Hilal Lashuel
Professeur associé
hilal.lashuel@epfl.ch +41 21 69 39691 http://lashuel-lab.epfl.ch
Nationalité : USA
EPFL SV BMI LMNN
AI 2151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
EPFL SV SSV-GE
AI 2151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
Publications
S. M. Deguire; F. S. Ruggeri; M.-B. Fares; A. Chiki; U. Cendrowska et al. : N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting; Journal of Biological Chemistry. 2018-09-05. DOI : 10.1074/jbc.RA118.004621.
B. Mollenhauer; B. F. DuBois; D. Drake; J. Duong; K. Blennow et al. : Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study; Journal of Neurochemistry. 2018-08-20. DOI : 10.1111/jnc.14569.
F. S. Ruggeri; F. Benedetti; T. P. J. Knowles; H. A. Lashuel; S. Sekatskii et al. : Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils; Proceedings of the National Academy of Sciences. 2018-06-25. DOI : 10.1073/pnas.1721220115.
D. Rodrigo; A. Tittl; N. Ait-Bouziad; A. John-Herpin; O. Limaj et al. : Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces; Nature Communications. 2018-06-04. DOI : 10.1038/s41467-018-04594-x.
D. Etezadi; J. B. Warner; H. A. Lashuel; H. Altug : Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas; ACS Sensors. 2018-05-30. DOI : 10.1021/acssensors.8b00115.
M. Haj Yahya; H. Lashuel : Protein semisynthesis provides access to Tau disease-associated post-translational modifications (PTMs) and paves the way to deciphering the Tau PTM code in health and diseased states.; Journal of American Chemical Society. 2018-04-24. DOI : 10.1021/jacs.8b02668.
A. Reif; A. Chiki; J. Ricci; H. Lashuel : Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy; Journal of Visualized Experiments. 2018-03-29. DOI : 10.3791/57506.
F. El Turk; E. De Genst; T. Guilliams; B. C. D. Fauvet; J. Kiwi et al. : Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding; Proteins Science. 2018-03-29. DOI : 10.1002/pro.3412.
A. Descloux; K. Grußmayer; E. Bostan; T. Lukes; A. Bouwens et al. : Combined Multi-Plane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4D Cell Microscopy; Nature Photonics. 2018. DOI : 10.1038/s41566-018-0109-4.
R. Burai; H. A. Lashuel; V. Mathur; A. Wyss-Coray ; Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy. 9809597 . 2017.
V. Mathus; R. Burai; R. Vest; L. Bonanno; B. Lehallier et al. : Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation; Neuron. 2017. DOI : 10.1016/j.neuron.2017.11.032.
C. Cariulo; L. Azzollini; M. Verani; P. Martufi; R. Boggio et al. : Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation; Proc. Natl. Acad. Sci. U.S.A. 2017. DOI : 10.1073/pnas.1705372114..
J. B. Warner IV; K. Ruff; P. Siong Tan; E. A. Lemke; R. V. Pappu et al. : Monomeric huntingtin exon 1 has similar overall structural features for wild type and pathological polyglutamine lengths; J. Am. Chem. Soc.,. 2017. DOI : 10.1021/jacs.7b06659.
N. Gopaldass; B. Fauvet; H. Lashuel; A. Roux; A. Mayer : Membrane scission driven by the PROPPIN Atg18; Embo Journal. 2017. DOI : 10.15252/embj.201796859.
N. Ait Bouziad / H. Lashuel (Dir.) : Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7985.
F. Ruggeri; A.-L. Mahul; S. Kasas; H. Lashuel; G. Longo et al. : Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection; Cell Death Discovery. 2017. DOI : 10.1038/cddiscovery.2017.53.
N. Ait-Bouziad; G. Lv; A. L. Mahul-Mellier; S. Xiao; G. Zorludemir et al. : Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease; Nature Communications. 2017. DOI : 10.1038/s41467-017-01575-4.
B. Mollenhauer; R. Batrla; O. El-Agnaf; D. R. Galasko; H. A. Lashuel et al. : A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations; Movement Disorders. 2017. DOI : 10.1002/mds.27090.
M. Daldin; V. Fodale; C. Cariulo; L. Azzollini; M. Verani et al. : Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models; Scientific Reports. 2017. DOI : 10.1038/s41598-017-05336-7.
K. M. Ruff; J. B. Warner; A. E. Posey; P. S. Tan; E. A. Lemke et al. : Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1. 2017. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 511A-511A.
H. Vicente Miranda; É. M. Szego; L. M. A. Oliveira; C. Breda; E. Darendelioglu et al. : Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies; Brain : a journal of neurology. 2017. DOI : 10.1093/brain/awx056.
A. Chiki; S. M. DeGuire; F. S. Ruggeri; D. Sanfelice; A. Ansaloni et al. : Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6; Angewandte Chemie (International ed. in English). 2017. DOI : 10.1002/anie.201611750.
R. I. Benmessaoud / L. Forró; H. Lashuel (Dir.) : Human and eco-toxicological impacts of organometallic halide perovskites. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.
D. Etezadi; J. B. Warner IV; F. S. Ruggeri; G. Dietler; H. A. Lashuel et al. : Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection; Light: Science & Applications. 2017. DOI : 10.1038/lsa.2017.29.
H. A. Lashuel : The America I believe in; Science (New York, N.Y.). 2017. DOI : 10.1126/science.355.6326.766.
R. M. de Oliveira; H. Vicente Miranda; L. Francelle; R. Pinho; É. M. Szegö et al. : The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease; PLoS biology. 2017. DOI : 10.1371/journal.pbio.2000374.
S. Vieweg / H. Lashuel (Dir.) : The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.
L. Awad; N. Jejelava; R. Burai; H. A. Lashuel : A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides; Chembiochem : a European journal of chemical biology. 2016. DOI : 10.1002/cbic.201600474.
I. Dikiy; B. Fauvet; A. Jovicic; A.-L. Mahul-Mellier; C. Desobry et al. : Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations; Acs Chemical Biology. 2016. DOI : 10.1021/acschembio.6b00539.
F. S. Ruggeri; S. Vieweg; U. Cendrowska; G. Longo; A. Chiki et al. : Nanoscale studies link amyloid maturity with polyglutamine diseases onset; Scientific Reports. 2016. DOI : 10.1038/srep31155.
S. Vieweg; A. Ansaloni; Z.-M. Wang; J. B. Warner; H. A. Lashuel : An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation; Journal Of Biological Chemistry. 2016. DOI : 10.1074/jbc.M116.713982.
P. H. Jacob Silva / F. Stellacci (Dir.) : Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7037.
I. R. Benmessaoud; A.-L. Mahul-Mellier; E. Horváth; B. Maco; M. Spina et al. : Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies; Toxicol. Res.. 2016. DOI : 10.1039/C5TX00303B.
M.-B. Fares; B. Maco; A. Oueslati; E. Rockenstein; N. Ninkina et al. : Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease; Proceedings of the National Academy of Sciences of the United States of America. 2016. DOI : 10.1073/pnas.1512876113.
J. Adamcik; A. Sanchez-Ferrer; N. Ait-Bouziad; N. P. Reynolds; H. A. Lashuel et al. : Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons; Angewandte Chemie-International Edition. 2016. DOI : 10.1002/anie.201508968.
B. Fauvet; H. A. Lashuel : Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein; Methods in molecular biology (Clifton, N.J.). 2015. DOI : 10.1007/978-1-4939-2978-8_1.
A. Oueslati; B. Lovisa; J. Perrin; G. Wagnières; H. van den Bergh et al. : Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease; PloS one. 2015. DOI : 10.1371/journal.pone.0140880.
Mahul-Mellier; F. Vercruysse; B. Maco; N. Ait-Bouziad; M. De Roo et al. : Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death; Cell death and differentiation. 2015. DOI : 10.1038/cdd.2015.79.
F. S. Ruggeri; J. Adamcik; J. S. Jeong; H. A. Lashuel; R. Mezzenga et al. : Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization; Angewandte Chemie (International ed. in English). 2015. DOI : 10.1002/anie.201409050.
P. Droste; A. Frenzel; M. Steinwand; T. Pelat; P. Thullier et al. : Structural differences of amyloid-beta fibrils revealed by antibodies from phage display; Bmc Biotechnology. 2015. DOI : 10.1186/s12896-015-0146-8.
M.-B. Fares / H. Lashuel (Dir.) : Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.
R. Burai; N. Ait-Bouziad; A. Chiki; H. A. Lashuel : Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis; Journal Of The American Chemical Society. 2015. DOI : 10.1021/ja5131726.
F. S. Ruggeri / G. Dietler (Dir.) : New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6597.
M. K. Mbefo; M.-B. Fares; K. Paleologou; A. Oueslati; G. Yin et al. : Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo; The Journal of biological chemistry. 2015. DOI : 10.1074/jbc.M114.610774.
N. Dhungel; S. Eleuteri; L.-B. Li; N. J. Kramer; J. W. Chartron et al. : Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein; Neuron. 2015. DOI : 10.1016/j.neuron.2014.11.027.
S. Eleuteri; S. Di Giovanni; E. Rockenstein; M. Mante; A. Adame et al. : Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease; Neurobiology of disease. 2015. DOI : 10.1016/j.nbd.2014.08.017.
C. Desobry / H. Lashuel (Dir.) : Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6412.
O. Khalaf; B. Fauvet; A. Oueslati; I. Dikiy; A.-L. Mahul-Mellier et al. : The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity; Journal Of Biological Chemistry. 2014. DOI : 10.1074/jbc.M114.553297.
M.-B. Fares; N. Ait-Bouziad; I. Dikiy; M. K. Mbefo; A. Jovicic et al. : The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells; Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu165.
F. Vercruysse / H. Lashuel (Dir.) : The role of fibril formation and growth in a-synuclein mediated extracellular toxicity. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6106.
M. Mbefo Kamdem / H. Lashuel (Dir.) : The role of S129 phosphorylation in regulating the cellular properties and secretion of alpha-synuclein. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6110.
A. Ansaloni / H. Lashuel (Dir.) : Elucidating the role of N-terminal phosphorylation in regulating the structure and the aggregation propensities of Huntingtin exon 1 using a semisynthetic strategy. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6188.
B. C. D. Fauvet / H. Lashuel (Dir.) : Protein semisynthesis and total synthesis approaches to elucidate the role of Alpha-Synuclein post-translational modifications. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6187.
A. Ansaloni; Z.-M. Wang; J. S. Jeong; F. S. Ruggeri; G. Dietler et al. : One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington's Disease; Angewandte Chemie-International Edition. 2014. DOI : 10.1002/anie.201307510.
H. A. Lashuel; S. Eleuteri; S. Di Giovanni; E. Rockenstein; M. Mante et al. : NOVEL MECHANISM-BASED INHIBITORS OF A beta AGGREGATION AND TOXICITY. 2014. 6th International Conference on Alzheimers Disease and Related Disorders in the Middle East, Istanbul, TURKEY, OCT 25-27, 2013. p. 720-721.
A.-L. Mahul-Mellier; B. Fauvet; A. Gysbers; I. Dikiy; A. Oueslati et al. : c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease; Human molecular genetics. 2014. DOI : 10.1093/hmg/ddt674.
G. Zorludemir : Characterization and stability of tau oligomer formation ; 2013.
A. W. Schmid; B. Fauvet; M. Moniatte; H. A. Lashuel : Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies; Molecular & Cellular Proteomics. 2013. DOI : 10.1074/mcp.R113.032730.
M. Fournier; A. Roux; J. Garrigue; M.-P. Muriel; P. Blanche et al. : Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in alpha-synuclein transgenic mice; BMC neuroscience. 2013. DOI : 10.1186/1471-2202-14-135.
S. Santi; V. Musi; E. Descrovi; V. Paeder; J. Di Francesco et al. : Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach; ChemPhysChem. 2013. DOI : 10.1002/cphc.201300633.
M. Haj-Yahya; B. Fauvet; Y. Herman-Bachinsky; M. Hejjaoui; S. N. Bavikar et al. : Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology; Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1315654110.
B. Fauvet; S. M. Butterfield; J. Fuks; A. Brik; H. A. Lashuel : One-pot total chemical synthesis of human α-synuclein; Chemical communications (Cambridge, England). 2013. DOI : 10.1039/c3cc45353g.
A. Oueslati; B. L. Schneider; P. Aebischer; H. A. Lashuel : Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo; Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1309991110.
S. Schildknecht; H. R. Gerding; C. Karreman; M. Drescher; H. A. Lashuel et al. : Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies; Journal of neurochemistry. 2013. DOI : 10.1111/jnc.12226.
J. S. Jeong; A. Ansaloni; R. Mezzenga; H. A. Lashuel; G. Dietler : Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation; Journal of molecular biology. 2013. DOI : 10.1016/j.jmb.2013.02.005.
H. A. Lashuel; C. R. Overk; A. Oueslati; E. Masliah : The many faces of α-synuclein: from structure and toxicity to therapeutic target; Nature reviews. Neuroscience. 2013. DOI : 10.1038/nrn3406.
F. El-Turk; B. Fauvet; A. Ashrafi; H. Ouertatani-Sakouhi; M.-K. Cho et al. : Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket; PLoS ONE. 2012. DOI : 10.1371/journal.pone.0045024.
Z.-M. Wang; H. A. Lashuel : Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity; Angewandte Chemie (International ed. in English). 2012. DOI : 10.1002/anie.201206561.
N. Shabek; Y. Herman-Bachinsky; S. Buchsbaum; O. Lewinson; M. Haj-Yahya et al. : The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation; Molecular cell. 2012. DOI : 10.1016/j.molcel.2012.07.011.
H. Kroth; A. Ansaloni; Y. Varisco; A. Jan; N. Sreenivasachary et al. : Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.357665.
M. Hejjaoui / H. Lashuel (Dir.) : Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis. Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5494.
B. Fauvet; M.-B. Fares; F. Samuel; I. Dikiy; A. Tandon et al. : Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.383711.
J. Adamcik; C. Lara; I. Usov; J. S. Jeong; F. S. Ruggeri et al. : Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method; Nanoscale. 2012. DOI : 10.1039/c2nr30768e.
H. S. Choi; H. Liew; A. Jang; Y.-M. Kim; H. Lashuel et al. : Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction; Biochemical and biophysical research communications. 2012. DOI : 10.1016/j.bbrc.2012.06.159.
B. Yang; X. Sun; H. Lashuel; Y. Zhang : Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons; Neuroscience Bulletin. 2012. DOI : 10.1007/s12264-012-1239-1.
A. Jan; H. A. Lashuel : Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches; Methods in molecular biology (Clifton, N.J.). 2012. DOI : 10.1007/978-1-61779-551-0_16.
B. Fauvet; M. K. Mbefo; M.-B. Fares; C. Desobry; S. Michael et al. : α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M111.318949.
M. Hejjaoui; S. Butterfield; B. Fauvet; F. Vercruysse; J. Cui et al. : Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125; Journal of the American Chemical Society. 2012. DOI : 10.1021/ja210866j.
S. Butterfield; M. Hejjaoui; B. Fauvet; L. Awad; H. A. Lashuel : Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity; Journal of molecular biology. 2012. DOI : 10.1016/j.jmb.2012.01.051.
A. Oueslati; K. E. Paleologou; B. L. Schneider; P. Aebischer; H. A. Lashuel : Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012. DOI : 10.1523/JNEUROSCI.3784-11.2012.
H. Lashuel; H. Ouertatani-sakouhi ; Method and compositions for inhibition of macrophage migration inhibitory factor (mif). WO2011066864 . 2011.
V. Vocat : Study of the PLK2-α-syn interaction ; 2011.
H. A. Lashuel; W. K. Al-Delaimy : Arab world needs its science diaspora; Nature. 2011.
B. Fauvet; S. M. Butterfield; M. Hejjaoui; D. Olschewski; M. Prudent et al. : Semisynthesis and Total Chemical Synthesis of alpha-synuclein to study Post-Translational Modifications in Health and Disease. 2011. 22nd American Peptide Symposium, San Diego, CA, Jun 25-30, 2011. p. 523-523.
L. Awad; N. Jejelava; A. Brik; H. Lashuel : Novel chemical tools to facilitate the synthesis and control the folding and Self-assembly of amyloid-forming polypeptides. 2011. 22nd American Peptide Symposium, San Diego, CA, Jun 25-30, 2011. p. 430-430.
H. A. Lashuel : Chemical Biology of alpha-synuclein: The role post-translational modification in the pathogenesis of Parkinson's disease & related disorders. 2011. 22nd American Peptide Symposium, San Diego, CA, Jun 25-30, 2011. p. 413-413.
Y. Lu; M. Prudent; B. Fauvet; H. A. Lashuel; H. H. Girault : Phosphorylation of alpha-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of alpha-Synuclein in the Pathogenesis of Parkinson's Disease and Related Disorders; Acs Chemical Neuroscience. 2011. DOI : 10.1021/cn200074d.
N. Jejelava : Characterization and application of novel chemical tools to control folding and amyloid formation ; 2011.
P. Siman; O. Blatt; T. Moyal; T. Danieli; M. Lebendiker et al. : Chemical Synthesis and Expression of the HIV-1 Rev Protein; Chembiochem.. 2011. DOI : 10.1002/cbic.201100033.
A. Jan; O. Adolfsson; I. Allaman; B. AL; M. PJ et al. : Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species; The journal of biological chemistry. 2011. DOI : 10.1074/jbc.M110.172411.
M. Hejjaoui; M. Haj-Yahya; K. KS; A. Brik; H. Lashuel : Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein; Angew Chem Int Ed Engl.. 2011. DOI : 10.1002/anie.201005546.
L. Conboy; E. Varea; J. E. Castro; H. Sakouhi-Ouertatani; T. Calandra et al. : Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors; Mol Psychiatry. 2011. DOI : 10.1038/mp.2010.15.
P. J. Khandelwal; S. B. Dumanis; L. R. Feng; K. Maguire-Zeiss; G. Rebeck et al. : Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model; Molecular neurodegeneration. 2010. DOI : 10.1186/1750-1326-5-47.
M.-P. Hinault; A. F. H. Cuendet; R. U. H. Mattoo; M. Mensi; G. Dietler et al. : Stable -Synuclein Oligomers Strongly Inhibit Chaperone Activity of the Hsp70 System by Weak Interactions with J-domain Co-chaperones; Journal of Biological Chemistry. 2010. DOI : 10.1074/jbc.M110.127753.
C. A. Braga; C. Follmer; F. L. Palhano; E. Khattar; M. S. Freitas et al. : The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species; Journal of molecular biology. 2010. DOI : 10.1016/j.jmb.2010.10.027.
H. Ouertatani-Sakouhi; F. El-Turk; B. Fauvet; M.-K. Cho; D. Pinar Karpinar et al. : Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action; The Journal of biological chemistry. 2010. DOI : 10.1074/jbc.M110.113951.
M. A. Jan Qureshi / H. Lashuel (Dir.) : Nucleation Dependent Polymerization of Amyloid-ß (Aß) as an Important Determinant of Aß Amyloid Formation and Neurotoxicity. Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4773.
A. Oueslati; M. Fournier; H. A. Lashuel : Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies; Progress in brain research. 2010. DOI : 10.1016/S0079-6123(10)83007-9.
F. El Turk; B. Fauvet; H. Ouertatani-Sakouhi; A. Lugari; S. Betzi et al. : An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity; Bioorganic & medicinal chemistry. 2010. DOI : 10.1016/j.bmc.2010.05.010.
H. Ouertatani-Sakouhi / H. Lashuel (Dir.) : Small Molecule Based Approaches to Inhibit Macrophage Migration Inhibitory Factor (MIF) Activities and Elucidate its Role in Health and Disease. Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4633.
Infoscience
S. M. Deguire; F. S. Ruggeri; M.-B. Fares; A. Chiki; U. Cendrowska et al. : N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting; Journal of Biological Chemistry. 2018-09-05. DOI : 10.1074/jbc.RA118.004621.
B. Mollenhauer; B. F. DuBois; D. Drake; J. Duong; K. Blennow et al. : Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study; Journal of Neurochemistry. 2018-08-20. DOI : 10.1111/jnc.14569.
F. S. Ruggeri; F. Benedetti; T. P. J. Knowles; H. A. Lashuel; S. Sekatskii et al. : Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils; Proceedings of the National Academy of Sciences. 2018-06-25. DOI : 10.1073/pnas.1721220115.
D. Rodrigo; A. Tittl; N. Ait-Bouziad; A. John-Herpin; O. Limaj et al. : Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces; Nature Communications. 2018-06-04. DOI : 10.1038/s41467-018-04594-x.
D. Etezadi; J. B. Warner; H. A. Lashuel; H. Altug : Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas; ACS Sensors. 2018-05-30. DOI : 10.1021/acssensors.8b00115.
M. Haj Yahya; H. Lashuel : Protein semisynthesis provides access to Tau disease-associated post-translational modifications (PTMs) and paves the way to deciphering the Tau PTM code in health and diseased states.; Journal of American Chemical Society. 2018-04-24. DOI : 10.1021/jacs.8b02668.
A. Reif; A. Chiki; J. Ricci; H. Lashuel : Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy; Journal of Visualized Experiments. 2018-03-29. DOI : 10.3791/57506.
F. El Turk; E. De Genst; T. Guilliams; B. C. D. Fauvet; J. Kiwi et al. : Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding; Proteins Science. 2018-03-29. DOI : 10.1002/pro.3412.
A. Descloux; K. Grußmayer; E. Bostan; T. Lukes; A. Bouwens et al. : Combined Multi-Plane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4D Cell Microscopy; Nature Photonics. 2018. DOI : 10.1038/s41566-018-0109-4.
R. Burai; H. A. Lashuel; V. Mathur; A. Wyss-Coray ; Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy. 9809597 . 2017.
V. Mathus; R. Burai; R. Vest; L. Bonanno; B. Lehallier et al. : Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation; Neuron. 2017. DOI : 10.1016/j.neuron.2017.11.032.
C. Cariulo; L. Azzollini; M. Verani; P. Martufi; R. Boggio et al. : Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation; Proc. Natl. Acad. Sci. U.S.A. 2017. DOI : 10.1073/pnas.1705372114..
J. B. Warner IV; K. Ruff; P. Siong Tan; E. A. Lemke; R. V. Pappu et al. : Monomeric huntingtin exon 1 has similar overall structural features for wild type and pathological polyglutamine lengths; J. Am. Chem. Soc.,. 2017. DOI : 10.1021/jacs.7b06659.
N. Gopaldass; B. Fauvet; H. Lashuel; A. Roux; A. Mayer : Membrane scission driven by the PROPPIN Atg18; Embo Journal. 2017. DOI : 10.15252/embj.201796859.
N. Ait Bouziad / H. Lashuel (Dir.) : Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7985.
F. Ruggeri; A.-L. Mahul; S. Kasas; H. Lashuel; G. Longo et al. : Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection; Cell Death Discovery. 2017. DOI : 10.1038/cddiscovery.2017.53.
N. Ait-Bouziad; G. Lv; A. L. Mahul-Mellier; S. Xiao; G. Zorludemir et al. : Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease; Nature Communications. 2017. DOI : 10.1038/s41467-017-01575-4.
B. Mollenhauer; R. Batrla; O. El-Agnaf; D. R. Galasko; H. A. Lashuel et al. : A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations; Movement Disorders. 2017. DOI : 10.1002/mds.27090.
M. Daldin; V. Fodale; C. Cariulo; L. Azzollini; M. Verani et al. : Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models; Scientific Reports. 2017. DOI : 10.1038/s41598-017-05336-7.
K. M. Ruff; J. B. Warner; A. E. Posey; P. S. Tan; E. A. Lemke et al. : Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1. 2017. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 511A-511A.
H. Vicente Miranda; É. M. Szego; L. M. A. Oliveira; C. Breda; E. Darendelioglu et al. : Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies; Brain : a journal of neurology. 2017. DOI : 10.1093/brain/awx056.
A. Chiki; S. M. DeGuire; F. S. Ruggeri; D. Sanfelice; A. Ansaloni et al. : Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6; Angewandte Chemie (International ed. in English). 2017. DOI : 10.1002/anie.201611750.
R. I. Benmessaoud / L. Forró; H. Lashuel (Dir.) : Human and eco-toxicological impacts of organometallic halide perovskites. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.
D. Etezadi; J. B. Warner IV; F. S. Ruggeri; G. Dietler; H. A. Lashuel et al. : Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection; Light: Science & Applications. 2017. DOI : 10.1038/lsa.2017.29.
H. A. Lashuel : The America I believe in; Science (New York, N.Y.). 2017. DOI : 10.1126/science.355.6326.766.
R. M. de Oliveira; H. Vicente Miranda; L. Francelle; R. Pinho; É. M. Szegö et al. : The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease; PLoS biology. 2017. DOI : 10.1371/journal.pbio.2000374.
S. Vieweg / H. Lashuel (Dir.) : The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.
L. Awad; N. Jejelava; R. Burai; H. A. Lashuel : A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides; Chembiochem : a European journal of chemical biology. 2016. DOI : 10.1002/cbic.201600474.
I. Dikiy; B. Fauvet; A. Jovicic; A.-L. Mahul-Mellier; C. Desobry et al. : Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations; Acs Chemical Biology. 2016. DOI : 10.1021/acschembio.6b00539.
F. S. Ruggeri; S. Vieweg; U. Cendrowska; G. Longo; A. Chiki et al. : Nanoscale studies link amyloid maturity with polyglutamine diseases onset; Scientific Reports. 2016. DOI : 10.1038/srep31155.
S. Vieweg; A. Ansaloni; Z.-M. Wang; J. B. Warner; H. A. Lashuel : An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation; Journal Of Biological Chemistry. 2016. DOI : 10.1074/jbc.M116.713982.
P. H. Jacob Silva / F. Stellacci (Dir.) : Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7037.
I. R. Benmessaoud; A.-L. Mahul-Mellier; E. Horváth; B. Maco; M. Spina et al. : Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies; Toxicol. Res.. 2016. DOI : 10.1039/C5TX00303B.
M.-B. Fares; B. Maco; A. Oueslati; E. Rockenstein; N. Ninkina et al. : Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease; Proceedings of the National Academy of Sciences of the United States of America. 2016. DOI : 10.1073/pnas.1512876113.
J. Adamcik; A. Sanchez-Ferrer; N. Ait-Bouziad; N. P. Reynolds; H. A. Lashuel et al. : Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons; Angewandte Chemie-International Edition. 2016. DOI : 10.1002/anie.201508968.
B. Fauvet; H. A. Lashuel : Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein; Methods in molecular biology (Clifton, N.J.). 2015. DOI : 10.1007/978-1-4939-2978-8_1.
A. Oueslati; B. Lovisa; J. Perrin; G. Wagnières; H. van den Bergh et al. : Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease; PloS one. 2015. DOI : 10.1371/journal.pone.0140880.
Mahul-Mellier; F. Vercruysse; B. Maco; N. Ait-Bouziad; M. De Roo et al. : Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death; Cell death and differentiation. 2015. DOI : 10.1038/cdd.2015.79.
F. S. Ruggeri; J. Adamcik; J. S. Jeong; H. A. Lashuel; R. Mezzenga et al. : Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization; Angewandte Chemie (International ed. in English). 2015. DOI : 10.1002/anie.201409050.
P. Droste; A. Frenzel; M. Steinwand; T. Pelat; P. Thullier et al. : Structural differences of amyloid-beta fibrils revealed by antibodies from phage display; Bmc Biotechnology. 2015. DOI : 10.1186/s12896-015-0146-8.
M.-B. Fares / H. Lashuel (Dir.) : Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.
R. Burai; N. Ait-Bouziad; A. Chiki; H. A. Lashuel : Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis; Journal Of The American Chemical Society. 2015. DOI : 10.1021/ja5131726.
F. S. Ruggeri / G. Dietler (Dir.) : New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6597.
M. K. Mbefo; M.-B. Fares; K. Paleologou; A. Oueslati; G. Yin et al. : Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo; The Journal of biological chemistry. 2015. DOI : 10.1074/jbc.M114.610774.
N. Dhungel; S. Eleuteri; L.-B. Li; N. J. Kramer; J. W. Chartron et al. : Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein; Neuron. 2015. DOI : 10.1016/j.neuron.2014.11.027.
S. Eleuteri; S. Di Giovanni; E. Rockenstein; M. Mante; A. Adame et al. : Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease; Neurobiology of disease. 2015. DOI : 10.1016/j.nbd.2014.08.017.
C. Desobry / H. Lashuel (Dir.) : Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6412.
O. Khalaf; B. Fauvet; A. Oueslati; I. Dikiy; A.-L. Mahul-Mellier et al. : The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity; Journal Of Biological Chemistry. 2014. DOI : 10.1074/jbc.M114.553297.
M.-B. Fares; N. Ait-Bouziad; I. Dikiy; M. K. Mbefo; A. Jovicic et al. : The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells; Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu165.
F. Vercruysse / H. Lashuel (Dir.) : The role of fibril formation and growth in a-synuclein mediated extracellular toxicity. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6106.
M. Mbefo Kamdem / H. Lashuel (Dir.) : The role of S129 phosphorylation in regulating the cellular properties and secretion of alpha-synuclein. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6110.
A. Ansaloni / H. Lashuel (Dir.) : Elucidating the role of N-terminal phosphorylation in regulating the structure and the aggregation propensities of Huntingtin exon 1 using a semisynthetic strategy. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6188.
B. C. D. Fauvet / H. Lashuel (Dir.) : Protein semisynthesis and total synthesis approaches to elucidate the role of Alpha-Synuclein post-translational modifications. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6187.
A. Ansaloni; Z.-M. Wang; J. S. Jeong; F. S. Ruggeri; G. Dietler et al. : One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington's Disease; Angewandte Chemie-International Edition. 2014. DOI : 10.1002/anie.201307510.
H. A. Lashuel; S. Eleuteri; S. Di Giovanni; E. Rockenstein; M. Mante et al. : NOVEL MECHANISM-BASED INHIBITORS OF A beta AGGREGATION AND TOXICITY. 2014. 6th International Conference on Alzheimers Disease and Related Disorders in the Middle East, Istanbul, TURKEY, OCT 25-27, 2013. p. 720-721.
A.-L. Mahul-Mellier; B. Fauvet; A. Gysbers; I. Dikiy; A. Oueslati et al. : c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease; Human molecular genetics. 2014. DOI : 10.1093/hmg/ddt674.
G. Zorludemir : Characterization and stability of tau oligomer formation ; 2013.
A. W. Schmid; B. Fauvet; M. Moniatte; H. A. Lashuel : Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies; Molecular & Cellular Proteomics. 2013. DOI : 10.1074/mcp.R113.032730.
M. Fournier; A. Roux; J. Garrigue; M.-P. Muriel; P. Blanche et al. : Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in alpha-synuclein transgenic mice; BMC neuroscience. 2013. DOI : 10.1186/1471-2202-14-135.
S. Santi; V. Musi; E. Descrovi; V. Paeder; J. Di Francesco et al. : Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach; ChemPhysChem. 2013. DOI : 10.1002/cphc.201300633.
M. Haj-Yahya; B. Fauvet; Y. Herman-Bachinsky; M. Hejjaoui; S. N. Bavikar et al. : Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology; Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1315654110.
B. Fauvet; S. M. Butterfield; J. Fuks; A. Brik; H. A. Lashuel : One-pot total chemical synthesis of human α-synuclein; Chemical communications (Cambridge, England). 2013. DOI : 10.1039/c3cc45353g.
A. Oueslati; B. L. Schneider; P. Aebischer; H. A. Lashuel : Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo; Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1309991110.
S. Schildknecht; H. R. Gerding; C. Karreman; M. Drescher; H. A. Lashuel et al. : Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies; Journal of neurochemistry. 2013. DOI : 10.1111/jnc.12226.
J. S. Jeong; A. Ansaloni; R. Mezzenga; H. A. Lashuel; G. Dietler : Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation; Journal of molecular biology. 2013. DOI : 10.1016/j.jmb.2013.02.005.
H. A. Lashuel; C. R. Overk; A. Oueslati; E. Masliah : The many faces of α-synuclein: from structure and toxicity to therapeutic target; Nature reviews. Neuroscience. 2013. DOI : 10.1038/nrn3406.
F. El-Turk; B. Fauvet; A. Ashrafi; H. Ouertatani-Sakouhi; M.-K. Cho et al. : Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket; PLoS ONE. 2012. DOI : 10.1371/journal.pone.0045024.
Z.-M. Wang; H. A. Lashuel : Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity; Angewandte Chemie (International ed. in English). 2012. DOI : 10.1002/anie.201206561.
N. Shabek; Y. Herman-Bachinsky; S. Buchsbaum; O. Lewinson; M. Haj-Yahya et al. : The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation; Molecular cell. 2012. DOI : 10.1016/j.molcel.2012.07.011.
H. Kroth; A. Ansaloni; Y. Varisco; A. Jan; N. Sreenivasachary et al. : Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.357665.
M. Hejjaoui / H. Lashuel (Dir.) : Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis. Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5494.
B. Fauvet; M.-B. Fares; F. Samuel; I. Dikiy; A. Tandon et al. : Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.383711.
J. Adamcik; C. Lara; I. Usov; J. S. Jeong; F. S. Ruggeri et al. : Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method; Nanoscale. 2012. DOI : 10.1039/c2nr30768e.
H. S. Choi; H. Liew; A. Jang; Y.-M. Kim; H. Lashuel et al. : Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction; Biochemical and biophysical research communications. 2012. DOI : 10.1016/j.bbrc.2012.06.159.
B. Yang; X. Sun; H. Lashuel; Y. Zhang : Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons; Neuroscience Bulletin. 2012. DOI : 10.1007/s12264-012-1239-1.
A. Jan; H. A. Lashuel : Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches; Methods in molecular biology (Clifton, N.J.). 2012. DOI : 10.1007/978-1-61779-551-0_16.
B. Fauvet; M. K. Mbefo; M.-B. Fares; C. Desobry; S. Michael et al. : α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M111.318949.
M. Hejjaoui; S. Butterfield; B. Fauvet; F. Vercruysse; J. Cui et al. : Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125; Journal of the American Chemical Society. 2012. DOI : 10.1021/ja210866j.
S. Butterfield; M. Hejjaoui; B. Fauvet; L. Awad; H. A. Lashuel : Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity; Journal of molecular biology. 2012. DOI : 10.1016/j.jmb.2012.01.051.
A. Oueslati; K. E. Paleologou; B. L. Schneider; P. Aebischer; H. A. Lashuel : Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012. DOI : 10.1523/JNEUROSCI.3784-11.2012.
H. Lashuel; H. Ouertatani-sakouhi ; Method and compositions for inhibition of macrophage migration inhibitory factor (mif). WO2011066864 . 2011.
V. Vocat : Study of the PLK2-α-syn interaction ; 2011.
H. A. Lashuel; W. K. Al-Delaimy : Arab world needs its science diaspora; Nature. 2011.
B. Fauvet; S. M. Butterfield; M. Hejjaoui; D. Olschewski; M. Prudent et al. : Semisynthesis and Total Chemical Synthesis of alpha-synuclein to study Post-Translational Modifications in Health and Disease. 2011. 22nd American Peptide Symposium, San Diego, CA, Jun 25-30, 2011. p. 523-523.
L. Awad; N. Jejelava; A. Brik; H. Lashuel : Novel chemical tools to facilitate the synthesis and control the folding and Self-assembly of amyloid-forming polypeptides. 2011. 22nd American Peptide Symposium, San Diego, CA, Jun 25-30, 2011. p. 430-430.
H. A. Lashuel : Chemical Biology of alpha-synuclein: The role post-translational modification in the pathogenesis of Parkinson's disease & related disorders. 2011. 22nd American Peptide Symposium, San Diego, CA, Jun 25-30, 2011. p. 413-413.
Y. Lu; M. Prudent; B. Fauvet; H. A. Lashuel; H. H. Girault : Phosphorylation of alpha-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of alpha-Synuclein in the Pathogenesis of Parkinson's Disease and Related Disorders; Acs Chemical Neuroscience. 2011. DOI : 10.1021/cn200074d.
N. Jejelava : Characterization and application of novel chemical tools to control folding and amyloid formation ; 2011.
P. Siman; O. Blatt; T. Moyal; T. Danieli; M. Lebendiker et al. : Chemical Synthesis and Expression of the HIV-1 Rev Protein; Chembiochem.. 2011. DOI : 10.1002/cbic.201100033.
A. Jan; O. Adolfsson; I. Allaman; B. AL; M. PJ et al. : Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species; The journal of biological chemistry. 2011. DOI : 10.1074/jbc.M110.172411.
M. Hejjaoui; M. Haj-Yahya; K. KS; A. Brik; H. Lashuel : Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein; Angew Chem Int Ed Engl.. 2011. DOI : 10.1002/anie.201005546.
L. Conboy; E. Varea; J. E. Castro; H. Sakouhi-Ouertatani; T. Calandra et al. : Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors; Mol Psychiatry. 2011. DOI : 10.1038/mp.2010.15.
P. J. Khandelwal; S. B. Dumanis; L. R. Feng; K. Maguire-Zeiss; G. Rebeck et al. : Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model; Molecular neurodegeneration. 2010. DOI : 10.1186/1750-1326-5-47.
M.-P. Hinault; A. F. H. Cuendet; R. U. H. Mattoo; M. Mensi; G. Dietler et al. : Stable -Synuclein Oligomers Strongly Inhibit Chaperone Activity of the Hsp70 System by Weak Interactions with J-domain Co-chaperones; Journal of Biological Chemistry. 2010. DOI : 10.1074/jbc.M110.127753.
C. A. Braga; C. Follmer; F. L. Palhano; E. Khattar; M. S. Freitas et al. : The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species; Journal of molecular biology. 2010. DOI : 10.1016/j.jmb.2010.10.027.
H. Ouertatani-Sakouhi; F. El-Turk; B. Fauvet; M.-K. Cho; D. Pinar Karpinar et al. : Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action; The Journal of biological chemistry. 2010. DOI : 10.1074/jbc.M110.113951.
M. A. Jan Qureshi / H. Lashuel (Dir.) : Nucleation Dependent Polymerization of Amyloid-ß (Aß) as an Important Determinant of Aß Amyloid Formation and Neurotoxicity. Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4773.
A. Oueslati; M. Fournier; H. A. Lashuel : Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies; Progress in brain research. 2010. DOI : 10.1016/S0079-6123(10)83007-9.
F. El Turk; B. Fauvet; H. Ouertatani-Sakouhi; A. Lugari; S. Betzi et al. : An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity; Bioorganic & medicinal chemistry. 2010. DOI : 10.1016/j.bmc.2010.05.010.
H. Ouertatani-Sakouhi / H. Lashuel (Dir.) : Small Molecule Based Approaches to Inhibit Macrophage Migration Inhibitory Factor (MIF) Activities and Elucidate its Role in Health and Disease. Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4633.
Enseignement & Phd
Enseignement
- Life Sciences Engineering,
Programmes doctoraux
- Doctoral Program in Biotechnology and Bioengineering
- Doctoral Program in Neuroscience
- Doctoral Program in Chemistry and Chemical Engineering
Doctorants
Altay Melek Firat
Cendrowska Urszula Beata
Chiki Anass
Jagannath Somanath
Limorenko Galina
Riguet Nathan Alain Denis
Syed Muhammed Muazzam Kamil
Aït Bouziad Nadine ...
Benmessaoud Ryma Iness ...
Desobry Carole ...
El Turk Farah ...
Fares Mohamed Bilal ...
Fauvet Bruno Claude Daniel ...
Hejjaoui Mirva ...
Jan Qureshi Mohammad Asad ...
Mbefo Kamdem Martial ...
Ouertatani-Sakouhi Hajer ...
Vercruysse Filip ...
Vieweg Sophie ...
Cendrowska Urszula Beata
Chiki Anass
Jagannath Somanath
Limorenko Galina
Riguet Nathan Alain Denis
Syed Muhammed Muazzam Kamil
A dirigé les thèses de
Ansaloni Annalisa ...Aït Bouziad Nadine ...
Benmessaoud Ryma Iness ...
Desobry Carole ...
El Turk Farah ...
Fares Mohamed Bilal ...
Fauvet Bruno Claude Daniel ...
Hejjaoui Mirva ...
Jan Qureshi Mohammad Asad ...
Mbefo Kamdem Martial ...
Ouertatani-Sakouhi Hajer ...
Vercruysse Filip ...
Vieweg Sophie ...
Cours
Neuroscience I: molecules & neurodegeneration
But du cours: guider les étudiants dans les aspects essentiels des neurosciences moléculaires & des maladies neurodégénératives. Possibilité de disséquer les mécanismes moléculaires impliqués dans les maladies neurodégénératives dans le but de comprendre ... 
Selected topics in life sciences
Le cours présente un aperçu de la manière dont la biologie, le génie biotechnologique, les sciences physiques et la médecine façonnent le paysage de la recherche biomédicale et contribuent à améliorer la qualité de la vie et à relever les défis de la sant...