Hilal Lashuel
hilal.lashuel@epfl.ch +41 21 693 96 91 http://lashuel-lab.epfl.ch
Nationalité : USA
Date de naissance : 15.01.1973
EPFL SV BMI LMNN
AI 2151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
+41 21 693 96 91
+41 21 693 07 92
Local: AI 2151
EPFL > SV > BMI > LMNN
Web site: Site web: https://lashuel-lab.epfl.ch/
+41 21 693 96 91
EPFL > SV > SV-DEC > CF-SV
Web site: Site web: https://sv.epfl.ch/Council
Publications
Publications Infoscience
U. Cendrowska; P. J. Silva; N. Ait-Bouziad; M. Mueller; Z. P. Guven et al. : Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2020-03-24. DOI : 10.1073/pnas.1916176117.
H. Lashuel : The busy lives of academics have hidden costs — and universities must take better care of their faculty members; Nature Careers Community. 2020-03-05. DOI : 10.1038/d41586-020-00661-w.
S. T. Kumar; S. Donzelli; A. Chiki; M. M. K. Syed; H. A. Lashuel : A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of alpha-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in alpha-synuclein research; Journal Of Neurochemistry. 2020-02-25. DOI : 10.1111/jnc.14955.
A.-L. Mahul-Mellier; J. Burtscher; N. Maharjan; L. Weerens; M. Croisier et al. : The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration; Proceedings of the National Academy of Sciences of United States of America. 2020-02-19. DOI : 10.1073/pnas.1913904117.
M. Haj-Yahya; P. Gopinath; K. Rajasekhar; H. Mirbaha; M. I. Diamond et al. : Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding; Angewandte Chemie-International Edition. 2020-01-28. DOI : 10.1002/anie.201913001.
C. Cariulo; M. Verani; P. Martufi; R. Ingenito; M. Finotto et al. : Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13; Biochemical And Biophysical Research Communications. 2020-01-15. DOI : 10.1016/j.bbrc.2019.09.097.
H. A. Lashuel : What about faculty?; Elife. 2020-01-08. DOI : 10.7554/eLife.54551.
U. B. Cendrowska / F. Stellacci; H. Lashuel (Dir.) : Gold nanoparticles as a new tool in amyloid studies. Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7471.
H. Yalinca; C. J. C. Gehin; V. Oleinikovas; H. A. Lashuel; F. L. Gervasio et al. : The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus; Frontiers in Molecular Biosciences. 2019-10-01. DOI : 10.3389/fmolb.2019.00095.
C. Cariulo; P. Martufi; M. Verani; L. Azzollini; G. Bruni et al. : Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay; Frontiers in Neuroscience. 2019-08-22. DOI : 10.3389/fnins.2019.00889.
J. Burtscher; J.-C. Copin; J. Rodrigues; S. T. Kumar; A. Chiki et al. : Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology; Neurobiology of Aging. 2019-08-14. DOI : 10.1016/j.neurobiolaging.2019.08.007.
B. Sonustun; C. Strand; S. Foti; T. T. Warner; H. Lashuel et al. : Investigation of alpha-synuclein post-translational modifications in idiopathic Parkinson's disease and multiple system atrophy. 2019-03-01. 120th Meeting of the British-Neuropathological-Society (BNS) / Developmental Neuropathology Symposium, London, ENGLAND, Mar 06-08, 2019. p. 19-19.
D. Ellmer; M. Brehs; M. Haj-Yahya; H. A. Lashuel; C. F. W. Becker : Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding; Angewandte Chemie-International Edition. 2019-02-04. DOI : 10.1002/anie.201805238.
P. M. Levine; A. Galesic; A. T. Balana; A.-L. Mahul-Mellier; M. X. Navarro et al. : alpha-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-29. DOI : 10.1073/pnas.1808845116.
H. A. Lashuel; N. Ait-Bouziad ; A method for preparing phfs-like tau aggregates. WO2019207164 . 2019.
V. Laversenne / B. Schneider; P. Aebischer (Dir.) : Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9751.
P. A. Gonschorek / C. Heinis (Dir.) : Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7676.
S. M. K. Nazeeruddin / B. Schneider; P. Aebischer (Dir.) : A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.
S. L. Barlatey / G. Courtine; J. Bloch (Dir.) : Axon regeneration and circuit reorganization after complete spinal cord injury. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7659.
S. M. Deguire; F. S. Ruggeri; M.-B. Fares; A. Chiki; U. Cendrowska et al. : N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting; Journal of Biological Chemistry. 2018-09-05. DOI : 10.1074/jbc.RA118.004621.
B. Mollenhauer; B. F. DuBois; D. Drake; J. Duong; K. Blennow et al. : Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study; Journal of Neurochemistry. 2018-08-20. DOI : 10.1111/jnc.14569.
F. S. Ruggeri; F. Benedetti; T. P. J. Knowles; H. A. Lashuel; S. Sekatskii et al. : Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils; Proceedings of the National Academy of Sciences. 2018-06-25. DOI : 10.1073/pnas.1721220115.
D. Rodrigo; A. Tittl; N. Ait-Bouziad; A. John-Herpin; O. Limaj et al. : Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces; Nature Communications. 2018-06-04. DOI : 10.1038/s41467-018-04594-x.
D. Etezadi; J. B. Warner; H. A. Lashuel; H. Altug : Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas; ACS Sensors. 2018-05-30. DOI : 10.1021/acssensors.8b00115.
M. Haj-Yahya; H. A. Lashuel : Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States; Journal of the American Chemical Society. 2018-04-24. DOI : 10.1021/jacs.8b02668.
A. Reif; A. Chiki; J. Ricci; H. Lashuel : Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy; Journal of Visualized Experiments. 2018-03-29. DOI : 10.3791/57506.
F. El Turk; E. De Genst; T. Guilliams; B. C. D. Fauvet; J. Kiwi et al. : Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding; Proteins Science. 2018-03-29. DOI : 10.1002/pro.3412.
A. Descloux; K. Grußmayer; E. Bostan; T. Lukes; A. Bouwens et al. : Combined Multi-Plane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4D Cell Microscopy; Nature Photonics. 2018. DOI : 10.1038/s41566-018-0109-4.
R. Burai; H. A. Lashuel; V. Mathur; A. Wyss-Coray ; Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy. US9809597 ; US2017050967 . 2017.
V. Mathus; R. Burai; R. Vest; L. Bonanno; B. Lehallier et al. : Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation; Neuron. 2017. DOI : 10.1016/j.neuron.2017.11.032.
C. Cariulo; L. Azzollini; M. Verani; P. Martufi; R. Boggio et al. : Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation; Proceedings of the National Academy of Sciences. 2017. DOI : 10.1073/pnas.1705372114.
J. B. Warner IV; K. Ruff; P. Siong Tan; E. A. Lemke; R. V. Pappu et al. : Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths; Journal of the American Chemical Society. 2017. DOI : 10.1021/jacs.7b06659.
N. Gopaldass; B. Fauvet; H. Lashuel; A. Roux; A. Mayer : Membrane scission driven by the PROPPIN Atg18; Embo Journal. 2017. DOI : 10.15252/embj.201796859.
N. Ait Bouziad / H. Lashuel (Dir.) : Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7985.
F. Ruggeri; A.-L. Mahul; S. Kasas; H. Lashuel; G. Longo et al. : Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection; Cell Death Discovery. 2017. DOI : 10.1038/cddiscovery.2017.53.
N. Ait-Bouziad; G. Lv; A. L. Mahul-Mellier; S. Xiao; G. Zorludemir et al. : Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease; Nature Communications. 2017. DOI : 10.1038/s41467-017-01575-4.
B. Mollenhauer; R. Batrla; O. El-Agnaf; D. R. Galasko; H. A. Lashuel et al. : A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations; Movement Disorders. 2017. DOI : 10.1002/mds.27090.
M. Daldin; V. Fodale; C. Cariulo; L. Azzollini; M. Verani et al. : Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models; Scientific Reports. 2017. DOI : 10.1038/s41598-017-05336-7.
K. M. Ruff; J. B. Warner; A. E. Posey; P. S. Tan; E. A. Lemke et al. : Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1. 2017. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 511A-511A.
H. Vicente Miranda; É. M. Szego; L. M. A. Oliveira; C. Breda; E. Darendelioglu et al. : Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies; Brain : a journal of neurology. 2017. DOI : 10.1093/brain/awx056.
A. Chiki; S. M. DeGuire; F. S. Ruggeri; D. Sanfelice; A. Ansaloni et al. : Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6; Angewandte Chemie (International ed. in English). 2017. DOI : 10.1002/anie.201611750.
R. I. Benmessaoud / L. Forró; H. Lashuel (Dir.) : Human and eco-toxicological impacts of organometallic halide perovskites. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.
D. Etezadi; J. B. Warner IV; F. S. Ruggeri; G. Dietler; H. A. Lashuel et al. : Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection; Light: Science and Applications. 2017. DOI : 10.1038/lsa.2017.29.
H. A. Lashuel : The America I believe in; Science (New York, N.Y.). 2017. DOI : 10.1126/science.355.6326.766.
R. M. de Oliveira; H. Vicente Miranda; L. Francelle; R. Pinho; É. M. Szegö et al. : The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease; PLoS biology. 2017. DOI : 10.1371/journal.pbio.2000374.
S. Vieweg / H. Lashuel (Dir.) : The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.
F. S. Ruggeri; S. Vieweg; U. Cendrowska; G. Longo; A. Chiki et al. : Nanoscale studies link amyloid maturity with polyglutamine diseases onset; Scientific Reports. 2016-08-01. DOI : 10.1038/srep31155.
L. Awad; N. Jejelava; R. Burai; H. A. Lashuel : A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides; Chembiochem : a European journal of chemical biology. 2016. DOI : 10.1002/cbic.201600474.
I. Dikiy; B. Fauvet; A. Jovicic; A.-L. Mahul-Mellier; C. Desobry et al. : Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations; Acs Chemical Biology. 2016. DOI : 10.1021/acschembio.6b00539.
S. Vieweg; A. Ansaloni; Z.-M. Wang; J. B. Warner; H. A. Lashuel : An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation; Journal Of Biological Chemistry. 2016. DOI : 10.1074/jbc.M116.713982.
P. H. Jacob Silva / F. Stellacci (Dir.) : Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7037.
I. R. Benmessaoud; A.-L. Mahul-Mellier; E. Horváth; B. Maco; M. Spina et al. : Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies; Toxicol. Res.. 2016. DOI : 10.1039/C5TX00303B.
M.-B. Fares; B. Maco; A. Oueslati; E. Rockenstein; N. Ninkina et al. : Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease; Proceedings of the National Academy of Sciences of the United States of America. 2016. DOI : 10.1073/pnas.1512876113.
J. Adamcik; A. Sanchez-Ferrer; N. Ait-Bouziad; N. P. Reynolds; H. A. Lashuel et al. : Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons; Angewandte Chemie-International Edition. 2016. DOI : 10.1002/anie.201508968.
M. B. Bustamante; A. Ansaloni; J. F. Pedersen; L. Azzollini; C. Cariulo et al. : Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ; Biochemical and Biophysical Research Communications. 2015-08-07. DOI : 10.1016/j.bbrc.2015.06.116.
B. Fauvet; H. A. Lashuel : Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein; Methods in molecular biology (Clifton, N.J.). 2015. DOI : 10.1007/978-1-4939-2978-8_1.
A. Oueslati; B. Lovisa; J. Perrin; G. Wagnières; H. van den Bergh et al. : Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease; PloS One. 2015. DOI : 10.1371/journal.pone.0140880.
Mahul-Mellier; F. Vercruysse; B. Maco; N. Ait-Bouziad; M. De Roo et al. : Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death; Cell death and differentiation. 2015. DOI : 10.1038/cdd.2015.79.
F. S. Ruggeri; J. Adamcik; J. S. Jeong; H. A. Lashuel; R. Mezzenga et al. : Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization; Angewandte Chemie (International ed. in English). 2015. DOI : 10.1002/anie.201409050.
P. Droste; A. Frenzel; M. Steinwand; T. Pelat; P. Thullier et al. : Structural differences of amyloid-beta fibrils revealed by antibodies from phage display; Bmc Biotechnology. 2015. DOI : 10.1186/s12896-015-0146-8.
M.-B. Fares / H. Lashuel (Dir.) : Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.
R. Burai; N. Ait-Bouziad; A. Chiki; H. A. Lashuel : Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis; Journal Of The American Chemical Society. 2015. DOI : 10.1021/ja5131726.
F. S. Ruggeri / G. Dietler (Dir.) : New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6597.
M. K. Mbefo; M.-B. Fares; K. Paleologou; A. Oueslati; G. Yin et al. : Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo; The Journal of biological chemistry. 2015. DOI : 10.1074/jbc.M114.610774.
N. Dhungel; S. Eleuteri; L.-B. Li; N. J. Kramer; J. W. Chartron et al. : Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein; Neuron. 2015. DOI : 10.1016/j.neuron.2014.11.027.
S. Eleuteri; S. Di Giovanni; E. Rockenstein; M. Mante; A. Adame et al. : Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease; Neurobiology of disease. 2015. DOI : 10.1016/j.nbd.2014.08.017.
C. Desobry / H. Lashuel (Dir.) : Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6412.
O. Khalaf; B. Fauvet; A. Oueslati; I. Dikiy; A.-L. Mahul-Mellier et al. : The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity; Journal Of Biological Chemistry. 2014. DOI : 10.1074/jbc.M114.553297.
M.-B. Fares; N. Ait-Bouziad; I. Dikiy; M. K. Mbefo; A. Jovicic et al. : The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells; Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu165.
F. Vercruysse / H. Lashuel (Dir.) : The role of fibril formation and growth in a-synuclein mediated extracellular toxicity. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6106.
M. Mbefo Kamdem / H. Lashuel (Dir.) : The role of S129 phosphorylation in regulating the cellular properties and secretion of alpha-synuclein. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6110.
A. Ansaloni / H. Lashuel (Dir.) : Elucidating the role of N-terminal phosphorylation in regulating the structure and the aggregation propensities of Huntingtin exon 1 using a semisynthetic strategy. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6188.
B. C. D. Fauvet / H. Lashuel (Dir.) : Protein semisynthesis and total synthesis approaches to elucidate the role of Alpha-Synuclein post-translational modifications. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6187.
A. Ansaloni; Z.-M. Wang; J. S. Jeong; F. S. Ruggeri; G. Dietler et al. : One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington's Disease; Angewandte Chemie-International Edition. 2014. DOI : 10.1002/anie.201307510.
H. A. Lashuel; S. Eleuteri; S. Di Giovanni; E. Rockenstein; M. Mante et al. : NOVEL MECHANISM-BASED INHIBITORS OF A beta AGGREGATION AND TOXICITY. 2014. 6th International Conference on Alzheimers Disease and Related Disorders in the Middle East, Istanbul, TURKEY, OCT 25-27, 2013. p. 720-721.
A.-L. Mahul-Mellier; B. Fauvet; A. Gysbers; I. Dikiy; A. Oueslati et al. : c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease; Human molecular genetics. 2014. DOI : 10.1093/hmg/ddt674.
G. Zorludemir : Characterization and stability of tau oligomer formation ; 2013.
A. W. Schmid; B. Fauvet; M. Moniatte; H. A. Lashuel : Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies; Molecular & Cellular Proteomics. 2013. DOI : 10.1074/mcp.R113.032730.
M. Fournier; A. Roux; J. Garrigue; M.-P. Muriel; P. Blanche et al. : Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in alpha-synuclein transgenic mice; BMC neuroscience. 2013. DOI : 10.1186/1471-2202-14-135.
S. Santi; V. Musi; E. Descrovi; V. Paeder; J. Di Francesco et al. : Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach; ChemPhysChem. 2013. DOI : 10.1002/cphc.201300633.
M. Haj-Yahya; B. Fauvet; Y. Herman-Bachinsky; M. Hejjaoui; S. N. Bavikar et al. : Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology; Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1315654110.
B. Fauvet; S. M. Butterfield; J. Fuks; A. Brik; H. A. Lashuel : One-pot total chemical synthesis of human α-synuclein; Chemical communications (Cambridge, England). 2013. DOI : 10.1039/c3cc45353g.
A. Oueslati; B. L. Schneider; P. Aebischer; H. A. Lashuel : Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo; Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1309991110.
S. Schildknecht; H. R. Gerding; C. Karreman; M. Drescher; H. A. Lashuel et al. : Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies; Journal of neurochemistry. 2013. DOI : 10.1111/jnc.12226.
J. S. Jeong; A. Ansaloni; R. Mezzenga; H. A. Lashuel; G. Dietler : Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation; Journal of molecular biology. 2013. DOI : 10.1016/j.jmb.2013.02.005.
H. A. Lashuel; C. R. Overk; A. Oueslati; E. Masliah : The many faces of α-synuclein: from structure and toxicity to therapeutic target; Nature reviews. Neuroscience. 2013. DOI : 10.1038/nrn3406.
F. El-Turk; B. Fauvet; A. Ashrafi; H. Ouertatani-Sakouhi; M.-K. Cho et al. : Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket; PLoS ONE. 2012. DOI : 10.1371/journal.pone.0045024.
Z.-M. Wang; H. A. Lashuel : Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity; Angewandte Chemie (International ed. in English). 2012. DOI : 10.1002/anie.201206561.
N. Shabek; Y. Herman-Bachinsky; S. Buchsbaum; O. Lewinson; M. Haj-Yahya et al. : The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation; Molecular cell. 2012. DOI : 10.1016/j.molcel.2012.07.011.
H. Kroth; A. Ansaloni; Y. Varisco; A. Jan; N. Sreenivasachary et al. : Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.357665.
M. Hejjaoui / H. Lashuel (Dir.) : Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis. Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5494.
B. Fauvet; M.-B. Fares; F. Samuel; I. Dikiy; A. Tandon et al. : Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.383711.
J. Adamcik; C. Lara; I. Usov; J. S. Jeong; F. S. Ruggeri et al. : Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method; Nanoscale. 2012. DOI : 10.1039/c2nr30768e.
H. S. Choi; H. Liew; A. Jang; Y.-M. Kim; H. Lashuel et al. : Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction; Biochemical and biophysical research communications. 2012. DOI : 10.1016/j.bbrc.2012.06.159.
B. Yang; X. Sun; H. Lashuel; Y. Zhang : Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons; Neuroscience Bulletin. 2012. DOI : 10.1007/s12264-012-1239-1.
A. Jan; H. A. Lashuel : Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches; Methods in molecular biology (Clifton, N.J.). 2012. DOI : 10.1007/978-1-61779-551-0_16.
B. Fauvet; M. K. Mbefo; M.-B. Fares; C. Desobry; S. Michael et al. : α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M111.318949.
M. Hejjaoui; S. Butterfield; B. Fauvet; F. Vercruysse; J. Cui et al. : Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125; Journal of the American Chemical Society. 2012. DOI : 10.1021/ja210866j.
S. Butterfield; M. Hejjaoui; B. Fauvet; L. Awad; H. A. Lashuel : Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity; Journal of molecular biology. 2012. DOI : 10.1016/j.jmb.2012.01.051.
A. Oueslati; K. E. Paleologou; B. L. Schneider; P. Aebischer; H. A. Lashuel : Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012. DOI : 10.1523/JNEUROSCI.3784-11.2012.
Infoscience
U. Cendrowska; P. J. Silva; N. Ait-Bouziad; M. Mueller; Z. P. Guven et al. : Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2020-03-24. DOI : 10.1073/pnas.1916176117.
H. Lashuel : The busy lives of academics have hidden costs — and universities must take better care of their faculty members; Nature Careers Community. 2020-03-05. DOI : 10.1038/d41586-020-00661-w.
S. T. Kumar; S. Donzelli; A. Chiki; M. M. K. Syed; H. A. Lashuel : A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of alpha-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in alpha-synuclein research; Journal Of Neurochemistry. 2020-02-25. DOI : 10.1111/jnc.14955.
A.-L. Mahul-Mellier; J. Burtscher; N. Maharjan; L. Weerens; M. Croisier et al. : The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration; Proceedings of the National Academy of Sciences of United States of America. 2020-02-19. DOI : 10.1073/pnas.1913904117.
M. Haj-Yahya; P. Gopinath; K. Rajasekhar; H. Mirbaha; M. I. Diamond et al. : Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding; Angewandte Chemie-International Edition. 2020-01-28. DOI : 10.1002/anie.201913001.
C. Cariulo; M. Verani; P. Martufi; R. Ingenito; M. Finotto et al. : Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13; Biochemical And Biophysical Research Communications. 2020-01-15. DOI : 10.1016/j.bbrc.2019.09.097.
H. A. Lashuel : What about faculty?; Elife. 2020-01-08. DOI : 10.7554/eLife.54551.
U. B. Cendrowska / F. Stellacci; H. Lashuel (Dir.) : Gold nanoparticles as a new tool in amyloid studies. Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7471.
H. Yalinca; C. J. C. Gehin; V. Oleinikovas; H. A. Lashuel; F. L. Gervasio et al. : The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus; Frontiers in Molecular Biosciences. 2019-10-01. DOI : 10.3389/fmolb.2019.00095.
C. Cariulo; P. Martufi; M. Verani; L. Azzollini; G. Bruni et al. : Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay; Frontiers in Neuroscience. 2019-08-22. DOI : 10.3389/fnins.2019.00889.
J. Burtscher; J.-C. Copin; J. Rodrigues; S. T. Kumar; A. Chiki et al. : Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology; Neurobiology of Aging. 2019-08-14. DOI : 10.1016/j.neurobiolaging.2019.08.007.
B. Sonustun; C. Strand; S. Foti; T. T. Warner; H. Lashuel et al. : Investigation of alpha-synuclein post-translational modifications in idiopathic Parkinson's disease and multiple system atrophy. 2019-03-01. 120th Meeting of the British-Neuropathological-Society (BNS) / Developmental Neuropathology Symposium, London, ENGLAND, Mar 06-08, 2019. p. 19-19.
D. Ellmer; M. Brehs; M. Haj-Yahya; H. A. Lashuel; C. F. W. Becker : Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding; Angewandte Chemie-International Edition. 2019-02-04. DOI : 10.1002/anie.201805238.
P. M. Levine; A. Galesic; A. T. Balana; A.-L. Mahul-Mellier; M. X. Navarro et al. : alpha-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-29. DOI : 10.1073/pnas.1808845116.
H. A. Lashuel; N. Ait-Bouziad ; A method for preparing phfs-like tau aggregates. WO2019207164 . 2019.
V. Laversenne / B. Schneider; P. Aebischer (Dir.) : Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9751.
P. A. Gonschorek / C. Heinis (Dir.) : Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7676.
S. M. K. Nazeeruddin / B. Schneider; P. Aebischer (Dir.) : A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.
S. L. Barlatey / G. Courtine; J. Bloch (Dir.) : Axon regeneration and circuit reorganization after complete spinal cord injury. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7659.
S. M. Deguire; F. S. Ruggeri; M.-B. Fares; A. Chiki; U. Cendrowska et al. : N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting; Journal of Biological Chemistry. 2018-09-05. DOI : 10.1074/jbc.RA118.004621.
B. Mollenhauer; B. F. DuBois; D. Drake; J. Duong; K. Blennow et al. : Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study; Journal of Neurochemistry. 2018-08-20. DOI : 10.1111/jnc.14569.
F. S. Ruggeri; F. Benedetti; T. P. J. Knowles; H. A. Lashuel; S. Sekatskii et al. : Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils; Proceedings of the National Academy of Sciences. 2018-06-25. DOI : 10.1073/pnas.1721220115.
D. Rodrigo; A. Tittl; N. Ait-Bouziad; A. John-Herpin; O. Limaj et al. : Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces; Nature Communications. 2018-06-04. DOI : 10.1038/s41467-018-04594-x.
D. Etezadi; J. B. Warner; H. A. Lashuel; H. Altug : Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas; ACS Sensors. 2018-05-30. DOI : 10.1021/acssensors.8b00115.
M. Haj-Yahya; H. A. Lashuel : Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States; Journal of the American Chemical Society. 2018-04-24. DOI : 10.1021/jacs.8b02668.
A. Reif; A. Chiki; J. Ricci; H. Lashuel : Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy; Journal of Visualized Experiments. 2018-03-29. DOI : 10.3791/57506.
F. El Turk; E. De Genst; T. Guilliams; B. C. D. Fauvet; J. Kiwi et al. : Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding; Proteins Science. 2018-03-29. DOI : 10.1002/pro.3412.
A. Descloux; K. Grußmayer; E. Bostan; T. Lukes; A. Bouwens et al. : Combined Multi-Plane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4D Cell Microscopy; Nature Photonics. 2018. DOI : 10.1038/s41566-018-0109-4.
R. Burai; H. A. Lashuel; V. Mathur; A. Wyss-Coray ; Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy. US9809597 ; US2017050967 . 2017.
V. Mathus; R. Burai; R. Vest; L. Bonanno; B. Lehallier et al. : Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation; Neuron. 2017. DOI : 10.1016/j.neuron.2017.11.032.
C. Cariulo; L. Azzollini; M. Verani; P. Martufi; R. Boggio et al. : Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation; Proceedings of the National Academy of Sciences. 2017. DOI : 10.1073/pnas.1705372114.
J. B. Warner IV; K. Ruff; P. Siong Tan; E. A. Lemke; R. V. Pappu et al. : Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths; Journal of the American Chemical Society. 2017. DOI : 10.1021/jacs.7b06659.
N. Gopaldass; B. Fauvet; H. Lashuel; A. Roux; A. Mayer : Membrane scission driven by the PROPPIN Atg18; Embo Journal. 2017. DOI : 10.15252/embj.201796859.
N. Ait Bouziad / H. Lashuel (Dir.) : Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7985.
F. Ruggeri; A.-L. Mahul; S. Kasas; H. Lashuel; G. Longo et al. : Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection; Cell Death Discovery. 2017. DOI : 10.1038/cddiscovery.2017.53.
N. Ait-Bouziad; G. Lv; A. L. Mahul-Mellier; S. Xiao; G. Zorludemir et al. : Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease; Nature Communications. 2017. DOI : 10.1038/s41467-017-01575-4.
B. Mollenhauer; R. Batrla; O. El-Agnaf; D. R. Galasko; H. A. Lashuel et al. : A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations; Movement Disorders. 2017. DOI : 10.1002/mds.27090.
M. Daldin; V. Fodale; C. Cariulo; L. Azzollini; M. Verani et al. : Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models; Scientific Reports. 2017. DOI : 10.1038/s41598-017-05336-7.
K. M. Ruff; J. B. Warner; A. E. Posey; P. S. Tan; E. A. Lemke et al. : Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1. 2017. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 511A-511A.
H. Vicente Miranda; É. M. Szego; L. M. A. Oliveira; C. Breda; E. Darendelioglu et al. : Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies; Brain : a journal of neurology. 2017. DOI : 10.1093/brain/awx056.
A. Chiki; S. M. DeGuire; F. S. Ruggeri; D. Sanfelice; A. Ansaloni et al. : Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6; Angewandte Chemie (International ed. in English). 2017. DOI : 10.1002/anie.201611750.
R. I. Benmessaoud / L. Forró; H. Lashuel (Dir.) : Human and eco-toxicological impacts of organometallic halide perovskites. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.
D. Etezadi; J. B. Warner IV; F. S. Ruggeri; G. Dietler; H. A. Lashuel et al. : Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection; Light: Science and Applications. 2017. DOI : 10.1038/lsa.2017.29.
H. A. Lashuel : The America I believe in; Science (New York, N.Y.). 2017. DOI : 10.1126/science.355.6326.766.
R. M. de Oliveira; H. Vicente Miranda; L. Francelle; R. Pinho; É. M. Szegö et al. : The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease; PLoS biology. 2017. DOI : 10.1371/journal.pbio.2000374.
S. Vieweg / H. Lashuel (Dir.) : The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.
F. S. Ruggeri; S. Vieweg; U. Cendrowska; G. Longo; A. Chiki et al. : Nanoscale studies link amyloid maturity with polyglutamine diseases onset; Scientific Reports. 2016-08-01. DOI : 10.1038/srep31155.
L. Awad; N. Jejelava; R. Burai; H. A. Lashuel : A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides; Chembiochem : a European journal of chemical biology. 2016. DOI : 10.1002/cbic.201600474.
I. Dikiy; B. Fauvet; A. Jovicic; A.-L. Mahul-Mellier; C. Desobry et al. : Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations; Acs Chemical Biology. 2016. DOI : 10.1021/acschembio.6b00539.
S. Vieweg; A. Ansaloni; Z.-M. Wang; J. B. Warner; H. A. Lashuel : An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation; Journal Of Biological Chemistry. 2016. DOI : 10.1074/jbc.M116.713982.
P. H. Jacob Silva / F. Stellacci (Dir.) : Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7037.
I. R. Benmessaoud; A.-L. Mahul-Mellier; E. Horváth; B. Maco; M. Spina et al. : Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies; Toxicol. Res.. 2016. DOI : 10.1039/C5TX00303B.
M.-B. Fares; B. Maco; A. Oueslati; E. Rockenstein; N. Ninkina et al. : Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease; Proceedings of the National Academy of Sciences of the United States of America. 2016. DOI : 10.1073/pnas.1512876113.
J. Adamcik; A. Sanchez-Ferrer; N. Ait-Bouziad; N. P. Reynolds; H. A. Lashuel et al. : Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons; Angewandte Chemie-International Edition. 2016. DOI : 10.1002/anie.201508968.
M. B. Bustamante; A. Ansaloni; J. F. Pedersen; L. Azzollini; C. Cariulo et al. : Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ; Biochemical and Biophysical Research Communications. 2015-08-07. DOI : 10.1016/j.bbrc.2015.06.116.
B. Fauvet; H. A. Lashuel : Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein; Methods in molecular biology (Clifton, N.J.). 2015. DOI : 10.1007/978-1-4939-2978-8_1.
A. Oueslati; B. Lovisa; J. Perrin; G. Wagnières; H. van den Bergh et al. : Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease; PloS One. 2015. DOI : 10.1371/journal.pone.0140880.
Mahul-Mellier; F. Vercruysse; B. Maco; N. Ait-Bouziad; M. De Roo et al. : Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death; Cell death and differentiation. 2015. DOI : 10.1038/cdd.2015.79.
F. S. Ruggeri; J. Adamcik; J. S. Jeong; H. A. Lashuel; R. Mezzenga et al. : Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization; Angewandte Chemie (International ed. in English). 2015. DOI : 10.1002/anie.201409050.
P. Droste; A. Frenzel; M. Steinwand; T. Pelat; P. Thullier et al. : Structural differences of amyloid-beta fibrils revealed by antibodies from phage display; Bmc Biotechnology. 2015. DOI : 10.1186/s12896-015-0146-8.
M.-B. Fares / H. Lashuel (Dir.) : Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.
R. Burai; N. Ait-Bouziad; A. Chiki; H. A. Lashuel : Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis; Journal Of The American Chemical Society. 2015. DOI : 10.1021/ja5131726.
F. S. Ruggeri / G. Dietler (Dir.) : New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6597.
M. K. Mbefo; M.-B. Fares; K. Paleologou; A. Oueslati; G. Yin et al. : Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo; The Journal of biological chemistry. 2015. DOI : 10.1074/jbc.M114.610774.
N. Dhungel; S. Eleuteri; L.-B. Li; N. J. Kramer; J. W. Chartron et al. : Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein; Neuron. 2015. DOI : 10.1016/j.neuron.2014.11.027.
S. Eleuteri; S. Di Giovanni; E. Rockenstein; M. Mante; A. Adame et al. : Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease; Neurobiology of disease. 2015. DOI : 10.1016/j.nbd.2014.08.017.
C. Desobry / H. Lashuel (Dir.) : Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6412.
O. Khalaf; B. Fauvet; A. Oueslati; I. Dikiy; A.-L. Mahul-Mellier et al. : The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity; Journal Of Biological Chemistry. 2014. DOI : 10.1074/jbc.M114.553297.
M.-B. Fares; N. Ait-Bouziad; I. Dikiy; M. K. Mbefo; A. Jovicic et al. : The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells; Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu165.
F. Vercruysse / H. Lashuel (Dir.) : The role of fibril formation and growth in a-synuclein mediated extracellular toxicity. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6106.
M. Mbefo Kamdem / H. Lashuel (Dir.) : The role of S129 phosphorylation in regulating the cellular properties and secretion of alpha-synuclein. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6110.
A. Ansaloni / H. Lashuel (Dir.) : Elucidating the role of N-terminal phosphorylation in regulating the structure and the aggregation propensities of Huntingtin exon 1 using a semisynthetic strategy. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6188.
B. C. D. Fauvet / H. Lashuel (Dir.) : Protein semisynthesis and total synthesis approaches to elucidate the role of Alpha-Synuclein post-translational modifications. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6187.
A. Ansaloni; Z.-M. Wang; J. S. Jeong; F. S. Ruggeri; G. Dietler et al. : One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington's Disease; Angewandte Chemie-International Edition. 2014. DOI : 10.1002/anie.201307510.
H. A. Lashuel; S. Eleuteri; S. Di Giovanni; E. Rockenstein; M. Mante et al. : NOVEL MECHANISM-BASED INHIBITORS OF A beta AGGREGATION AND TOXICITY. 2014. 6th International Conference on Alzheimers Disease and Related Disorders in the Middle East, Istanbul, TURKEY, OCT 25-27, 2013. p. 720-721.
A.-L. Mahul-Mellier; B. Fauvet; A. Gysbers; I. Dikiy; A. Oueslati et al. : c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease; Human molecular genetics. 2014. DOI : 10.1093/hmg/ddt674.
G. Zorludemir : Characterization and stability of tau oligomer formation ; 2013.
A. W. Schmid; B. Fauvet; M. Moniatte; H. A. Lashuel : Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies; Molecular & Cellular Proteomics. 2013. DOI : 10.1074/mcp.R113.032730.
M. Fournier; A. Roux; J. Garrigue; M.-P. Muriel; P. Blanche et al. : Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in alpha-synuclein transgenic mice; BMC neuroscience. 2013. DOI : 10.1186/1471-2202-14-135.
S. Santi; V. Musi; E. Descrovi; V. Paeder; J. Di Francesco et al. : Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach; ChemPhysChem. 2013. DOI : 10.1002/cphc.201300633.
M. Haj-Yahya; B. Fauvet; Y. Herman-Bachinsky; M. Hejjaoui; S. N. Bavikar et al. : Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology; Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1315654110.
B. Fauvet; S. M. Butterfield; J. Fuks; A. Brik; H. A. Lashuel : One-pot total chemical synthesis of human α-synuclein; Chemical communications (Cambridge, England). 2013. DOI : 10.1039/c3cc45353g.
A. Oueslati; B. L. Schneider; P. Aebischer; H. A. Lashuel : Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo; Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1309991110.
S. Schildknecht; H. R. Gerding; C. Karreman; M. Drescher; H. A. Lashuel et al. : Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies; Journal of neurochemistry. 2013. DOI : 10.1111/jnc.12226.
J. S. Jeong; A. Ansaloni; R. Mezzenga; H. A. Lashuel; G. Dietler : Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation; Journal of molecular biology. 2013. DOI : 10.1016/j.jmb.2013.02.005.
H. A. Lashuel; C. R. Overk; A. Oueslati; E. Masliah : The many faces of α-synuclein: from structure and toxicity to therapeutic target; Nature reviews. Neuroscience. 2013. DOI : 10.1038/nrn3406.
F. El-Turk; B. Fauvet; A. Ashrafi; H. Ouertatani-Sakouhi; M.-K. Cho et al. : Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket; PLoS ONE. 2012. DOI : 10.1371/journal.pone.0045024.
Z.-M. Wang; H. A. Lashuel : Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity; Angewandte Chemie (International ed. in English). 2012. DOI : 10.1002/anie.201206561.
N. Shabek; Y. Herman-Bachinsky; S. Buchsbaum; O. Lewinson; M. Haj-Yahya et al. : The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation; Molecular cell. 2012. DOI : 10.1016/j.molcel.2012.07.011.
H. Kroth; A. Ansaloni; Y. Varisco; A. Jan; N. Sreenivasachary et al. : Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.357665.
M. Hejjaoui / H. Lashuel (Dir.) : Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis. Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5494.
B. Fauvet; M.-B. Fares; F. Samuel; I. Dikiy; A. Tandon et al. : Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.383711.
J. Adamcik; C. Lara; I. Usov; J. S. Jeong; F. S. Ruggeri et al. : Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method; Nanoscale. 2012. DOI : 10.1039/c2nr30768e.
H. S. Choi; H. Liew; A. Jang; Y.-M. Kim; H. Lashuel et al. : Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction; Biochemical and biophysical research communications. 2012. DOI : 10.1016/j.bbrc.2012.06.159.
B. Yang; X. Sun; H. Lashuel; Y. Zhang : Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons; Neuroscience Bulletin. 2012. DOI : 10.1007/s12264-012-1239-1.
A. Jan; H. A. Lashuel : Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches; Methods in molecular biology (Clifton, N.J.). 2012. DOI : 10.1007/978-1-61779-551-0_16.
B. Fauvet; M. K. Mbefo; M.-B. Fares; C. Desobry; S. Michael et al. : α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer; The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M111.318949.
M. Hejjaoui; S. Butterfield; B. Fauvet; F. Vercruysse; J. Cui et al. : Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125; Journal of the American Chemical Society. 2012. DOI : 10.1021/ja210866j.
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Enseignement & Phd
Enseignement
Life Sciences Engineering