Purification methods (distillation, crystallization, chromatography), simple organic syntheses: bromination, reduction, acylation, imine, nitration, Grignard, Reformatsky)
Acquisition of knowledge on the chemical hazards and how to protect ourself. Knowledge of legal commitments.
The course will focus on the reactivity of carbonyl compounds: their structure, reactivity and transformations; the reaction of enols/enolates. The understanding of reaction mechanisms, chemo-, regio- and stereo-selectivities will be emphasized.
Complex polycyclic natural products are chosen to illustrate the evolution of the state-of-the-art of the field, the interplay between strategy and new reactions as well as the importance of implementing multi-bond forming processes in a synthesis.
Retro-synthessis, Total Synthesis, Atom-economy
Total synthesis, Natural product, Green chemistry, nantioselective synthesis, Organo-catalysis, Lewis acid,Transition-metal, Drug