Biology Approaches to Membrane Homeostasis and Function
Chimia. 2011. DOI : 10.2533/chimia.2011.849.Multiplexed detection of nucleic acids - testing and benchmarking of a novel platform developed by Biocartis
2011Development of high content image-based cell viability assays
2010Cellular transfection of small interfering ribonucleic acids. Electroporation as an alternative to liposome-based delivery transfection methods
2010Leads for antitubercular compounds from kinase inhibitor library screens
Tuberculosis. 2010. DOI : 10.1016/j.tube.2010.09.001.Preparation of nucleic acid templates for solid phase amplification
EP2918686 ; EP1957668 ; WO2007060456 ; US8168388 ; US2010041561 ; EP1957668 ; WO2007060456 ; GB0524069 . 2010.Preparation of templates for nucleic acid sequencing
ES2398808 ; EP2298930 ; US10710046 ; US2018353926 ; US9999866 ; US2017021325 ; US9498763 ; US2015343410 ; US9085802 ; US2014349891 ; US8715966 ; ES2398808 ; EP2298930 ; US2012208194 ; EP1910559 ; HK1154636 ; EP2298930 ; US2009118128 ; EP1910559 ; WO2007010251 ; WO2007010251 ; GB0514936 . 2009.Method of Nucleotide Detection
EP1828412 ; US9970055 ; US2016208324 ; US9303290 ; US9217178 ; US2014378323 ; EP1828412 ; US2008280773 ; EP1828412 ; WO2006064199 ; GB0514933 ; GB0427236 . 2008.Accurate whole human genome sequencing using reversible terminator chemistry
Nature. 2008. DOI : 10.1038/nature07517.A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis
Nucleic Acids Research. 2008. DOI : 10.1093/nar/gkn021.Conversion of amine- to carboxyl groups on solid surfaces
US7704543 ; US2007042109 ; EP1692090 ; WO2005030695 . 2007.Improved method of nucleotide detection
EP1828412 ; US9970055 ; US2016208324 ; US9303290 ; US9217178 ; US2014378323 ; EP1828412 ; US2008280773 ; EP1828412 ; WO2006064199 ; GB0514933 ; GB0427236 . 2007.Low- to high-throughput analysis of telomerase modulators with Telospot
Nature Methods. 2007. DOI : 10.1038/nmeth1099.Aryldithioethyloxycarbonyl (Ardec): A new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis
Chemistry - A European Journal. 2006. DOI : 10.1002/chem.200501538.BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies
Nucleic Acids Research. 2006. DOI : 10.1093/nar/gnj023.A microfluidic platform using molecular beacon-based temperature calibration for thermal dehybridization of surface-bound DNA
Analytical Chemistry. 2004. DOI : 10.1021/ac034377+.Nucleotide detection by fluorescence resonance energy transfer and methods thereof
BR0303224 ; NO20034592 ; NO20034592 ; AU2003226829 ; WO03068986 . 2003.Development of a Microfluidic Device for Genetic Analysis Based on Hybridization of Surface-bound DNA
2002.Synthesis and characterization of fluorescent and photoactivatable MIP-1alpha ligands and interactions with chemokine receptors CCR1 and CCR5
Journal of Medicinal Chemistry. 2001. DOI : 10.1021/jm000982i.Methods of nucleic acid amplification and sequencing
US10370652 ; US2016319274 ; US9297006 ; US2014228254 ; US8652810 ; EP1634963 ; EP1117827 ; US2008160580 ; US7115400 ; DE69928683 ; EP1634963 ; DE69928683 ; AT311474 ; EP1117827 ; AU771073 ; EA004271 ; HU0105052 ; NZ510599 ; HK1042525 ; JP2002525125 ; AR021833 ; EE200100195 ; HU0105052 ; PL347125 ; BG105363 ; CN1325458 ; SK4292001 ; EA200100402 ; ZA200102420 ; CZ20011183 ; KR20010085860 ; EP1117827 ; TR200100911 ; BR9914159 ; NO20011303 ; NO20011303 ; AU6108899 ; CA2344575 ; WO0018957 . 2000.Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms
Nucleic acids research. 2000. DOI : 10.1093/nar/28.20.e87.Fluorescent pseudo-peptide linear vasopressin antagonists: Design, synthesis, and applications
Journal of Medicinal Chemistry. 1999. DOI : 10.1021/jm9804782.Biophysical approaches to G protein-coupled receptors: Structure, function and dynamics
Journal of Computer-Aided Molecular Design. 1999. DOI : 10.1023/A:1008052002695.Mapping the binding sites of peptide and non-peptide molecules to G protein-coupled receptors by fluorescence
Letters in Peptide Science. 1998. DOI : 10.1007/BF02443443.Probing ligand-receptor recognition in G protein-coupled receptors through biosynthetic incorporation of fluorescent amino acids at specific sites and measurement of distances by fluorescence energy transfer
1998. 2nd Conference on Fluorescence Microscopy and Fluorescent Probes, Prague, Apr. 9-12, 1997. p. 87-92.Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands
Journal of Biological Chemistry. 1997. DOI : 10.1074/jbc.272.34.21167.Fluorescent labeling of NK2 receptor at specific sites in vivo and fluorescence energy transfer analysis of NK2 ligand-receptor complexes
Receptors and Channels. 1997.Probing the structure and function of the tachykinin neurokinin-2 receptor through biosynthetic incorporation of fluorescent amino acids at specific sites
Journal of Biological Chemistry. 1996. DOI : 10.1074/jbc.271.33.19991.Probing the Binding Domain of the NK2 Receptor with Fluorescent Ligands: Evidence That Heptapeptide Agonists and Antagonists Bind Differently
Biochemistry. 1995. DOI : 10.1021/bi00012a015.Novel fluorescence - based approaches to probe ligand recognition and structure of the tachykinin NK2 receptor
Lausanne, EPFL, 1995. DOI : 10.5075/epfl-thesis-1426.Purification, cDNA cloning and heterologous expression of human phosphomannose isomerase
European Journal of Biochemistry. 1994. DOI : 10.1111/j.1432-1033.1994.tb19954.x.Synthesis and characterization of selective fluorescent ligands for the neurokinin NK2 receptor
Journal of Medicinal Chemistry. 1994. DOI : 10.1021/jm00039a012.Biochemical characterization and solubilization of human NK2 receptor expressed in Chinese hamster ovary cells
Journal of Receptor Research. 1993. DOI : 10.3109/10799899309073684.Role of cysteine62 in DNA recognition by the p50 subunit of NF-kappa B
Nucleic Acids Research. 1993. DOI : 10.1093/nar/21.8.1727.Partial characterization of natural and recombinant human soluble CD23
Biochemical Journal. 1992. DOI : 10.1042/bj2860819.Purification and characterization of biologically active human recombinant 37 kDa soluble CD23 (sFc epsilon RII) expressed in insect cells
Journal of Immunological Methods. 1992. DOI : 10.1016/0022-1759(92)90253-P.Human interleukin-5 expressed in Escherichia coli: Assignment of the disulfide bridges of the purified unglycosylated protein
FEBS Letters. 1991. DOI : 10.1016/0014-5793(91)80553-F.Purification and partial characterization of rat factor D
Biochemical Journal. 1991. DOI : 10.1042/bj2790775.Tumor necrosis factor inhibitor: purification, NH2-terminal amino acid sequence and evidence for anti-inflammatory and immunomodulatory activities
European Journal of Immunology. 1990.Structure and partial amino acid sequence of calf thymus DNA topoisomerase II: Comparison with other type II enzymes
Biochemical and Biophysical Research Communications. 1990. DOI : 10.1016/0006-291X(90)92156-T.Purification and characterization of a methionine-specific aminopeptidase from Salmonella typhimurium
European Journal of Biochemistry. 1989. DOI : 10.1111/j.1432-1033.1989.tb14610.x.Characterization of recombinant-derived granulocyte-colony stimulating factor (G-CSF)
Biochemical Journal. 1988. DOI : 10.1042/bj2560213.Insulin proteinase liberates from glucagon a fragment known to have enhanced activity against Ca2+ + Mg2+-dependent ATPase
Biochemical Journal. 1988. DOI : 10.1042/bj2560847.Articles de journaux
Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor
Blood Advances. 2023-12-29. DOI : 10.1182/bloodadvances.2023009964.In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit
Blood Transfusion. 2023-07-01. DOI : 10.2450/2022.0086-22.Automated Dual-Mode Cell Monitoring To Simultaneously Explore Calcium Dynamics and Contraction-Relaxation Kinetics within Drug-Treated Stem Cell-Derived Cardiomyocytes
Acs Sensors. 2023-06-19. DOI : 10.1021/acssensors.3c00073.High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Scientific Data. 2022-10-08. DOI : 10.1038/s41597-022-01733-4.Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway
Pharmaceuticals. 2022-05-27. DOI : 10.3390/ph15060669.Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening
Cancers. 2022-03-01. DOI : 10.3390/cancers14061575.Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern
Current Research in Virological Science. 2022. DOI : 10.1016/j.crviro.2022.100019.Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier
Mbio. 2021-11-01. DOI : 10.1128/mBio.02621-21.Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer
Angewandte Chemie-International Edition. 2021-08-25. DOI : 10.1002/anie.202107815.Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules
International Journal of Molecular Sciences. 2021-04-20. DOI : 10.3390/ijms22084293.Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity
Viruses. 2021-01-18. DOI : 10.3390/v13010128.The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus
Antimicrobial Agents and Chemotherapy. 2020-08-20. DOI : 10.1128/AAC.01002-20.A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus
Scientific Data. 2020-08-12. DOI : 10.1038/s41597-020-00604-0.High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays
Nature Biomedical Engineering. 2020-06-08. DOI : 10.1038/s41551-020-0565-2.Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics
mBio. 2020-05-05. DOI : 10.1128/mBio.00538-20.Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging
Acs Photonics. 2020-01-01. DOI : 10.1021/acsphotonics.9b01152.Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators
Slas Discovery. 2019-11-28. DOI : 10.1177/2472555219887142.Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands
Science Advances. 2019-08-21. DOI : 10.1126/sciadv.aaw2851.Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis
Plos One. 2019-01-29. DOI : 10.1371/journal.pone.0211268.A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery
Analytical Chemistry. 2019-01-01. DOI : 10.1021/acs.analchem.8b04672.Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging
Biomedical Optics Express. 2018-10-01. DOI : 10.1364/BOE.9.004714.Targeting STING with covalent small-molecule inhibitors
Nature. 2018. DOI : 10.1038/s41586-018-0287-8.High-throughput, nonperturbing quantification of lipid droplets with digital holographic microscopy
JOURNAL OF LIPID RESEARCH. 2018. DOI : 10.1194/jlr.D085217.Red blood cells ageing markers: a multi-parametric analysis
Blood Transfusion. 2017. DOI : 10.2450/2017.0318-16.Repositioning approved drugs for the treatment of problematic cancers using a screening approach
Plos One. 2017. DOI : 10.1371/journal.pone.0171052.Screening out irrelevant cell-based models of disease
Nature Reviews Drug Discovery. 2016. DOI : 10.1038/nrd.2016.175.Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus
Nature Microbiology. 2016. DOI : 10.1038/nmicrobiol.2016.8.Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
Embo Reports. 2015. DOI : 10.15252/embr.201540081.Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy
Optics Express. 2015. DOI : 10.1364/OE.23.013333.Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland
Combinatorial Chemistry & High Throughput Screening. 2014. DOI : 10.2174/1386207317666140323194716.Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening
Combinatorial chemistry & high throughput screening. 2014. DOI : 10.2174/13862073113166660062.Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from
Chemistry - A European Journal. 2013. DOI : 10.1002/chem.201203296.Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy
ASSAY and Drug Development Technologies. 2013. DOI : 10.1089/adt.2012.476.Leads for antitubercular compounds from kinase inhibitor library screens
Tuberculosis. 2010. DOI : 10.1016/j.tube.2010.09.001.Accurate whole human genome sequencing using reversible terminator chemistry
Nature. 2008. DOI : 10.1038/nature07517.A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis
Nucleic Acids Research. 2008. DOI : 10.1093/nar/gkn021.Low- to high-throughput analysis of telomerase modulators with Telospot
Nature Methods. 2007. DOI : 10.1038/nmeth1099.Aryldithioethyloxycarbonyl (Ardec): A new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis
Chemistry - A European Journal. 2006. DOI : 10.1002/chem.200501538.BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies
Nucleic Acids Research. 2006. DOI : 10.1093/nar/gnj023.A microfluidic platform using molecular beacon-based temperature calibration for thermal dehybridization of surface-bound DNA
Analytical Chemistry. 2004. DOI : 10.1021/ac034377+.Synthesis and characterization of fluorescent and photoactivatable MIP-1alpha ligands and interactions with chemokine receptors CCR1 and CCR5
Journal of Medicinal Chemistry. 2001. DOI : 10.1021/jm000982i.Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms
Nucleic acids research. 2000. DOI : 10.1093/nar/28.20.e87.Fluorescent pseudo-peptide linear vasopressin antagonists: Design, synthesis, and applications
Journal of Medicinal Chemistry. 1999. DOI : 10.1021/jm9804782.Biophysical approaches to G protein-coupled receptors: Structure, function and dynamics
Journal of Computer-Aided Molecular Design. 1999. DOI : 10.1023/A:1008052002695.Mapping the binding sites of peptide and non-peptide molecules to G protein-coupled receptors by fluorescence
Letters in Peptide Science. 1998. DOI : 10.1007/BF02443443.Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands
Journal of Biological Chemistry. 1997. DOI : 10.1074/jbc.272.34.21167.Fluorescent labeling of NK2 receptor at specific sites in vivo and fluorescence energy transfer analysis of NK2 ligand-receptor complexes
Receptors and Channels. 1997.Probing the structure and function of the tachykinin neurokinin-2 receptor through biosynthetic incorporation of fluorescent amino acids at specific sites
Journal of Biological Chemistry. 1996. DOI : 10.1074/jbc.271.33.19991.Probing the Binding Domain of the NK2 Receptor with Fluorescent Ligands: Evidence That Heptapeptide Agonists and Antagonists Bind Differently
Biochemistry. 1995. DOI : 10.1021/bi00012a015.Purification, cDNA cloning and heterologous expression of human phosphomannose isomerase
European Journal of Biochemistry. 1994. DOI : 10.1111/j.1432-1033.1994.tb19954.x.Synthesis and characterization of selective fluorescent ligands for the neurokinin NK2 receptor
Journal of Medicinal Chemistry. 1994. DOI : 10.1021/jm00039a012.Biochemical characterization and solubilization of human NK2 receptor expressed in Chinese hamster ovary cells
Journal of Receptor Research. 1993. DOI : 10.3109/10799899309073684.Role of cysteine62 in DNA recognition by the p50 subunit of NF-kappa B
Nucleic Acids Research. 1993. DOI : 10.1093/nar/21.8.1727.Partial characterization of natural and recombinant human soluble CD23
Biochemical Journal. 1992. DOI : 10.1042/bj2860819.Purification and characterization of biologically active human recombinant 37 kDa soluble CD23 (sFc epsilon RII) expressed in insect cells
Journal of Immunological Methods. 1992. DOI : 10.1016/0022-1759(92)90253-P.Human interleukin-5 expressed in Escherichia coli: Assignment of the disulfide bridges of the purified unglycosylated protein
FEBS Letters. 1991. DOI : 10.1016/0014-5793(91)80553-F.Purification and partial characterization of rat factor D
Biochemical Journal. 1991. DOI : 10.1042/bj2790775.Tumor necrosis factor inhibitor: purification, NH2-terminal amino acid sequence and evidence for anti-inflammatory and immunomodulatory activities
European Journal of Immunology. 1990.Structure and partial amino acid sequence of calf thymus DNA topoisomerase II: Comparison with other type II enzymes
Biochemical and Biophysical Research Communications. 1990. DOI : 10.1016/0006-291X(90)92156-T.Purification and characterization of a methionine-specific aminopeptidase from Salmonella typhimurium
European Journal of Biochemistry. 1989. DOI : 10.1111/j.1432-1033.1989.tb14610.x.Characterization of recombinant-derived granulocyte-colony stimulating factor (G-CSF)
Biochemical Journal. 1988. DOI : 10.1042/bj2560213.Insulin proteinase liberates from glucagon a fragment known to have enhanced activity against Ca2+ + Mg2+-dependent ATPase
Biochemical Journal. 1988. DOI : 10.1042/bj2560847.Papiers de conférences
Repurposing drug screen of patient-derived malignant pleural mesothelioma cells reveals potential anti-cancer activity
2023-04-01. p. S117-S118.A Label-Free, High-Throughput Phenotypic Screen Of Adipocytic Differentiation Modulators To Accelerate Hematopoietic Recovery
2022-01-01. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S38-S38.Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway
2016. 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, JUN 09-12, 2016. p. 29-29.Identification of CDC-48 inhibitors in C. elegans
2015. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Berlin, GERMANY, JUL 04-09, 2015. p. 389-389.Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology
2014. AABB Annual Meeting, Philadelphia, PA, OCT 25-28, 2014. p. 49A-50A.Probing ligand-receptor recognition in G protein-coupled receptors through biosynthetic incorporation of fluorescent amino acids at specific sites and measurement of distances by fluorescence energy transfer
1998. 2nd Conference on Fluorescence Microscopy and Fluorescent Probes, Prague, Apr. 9-12, 1997. p. 87-92.Chapitres de livres
Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening
Label-Free Biosensor Methods in Drug Discovery; New York: Springer, 2015. p. 307-325.Brevets
Preparation of nucleic acid templates for solid phase amplification
EP2918686 ; EP1957668 ; WO2007060456 ; US8168388 ; US2010041561 ; EP1957668 ; WO2007060456 ; GB0524069 . 2010.Preparation of templates for nucleic acid sequencing
ES2398808 ; EP2298930 ; US10710046 ; US2018353926 ; US9999866 ; US2017021325 ; US9498763 ; US2015343410 ; US9085802 ; US2014349891 ; US8715966 ; ES2398808 ; EP2298930 ; US2012208194 ; EP1910559 ; HK1154636 ; EP2298930 ; US2009118128 ; EP1910559 ; WO2007010251 ; WO2007010251 ; GB0514936 . 2009.Method of Nucleotide Detection
EP1828412 ; US9970055 ; US2016208324 ; US9303290 ; US9217178 ; US2014378323 ; EP1828412 ; US2008280773 ; EP1828412 ; WO2006064199 ; GB0514933 ; GB0427236 . 2008.Conversion of amine- to carboxyl groups on solid surfaces
US7704543 ; US2007042109 ; EP1692090 ; WO2005030695 . 2007.Improved method of nucleotide detection
EP1828412 ; US9970055 ; US2016208324 ; US9303290 ; US9217178 ; US2014378323 ; EP1828412 ; US2008280773 ; EP1828412 ; WO2006064199 ; GB0514933 ; GB0427236 . 2007.Nucleotide detection by fluorescence resonance energy transfer and methods thereof
BR0303224 ; NO20034592 ; NO20034592 ; AU2003226829 ; WO03068986 . 2003.Methods of nucleic acid amplification and sequencing
US10370652 ; US2016319274 ; US9297006 ; US2014228254 ; US8652810 ; EP1634963 ; EP1117827 ; US2008160580 ; US7115400 ; DE69928683 ; EP1634963 ; DE69928683 ; AT311474 ; EP1117827 ; AU771073 ; EA004271 ; HU0105052 ; NZ510599 ; HK1042525 ; JP2002525125 ; AR021833 ; EE200100195 ; HU0105052 ; PL347125 ; BG105363 ; CN1325458 ; SK4292001 ; EA200100402 ; ZA200102420 ; CZ20011183 ; KR20010085860 ; EP1117827 ; TR200100911 ; BR9914159 ; NO20011303 ; NO20011303 ; AU6108899 ; CA2344575 ; WO0018957 . 2000.Projets d'étudiants
Multiplexed detection of nucleic acids - testing and benchmarking of a novel platform developed by Biocartis
2011Development of high content image-based cell viability assays
2010Cellular transfection of small interfering ribonucleic acids. Electroporation as an alternative to liposome-based delivery transfection methods
2010Enseignement & Phd
Enseignement
Life Sciences Engineering