Joerg Huelsken
EPFL SV ISREC UPHUELSKEN
SV 2823 (Bâtiment SV)
Station 19
CH-1015 Lausanne
+41 21 693 07 51
+41 21 693 07 52
Office:
SV 2823
EPFL
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SV
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ISREC
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UPHUELSKEN
Web site: Web site: https://huelsken-lab.epfl.ch
+41 21 693 07 51
EPFL
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SV
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SV-SSV
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SSV-ENS
Web site: Web site: https://sv.epfl.ch/education
Web site: Web site: https://go.epfl.ch/edms
Fields of expertise
Tumor Heterogeneity and Stemness in Cancer
Biography
Prof. Joerg Huelsken received his PhD in 1998 at the Humboldt University and did postdoctoral research in the laboratory of Walter Birchmeier at the Max-Delbrueck Center for Molecular Medicine, Berlin. He joined ISREC as an associate scientist and an NCCR project leader in January 2003 and, in 2005, was nominated Tenure Track Assistant Professor at the EPFL School of Life Sciences.Publications
Infoscience publications
Journal Articles
2022
Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function
Iscience. 2022-10-21. DOI : 10.1016/j.isci.2022.105171.2021
High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer
Cell Reports. 2021-04-20. DOI : 10.1016/j.celrep.2021.109026.Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes
Cancers. 2021-04-12. DOI : 10.3390/cancers13061267.Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen
Journal Of Immunology. 2021-04-01. DOI : 10.4049/jimmunol.2001066.2020
The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver
Stem Cell Reports. 2020-08-11. DOI : 10.1016/j.stemcr.2020.06.022.2019
γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia
Cancer Cell. 2019-04-15. DOI : 10.1016/j.ccell.2019.03.005.2018
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Cell. 2018-04-05. DOI : 10.1016/j.cell.2018.03.034.A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance
CELL. 2018. DOI : 10.1016/j.cell.2018.01.028.2017
Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature
Stem Cells. 2017. DOI : 10.1002/stem.2719.Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue
Cell Reports. 2017. DOI : 10.1016/j.celrep.2017.05.051.Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation
Cell Stem Cell. 2017. DOI : 10.1016/j.stem.2017.07.004.2016
Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
Nature Communications. 2016-12-01. DOI : 10.1038/ncomms13500.Microfluidic co-culture platform to quantify chemotaxis of primary stem cells
Lab On A Chip. 2016. DOI : 10.1039/c6lc00236f.Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity
Cell Stem Cell. 2016. DOI : 10.1016/j.stem.2015.09.019.Phage selection of chemically stabilized alpha-helical peptide ligands
ACS Chemical Biology. 2016. DOI : 10.1021/acschembio.5b00963.Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling
ChemMedChem. 2016. DOI : 10.1002/cmdc.201500557.2015
HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
Cancer Cell. 2015. DOI : 10.1016/j.ccell.2015.11.001.2014
SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer
Oncogene. 2014. DOI : 10.1038/onc.2013.140.2013
Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk
The EMBO Journal. 2013. DOI : 10.1038/emboj.2013.123.2012
β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
British Journal of Cancer. 2012. DOI : 10.1038/bjc.2012.430.Interactions between cancer stem cells and their niche govern metastatic colonization
Nature. 2012. DOI : 10.1038/nature10694.2011
β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells
Gut. 2011. DOI : 10.1136/gutjnl-2011-300817.Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death
European Journal of Neuroscience. 2011. DOI : 10.1111/j.1460-9568.2011.07632.x.2010
Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
Proceedings of the National Academy of Sciences of the United States of America. 2010. DOI : 10.1073/pnas.0914127107.SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
PLoS One. 2010. DOI : 10.1371/journal.pone.0008960.Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
PLoS genetics. 2010. DOI : 10.1371/journal.pgen.1000816.2009
Canonical Wnt signalling plays essential roles
European Journal of Immunology. 2009. DOI : 10.1002/eji.200838982.Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta- catenin signaling pathways in hair follicle induction
Developmental Cell. 2009. DOI : 10.1016/j.devcel.2009.05.011.Tissue-specific stem cells: friend or foe?
Cell Res. 2009. DOI : 10.1038/cr.2009.24.Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1
Drug Metab Dispos. 2009. DOI : 10.1124/dmd.108.026179.Cancer stem cells: never Wnt away from the niche
Current Opinion in Oncology. 2009. DOI : 10.1097/CCO.0b013e32831d1faf.2008
Differential requirement for beta-catenin in epithelial and fiber cells during lens development
Dev. Biol.. 2008. DOI : 10.1016/j.ydbio.2008.07.002.Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
Nature. 2008. DOI : 10.1038/nature06835.Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels
Molecular genetics and metabolism. 2008. DOI : 10.1016/j.ymgme.2008.01.013.Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
Blood. 2008. DOI : 10.1182/blood-2007-07-102558.2007
Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
Molecular and Cellular Biology. 2007. DOI : 10.1128/MCB.01034-07.Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2007. DOI : 10.1073/pnas.0702555104.beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells
FEBS Letters. 2007. DOI : 10.1016/j.febslet.2007.01.053.Beta-catenin downregulation is required for adaptive cardiac remodeling
Circulation Research. 2007. DOI : 10.1161/01.RES.0000266605.63681.5a.2006
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
Nature Immunology. 2006. DOI : 10.1038/ni1387.2005
Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival
Blood. 2005. DOI : 10.1182/blood-2005-01-0337.Cell-type-specific transcriptomics in chimeric models using transcriptome-based masks
Nucleic Acids Res. 2005. DOI : 10.1093/nar/gni104.Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development
Current Biology. 2005. DOI : 10.1016/j.cub.2005.08.037.2004
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation
Journal of Cell Biology. 2004. DOI : 10.1083/jcb.200402096.beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation
Molecular and Cellular Biology. 2004. DOI : 10.1128/MCB.24.19.8649-8661.2004.2003
Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
Neuron. 2003. DOI : 10.1016/S0896-6273(03)00718-9.Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
Genes & Development. 2003. DOI : 10.1101/gad.263003.Deletion of beta-catenin impairs T cell development
Nature Immunology. 2003. DOI : 10.1038/ni1008.beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Developmental Biology. 2003. DOI : 10.1016/S0012-1606(03)00123-4.Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
Development. 2003. DOI : 10.1242/dev.00859.beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
Journal of Biological Chemistry. 2003. DOI : 10.1074/jbc.M305892200.2002
The Wnt signalling pathway
Journal of Cell Science. 2002. DOI : 10.1242/jcs.00089.Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling
Journal of Biological Chemistry. 2002. DOI : 10.1074/jbc.M200184200.Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
Development. 2002.The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling
Genes & Development. 2002. DOI : 10.1101/gad.230402.2001
Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices
Development. 2001.beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
Cell. 2001. DOI : 10.1016/S0092-8674(01)00336-1.2000
Requirement for beta-catenin in anterior-posterior axis formation in mice
Journal of Cell Biology. 2000. DOI : 10.1083/jcb.148.3.567.Essential role of Gab1 for signaling by the c-Met receptor in vivo
Journal of Cell Biology. 2000. DOI : 10.1083/jcb.150.6.1375.1997
Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines
Cancer Lett. 1997. DOI : 10.1016/S0304-3835(97)00308-X.1994
Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development
Genomics. 1994. DOI : 10.1006/geno.1994.1493.E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
Journal of Cell Biology. 1994. DOI : 10.1083/jcb.127.6.2061.Conference Papers
2022
Role Of Outside-In Integrin Signaling In Hematopoietic Development Of Mouse Embryo
2022-01-01. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S62-S62.2018
Comprehensive analysis of cancer stemness
2018-07-01. Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, Apr 14-18, 2018. DOI : 10.1158/1538-7445.AM2018-LB-373.2016
Successful immunotherapy of cancer stem cells requires memory and the adaptive immune system of the host
2016. DOI : 10.1158/2326-6074.Cricimteatiaacr15-B067.2015
Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host
2015. 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), New Orleans, LA, MAY 13-16, 2015. p. S167-S168.2014
Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation
2014. 43rd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Montreal, CANADA, AUG 21-24, 2014. p. S42-S42. DOI : 10.1016/j.exphem.2014.07.156.2013
Putting cancer stem cells in context
2013. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam, NETHERLANDS, SEP 27-OCT 01, 2013. p. S7-S7.2012
Interactions Between Breast Cancer Stem Cells and their Niche Govern Metastatic Colonization of the Lung
2012. 22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN, JUL 07-10, 2012. p. S15-S15.Reviews
2014
Complex metastatic niches: already a target for therapy?
Current Opinion in Cell Biology. 2014. DOI : 10.1016/j.ceb.2014.06.012.2013
Metastasis: New insights into organ-specific extravasation and metastatic niches
Experimental Cell Research. 2013. DOI : 10.1016/j.yexcr.2013.02.012.The niche under siege: novel targets for metastasis therapy
Journal of internal medicine. 2013. DOI : 10.1111/joim.12024.2012
Lrig1: a new master regulator of epithelial stem cells
The EMBO Journal. 2012. DOI : 10.1038/emboj.2012.73.2001
New aspects of Wnt signaling pathways in higher vertebrates
Current Opinion in Genetics & Development. 2001. DOI : 10.1016/S0959-437X(00)00231-8.1995
Adherens junction proteins in tumour progression
Cancer Surveys. 1995.E-cadherin as an invasion suppressor
Ciba Found Symp. 1995.1994
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection
Current Opinion in Cell Biology. 1994. DOI : 10.1016/0955-0674(94)90098-1.1993
Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas
Seminars in Cancer Biology. 1993.Theses
2017
Targeting cancer stem cells by T cell engineering
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7960.2016
Development of microfluidic devices for chemotaxis of primary stem cells
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7071.2014
The role of recruited bone-marrow derived mesenchymal stem cells in the establishment of the tumor stroma and a growth-supportive environment
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6143.Identification of tumor-stroma interactions crucial for the establishment of liver metastasis
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6148.2012
Identification of a Novel Wnt Inhibitor
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5431.Asymmetric Cell Division in the Skin
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5024.Book Chapters
1996
Epithelial differentiation and the control of metastasis in carcinomas
Attempts to Understand Metastasis Formation II: Regulatory Factors; 1996. p. 117-135.Talks
2008
T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin
Annual Joint Meeting of the Swiss Societies for Pneumology, Paediatric Pneumology, Allergology and Immunology, Thoracic Surgery, Fribourg, April 17-18, 2008.Patents
2011
Targeting extracellular matrix molecules for the treatment of cancer
WO2011024114 . 2011.Student Projects
2009
A novel approach for the isolation of mesenchymal stem cells
2009Infoscience
Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function
Iscience. 2022-10-21. DOI : 10.1016/j.isci.2022.105171.Role Of Outside-In Integrin Signaling In Hematopoietic Development Of Mouse Embryo
2022-01-01. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S62-S62.High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer
Cell Reports. 2021-04-20. DOI : 10.1016/j.celrep.2021.109026.Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes
Cancers. 2021-04-12. DOI : 10.3390/cancers13061267.Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen
Journal Of Immunology. 2021-04-01. DOI : 10.4049/jimmunol.2001066.The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver
Stem Cell Reports. 2020-08-11. DOI : 10.1016/j.stemcr.2020.06.022.γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia
Cancer Cell. 2019-04-15. DOI : 10.1016/j.ccell.2019.03.005.Comprehensive analysis of cancer stemness
2018-07-01. Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, Apr 14-18, 2018. DOI : 10.1158/1538-7445.AM2018-LB-373.Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Cell. 2018-04-05. DOI : 10.1016/j.cell.2018.03.034.A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance
CELL. 2018. DOI : 10.1016/j.cell.2018.01.028.Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature
Stem Cells. 2017. DOI : 10.1002/stem.2719.Targeting cancer stem cells by T cell engineering
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7960.Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue
Cell Reports. 2017. DOI : 10.1016/j.celrep.2017.05.051.Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation
Cell Stem Cell. 2017. DOI : 10.1016/j.stem.2017.07.004.Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
Nature Communications. 2016-12-01. DOI : 10.1038/ncomms13500.Microfluidic co-culture platform to quantify chemotaxis of primary stem cells
Lab On A Chip. 2016. DOI : 10.1039/c6lc00236f.Successful immunotherapy of cancer stem cells requires memory and the adaptive immune system of the host
2016. DOI : 10.1158/2326-6074.Cricimteatiaacr15-B067.Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity
Cell Stem Cell. 2016. DOI : 10.1016/j.stem.2015.09.019.Phage selection of chemically stabilized alpha-helical peptide ligands
ACS Chemical Biology. 2016. DOI : 10.1021/acschembio.5b00963.Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling
ChemMedChem. 2016. DOI : 10.1002/cmdc.201500557.Development of microfluidic devices for chemotaxis of primary stem cells
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7071.HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
Cancer Cell. 2015. DOI : 10.1016/j.ccell.2015.11.001.Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host
2015. 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), New Orleans, LA, MAY 13-16, 2015. p. S167-S168.Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation
2014. 43rd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Montreal, CANADA, AUG 21-24, 2014. p. S42-S42. DOI : 10.1016/j.exphem.2014.07.156.Complex metastatic niches: already a target for therapy?
Current Opinion in Cell Biology. 2014. DOI : 10.1016/j.ceb.2014.06.012.The role of recruited bone-marrow derived mesenchymal stem cells in the establishment of the tumor stroma and a growth-supportive environment
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6143.SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer
Oncogene. 2014. DOI : 10.1038/onc.2013.140.Identification of tumor-stroma interactions crucial for the establishment of liver metastasis
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6148.Putting cancer stem cells in context
2013. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam, NETHERLANDS, SEP 27-OCT 01, 2013. p. S7-S7.Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk
The EMBO Journal. 2013. DOI : 10.1038/emboj.2013.123.Metastasis: New insights into organ-specific extravasation and metastatic niches
Experimental Cell Research. 2013. DOI : 10.1016/j.yexcr.2013.02.012.The niche under siege: novel targets for metastasis therapy
Journal of internal medicine. 2013. DOI : 10.1111/joim.12024.Interactions Between Breast Cancer Stem Cells and their Niche Govern Metastatic Colonization of the Lung
2012. 22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN, JUL 07-10, 2012. p. S15-S15.Identification of a Novel Wnt Inhibitor
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5431.β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
British Journal of Cancer. 2012. DOI : 10.1038/bjc.2012.430.Lrig1: a new master regulator of epithelial stem cells
The EMBO Journal. 2012. DOI : 10.1038/emboj.2012.73.Interactions between cancer stem cells and their niche govern metastatic colonization
Nature. 2012. DOI : 10.1038/nature10694.Asymmetric Cell Division in the Skin
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5024.Targeting extracellular matrix molecules for the treatment of cancer
WO2011024114 . 2011.β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells
Gut. 2011. DOI : 10.1136/gutjnl-2011-300817.Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death
European Journal of Neuroscience. 2011. DOI : 10.1111/j.1460-9568.2011.07632.x.Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
Proceedings of the National Academy of Sciences of the United States of America. 2010. DOI : 10.1073/pnas.0914127107.SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
PLoS One. 2010. DOI : 10.1371/journal.pone.0008960.Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
PLoS genetics. 2010. DOI : 10.1371/journal.pgen.1000816.A novel approach for the isolation of mesenchymal stem cells
2009Canonical Wnt signalling plays essential roles
European Journal of Immunology. 2009. DOI : 10.1002/eji.200838982.Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta- catenin signaling pathways in hair follicle induction
Developmental Cell. 2009. DOI : 10.1016/j.devcel.2009.05.011.Tissue-specific stem cells: friend or foe?
Cell Res. 2009. DOI : 10.1038/cr.2009.24.Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1
Drug Metab Dispos. 2009. DOI : 10.1124/dmd.108.026179.Cancer stem cells: never Wnt away from the niche
Current Opinion in Oncology. 2009. DOI : 10.1097/CCO.0b013e32831d1faf.T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin
Annual Joint Meeting of the Swiss Societies for Pneumology, Paediatric Pneumology, Allergology and Immunology, Thoracic Surgery, Fribourg, April 17-18, 2008.Differential requirement for beta-catenin in epithelial and fiber cells during lens development
Dev. Biol.. 2008. DOI : 10.1016/j.ydbio.2008.07.002.Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
Nature. 2008. DOI : 10.1038/nature06835.Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels
Molecular genetics and metabolism. 2008. DOI : 10.1016/j.ymgme.2008.01.013.Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
Blood. 2008. DOI : 10.1182/blood-2007-07-102558.Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
Molecular and Cellular Biology. 2007. DOI : 10.1128/MCB.01034-07.Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2007. DOI : 10.1073/pnas.0702555104.beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells
FEBS Letters. 2007. DOI : 10.1016/j.febslet.2007.01.053.Beta-catenin downregulation is required for adaptive cardiac remodeling
Circulation Research. 2007. DOI : 10.1161/01.RES.0000266605.63681.5a.Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
Nature Immunology. 2006. DOI : 10.1038/ni1387.Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival
Blood. 2005. DOI : 10.1182/blood-2005-01-0337.Cell-type-specific transcriptomics in chimeric models using transcriptome-based masks
Nucleic Acids Res. 2005. DOI : 10.1093/nar/gni104.Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development
Current Biology. 2005. DOI : 10.1016/j.cub.2005.08.037.Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation
Journal of Cell Biology. 2004. DOI : 10.1083/jcb.200402096.beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation
Molecular and Cellular Biology. 2004. DOI : 10.1128/MCB.24.19.8649-8661.2004.Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
Neuron. 2003. DOI : 10.1016/S0896-6273(03)00718-9.Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
Genes & Development. 2003. DOI : 10.1101/gad.263003.Deletion of beta-catenin impairs T cell development
Nature Immunology. 2003. DOI : 10.1038/ni1008.beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Developmental Biology. 2003. DOI : 10.1016/S0012-1606(03)00123-4.Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
Development. 2003. DOI : 10.1242/dev.00859.beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
Journal of Biological Chemistry. 2003. DOI : 10.1074/jbc.M305892200.The Wnt signalling pathway
Journal of Cell Science. 2002. DOI : 10.1242/jcs.00089.Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling
Journal of Biological Chemistry. 2002. DOI : 10.1074/jbc.M200184200.Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
Development. 2002.The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling
Genes & Development. 2002. DOI : 10.1101/gad.230402.Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices
Development. 2001.beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
Cell. 2001. DOI : 10.1016/S0092-8674(01)00336-1.New aspects of Wnt signaling pathways in higher vertebrates
Current Opinion in Genetics & Development. 2001. DOI : 10.1016/S0959-437X(00)00231-8.Requirement for beta-catenin in anterior-posterior axis formation in mice
Journal of Cell Biology. 2000. DOI : 10.1083/jcb.148.3.567.Essential role of Gab1 for signaling by the c-Met receptor in vivo
Journal of Cell Biology. 2000. DOI : 10.1083/jcb.150.6.1375.Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines
Cancer Lett. 1997. DOI : 10.1016/S0304-3835(97)00308-X.Epithelial differentiation and the control of metastasis in carcinomas
Attempts to Understand Metastasis Formation II: Regulatory Factors; 1996. p. 117-135.Adherens junction proteins in tumour progression
Cancer Surveys. 1995.E-cadherin as an invasion suppressor
Ciba Found Symp. 1995.Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development
Genomics. 1994. DOI : 10.1006/geno.1994.1493.E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
Journal of Cell Biology. 1994. DOI : 10.1083/jcb.127.6.2061.Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection
Current Opinion in Cell Biology. 1994. DOI : 10.1016/0955-0674(94)90098-1.Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas
Seminars in Cancer Biology. 1993.Teaching & PhD
Teaching
Life Sciences Engineering
PhD Programs
PhD Students
Gajera Krishna Rasik, Girardin Mathieu, Madurga Alonso Angela, Wyss Laura Fabienne, Young Candice Megan T,Past EPFL PhD Students
Abbühl Jean-Paul , Dafflon Caroline , Desbaillets Nicolas Pierre , Evelyn Evelyn , Fan Wan-Hung , Norkin Maxim , Spisak Luisa , Tatárová Zuzana ,Courses
Cancer biology II
The course covers in detail the interactions of cancer cells with their environment with an emphasis on tumor-angiogenesis, inflammation, adaptive and innate immunity and cancer-induced immune suppression. Additional topics are cancer metabolism, cancer stem cells and metastasis.
Practical - Huelsken Lab (EDMS)
Assessment of signaling mechanisms in cancer.
The objectives of the course are:
- to understand the importance of signaling and cell-cell interactions in cancer stroma interactions
- to learn techniques involved in assessing the function of such interactions in vitro and in vivo.