Jacques Fellay

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Associate Professor

jacques.fellay@epfl.ch +41 21 693 18 49 http://fellay-lab.epfl.ch

https://orcid.org/0000-0002-8240-939X

Google Scholar ID

EPFL SV GHI UPFELLAY
AAB 2 40 (Bâtiment AAB)
Station 19
1015 Lausanne

+41 21 693 18 49
+41 21 693 72 32
Office: AAB 2 40
EPFL > SV > GHI > UPFELLAY

Web site: Web site: https://fellay-lab.epfl.ch

+41 21 693 18 49
EPFL > VPO-DC > EPFLGE > EPFLGE-CC

+41 21 693 18 49
EPFL > VPA-AVP-DLE > AVP-DLE-EDOC > EDCB-GE

Web site: Web site: https://go.epfl.ch/phd-edcb

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Administrative data

Fields of expertise

Human genomics of infectious diseases - Immunogenetics - Virus-host interactions - Translational genomics - Personalized health

Mission

Human genetic variation plays a key role in modulating immunity and determining individual outcomes after exposure to infectious agents. The mission of our laboratory is to contribute to a better understanding of inter-individual differences in response to infections, using a range of contemporary genomic tools. Approaches include genome-wide genotyping and association analysis, exome/genome sequencing and transcriptomics.

Biography

Jacques Fellay is a medical scientist with expertise in human genomics, infectious diseases, and personalized health. He obtained his MD from the University of Lausanne in 2002 and his PhD from University of Utrecht. After a clinical training in infectious diseases in Switzerland and a 4-years postdoctoral fellowship at Duke University, he joined the EPFL in April 2011 with an SNF Professorship. On top of his EPFL position, Jacques is also Head of Precision Medicine at the University Hospital (CHUV) in Lausanne, Group Leader at the Swiss Institute of Bioinformatics (SIB), Faculty member at the Swiss School of Public Health (SSPH ), and Chief Scientist at the Health2030 Genome Center at Campus Biotech in Geneva.

Awards

2012 : National Latsis Prize : Latsis foundation

2015 : Leenaards Prize for translational medical research : Leenaards foundation

2013 : « Divisionnaire F.-K. Rünzi » Foundation Award

2017 : Excellence in Basic Research Award : Swiss Society for Infectious Diseases

Publications

Infoscience publications

Infoscience

Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation

Z. M. Xu; G. E. Gnouamozi; S. Rueger; P. R. Shea; M. Buti et al.

American Journal Of Human Genetics. 2024-06-06. DOI : 10.1016/j.ajhg.2024.04.013.

Jacques Fellay

Associate Professor

Fields of expertise

Mission

Biography

Awards

Publications

Infoscience publications

Infoscience

Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation

Diagnostic accuracy of a sequence-specific Mtb-DNA hybridization assay in urine: a case-control study including subclinical TB cases

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (vol 15, 22, 2023)

Prevalence of actionable pharmacogenetic variants in a Swiss hospital cohort

Inborn errors of type I interferon immunity in patients with severe acute hepatitis E

Prevalence of clonal hematopoiesis in people living with HIV

The impact of human genetics on Mycobacterium tuberculosis intra-host evolution

The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control

Inborn errors of type I interferon immunity in patients with symptomatic acute hepatitis E

Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn Errors of Type I Interferon Immunity in Patients with Severe Acute Hepatitis E

Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Variation in African genomes linked to control of HIV

A metagenome-wide association study of HIV disease progression in HIV controllers

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in & SIM;40% of patients

Multiancestry sex-stratified genomic associations with HIV viral load and controller status from the ICGH

Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study

A polygenic risk score to predict sudden cardiac arrest in patients with cardiovascular disease

Host genomic susceptibility to severe respiratory syncytial virus infection

A polygenic risk score improves the prediction of cardiovascular risk associated with obstructive sleep-apnoea

Secondary structure of the human mitochondrial genome affects formation of deletions

Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort

Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

Associations of genetic and infectious risk factors with coronary heart disease

Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

Multivalent Virucidal Antivirals: Synthesis, Mechanisms of Action, and Immune-stimulating Effects

Genetic features and genomic targets of human KRAB-zinc finger proteins

Host-Pathogen Interactions Through the Genomic Lens

Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype

Variability of Primary Sjogren's Syndrome Is Driven by Interferon alpha and Interferon alpha Blood Levels Are Associated With the Class II HLA-DQ Locus

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

Polygenic Risk Scores for Prediction of Subclinical Coronary Artery Disease in Persons Living With HIV: The Swiss HIV Cohort Study

A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease Traits

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913

Improving polygenic prediction with genetically inferred ancestry

Host genomics of SARS-CoV-2 infection

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group (vol 74, pg 1468, 2022)

CD38 Expression by Antigen-Specific CD4 T Cells Is Significantly Restored 5 Months After Treatment Initiation Independently of Sputum Bacterial Load at the Time of Tuberculosis Diagnosis

Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load

A polygenic risk score to predict sudden cardiac arrest in patients with cardiovascular disease

Risk of mitochondrial deletions is affected by the global secondary structure of the mitochondrial genome

Increased CHIP prevalence amongst people living with HIV

A billion-year trend of amino acid substitutions in the mitochondrial genome

Mitochondrial mutational spectrum in human cancers is sensitive to cellular hypoxia

A highly virulent variant of HIV-1 circulating in the Netherlands

Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV

Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Telomere Length Declines in Persons With Human Immunodeficiency Virus Before Antiretroviral Therapy Start but Not After Viral Suppression: A Longitudinal Study Over >17 Years

Human genomics of the humoral immune response against polyomaviruses

Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study

Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure

Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryption

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Immunological lessons from genome-wide association studies of infections

Autoantibodies neutralizing type I IFNs are present in similar to 4% of uninfected individuals over 70 years old and account for similar to 20% of COVID-19 deaths

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

HIV-1 and human genetic variation

Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores

Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link