Hilal Lashuel
hilal.lashuel@epfl.ch +41 21 693 96 91 http://lashuel-lab.epfl.ch
Nationalité: USA
Date de naissance: 15.01.1973
EPFL SV BMI LMNN
AI 2151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
+41 21 693 96 91
+41 21 693 07 92
Local:
AI 2151
EPFL
>
SV
>
BMI
>
LMNN
Web site: Site web: https://lashuel-lab.epfl.ch/
EPFL SV SSV-GE
AI 2151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
Web site: Site web: https://sv.epfl.ch/education
Publications
Publications Infoscience
Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery
Npj Parkinsons Disease. 2022-04-12. DOI : 10.1038/s41531-022-00310-1.Alpha-synuclein as a Potential Biomarker for Parkinson’s Disease and Other Synucleinopathies: Gaps, Challenges, and Opportunities
2022-03-12.Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer's Disease
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8532.An integrative approach to elucidate the mechanisms and dynamics of Huntingtin aggregation and inclusion formation in neuronal models of Huntington's Disease
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9296.Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations
Computational and Structural Biotechnology Journal. 2021-12-15. DOI : 10.1016/j.csbj.2021.12.017.Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
Chemical Society Reviews. 2021-12-10. DOI : 10.1039/d1cs00127b.To target Tau pathologies, we must embrace and reconstruct their complexities
Neurobiology Of Disease. 2021-12-01. DOI : 10.1016/j.nbd.2021.105536.Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
Nature Communications. 2021-11-12. DOI : 10.1038/s41467-021-26684-z.Fatal attraction-The role of hypoxia when alpha-synuclein gets intimate with mitochondria
Neurobiology Of Aging. 2021-11-01. DOI : 10.1016/j.neurobiolaging.2021.07.017.The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1
Journal of Molecular Biology. 2021-10-15. DOI : 10.1016/j.jmb.2021.167222.Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
Scientific Reports. 2021-09-09. DOI : 10.1038/s41598-021-97334-z.Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease
Npj Parkinsons Disease. 2021-07-26. DOI : 10.1038/s41531-021-00203-9.Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation
Frontiers in Molecular Biosciences. 2021-07-26. DOI : 10.3389/fmolb.2021.686086.A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation
Journal of the American Chemical Society. 2021-06-23. DOI : 10.1021/jacs.1c03108.Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?
Current Opinion in Chemical Biology. 2021-06-23. DOI : 10.1016/j.cbpa.2021.05.006.Lewy body-associated proteins: Victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein
Neurobiology of Disease. 2021-06-06. DOI : 10.1016/j.nbd.2021.105417.Parkinson mice show functional and molecular changes in the gut long before motoric disease onset
Molecular Neurodegeneration. 2021-06-02. DOI : 10.1186/s13024-021-00439-2.Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
Molecular Therapy. 2021-05-05. DOI : 10.1016/j.ymthe.2021.01.033.Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease
Acta Neuropathologica Communications. 2021-04-14. DOI : 10.1186/s40478-021-01172-z.Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model This is the reply to a comment "Alpha-synuclein oligomerization and aggregation: A model will always be a model" on the original article "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". The articles are accompanied by a Preface "How good are cellular models?".
Journal Of Neurochemistry. 2021-03-22. DOI : 10.1111/jnc.15275.Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?
Movement Disorders. 2021-02-27. DOI : 10.1002/mds.28544.Reverse engineering Lewy bodies: how far have we come and how far can we go?
Nature Reviews Neuroscience. 2021-01-11. DOI : 10.1038/s41583-020-00416-6.Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8834.Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get
Journal of Neurochemistry. 2021. DOI : 10.1111/jnc.15147.Site-Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
Chembiochem. 2020-10-13. DOI : 10.1002/cbic.202000508.How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology
Neurobiology of Disease. 2020-09-22. DOI : 10.1016/j.nbd.2020.105086.TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
The EMBO Journal. 2020-08-05. DOI : 10.15252/embj.2020104671.Half a century of amyloids: past, present and future
Chemical Society Reviews. 2020-07-07. DOI : 10.1039/C9CS00199A.Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports
Neurobiology Of Disease. 2020-07-01. DOI : 10.1016/j.nbd.2020.104876.Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
Journal Of Biological Chemistry. 2020-06-05. DOI : 10.1074/jbc.RA119.012517.Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
Nature Communications. 2020-06-04. DOI : 10.1038/s41467-020-16564-3.Education and research are essential for lasting peace in Yemen
Lancet. 2020-04-04. DOI : 10.1016/S0140-6736(20)30162-8.Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2020-03-24. DOI : 10.1073/pnas.1916176117.The busy lives of academics have hidden costs — and universities must take better care of their faculty members
Nature Careers Community. 2020-03-05. DOI : 10.1038/d41586-020-00661-w.A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of alpha-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in alpha-synuclein research
Journal Of Neurochemistry. 2020-02-25. DOI : 10.1111/jnc.14955.The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Proceedings of the National Academy of Sciences of United States of America. 2020-02-19. DOI : 10.1073/pnas.1913904117.Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding
Angewandte Chemie-International Edition. 2020-01-28. DOI : 10.1002/anie.201913001.Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13
Biochemical And Biophysical Research Communications. 2020-01-15. DOI : 10.1016/j.bbrc.2019.09.097.What about faculty?
Elife. 2020-01-08. DOI : 10.7554/eLife.54551.Development of novel methods and tools to decipher the huntingtin post-translation modifications code
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7537.Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala
eNeuro. 2020. DOI : 10.1523/ENEURO.0110-20.2020.Gold nanoparticles as a new tool in amyloid studies
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7471.The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus
Frontiers in Molecular Biosciences. 2019-10-01. DOI : 10.3389/fmolb.2019.00095.Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay
Frontiers in Neuroscience. 2019-08-22. DOI : 10.3389/fnins.2019.00889.Investigation of alpha-synuclein post-translational modifications in idiopathic Parkinson's disease and multiple system atrophy
2019-03-01. 120th Meeting of the British-Neuropathological-Society (BNS) / Developmental Neuropathology Symposium, London, ENGLAND, Mar 06-08, 2019. p. 19-19.Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding
Angewandte Chemie-International Edition. 2019-02-04. DOI : 10.1002/anie.201805238.alpha-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-29. DOI : 10.1073/pnas.1808845116.A method for preparing phfs-like tau aggregates
US2021238242 ; EP3784687 ; WO2019207164 . 2019.Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology
Neurobiol Aging. 2019. DOI : 10.1016/j.neurobiolaging.2019.08.007.Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9751.Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7676.A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.Axon regeneration and circuit reorganization after complete spinal cord injury
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7659.Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study
Journal of Neurochemistry. 2019. DOI : 10.1111/jnc.14569.N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
Journal of Biological Chemistry. 2018-09-05. DOI : 10.1074/jbc.RA118.004621.Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils
Proceedings of the National Academy of Sciences. 2018-06-25. DOI : 10.1073/pnas.1721220115.Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces
Nature Communications. 2018-06-04. DOI : 10.1038/s41467-018-04594-x.Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas
ACS Sensors. 2018-05-30. DOI : 10.1021/acssensors.8b00115.Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States
Journal of the American Chemical Society. 2018-04-24. DOI : 10.1021/jacs.8b02668.Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
Journal of Visualized Experiments. 2018-03-29. DOI : 10.3791/57506.Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding
Proteins Science. 2018-03-29. DOI : 10.1002/pro.3412.Combined Multi-Plane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4D Cell Microscopy
Nature Photonics. 2018. DOI : 10.1038/s41566-018-0109-4.Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy
US9809597 ; US2017050967 . 2017.Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation
Neuron. 2017. DOI : 10.1016/j.neuron.2017.11.032.Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
Proceedings of the National Academy of Sciences. 2017. DOI : 10.1073/pnas.1705372114.Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
Journal of the American Chemical Society. 2017. DOI : 10.1021/jacs.7b06659.Membrane scission driven by the PROPPIN Atg18
Embo Journal. 2017. DOI : 10.15252/embj.201796859.Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7985.Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection
Cell Death Discovery. 2017. DOI : 10.1038/cddiscovery.2017.53.Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease
Nature Communications. 2017. DOI : 10.1038/s41467-017-01575-4.A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations
Movement Disorders. 2017. DOI : 10.1002/mds.27090.Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
Scientific Reports. 2017. DOI : 10.1038/s41598-017-05336-7.Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1
2017. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 511A-511A.Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
Brain : a journal of neurology. 2017. DOI : 10.1093/brain/awx056.Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6
Angewandte Chemie (International ed. in English). 2017. DOI : 10.1002/anie.201611750.Human and eco-toxicological impacts of organometallic halide perovskites
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection
Light: Science and Applications. 2017. DOI : 10.1038/lsa.2017.29.The America I believe in
Science (New York, N.Y.). 2017. DOI : 10.1126/science.355.6326.766.The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
PLoS Biology. 2017. DOI : 10.1371/journal.pbio.2000374.The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.Nanoscale studies link amyloid maturity with polyglutamine diseases onset
Scientific Reports. 2016-08-01. DOI : 10.1038/srep31155.A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
Chembiochem : a European journal of chemical biology. 2016. DOI : 10.1002/cbic.201600474.Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations
Acs Chemical Biology. 2016. DOI : 10.1021/acschembio.6b00539.An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation
Journal Of Biological Chemistry. 2016. DOI : 10.1074/jbc.M116.713982.Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7037.Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies
Toxicol. Res.. 2016. DOI : 10.1039/C5TX00303B.Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease
Proceedings of the National Academy of Sciences of the United States of America. 2016. DOI : 10.1073/pnas.1512876113.Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons
Angewandte Chemie-International Edition. 2016. DOI : 10.1002/anie.201508968.Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ
Biochemical and Biophysical Research Communications. 2015-08-07. DOI : 10.1016/j.bbrc.2015.06.116.Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein
Methods in molecular biology (Clifton, N.J.). 2015. DOI : 10.1007/978-1-4939-2978-8_1.Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease
PloS One. 2015. DOI : 10.1371/journal.pone.0140880.Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
Cell death and differentiation. 2015. DOI : 10.1038/cdd.2015.79.Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization
Angewandte Chemie (International ed. in English). 2015. DOI : 10.1002/anie.201409050.Structural differences of amyloid-beta fibrils revealed by antibodies from phage display
Bmc Biotechnology. 2015. DOI : 10.1186/s12896-015-0146-8.Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis
Journal Of The American Chemical Society. 2015. DOI : 10.1021/ja5131726.New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6597.Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo
The Journal of biological chemistry. 2015. DOI : 10.1074/jbc.M114.610774.Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
Neuron. 2015. DOI : 10.1016/j.neuron.2014.11.027.Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease
Neurobiology of disease. 2015. DOI : 10.1016/j.nbd.2014.08.017.Infoscience
Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery
Npj Parkinsons Disease. 2022-04-12. DOI : 10.1038/s41531-022-00310-1.Alpha-synuclein as a Potential Biomarker for Parkinson’s Disease and Other Synucleinopathies: Gaps, Challenges, and Opportunities
2022-03-12.Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer's Disease
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8532.An integrative approach to elucidate the mechanisms and dynamics of Huntingtin aggregation and inclusion formation in neuronal models of Huntington's Disease
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9296.Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations
Computational and Structural Biotechnology Journal. 2021-12-15. DOI : 10.1016/j.csbj.2021.12.017.Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
Chemical Society Reviews. 2021-12-10. DOI : 10.1039/d1cs00127b.To target Tau pathologies, we must embrace and reconstruct their complexities
Neurobiology Of Disease. 2021-12-01. DOI : 10.1016/j.nbd.2021.105536.Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
Nature Communications. 2021-11-12. DOI : 10.1038/s41467-021-26684-z.Fatal attraction-The role of hypoxia when alpha-synuclein gets intimate with mitochondria
Neurobiology Of Aging. 2021-11-01. DOI : 10.1016/j.neurobiolaging.2021.07.017.The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1
Journal of Molecular Biology. 2021-10-15. DOI : 10.1016/j.jmb.2021.167222.Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
Scientific Reports. 2021-09-09. DOI : 10.1038/s41598-021-97334-z.Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease
Npj Parkinsons Disease. 2021-07-26. DOI : 10.1038/s41531-021-00203-9.Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation
Frontiers in Molecular Biosciences. 2021-07-26. DOI : 10.3389/fmolb.2021.686086.A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation
Journal of the American Chemical Society. 2021-06-23. DOI : 10.1021/jacs.1c03108.Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?
Current Opinion in Chemical Biology. 2021-06-23. DOI : 10.1016/j.cbpa.2021.05.006.Lewy body-associated proteins: Victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein
Neurobiology of Disease. 2021-06-06. DOI : 10.1016/j.nbd.2021.105417.Parkinson mice show functional and molecular changes in the gut long before motoric disease onset
Molecular Neurodegeneration. 2021-06-02. DOI : 10.1186/s13024-021-00439-2.Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
Molecular Therapy. 2021-05-05. DOI : 10.1016/j.ymthe.2021.01.033.Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease
Acta Neuropathologica Communications. 2021-04-14. DOI : 10.1186/s40478-021-01172-z.Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model This is the reply to a comment "Alpha-synuclein oligomerization and aggregation: A model will always be a model" on the original article "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". The articles are accompanied by a Preface "How good are cellular models?".
Journal Of Neurochemistry. 2021-03-22. DOI : 10.1111/jnc.15275.Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?
Movement Disorders. 2021-02-27. DOI : 10.1002/mds.28544.Reverse engineering Lewy bodies: how far have we come and how far can we go?
Nature Reviews Neuroscience. 2021-01-11. DOI : 10.1038/s41583-020-00416-6.Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8834.Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get
Journal of Neurochemistry. 2021. DOI : 10.1111/jnc.15147.Site-Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
Chembiochem. 2020-10-13. DOI : 10.1002/cbic.202000508.How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology
Neurobiology of Disease. 2020-09-22. DOI : 10.1016/j.nbd.2020.105086.TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
The EMBO Journal. 2020-08-05. DOI : 10.15252/embj.2020104671.Half a century of amyloids: past, present and future
Chemical Society Reviews. 2020-07-07. DOI : 10.1039/C9CS00199A.Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports
Neurobiology Of Disease. 2020-07-01. DOI : 10.1016/j.nbd.2020.104876.Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
Journal Of Biological Chemistry. 2020-06-05. DOI : 10.1074/jbc.RA119.012517.Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
Nature Communications. 2020-06-04. DOI : 10.1038/s41467-020-16564-3.Education and research are essential for lasting peace in Yemen
Lancet. 2020-04-04. DOI : 10.1016/S0140-6736(20)30162-8.Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2020-03-24. DOI : 10.1073/pnas.1916176117.The busy lives of academics have hidden costs — and universities must take better care of their faculty members
Nature Careers Community. 2020-03-05. DOI : 10.1038/d41586-020-00661-w.A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of alpha-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in alpha-synuclein research
Journal Of Neurochemistry. 2020-02-25. DOI : 10.1111/jnc.14955.The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Proceedings of the National Academy of Sciences of United States of America. 2020-02-19. DOI : 10.1073/pnas.1913904117.Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding
Angewandte Chemie-International Edition. 2020-01-28. DOI : 10.1002/anie.201913001.Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13
Biochemical And Biophysical Research Communications. 2020-01-15. DOI : 10.1016/j.bbrc.2019.09.097.What about faculty?
Elife. 2020-01-08. DOI : 10.7554/eLife.54551.Development of novel methods and tools to decipher the huntingtin post-translation modifications code
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7537.Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala
eNeuro. 2020. DOI : 10.1523/ENEURO.0110-20.2020.Gold nanoparticles as a new tool in amyloid studies
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7471.The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus
Frontiers in Molecular Biosciences. 2019-10-01. DOI : 10.3389/fmolb.2019.00095.Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay
Frontiers in Neuroscience. 2019-08-22. DOI : 10.3389/fnins.2019.00889.Investigation of alpha-synuclein post-translational modifications in idiopathic Parkinson's disease and multiple system atrophy
2019-03-01. 120th Meeting of the British-Neuropathological-Society (BNS) / Developmental Neuropathology Symposium, London, ENGLAND, Mar 06-08, 2019. p. 19-19.Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding
Angewandte Chemie-International Edition. 2019-02-04. DOI : 10.1002/anie.201805238.alpha-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-29. DOI : 10.1073/pnas.1808845116.A method for preparing phfs-like tau aggregates
US2021238242 ; EP3784687 ; WO2019207164 . 2019.Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology
Neurobiol Aging. 2019. DOI : 10.1016/j.neurobiolaging.2019.08.007.Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9751.Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7676.A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.Axon regeneration and circuit reorganization after complete spinal cord injury
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-7659.Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study
Journal of Neurochemistry. 2019. DOI : 10.1111/jnc.14569.N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
Journal of Biological Chemistry. 2018-09-05. DOI : 10.1074/jbc.RA118.004621.Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils
Proceedings of the National Academy of Sciences. 2018-06-25. DOI : 10.1073/pnas.1721220115.Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces
Nature Communications. 2018-06-04. DOI : 10.1038/s41467-018-04594-x.Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas
ACS Sensors. 2018-05-30. DOI : 10.1021/acssensors.8b00115.Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States
Journal of the American Chemical Society. 2018-04-24. DOI : 10.1021/jacs.8b02668.Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
Journal of Visualized Experiments. 2018-03-29. DOI : 10.3791/57506.Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding
Proteins Science. 2018-03-29. DOI : 10.1002/pro.3412.Combined Multi-Plane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4D Cell Microscopy
Nature Photonics. 2018. DOI : 10.1038/s41566-018-0109-4.Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy
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Neuron. 2017. DOI : 10.1016/j.neuron.2017.11.032.Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
Proceedings of the National Academy of Sciences. 2017. DOI : 10.1073/pnas.1705372114.Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
Journal of the American Chemical Society. 2017. DOI : 10.1021/jacs.7b06659.Membrane scission driven by the PROPPIN Atg18
Embo Journal. 2017. DOI : 10.15252/embj.201796859.Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7985.Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection
Cell Death Discovery. 2017. DOI : 10.1038/cddiscovery.2017.53.Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease
Nature Communications. 2017. DOI : 10.1038/s41467-017-01575-4.A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations
Movement Disorders. 2017. DOI : 10.1002/mds.27090.Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
Scientific Reports. 2017. DOI : 10.1038/s41598-017-05336-7.Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1
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Brain : a journal of neurology. 2017. DOI : 10.1093/brain/awx056.Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6
Angewandte Chemie (International ed. in English). 2017. DOI : 10.1002/anie.201611750.Human and eco-toxicological impacts of organometallic halide perovskites
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection
Light: Science and Applications. 2017. DOI : 10.1038/lsa.2017.29.The America I believe in
Science (New York, N.Y.). 2017. DOI : 10.1126/science.355.6326.766.The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
PLoS Biology. 2017. DOI : 10.1371/journal.pbio.2000374.The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.Nanoscale studies link amyloid maturity with polyglutamine diseases onset
Scientific Reports. 2016-08-01. DOI : 10.1038/srep31155.A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
Chembiochem : a European journal of chemical biology. 2016. DOI : 10.1002/cbic.201600474.Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations
Acs Chemical Biology. 2016. DOI : 10.1021/acschembio.6b00539.An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation
Journal Of Biological Chemistry. 2016. DOI : 10.1074/jbc.M116.713982.Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7037.Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies
Toxicol. Res.. 2016. DOI : 10.1039/C5TX00303B.Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease
Proceedings of the National Academy of Sciences of the United States of America. 2016. DOI : 10.1073/pnas.1512876113.Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons
Angewandte Chemie-International Edition. 2016. DOI : 10.1002/anie.201508968.Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ
Biochemical and Biophysical Research Communications. 2015-08-07. DOI : 10.1016/j.bbrc.2015.06.116.Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein
Methods in molecular biology (Clifton, N.J.). 2015. DOI : 10.1007/978-1-4939-2978-8_1.Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease
PloS One. 2015. DOI : 10.1371/journal.pone.0140880.Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
Cell death and differentiation. 2015. DOI : 10.1038/cdd.2015.79.Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization
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Bmc Biotechnology. 2015. DOI : 10.1186/s12896-015-0146-8.Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis
Journal Of The American Chemical Society. 2015. DOI : 10.1021/ja5131726.New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6597.Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo
The Journal of biological chemistry. 2015. DOI : 10.1074/jbc.M114.610774.Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
Neuron. 2015. DOI : 10.1016/j.neuron.2014.11.027.Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease
Neurobiology of disease. 2015. DOI : 10.1016/j.nbd.2014.08.017.Enseignement & Phd
Enseignement
Life Sciences Engineering
Programmes doctoraux
Doctoral Program in Biotechnology and Bioengineering
Doctoral Program in Neuroscience
Doctorants
Altay Melek Firat, Ibrahim Khalid Ashraf Mohie, Jagannath Somanath, Kavungal Deepthy, Limorenko Galina, Morro Enzo Sébastien Benjamin, Ryser Till Jonathan, Sadek Ahmed Sherif Saad Zaghloul Mohamed, Yang Lixin, Zhang Zhidian,A dirigé les thèses EPFL de
Ansaloni Annalisa , Aït Bouziad Nadine , Benmessaoud Ryma Iness , Cendrowska Urszula Beata , Chiki Anass , Desobry Carole , El Turk Farah , Fares Mohamed Bilal , Fauvet Bruno Claude Daniel , Hejjaoui Mirva , Jan Qureshi Mohammad Asad , Mbefo Kamdem Martial , Ouertatani-Sakouhi Hajer , Riguet Nathan Alain Denis , Vercruysse Filip , Vieweg Sophie ,Cours
Neuroscience: from molecular mechanisms to disease
But du cours: guider les étudiants dans les aspects essentiels des neurosciences moléculaires & des maladies neurodégénératives. Possibilité de disséquer les mécanismes moléculaires impliqués dans les maladies neurodégénératives dans le but de comprendre & d'identifier des stratégies thérapeutiques.
Selected topics in life sciences
Le cours présente un aperçu de la manière dont la biologie, le génie biotechnologique, les sciences physiques et la médecine façonnent le paysage de la recherche biomédicale et contribuent à améliorer la qualité de la vie et à relever les défis de la santé mondiale à l¿heure actuelle.