Gerardo Turcatti

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gerardo.turcatti@epfl.ch +41 21 693 96 66 http://bsf.epfl.ch/

https://orcid.org/0000-0003-0139-223X

EPFL > SV > SV-SSV > SSV-ENS

Web site: Site web: https://sv.epfl.ch/education

EPFL SV PTECH PTCB
AAB 0 03 (Bâtiment AAB)
Station 15
1015 Lausanne

+41 21 693 96 66
Local: AAB 0 03
EPFL > SV > PTECH > PTCB

Web site: Site web: https://bsf.epfl.ch/

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Données administratives

Domaines de compétences

PROFILE

Senior scientific level (R&D) with extensive experience in the management of multidisciplinary technological projects. Long industrial experience in Biotechnology and Pharmaceutical-oriented companies with increasing responsibilities in challenging environments. Broad experience in evaluation of technologies, scientific projects and transfer of technological know-how. Expertise in several fields such as Bio-analytical Chemistry, Receptor Biochemistry, DNA and Protein Chemistry and periodically acting as an advisor for academic institutions and as a consultant for biotechnological and pharmaceutical companies.

Publications

Publications Infoscience

Infoscience

Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor

M. Bardyn; D. Crettaz; B. Rappaz; R. Hamelin; F. Armand et al.

Blood Advances. 2023-12-29. DOI : 10.1182/bloodadvances.2023009964.

Gerardo Turcatti

Domaines de compétences

Publications

Publications Infoscience

Infoscience

Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor

In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit

Automated Dual-Mode Cell Monitoring To Simultaneously Explore Calcium Dynamics and Contraction-Relaxation Kinetics within Drug-Treated Stem Cell-Derived Cardiomyocytes

Repurposing drug screen of patient-derived malignant pleural mesothelioma cells reveals potential anti-cancer activity

High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections

Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening

A Label-Free, High-Throughput Phenotypic Screen Of Adipocytic Differentiation Modulators To Accelerate Hematopoietic Recovery

Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier

Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer

Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules

Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity

The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus

A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus

Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics

Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis

A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery

Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging

Targeting STING with covalent small-molecule inhibitors

High-throughput, nonperturbing quantification of lipid droplets with digital holographic microscopy

Red blood cells ageing markers: a multi-parametric analysis

Repositioning approved drugs for the treatment of problematic cancers using a screening approach

Screening out irrelevant cell-based models of disease

Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway

Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus

Identification of CDC-48 inhibitors in C. elegans

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy

Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening

Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland

Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening

Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from

Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy

Chemical Biology Approaches to Membrane Homeostasis and Function

Multiplexed detection of nucleic acids - testing and benchmarking of a novel platform developed by Biocartis

Development of high content image-based cell viability assays

Cellular transfection of small interfering ribonucleic acids. Electroporation as an alternative to liposome-based delivery transfection methods

Leads for antitubercular compounds from kinase inhibitor library screens

Preparation of nucleic acid templates for solid phase amplification

Preparation of templates for nucleic acid sequencing

Method of Nucleotide Detection

Accurate whole human genome sequencing using reversible terminator chemistry

A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis

Conversion of amine- to carboxyl groups on solid surfaces

Improved method of nucleotide detection

Low- to high-throughput analysis of telomerase modulators with Telospot

Aryldithioethyloxycarbonyl (Ardec): A new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis

BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies

A microfluidic platform using molecular beacon-based temperature calibration for thermal dehybridization of surface-bound DNA

Nucleotide detection by fluorescence resonance energy transfer and methods thereof

Development of a Microfluidic Device for Genetic Analysis Based on Hybridization of Surface-bound DNA

Synthesis and characterization of fluorescent and photoactivatable MIP-1alpha ligands and interactions with chemokine receptors CCR1 and CCR5

Methods of nucleic acid amplification and sequencing

Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms

Fluorescent pseudo-peptide linear vasopressin antagonists: Design, synthesis, and applications

Biophysical approaches to G protein-coupled receptors: Structure, function and dynamics

Mapping the binding sites of peptide and non-peptide molecules to G protein-coupled receptors by fluorescence

Probing ligand-receptor recognition in G protein-coupled receptors through biosynthetic incorporation of fluorescent amino acids at specific sites and measurement of distances by fluorescence energy transfer

Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands

Fluorescent labeling of NK2 receptor at specific sites in vivo and fluorescence energy transfer analysis of NK2 ligand-receptor complexes

Probing the structure and function of the tachykinin neurokinin-2 receptor through biosynthetic incorporation of fluorescent amino acids at specific sites

Probing the Binding Domain of the NK2 Receptor with Fluorescent Ligands: Evidence That Heptapeptide Agonists and Antagonists Bind Differently

Novel fluorescence - based approaches to probe ligand recognition and structure of the tachykinin NK2 receptor

Purification, cDNA cloning and heterologous expression of human phosphomannose isomerase

Synthesis and characterization of selective fluorescent ligands for the neurokinin NK2 receptor

Biochemical characterization and solubilization of human NK2 receptor expressed in Chinese hamster ovary cells