Hilal Lashuel

hilal.lashuel@epfl.ch +41 21 693 96 91 http://lashuel-lab.epfl.ch
Nationalité : USA
Date de naissance : 15.01.1973
EPFL SV BMI LMNN
AI 2151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
+41 21 693 96 91
+41 21 693 07 92
Local: AI 2151
EPFL
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SV
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BMI
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LMNN
Web site: Site web: https://lashuel-lab.epfl.ch/
EPFL SV SSV-GE
AI 2151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
Web site: Site web: https://sv.epfl.ch/education
Publications
Publications Infoscience
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Nature Reviews Neuroscience. 2021-01-11. DOI : 10.1038/s41583-020-00416-6.Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8834.Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get
Journal of Neurochemistry. 2020-10-27. DOI : 10.1111/jnc.15147.TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
The EMBO Journal. 2020-08-05. DOI : 10.15252/embj.2020104671.Half a century of amyloids: past, present and future
Chemical Society Reviews. 2020-07-07. DOI : 10.1039/C9CS00199A.Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2020-03-24. DOI : 10.1073/pnas.1916176117.The busy lives of academics have hidden costs — and universities must take better care of their faculty members
Nature Careers Community. 2020-03-05. DOI : 10.1038/d41586-020-00661-w.A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of alpha-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in alpha-synuclein research
Journal Of Neurochemistry. 2020-02-25. DOI : 10.1111/jnc.14955.The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Proceedings of the National Academy of Sciences of United States of America. 2020-02-19. DOI : 10.1073/pnas.1913904117.Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding
Angewandte Chemie-International Edition. 2020-01-28. DOI : 10.1002/anie.201913001.Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13
Biochemical And Biophysical Research Communications. 2020-01-15. DOI : 10.1016/j.bbrc.2019.09.097.What about faculty?
Elife. 2020-01-08. DOI : 10.7554/eLife.54551.Development of novel methods and tools to decipher the huntingtin post-translation modifications code
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7537.Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala
eNeuro. 2020. DOI : 10.1523/ENEURO.0110-20.2020.Gold nanoparticles as a new tool in amyloid studies
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7471.The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus
Frontiers in Molecular Biosciences. 2019-10-01. DOI : 10.3389/fmolb.2019.00095.Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay
Frontiers in Neuroscience. 2019-08-22. DOI : 10.3389/fnins.2019.00889.Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology
Neurobiology of Aging. 2019-08-14. DOI : 10.1016/j.neurobiolaging.2019.08.007.Investigation of alpha-synuclein post-translational modifications in idiopathic Parkinson's disease and multiple system atrophy
2019-03-01. 120th Meeting of the British-Neuropathological-Society (BNS) / Developmental Neuropathology Symposium, London, ENGLAND, Mar 06-08, 2019. p. 19-19.Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding
Angewandte Chemie-International Edition. 2019-02-04. DOI : 10.1002/anie.201805238.alpha-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-29. DOI : 10.1073/pnas.1808845116.A method for preparing phfs-like tau aggregates
WO2019207164 . 2019.Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9751.Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7676.A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.Axon regeneration and circuit reorganization after complete spinal cord injury
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7659.N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
Journal of Biological Chemistry. 2018-09-05. DOI : 10.1074/jbc.RA118.004621.Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study
Journal of Neurochemistry. 2018-08-20. DOI : 10.1111/jnc.14569.Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils
Proceedings of the National Academy of Sciences. 2018-06-25. DOI : 10.1073/pnas.1721220115.Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces
Nature Communications. 2018-06-04. DOI : 10.1038/s41467-018-04594-x.Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas
ACS Sensors. 2018-05-30. DOI : 10.1021/acssensors.8b00115.Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States
Journal of the American Chemical Society. 2018-04-24. DOI : 10.1021/jacs.8b02668.Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
Journal of Visualized Experiments. 2018-03-29. DOI : 10.3791/57506.Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding
Proteins Science. 2018-03-29. DOI : 10.1002/pro.3412.Combined Multi-Plane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4D Cell Microscopy
Nature Photonics. 2018. DOI : 10.1038/s41566-018-0109-4.Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy
US9809597 ; US2017050967 . 2017.Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation
Neuron. 2017. DOI : 10.1016/j.neuron.2017.11.032.Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
Proceedings of the National Academy of Sciences. 2017. DOI : 10.1073/pnas.1705372114.Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
Journal of the American Chemical Society. 2017. DOI : 10.1021/jacs.7b06659.Membrane scission driven by the PROPPIN Atg18
Embo Journal. 2017. DOI : 10.15252/embj.201796859.Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7985.Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection
Cell Death Discovery. 2017. DOI : 10.1038/cddiscovery.2017.53.Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease
Nature Communications. 2017. DOI : 10.1038/s41467-017-01575-4.A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations
Movement Disorders. 2017. DOI : 10.1002/mds.27090.Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
Scientific Reports. 2017. DOI : 10.1038/s41598-017-05336-7.Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1
2017. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 511A-511A.Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
Brain : a journal of neurology. 2017. DOI : 10.1093/brain/awx056.Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6
Angewandte Chemie (International ed. in English). 2017. DOI : 10.1002/anie.201611750.Human and eco-toxicological impacts of organometallic halide perovskites
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection
Light: Science and Applications. 2017. DOI : 10.1038/lsa.2017.29.The America I believe in
Science (New York, N.Y.). 2017. DOI : 10.1126/science.355.6326.766.The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
PLoS Biology. 2017. DOI : 10.1371/journal.pbio.2000374.The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.Nanoscale studies link amyloid maturity with polyglutamine diseases onset
Scientific Reports. 2016-08-01. DOI : 10.1038/srep31155.A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
Chembiochem : a European journal of chemical biology. 2016. DOI : 10.1002/cbic.201600474.Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations
Acs Chemical Biology. 2016. DOI : 10.1021/acschembio.6b00539.An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation
Journal Of Biological Chemistry. 2016. DOI : 10.1074/jbc.M116.713982.Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7037.Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies
Toxicol. Res.. 2016. DOI : 10.1039/C5TX00303B.Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease
Proceedings of the National Academy of Sciences of the United States of America. 2016. DOI : 10.1073/pnas.1512876113.Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons
Angewandte Chemie-International Edition. 2016. DOI : 10.1002/anie.201508968.Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ
Biochemical and Biophysical Research Communications. 2015-08-07. DOI : 10.1016/j.bbrc.2015.06.116.Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein
Methods in molecular biology (Clifton, N.J.). 2015. DOI : 10.1007/978-1-4939-2978-8_1.Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease
PloS One. 2015. DOI : 10.1371/journal.pone.0140880.Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
Cell death and differentiation. 2015. DOI : 10.1038/cdd.2015.79.Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization
Angewandte Chemie (International ed. in English). 2015. DOI : 10.1002/anie.201409050.Structural differences of amyloid-beta fibrils revealed by antibodies from phage display
Bmc Biotechnology. 2015. DOI : 10.1186/s12896-015-0146-8.Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis
Journal Of The American Chemical Society. 2015. DOI : 10.1021/ja5131726.New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6597.Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo
The Journal of biological chemistry. 2015. DOI : 10.1074/jbc.M114.610774.Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
Neuron. 2015. DOI : 10.1016/j.neuron.2014.11.027.Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease
Neurobiology of disease. 2015. DOI : 10.1016/j.nbd.2014.08.017.Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6412.The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity
Journal Of Biological Chemistry. 2014. DOI : 10.1074/jbc.M114.553297.The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells
Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu165.The role of fibril formation and growth in a-synuclein mediated extracellular toxicity
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6106.The role of S129 phosphorylation in regulating the cellular properties and secretion of alpha-synuclein
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6110.Elucidating the role of N-terminal phosphorylation in regulating the structure and the aggregation propensities of Huntingtin exon 1 using a semisynthetic strategy
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6188.Protein semisynthesis and total synthesis approaches to elucidate the role of Alpha-Synuclein post-translational modifications
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6187.One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington's Disease
Angewandte Chemie-International Edition. 2014. DOI : 10.1002/anie.201307510.NOVEL MECHANISM-BASED INHIBITORS OF A beta AGGREGATION AND TOXICITY
2014. 6th International Conference on Alzheimers Disease and Related Disorders in the Middle East, Istanbul, TURKEY, OCT 25-27, 2013. p. 720-721.c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
Human molecular genetics. 2014. DOI : 10.1093/hmg/ddt674.Characterization and stability of tau oligomer formation
2013Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies
Molecular & Cellular Proteomics. 2013. DOI : 10.1074/mcp.R113.032730.Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in alpha-synuclein transgenic mice
BMC neuroscience. 2013. DOI : 10.1186/1471-2202-14-135.Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach
ChemPhysChem. 2013. DOI : 10.1002/cphc.201300633.Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1315654110.One-pot total chemical synthesis of human α-synuclein
Chemical communications (Cambridge, England). 2013. DOI : 10.1039/c3cc45353g.Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1309991110.Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies
Journal of neurochemistry. 2013. DOI : 10.1111/jnc.12226.Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation
Journal of molecular biology. 2013. DOI : 10.1016/j.jmb.2013.02.005.The many faces of α-synuclein: from structure and toxicity to therapeutic target
Nature reviews. Neuroscience. 2013. DOI : 10.1038/nrn3406.Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket
PLoS ONE. 2012. DOI : 10.1371/journal.pone.0045024.Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity
Angewandte Chemie (International ed. in English). 2012. DOI : 10.1002/anie.201206561.The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation
Molecular cell. 2012. DOI : 10.1016/j.molcel.2012.07.011.Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation
The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.357665.Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5494.Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein
The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.383711.Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method
Nanoscale. 2012. DOI : 10.1039/c2nr30768e.Infoscience
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Nature Reviews Neuroscience. 2021-01-11. DOI : 10.1038/s41583-020-00416-6.Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8834.Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get
Journal of Neurochemistry. 2020-10-27. DOI : 10.1111/jnc.15147.TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
The EMBO Journal. 2020-08-05. DOI : 10.15252/embj.2020104671.Half a century of amyloids: past, present and future
Chemical Society Reviews. 2020-07-07. DOI : 10.1039/C9CS00199A.Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2020-03-24. DOI : 10.1073/pnas.1916176117.The busy lives of academics have hidden costs — and universities must take better care of their faculty members
Nature Careers Community. 2020-03-05. DOI : 10.1038/d41586-020-00661-w.A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of alpha-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in alpha-synuclein research
Journal Of Neurochemistry. 2020-02-25. DOI : 10.1111/jnc.14955.The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Proceedings of the National Academy of Sciences of United States of America. 2020-02-19. DOI : 10.1073/pnas.1913904117.Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding
Angewandte Chemie-International Edition. 2020-01-28. DOI : 10.1002/anie.201913001.Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13
Biochemical And Biophysical Research Communications. 2020-01-15. DOI : 10.1016/j.bbrc.2019.09.097.What about faculty?
Elife. 2020-01-08. DOI : 10.7554/eLife.54551.Development of novel methods and tools to decipher the huntingtin post-translation modifications code
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7537.Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala
eNeuro. 2020. DOI : 10.1523/ENEURO.0110-20.2020.Gold nanoparticles as a new tool in amyloid studies
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7471.The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus
Frontiers in Molecular Biosciences. 2019-10-01. DOI : 10.3389/fmolb.2019.00095.Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay
Frontiers in Neuroscience. 2019-08-22. DOI : 10.3389/fnins.2019.00889.Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology
Neurobiology of Aging. 2019-08-14. DOI : 10.1016/j.neurobiolaging.2019.08.007.Investigation of alpha-synuclein post-translational modifications in idiopathic Parkinson's disease and multiple system atrophy
2019-03-01. 120th Meeting of the British-Neuropathological-Society (BNS) / Developmental Neuropathology Symposium, London, ENGLAND, Mar 06-08, 2019. p. 19-19.Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding
Angewandte Chemie-International Edition. 2019-02-04. DOI : 10.1002/anie.201805238.alpha-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-29. DOI : 10.1073/pnas.1808845116.A method for preparing phfs-like tau aggregates
WO2019207164 . 2019.Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9751.Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7676.A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.Axon regeneration and circuit reorganization after complete spinal cord injury
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7659.N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
Journal of Biological Chemistry. 2018-09-05. DOI : 10.1074/jbc.RA118.004621.Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study
Journal of Neurochemistry. 2018-08-20. DOI : 10.1111/jnc.14569.Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils
Proceedings of the National Academy of Sciences. 2018-06-25. DOI : 10.1073/pnas.1721220115.Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces
Nature Communications. 2018-06-04. DOI : 10.1038/s41467-018-04594-x.Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas
ACS Sensors. 2018-05-30. DOI : 10.1021/acssensors.8b00115.Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States
Journal of the American Chemical Society. 2018-04-24. DOI : 10.1021/jacs.8b02668.Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
Journal of Visualized Experiments. 2018-03-29. DOI : 10.3791/57506.Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding
Proteins Science. 2018-03-29. DOI : 10.1002/pro.3412.Combined Multi-Plane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4D Cell Microscopy
Nature Photonics. 2018. DOI : 10.1038/s41566-018-0109-4.Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy
US9809597 ; US2017050967 . 2017.Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation
Neuron. 2017. DOI : 10.1016/j.neuron.2017.11.032.Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
Proceedings of the National Academy of Sciences. 2017. DOI : 10.1073/pnas.1705372114.Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
Journal of the American Chemical Society. 2017. DOI : 10.1021/jacs.7b06659.Membrane scission driven by the PROPPIN Atg18
Embo Journal. 2017. DOI : 10.15252/embj.201796859.Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7985.Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection
Cell Death Discovery. 2017. DOI : 10.1038/cddiscovery.2017.53.Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease
Nature Communications. 2017. DOI : 10.1038/s41467-017-01575-4.A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations
Movement Disorders. 2017. DOI : 10.1002/mds.27090.Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
Scientific Reports. 2017. DOI : 10.1038/s41598-017-05336-7.Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1
2017. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 511A-511A.Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
Brain : a journal of neurology. 2017. DOI : 10.1093/brain/awx056.Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6
Angewandte Chemie (International ed. in English). 2017. DOI : 10.1002/anie.201611750.Human and eco-toxicological impacts of organometallic halide perovskites
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection
Light: Science and Applications. 2017. DOI : 10.1038/lsa.2017.29.The America I believe in
Science (New York, N.Y.). 2017. DOI : 10.1126/science.355.6326.766.The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
PLoS Biology. 2017. DOI : 10.1371/journal.pbio.2000374.The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.Nanoscale studies link amyloid maturity with polyglutamine diseases onset
Scientific Reports. 2016-08-01. DOI : 10.1038/srep31155.A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
Chembiochem : a European journal of chemical biology. 2016. DOI : 10.1002/cbic.201600474.Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations
Acs Chemical Biology. 2016. DOI : 10.1021/acschembio.6b00539.An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation
Journal Of Biological Chemistry. 2016. DOI : 10.1074/jbc.M116.713982.Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7037.Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies
Toxicol. Res.. 2016. DOI : 10.1039/C5TX00303B.Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease
Proceedings of the National Academy of Sciences of the United States of America. 2016. DOI : 10.1073/pnas.1512876113.Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons
Angewandte Chemie-International Edition. 2016. DOI : 10.1002/anie.201508968.Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ
Biochemical and Biophysical Research Communications. 2015-08-07. DOI : 10.1016/j.bbrc.2015.06.116.Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein
Methods in molecular biology (Clifton, N.J.). 2015. DOI : 10.1007/978-1-4939-2978-8_1.Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease
PloS One. 2015. DOI : 10.1371/journal.pone.0140880.Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
Cell death and differentiation. 2015. DOI : 10.1038/cdd.2015.79.Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization
Angewandte Chemie (International ed. in English). 2015. DOI : 10.1002/anie.201409050.Structural differences of amyloid-beta fibrils revealed by antibodies from phage display
Bmc Biotechnology. 2015. DOI : 10.1186/s12896-015-0146-8.Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis
Journal Of The American Chemical Society. 2015. DOI : 10.1021/ja5131726.New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6597.Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo
The Journal of biological chemistry. 2015. DOI : 10.1074/jbc.M114.610774.Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
Neuron. 2015. DOI : 10.1016/j.neuron.2014.11.027.Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease
Neurobiology of disease. 2015. DOI : 10.1016/j.nbd.2014.08.017.Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6412.The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity
Journal Of Biological Chemistry. 2014. DOI : 10.1074/jbc.M114.553297.The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells
Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu165.The role of fibril formation and growth in a-synuclein mediated extracellular toxicity
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6106.The role of S129 phosphorylation in regulating the cellular properties and secretion of alpha-synuclein
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6110.Elucidating the role of N-terminal phosphorylation in regulating the structure and the aggregation propensities of Huntingtin exon 1 using a semisynthetic strategy
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6188.Protein semisynthesis and total synthesis approaches to elucidate the role of Alpha-Synuclein post-translational modifications
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6187.One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington's Disease
Angewandte Chemie-International Edition. 2014. DOI : 10.1002/anie.201307510.NOVEL MECHANISM-BASED INHIBITORS OF A beta AGGREGATION AND TOXICITY
2014. 6th International Conference on Alzheimers Disease and Related Disorders in the Middle East, Istanbul, TURKEY, OCT 25-27, 2013. p. 720-721.c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
Human molecular genetics. 2014. DOI : 10.1093/hmg/ddt674.Characterization and stability of tau oligomer formation
2013Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies
Molecular & Cellular Proteomics. 2013. DOI : 10.1074/mcp.R113.032730.Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in alpha-synuclein transgenic mice
BMC neuroscience. 2013. DOI : 10.1186/1471-2202-14-135.Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach
ChemPhysChem. 2013. DOI : 10.1002/cphc.201300633.Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1315654110.One-pot total chemical synthesis of human α-synuclein
Chemical communications (Cambridge, England). 2013. DOI : 10.1039/c3cc45353g.Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI : 10.1073/pnas.1309991110.Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies
Journal of neurochemistry. 2013. DOI : 10.1111/jnc.12226.Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation
Journal of molecular biology. 2013. DOI : 10.1016/j.jmb.2013.02.005.The many faces of α-synuclein: from structure and toxicity to therapeutic target
Nature reviews. Neuroscience. 2013. DOI : 10.1038/nrn3406.Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket
PLoS ONE. 2012. DOI : 10.1371/journal.pone.0045024.Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity
Angewandte Chemie (International ed. in English). 2012. DOI : 10.1002/anie.201206561.The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation
Molecular cell. 2012. DOI : 10.1016/j.molcel.2012.07.011.Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation
The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.357665.Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5494.Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein
The Journal of biological chemistry. 2012. DOI : 10.1074/jbc.M112.383711.Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method
Nanoscale. 2012. DOI : 10.1039/c2nr30768e.Enseignement & Phd
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