Hilal Lashuel
Nationalité: USA
Formation
|
1994 – 2000
Texas A&M University and The Scripps Research Institute
Dirigée par
Prof. Jeffery W. Kelly
|
1990 – 1994 City University of New York, Brooklyn College
A Site-Specific Organometallic Approach for Installing Tyrosine Phosphorylation Mimics to Decipher the Role of Phosphorylation in Alpha-Synuclein (aSyn) Aggregation and Seeding
2025A Microfluidic Platform for Whole-Membrane Integrity Profiling in Live Neuronal Cells
2025Defined human tri-lineage brain microtissues
2025Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging
Nature Communications. 2025. DOI : 10.1038/s41467-025-60912-0.Mapping the Structural Landscape of Amyloid Fibrils to Guide Polymorph-Specific Therapeutics
2025Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington’s disease human cerebral cortex
Scientific Reports. 2025. DOI : 10.1038/s41598-025-00465-w.Amyotrophic lateral sclerosis caused by TARDBP mutations: from genetics to TDP-43 proteinopathy
The Lancet Neurology. 2025. DOI : 10.1016/S1474-4422(25)00109-7.Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use
Science Advances. 2025. DOI : 10.1126/sciadv.adt7195.<i>Multi‐Targeting</i> Makrozyklische Peptide als Nanomolare Inhibitoren der Selbst‐ und Kreuznukleation der Amyloiden Selbstassemblierung von α‐Synuclein
Angewandte Chemie. 2025. DOI : 10.1002/ange.202422834.Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2025. DOI : 10.1002/anie.202422834.Qatar national cancer care and research: pioneering strategies for global health excellence
The Lancet Oncology. 2025. DOI : 10.1016/s1470-2045(25)00132-9.Uses of aerolysin nanopores
WO2025003492 . 2025.Intelligent and Self-Driving Microscopy of Protein Aggregation in Neurodegenerative Diseases
Lausanne, EPFL, 2025. DOI : 10.5075/epfl-thesis-11337.Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker-Based Drug Screening for Neurodegenerative Diseases
Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025. DOI : 10.1002/advs.202500320.Nanoplasmonic infrared biosensors enabling detection of misfolded protein biomarkers and drug screening for neurodegenerative diseases
Lausanne, EPFL, 2025. DOI : 10.5075/epfl-thesis-10478.Towards Conformational Targeting of Alpha-Synuclein Fibrils
Lausanne, EPFL, 2025. DOI : 10.5075/epfl-thesis-10710.Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
Science advances. 2024. DOI : 10.1126/sciadv.adq3539.Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis
Movement disorders : official journal of the Movement Disorder Society. 2024. DOI : 10.1002/mds.29897.A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins
Journal of the American Chemical Society. 2024. DOI : 10.1021/jacs.4c08416.Differential Effects of Post-translational Modifications on the Membrane Interaction of Huntingtin Protein
Acs Chemical Neuroscience. 2024. DOI : 10.1021/acschemneuro.4c00091.Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
2024Post-translational glycosylation diminishes α-synuclein pathology formation
Nature Chemical Biology. 2024. DOI : 10.1038/s41589-024-01553-0.O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
Nature Chemical Biology. 2024. DOI : 10.1038/s41589-024-01551-2.Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases (vol 10, 19, 2024)
NPJ PARKINSONS DISEASE. 2024. DOI : 10.1038/s41531-024-00634-0.Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization
Lausanne, EPFL, 2024. DOI : 10.5075/epfl-thesis-10555.Author Correction: Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates
Nature Communications. 2024. DOI : 10.1038/s41467-024-48976-w.Deep learning augmented nanoplasmonic infrared sensor for structural protein biomarker-based detection of neurodegenerative diseases
2024. 21 Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications, San Francisco, United States, 2024-01-28 - 2024-01-28. DOI : 10.1117/12.3003239.Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions
Lausanne, EPFL, 2024. DOI : 10.5075/epfl-thesis-10530.Effective Inhibition of TDP-43 Aggregation by Native State Stabilization
Angewandte Chemie International Edition. 2024. DOI : 10.1002/anie.202314587.Transactive response dna-binding protein 43kda (tdp-43) mutants and uses thereof
WO2024223615 . 2024.Exploring the therapeutic potential of Huntingtin native state stabilization through targeting its interacting partners
Lausanne, EPFL, 2024. DOI : 10.5075/epfl-thesis-10915.Method of preparation of amyloidogenic protein aggregates and uses thereof
WO2024094597 . 2024.Dielectrophoretic Manipulation of Biological Species: Novel Microfluidic Approaches to Study Cell-Cell Interactions and the Role of Alpha-Synuclein in Neurodegeneration
Lausanne, EPFL, 2024. DOI : 10.5075/epfl-thesis-10597.Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro
Acs Chemical Neuroscience. 2023. DOI : 10.1021/acschemneuro.3c00691.Deep Learning-Assisted Single-Molecule Detection of Protein Post-translational Modifications with a Biological Nanopore
Acs Nano. 2023. DOI : 10.1021/acsnano.3c08623.Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases
Npj Parkinsons Disease. 2023. DOI : 10.1038/s41531-023-00604-y.Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates
Nature Communications. 2023. DOI : 10.1038/s41467-023-39314-7.Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease
Molecular Neurodegeneration. 2023. DOI : 10.1186/s13024-023-00628-1.Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases
Science Advances. 2023. DOI : 10.1126/sciadv.adg9644.Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage
Nature Neuroscience. 2023. DOI : 10.1038/s41593-023-01341-4.Neuronal growth on high-aspect-ratio diamond nanopillar arrays for biosensing applications
Scientific Reports. 2023. DOI : 10.1038/s41598-023-32235-x.Deconstructing and Reconstructing the Complexity of Tau pathology
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-9911.Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders
Acta Neuropathologica Communications. 2022. DOI : 10.1186/s40478-022-01468-8.Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity
Npj Parkinsons Disease. 2022. DOI : 10.1038/s41531-022-00388-7.N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease
Neurobiology Of Disease. 2022. DOI : 10.1016/j.nbd.2022.105884.Pathological substrate of memory impairment in multiple system atrophy
Neuropathology And Applied Neurobiology. 2022. DOI : 10.1111/nan.12844.Identification of key segments of IAPP/aSyn cross-amyloid interactions
2022.Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies
Npj Parkinsons Disease. 2022. DOI : 10.1038/s41531-022-00357-0.On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid
Analytical Chemistry. 2022. DOI : 10.1021/acs.analchem.2c01577.Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils
Journal Of The American Chemical Society. 2022. DOI : 10.1021/jacs.2c00509.Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery
Npj Parkinsons Disease. 2022. DOI : 10.1038/s41531-022-00310-1.A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity
Science Advances. 2022. DOI : 10.1126/sciadv.abn0044.Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy
Cells. 2022. DOI : 10.3390/cells11050906.The role of PTM crosstalks in Httex1 structure, aggregation and membrane interaction
2022. p. 38 - 38. DOI : 10.1016/j.bpj.2021.11.2495.An integrative approach to elucidate the mechanisms and dynamics of Huntingtin aggregation and inclusion formation in neuronal models of Huntington's Disease
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9296.Capturing the heterogeneity of alpha-synuclein pathology in synucleinopathies
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8480.Towards elucidating the structural and cellular determinants of a-synuclein seeding and toxicity
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9365.Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
Chemical Society Reviews. 2022. DOI : 10.1039/d1cs00127b.Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations
Computational and Structural Biotechnology Journal. 2022. DOI : 10.1016/j.csbj.2021.12.017.Comparative Analysis of Total Alpha-Synuclein (alpha SYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified alpha SYN Proteoforms
Journal Of Parkinsons Disease. 2022. DOI : 10.3233/JPD-223285.To target Tau pathologies, we must embrace and reconstruct their complexities
Neurobiology Of Disease. 2021. DOI : 10.1016/j.nbd.2021.105536.Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
Nature Communications. 2021. DOI : 10.1038/s41467-021-26684-z.Fatal attraction-The role of hypoxia when alpha-synuclein gets intimate with mitochondria
Neurobiology Of Aging. 2021. DOI : 10.1016/j.neurobiolaging.2021.07.017.The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1
Journal of Molecular Biology. 2021. DOI : 10.1016/j.jmb.2021.167222.Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
Scientific Reports. 2021. DOI : 10.1038/s41598-021-97334-z.Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation
Frontiers in Molecular Biosciences. 2021. DOI : 10.3389/fmolb.2021.686086.Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease
Npj Parkinsons Disease. 2021. DOI : 10.1038/s41531-021-00203-9.A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation
Journal of the American Chemical Society. 2021. DOI : 10.1021/jacs.1c03108.Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?
Current Opinion in Chemical Biology. 2021. DOI : 10.1016/j.cbpa.2021.05.006.Lewy body-associated proteins: Victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein
Neurobiology of Disease. 2021. DOI : 10.1016/j.nbd.2021.105417.Parkinson mice show functional and molecular changes in the gut long before motoric disease onset
Molecular Neurodegeneration. 2021. DOI : 10.1186/s13024-021-00439-2.Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
Molecular Therapy. 2021. DOI : 10.1016/j.ymthe.2021.01.033.Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease
Acta Neuropathologica Communications. 2021. DOI : 10.1186/s40478-021-01172-z.Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model This is the reply to a comment "Alpha-synuclein oligomerization and aggregation: A model will always be a model" on the original article "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". The articles are accompanied by a Preface "How good are cellular models?".
Journal of Neurochemistry (JNC). 2021. DOI : 10.1111/jnc.15275.Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?
Movement Disorders. 2021. DOI : 10.1002/mds.28544.Reverse engineering Lewy bodies: how far have we come and how far can we go?
Nature Reviews Neuroscience. 2021. DOI : 10.1038/s41583-020-00416-6.Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get
Journal of Neurochemistry (JNC). 2021. DOI : 10.1111/jnc.15147.Site-Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
Chembiochem. 2020. DOI : 10.1002/cbic.202000508.How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology
Neurobiology of Disease. 2020. DOI : 10.1016/j.nbd.2020.105086.TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
The EMBO Journal. 2020. DOI : 10.15252/embj.2020104671.Half a century of amyloids: past, present and future
Chemical Society Reviews. 2020. DOI : 10.1039/C9CS00199A.Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports
Neurobiology Of Disease. 2020. DOI : 10.1016/j.nbd.2020.104876.Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
Journal of Biological Chemistry. 2020. DOI : 10.1074/jbc.RA119.012517.Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
Nature Communications. 2020. DOI : 10.1038/s41467-020-16564-3.Education and research are essential for lasting peace in Yemen
Lancet. 2020. DOI : 10.1016/S0140-6736(20)30162-8.Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2020. DOI : 10.1073/pnas.1916176117.The busy lives of academics have hidden costs — and universities must take better care of their faculty members
Nature Careers Community. 2020. DOI : 10.1038/d41586-020-00661-w.A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of alpha-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in alpha-synuclein research
Journal of Neurochemistry (JNC). 2020. DOI : 10.1111/jnc.14955.The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2020. DOI : 10.1073/pnas.1913904117.Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding
Angewandte Chemie International Edition. 2020. DOI : 10.1002/anie.201913001.Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13
Biochemical And Biophysical Research Communications. 2020. DOI : 10.1016/j.bbrc.2019.09.097.What about faculty?
Elife. 2020. DOI : 10.7554/eLife.54551.Gold nanoparticles as a new tool in amyloid studies
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7471.Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala
eNeuro. 2020. DOI : 10.1523/ENEURO.0110-20.2020.Development of novel methods and tools to decipher the huntingtin post-translation modifications code
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7537.The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus
Frontiers in Molecular Biosciences. 2019. DOI : 10.3389/fmolb.2019.00095.Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay
Frontiers in Neuroscience. 2019. DOI : 10.3389/fnins.2019.00889.Investigation of alpha-synuclein post-translational modifications in idiopathic Parkinson's disease and multiple system atrophy
2019. 120th Meeting of the British-Neuropathological-Society (BNS) / Developmental Neuropathology Symposium, London, ENGLAND, Mar 06-08, 2019. p. 19 - 19.Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding
Angewandte Chemie International Edition. 2019. DOI : 10.1002/anie.201805238.alpha-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2019. DOI : 10.1073/pnas.1808845116.A method for preparing phfs-like tau aggregates
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Proteins Science. 2018. DOI : 10.1002/pro.3412.Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
Journal of Visualized Experiments. 2018. DOI : 10.3791/57506.Combined Multi-Plane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4D Cell Microscopy
Nature Photonics. 2018. DOI : 10.1038/s41566-018-0109-4.Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
Journal of the American Chemical Society. 2017. DOI : 10.1021/jacs.7b06659.Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7985.Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy
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Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6
Angewandte Chemie (International ed. in English). 2017. DOI : 10.1002/anie.201611750.The America I believe in
Science. 2017. DOI : 10.1126/science.355.6326.766.Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation
Neuron. 2017. DOI : 10.1016/j.neuron.2017.11.032.Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection
Cell Death Discovery. 2017. DOI : 10.1038/cddiscovery.2017.53.Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
Scientific Reports. 2017. DOI : 10.1038/s41598-017-05336-7.Membrane scission driven by the PROPPIN Atg18
Embo Journal. 2017. DOI : 10.15252/embj.201796859.The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
PLoS Biology. 2017. DOI : 10.1371/journal.pbio.2000374.Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
Brain : a journal of neurology. 2017. DOI : 10.1093/brain/awx056.Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1
2017. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 511A - 511A. DOI : 10.1016/j.bpj.2016.11.2762.A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations
Movement Disorders. 2017. DOI : 10.1002/mds.27090.Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease
Nature Communications. 2017. DOI : 10.1038/s41467-017-01575-4.An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation
Journal of Biological Chemistry. 2016. DOI : 10.1074/jbc.M116.713982.A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
Chembiochem : a European journal of chemical biology. 2016. DOI : 10.1002/cbic.201600474.Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2016. DOI : 10.1073/pnas.1512876113.Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons
Angewandte Chemie International Edition. 2016. DOI : 10.1002/anie.201508968.Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies
Toxicol. Res.. 2016. DOI : 10.1039/C5TX00303B.Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations
Acs Chemical Biology. 2016. DOI : 10.1021/acschembio.6b00539.Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease
Neurobiology of disease. 2015. DOI : 10.1016/j.nbd.2014.08.017.Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
Cell death and differentiation. 2015. DOI : 10.1038/cdd.2015.79.Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease
PloS One. 2015. DOI : 10.1371/journal.pone.0140880.Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein
Methods in molecular biology (Clifton, N.J.). 2015. DOI : 10.1007/978-1-4939-2978-8_1.Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis
Journal Of The American Chemical Society. 2015. DOI : 10.1021/ja5131726.Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization
Angewandte Chemie (International ed. in English). 2015. DOI : 10.1002/anie.201409050.Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo
Journal of Biological Chemistry. 2015. DOI : 10.1074/jbc.M114.610774.Structural differences of amyloid-beta fibrils revealed by antibodies from phage display
Bmc Biotechnology. 2015. DOI : 10.1186/s12896-015-0146-8.Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
Neuron. 2015. DOI : 10.1016/j.neuron.2014.11.027.The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells
Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu165.Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6412.One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington's Disease
Angewandte Chemie International Edition. 2014. DOI : 10.1002/anie.201307510.c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddt674.Protein semisynthesis and total synthesis approaches to elucidate the role of Alpha-Synuclein post-translational modifications
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6187.The role of S129 phosphorylation in regulating the cellular properties and secretion of alpha-synuclein : implication for alpha-synuclein function in health and disease
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6110.The role of fibril formation and growth in a-synuclein mediated extracellular toxicity
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6106.NOVEL MECHANISM-BASED INHIBITORS OF A beta AGGREGATION AND TOXICITY
2014. 6th International Conference on Alzheimers Disease and Related Disorders in the Middle East, Istanbul, TURKEY, OCT 25-27, 2013. p. 720 - 721.Elucidating the role of N-terminal phosphorylation in regulating the structure and the aggregation propensities of Huntingtin exon 1 using a semisynthetic strategy
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6188.Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies
Molecular & Cellular Proteomics. 2013. DOI : 10.1074/mcp.R113.032730.Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies
Journal of Neurochemistry (JNC). 2013. DOI : 10.1111/jnc.12226.Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation
Journal of Molecular Biology. 2013. DOI : 10.1016/j.jmb.2013.02.005.The many faces of α-synuclein: from structure and toxicity to therapeutic target
Nature reviews. Neuroscience. 2013. DOI : 10.1038/nrn3406.Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach
ChemPhysChem. 2013. DOI : 10.1002/cphc.201300633.Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2013. DOI : 10.1073/pnas.1315654110.One-pot total chemical synthesis of human α-synuclein
Chemical Communications (ChemComm). 2013. DOI : 10.1039/c3cc45353g.Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in alpha-synuclein transgenic mice
BMC neuroscience. 2013. DOI : 10.1186/1471-2202-14-135.Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2013. DOI : 10.1073/pnas.1309991110.Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons
Neuroscience Bulletin. 2012. DOI : 10.1007/s12264-012-1239-1.Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket
PLoS ONE. 2012. DOI : 10.1371/journal.pone.0045024.Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity
Angewandte Chemie (International ed. in English). 2012. DOI : 10.1002/anie.201206561.α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer
Journal of Biological Chemistry. 2012. DOI : 10.1074/jbc.M111.318949.Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125
Journal of the American Chemical Society. 2012. DOI : 10.1021/ja210866j.Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity
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Doctorant·es actuel·les
A dirigé les thèses EPFL de
Hajer Ouertatani-Sakouhi, Mohammad Asad Jan Qureshi, Farah El Turk, Mirva Hejjaoui, Bruno Claude Daniel Fauvet, Carole Desobry, Martial Mbefo Kamdem, Filip Vercruysse, Annalisa Ansaloni, Mohamed Bilal Fares, Nadine Aït Bouziad, Sophie Vieweg, Anass Chiki, Melek Firat Altay, Nathan Riguet, Somanath Jagannath, Galina Limorenko, Enzo Morro, Lixin Yang
A co-dirigé les thèses EPFL de
Alessandra Musso, Ryma Iness Benmessaoud, Urszula Beata Cendrowska, Zhidian Zhang, Till Jonathan Ryser, Ahmed Sadek, Deepthy Kavungal, Khalid Ibrahim