Joerg Huelsken

joerg.huelsken@epfl.ch +41 21 693 07 51

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EPFL SV ISREC UPHUELSKEN
SV 2823 (Bâtiment SV)
Station 19
1015 Lausanne

+41 21 693 07 51
+41 21 693 07 52
Office: SV 2823
EPFL › SV › ISREC › UPHUELSKEN

Site web: https://huelsken-lab.epfl.ch

+41 21 693 07 51
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Site web: https://sv.epfl.ch/education

+41 21 693 07 51
EPFL › VPA › VPA-AVP-DLE › AVP-DLE-EDOC › EDMS-ENS

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Prix et distinctions Publications Enseignement et PhD

Prix et distinctions

Leenaards foundation

2006

2009

2015

Intestinal stem and progenitor cells exhibit distinct adaptive responses to inflammatory stress in IBD

B. Balasubramanian; S. Patel; L. Gall; N. Hannan; W. Dalleywater et al.

Stem Cell Research & Therapy. 2025. DOI : 10.1186/s13287-025-04872-8.

Detailed record

Intestinal Stem and Progenitor Cells Exhibit Distinct Adaptive Responses to Inflammatory Stress in IBD

P. Ordonez-Moran; B. Balasubramanian; S. Patel; W. Dalleywater; N. Hannan et al.

2025

Detailed record

Abstract 4588: Cell states and resistance in colorectal cancer: What can we learn from patient-derived organoids?

M. Norkin; P. H. Lopez; C. Esposito; G. M. Ramzy; M. Armengot‐Carbó et al.

Cancer Research. 2025. DOI : 10.1158/1538-7445.am2025-4588.

Detailed record

Lat-based nk cars and their use

M. Girardin; A. Madurga Alonso; J. Huelsken

WO2024153707 . 2024.

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Metabolic dependencies of metastasis-initiating cells in female breast cancer

C. M. Young; L. N. K. Beziaud; P. V. Dessen; A. M. Alonso; A. Santamaria-Martinez et al.

Nature Communications. 2023. DOI : 10.1038/s41467-023-42748-8.

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IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

L. Beziaud; C. M. Young; A. R. Minafra; M. Norkin; A. Madurga Alonso et al.

Cell Stem Cell. 2023. DOI : 10.1016/j.stem.2023.05.007.

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Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma

G. M. Ramzy; M. Norkin; T. Koessler; L. Voirol; M. Tihy et al.

Journal Of Experimental & Clinical Cancer Research. 2023. DOI : 10.1186/s13046-023-02650-z.

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Metabolic dependencies of metastasis-initiating cells in breast cancer

C. M. T. Young / J. Hülsken (Dir.)

Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-8855.

Detailed record

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

A. Madurga Alonso / J. Hülsken (Dir.)

Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-9093.

Detailed record

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

M. Girardin / J. Hülsken; B. E. Ferreira De Sousa Correia (Dir.)

Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-8912.

Detailed record

Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

I. M. Roy; P. V. Anu; S. Zaunz; S. Reddi; A. M. Giri et al.

Iscience. 2022. DOI : 10.1016/j.isci.2022.105171.

Detailed record

The role of eosinophils in breast cancer

L. Spisak / J. Hülsken (Dir.)

Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8575.

Detailed record

Role Of Outside-In Integrin Signaling In Hematopoietic Development Of Mouse Embryo

A. Biswas; I. Roy; J. Huelsken; A. Lacy-Hulbert; C. Verfaillie et al.

2022. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S62 - S62.

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High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer

M. Norkin; P. Ordóñez-Morán; J. Huelsken

Cell Reports. 2021. DOI : 10.1016/j.celrep.2021.109026.

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Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes

V. S. Dionellis; M. Norkin; A. Karamichali; G. G. Rossetti; J. Huelsken et al.

Cancers. 2021. DOI : 10.3390/cancers13061267.

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Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen

S. H. Mehatre; I. M. Roy; A. Biswas; D. Prit; S. Schouteden et al.

The Journal of Immunology. 2021. DOI : 10.4049/jimmunol.2001066.

Detailed record

Intestinal stem cells differentiation and its application in cancer therapy

M. Norkin / J. Hülsken (Dir.)

Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8868.

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The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver

A. Biswas; I. M. Roy; P. C. Babu; J. Manesia; S. Schouteden et al.

Stem Cell Reports. 2020. DOI : 10.1016/j.stemcr.2020.06.022.

Detailed record

γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia

N. Luong-Gardiol; I. Siddiqui; I. Pizzitola; B. Jeevan-Raj; M. Charmoy et al.

Cancer Cell. 2019. DOI : 10.1016/j.ccell.2019.03.005.

Detailed record

Comprehensive analysis of cancer stemness

T. M. Malta; A. Sokolov; A. J. Gentles; T. Burzykowski; L. Poisson et al.

2018. Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, Apr 14-18, 2018. DOI : 10.1158/1538-7445.AM2018-LB-373.

Detailed record

Targeting cancer stem cells by T cell engineering

N. P. Desbaillets / J. Hülsken (Dir.)

Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7960.

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Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation

J.-P. Abbuehl; Z. Tatarova; W. Held; J. Huelsken

Cell Stem Cell. 2017. DOI : 10.1016/j.stem.2017.07.004.

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Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature

P. C. Schwalie; P. Ordonez-Moran; J. Huelsken; B. Deplancke

Stem Cells. 2017. DOI : 10.1002/stem.2719.

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Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue

N. Lugli; V. S. Dionellis; P. Ordonez-Moran; I. Kamileri; S. K. Sotiriou et al.

Cell Reports. 2017. DOI : 10.1016/j.celrep.2017.05.051.

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Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

S. Khurana; S. Schouteden; J. K. Manesia; A. Santamaria-Martinez; J. Huelsken et al.

Nature Communications. 2016. DOI : 10.1038/ncomms13500.

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Phage selection of chemically stabilized alpha-helical peptide ligands

P. Diderich; D. Bertoldo; P. Dessen; M. M. Khan; I. Pizzitola et al.

ACS Chemical Biology. 2016. DOI : 10.1021/acschembio.5b00963.

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Successful immunotherapy of cancer stem cells requires memory and the adaptive immune system of the host

P. Schmidt; N. Desbaillets; P. Dessen; N. Thompson; J. Huelsken et al.

2016. DOI : 10.1158/2326-6074.Cricimteatiaacr15-B067.

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Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

D. Bertoldo; M. M. G. Khan; P. Dessen; W. Held; J. Huelsken et al.

ChemMedChem. 2016. DOI : 10.1002/cmdc.201500557.

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Development of microfluidic devices for chemotaxis of primary stem cells

Z. Tatárová / J. Hülsken; S. Maerkl (Dir.)

Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7071.

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Microfluidic co-culture platform to quantify chemotaxis of primary stem cells

Z. Tatarova; J. P. Abbuehl; S. Maerkl; J. Huelsken

Lab On A Chip. 2016. DOI : 10.1039/c6lc00236f.

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Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity

F. Chiacchiera; A. Rossi; S. Jammula; A. Piunti; A. Scelfo et al.

Cell Stem Cell. 2016. DOI : 10.1016/j.stem.2015.09.019.

Detailed record

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

P. Ordonez-Moran; C. Dafflon; M. Imajo; E. Nishida; J. Huelsken

Cancer Cell. 2015. DOI : 10.1016/j.ccell.2015.11.001.

Detailed record

Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host

P. Schmidt; N. Desbaillets; P. Dessen; N. Thompson; J. Huelsken

2015. 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), New Orleans, LA, MAY 13-16, 2015. p. S167 - S168.

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Complex metastatic niches: already a target for therapy?

P. Ordóñez-Morán; J. Huelsken

Current Opinion in Cell Biology. 2014. DOI : 10.1016/j.ceb.2014.06.012.

Detailed record

Identification of tumor-stroma interactions crucial for the establishment of liver metastasis

C. Urech / J. Huelsken (Dir.)

Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6148.

Detailed record

SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer

P. Ordóñez-Morán; A. Irmisch; A. Barbáchano; I. Chicote; S. Tenbaum et al.

Oncogene. 2014. DOI : 10.1038/onc.2013.140.

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The role of recruited bone-marrow derived mesenchymal stem cells in the establishment of the tumor stroma and a growth-supportive environment

J.-P. Abbühl / J. Huelsken (Dir.)

Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6143.

Detailed record

Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation

S. Khurana; N. Van Gastel; A. Santamaria-Martinez; S. Schouteden; J. Huelsken et al.

2014. 43rd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Montreal, CANADA, AUG 21-24, 2014. p. S42 - S42. DOI : 10.1016/j.exphem.2014.07.156.

Detailed record

Putting cancer stem cells in context

I. Malanchi; A. Santamaria-Martinez; J. Huelsken

2013. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam, NETHERLANDS, SEP 27-OCT 01, 2013. p. S7 - S7.

Detailed record

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

K. J. Petherick; A. C. Williams; J. D. Lane; P. Ordóñez-Morán; J. Huelsken et al.

The EMBO Journal. 2013. DOI : 10.1038/emboj.2013.123.

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Metastasis: New insights into organ-specific extravasation and metastatic niches

A. Irmisch; J. Huelsken

Experimental Cell Research. 2013. DOI : 10.1016/j.yexcr.2013.02.012.

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The niche under siege: novel targets for metastasis therapy

A. S. Martínez; J. Huelsken

Journal of internal medicine. 2013. DOI : 10.1111/joim.12024.

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Lrig1: a new master regulator of epithelial stem cells

P. Ordóñez-Morán; J. Huelsken

The EMBO Journal. 2012. DOI : 10.1038/emboj.2012.73.

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Interactions between cancer stem cells and their niche govern metastatic colonization

I. Malanchi; A. Santamaria-Martínez; E. Susanto; H. Peng; H.-A. Lehr et al.

Nature. 2012. DOI : 10.1038/nature10694.

Detailed record

β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

H. J. M. Smartt; A. Greenhough; P. Ordóñez-Morán; M. Al-Kharusi; T. J. Collard et al.

British Journal of Cancer. 2012. DOI : 10.1038/bjc.2012.430.

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Interactions Between Breast Cancer Stem Cells and their Niche Govern Metastatic Colonization of the Lung

I. Malanchi; A. Santamaria-Martinez; E. Susanto; H. Peng; H. -A. Lehr et al.

2012. 22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN, JUL 07-10, 2012. p. S15 - S15.

Detailed record

Asymmetric Cell Division in the Skin

W.-H. Fan / J. Hülsken (Dir.)

Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5024.

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Identification of a Novel Wnt Inhibitor

E. Susanto / J. Huelsken (Dir.)

Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5431.

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β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

H. J. M. Smartt; A. Greenhough; P. Ordóñez-Morán; E. Talero; C. A. Cherry et al.

Gut. 2011. DOI : 10.1136/gutjnl-2011-300817.

Detailed record

Targeting extracellular matrix molecules for the treatment of cancer

J. Huelsken; I. Malanchi

WO2011024114 . 2011.

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Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death

T. Holowacz; J. Huelsken; D. Dufort; D. Van Der Kooy

European Journal of Neuroscience. 2011. DOI : 10.1111/j.1460-9568.2011.07632.x.

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SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

T. Hussenet; S. Dali; J. Exinger; B. Monga; B. Jost et al.

PLoS One. 2010. DOI : 10.1371/journal.pone.0008960.

Detailed record

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

G. Jeannet; C. Boudousquié; N. Gardiol; J. Kang; J. Huelsken et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2010. DOI : 10.1073/pnas.0914127107.

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Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

M. Buchert; D. Athineos; H. E. Abud; Z. D. Burke; M. C. Faux et al.

PLoS genetics. 2010. DOI : 10.1371/journal.pgen.1000816.

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Cancer stem cells: never Wnt away from the niche

I. Malanchi; J. Huelsken

Current Opinion in Oncology. 2009. DOI : 10.1097/CCO.0b013e32831d1faf.

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Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta- catenin signaling pathways in hair follicle induction

Y. Zhang; P. Tomann; T. Andl; N. Gallant; J. Huelsken et al.

Developmental Cell. 2009. DOI : 10.1016/j.devcel.2009.05.011.

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Tissue-specific stem cells: friend or foe?

J. Huelsken

Cell Res. 2009. DOI : 10.1038/cr.2009.24.

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Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1

A. Braeuning; R. Sanna; J. Huelsken; M. Schwarz

Drug Metab Dispos. 2009. DOI : 10.1124/dmd.108.026179.

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Canonical Wnt signalling plays essential roles

J. Huelsken; W. Held

European Journal of Immunology. 2009. DOI : 10.1002/eji.200838982.

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Differential requirement for beta-catenin in epithelial and fiber cells during lens development

S. Cain; G. Martinez; M. Kokkinos; K. Turner; R. Richardson et al.

Developmental Biology. 2008. DOI : 10.1016/j.ydbio.2008.07.002.

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Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin

G. Jeannet; M. Scheller; L. Scarpellino; S. Duboux; N. Gardiol et al.

Blood. 2008. DOI : 10.1182/blood-2007-07-102558.

Detailed record

T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin

G. Jeannet; M. Scheller; L. Scarpellino; S. Duboux; N. Gardiol et al.

Annual Joint Meeting of the Swiss Societies for Pneumology, Paediatric Pneumology, Allergology and Immunology, Thoracic Surgery, Fribourg, April 17-18, 2008.

Detailed record

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

I. Malanchi; H. Peinado; D. Kassen; T. Hussenet; D. Metzger et al.

Nature. 2008. DOI : 10.1038/nature06835.

Detailed record

Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels

Y. Xu; R. Reboulet; B. Quinn; J. Huelsken; D. Witte et al.

Molecular genetics and metabolism. 2008. DOI : 10.1016/j.ymgme.2008.01.013.

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Beta-catenin downregulation is required for adaptive cardiac remodeling

A. Baurand; L. Zelarayan; R. Betney; C. Gehrke; S. Dunger et al.

Circulation Research. 2007. DOI : 10.1161/01.RES.0000266605.63681.5a.

Detailed record

Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells

T. Fevr; S. Robine; D. Louvard; J. Huelsken

Molecular and Cellular Biology. 2007. DOI : 10.1128/MCB.01034-07.

Detailed record

Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

U. Schaeper; R. Vogel; J. Chmielowiec; J. Huelsken; M. Rosario et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2007. DOI : 10.1073/pnas.0702555104.

Detailed record

beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells

M. M. Faraldo; J. Teuliere; M. A. Deugnier; W. Birchmeier; J. Huelsken et al.

FEBS Letters. 2007. DOI : 10.1016/j.febslet.2007.01.053.

Detailed record

Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation

M. Scheller; J. Huelsken; F. Rosenbauer; M. M. Taketo; W. Birchmeier et al.

Nature Immunology. 2006. DOI : 10.1038/ni1387.

Detailed record

Cell-type-specific transcriptomics in chimeric models using transcriptome-based masks

F. Naef; J. Huelsken

Nucleic Acids Res. 2005. DOI : 10.1093/nar/gni104.

Detailed record

Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development

J. Dessimoz; C. Bonnard; J. Huelsken; A. Grapin-Botton

Current Biology. 2005. DOI : 10.1016/j.cub.2005.08.037.

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Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival

D. Goux; J. D. Coudert; D. Maurice; L. Scarpellino; G. Jeannet et al.

Blood. 2005. DOI : 10.1182/blood-2005-01-0337.

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Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation

K. S. Grossmann; C. Grund; J. Huelsken; M. Behrend; B. Erdmann et al.

Journal of Cell Biology (JCB). 2004. DOI : 10.1083/jcb.200402096.

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beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation

J. Teuliere; M. M. Faraldo; M. Shtutman; W. Birchmeier; J. Huelsken et al.

Molecular and Cellular Biology. 2004. DOI : 10.1128/MCB.24.19.8649-8661.2004.

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beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis

M. L. Mucenski; S. E. Wert; J. M. Nation; D. E. Loudy; J. Huelsken et al.

Journal of Biological Chemistry. 2003. DOI : 10.1074/jbc.M305892200.

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Role of beta-catenin in synaptic vesicle localization and presynaptic assembly

S. X. Bamji; K. Shimazu; N. Kimes; J. Huelsken; W. Birchmeier et al.

Neuron. 2003. DOI : 10.1016/S0896-6273(03)00718-9.

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Deletion of beta-catenin impairs T cell development

Y. Xu; D. Banerjee; J. Huelsken; W. Birchmeier; J. M. Sen

Nature Immunology. 2003. DOI : 10.1038/ni1008.

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Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

N. Soshnikova; D. Zechner; J. Huelsken; Y. Mishina; R. R. Behringer et al.

Genes & Development. 2003. DOI : 10.1101/gad.263003.

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beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

D. Zechner; Y. Fujita; J. Huelsken; T. Muller; I. Walther et al.

Developmental Biology. 2003. DOI : 10.1016/S0012-1606(03)00123-4.

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Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

M. Morkel; J. Huelsken; M. Wakamiya; J. Ding; M. van de Wetering et al.

Development. 2003. DOI : 10.1242/dev.00859.

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The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

T. Schwarz-Romond; C. Asbrand; J. Bakkers; M. Kuhl; H. J. Schaeffer et al.

Genes & Development. 2002. DOI : 10.1101/gad.230402.

Detailed record

Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling

M. H. Wong; J. Huelsken; W. Birchmeier; J. I. Gordon

Journal of Biological Chemistry. 2002. DOI : 10.1074/jbc.M200184200.

Detailed record

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

C. Niemann; D. M. Owens; J. Huelsken; W. Birchmeier; F. M. Watt

Development. 2002.

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The Wnt signalling pathway

J. Huelsken; J. Behrens

Journal of Cell Science. 2002. DOI : 10.1242/jcs.00089.

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beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

J. Huelsken; R. Vogel; B. Erdmann; G. Cotsarelis; W. Birchmeier

Cell. 2001. DOI : 10.1016/S0092-8674(01)00336-1.

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Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices

R. Schmidt-Ullrich; T. Aebischer; J. Huelsken; W. Birchmeier; U. Klemm et al.

Development. 2001.

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New aspects of Wnt signaling pathways in higher vertebrates

J. Huelsken; W. Birchmeier

Current Opinion in Genetics & Development. 2001. DOI : 10.1016/S0959-437X(00)00231-8.

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

M. Sachs; H. Brohmann; D. Zechner; T. Muller; J. Huelsken et al.

Journal of Cell Biology (JCB). 2000. DOI : 10.1083/jcb.150.6.1375.

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Requirement for beta-catenin in anterior-posterior axis formation in mice

J. Huelsken; R. Vogel; V. Brinkmann; B. Erdmann; C. Birchmeier et al.

Journal of Cell Biology (JCB). 2000. DOI : 10.1083/jcb.148.3.567.

Detailed record

Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines

C. Denk; J. Huelsken; E. Schwarz

Cancer Lett. 1997. DOI : 10.1016/S0304-3835(97)00308-X.

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Epithelial differentiation and the control of metastasis in carcinomas

W. Birchmeier; J. Behrens; K. M. Weidner; J. Huelsken; C. Birchmeier

Attempts to Understand Metastasis Formation II: Regulatory Factors; 1996. p. 117 - 135.

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E-cadherin as an invasion suppressor

W. Birchmeier; J. Huelsken; J. Behrens

Ciba Found Symp. 1995.

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Adherens junction proteins in tumour progression

W. Birchmeier; J. Huelsken; J. Behrens

Cancer Surveys. 1995.

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E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

J. Huelsken; W. Birchmeier; J. Behrens

Journal of Cell Biology (JCB). 1994. DOI : 10.1083/jcb.127.6.2061.

Detailed record

Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development

C. Kraus; T. Liehr; J. Huelsken; J. Behrens; W. Birchmeier et al.

Genomics. 1994. DOI : 10.1006/geno.1994.1493.

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Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection

J. Huelsken; J. Behrens; W. Birchmeier

Current Opinion in Cell Biology. 1994. DOI : 10.1016/0955-0674(94)90098-1.

Detailed record

Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas

W. Birchmeier; K. M. Weidner; J. Huelsken; J. Behrens

Seminars in Cancer Biology. 1993.

Detailed record

Journal Articles

2025

Intestinal stem and progenitor cells exhibit distinct adaptive responses to inflammatory stress in IBD

B. Balasubramanian; S. Patel; L. Gall; N. Hannan; W. Dalleywater et al.

Stem Cell Research & Therapy. 2025. DOI : 10.1186/s13287-025-04872-8.

Detailed record

Abstract 4588: Cell states and resistance in colorectal cancer: What can we learn from patient-derived organoids?

M. Norkin; P. H. Lopez; C. Esposito; G. M. Ramzy; M. Armengot‐Carbó et al.

Cancer Research. 2025. DOI : 10.1158/1538-7445.am2025-4588.

Detailed record

2023

Metabolic dependencies of metastasis-initiating cells in female breast cancer

C. M. Young; L. N. K. Beziaud; P. V. Dessen; A. M. Alonso; A. Santamaria-Martinez et al.

Nature Communications. 2023. DOI : 10.1038/s41467-023-42748-8.

Detailed record

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

L. Beziaud; C. M. Young; A. R. Minafra; M. Norkin; A. Madurga Alonso et al.

Cell Stem Cell. 2023. DOI : 10.1016/j.stem.2023.05.007.

Detailed record

Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma

G. M. Ramzy; M. Norkin; T. Koessler; L. Voirol; M. Tihy et al.

Journal Of Experimental & Clinical Cancer Research. 2023. DOI : 10.1186/s13046-023-02650-z.

Detailed record

2022

Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

I. M. Roy; P. V. Anu; S. Zaunz; S. Reddi; A. M. Giri et al.

Iscience. 2022. DOI : 10.1016/j.isci.2022.105171.

Detailed record

2021

High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer

M. Norkin; P. Ordóñez-Morán; J. Huelsken

Cell Reports. 2021. DOI : 10.1016/j.celrep.2021.109026.

Detailed record

Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes

V. S. Dionellis; M. Norkin; A. Karamichali; G. G. Rossetti; J. Huelsken et al.

Cancers. 2021. DOI : 10.3390/cancers13061267.

Detailed record

Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen

S. H. Mehatre; I. M. Roy; A. Biswas; D. Prit; S. Schouteden et al.

The Journal of Immunology. 2021. DOI : 10.4049/jimmunol.2001066.

Detailed record

2020

The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver

A. Biswas; I. M. Roy; P. C. Babu; J. Manesia; S. Schouteden et al.

Stem Cell Reports. 2020. DOI : 10.1016/j.stemcr.2020.06.022.

Detailed record

2019

γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia

N. Luong-Gardiol; I. Siddiqui; I. Pizzitola; B. Jeevan-Raj; M. Charmoy et al.

Cancer Cell. 2019. DOI : 10.1016/j.ccell.2019.03.005.

Detailed record

2017

Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation

J.-P. Abbuehl; Z. Tatarova; W. Held; J. Huelsken

Cell Stem Cell. 2017. DOI : 10.1016/j.stem.2017.07.004.

Detailed record

Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature

P. C. Schwalie; P. Ordonez-Moran; J. Huelsken; B. Deplancke

Stem Cells. 2017. DOI : 10.1002/stem.2719.

Detailed record

Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue

N. Lugli; V. S. Dionellis; P. Ordonez-Moran; I. Kamileri; S. K. Sotiriou et al.

Cell Reports. 2017. DOI : 10.1016/j.celrep.2017.05.051.

Detailed record

2016

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

S. Khurana; S. Schouteden; J. K. Manesia; A. Santamaria-Martinez; J. Huelsken et al.

Nature Communications. 2016. DOI : 10.1038/ncomms13500.

Detailed record

Phage selection of chemically stabilized alpha-helical peptide ligands

P. Diderich; D. Bertoldo; P. Dessen; M. M. Khan; I. Pizzitola et al.

ACS Chemical Biology. 2016. DOI : 10.1021/acschembio.5b00963.

Detailed record

Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

D. Bertoldo; M. M. G. Khan; P. Dessen; W. Held; J. Huelsken et al.

ChemMedChem. 2016. DOI : 10.1002/cmdc.201500557.

Detailed record

Microfluidic co-culture platform to quantify chemotaxis of primary stem cells

Z. Tatarova; J. P. Abbuehl; S. Maerkl; J. Huelsken

Lab On A Chip. 2016. DOI : 10.1039/c6lc00236f.

Detailed record

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity

F. Chiacchiera; A. Rossi; S. Jammula; A. Piunti; A. Scelfo et al.

Cell Stem Cell. 2016. DOI : 10.1016/j.stem.2015.09.019.

Detailed record

2015

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

P. Ordonez-Moran; C. Dafflon; M. Imajo; E. Nishida; J. Huelsken

Cancer Cell. 2015. DOI : 10.1016/j.ccell.2015.11.001.

Detailed record

2014

SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer

P. Ordóñez-Morán; A. Irmisch; A. Barbáchano; I. Chicote; S. Tenbaum et al.

Oncogene. 2014. DOI : 10.1038/onc.2013.140.

Detailed record

2013

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

K. J. Petherick; A. C. Williams; J. D. Lane; P. Ordóñez-Morán; J. Huelsken et al.

The EMBO Journal. 2013. DOI : 10.1038/emboj.2013.123.

Detailed record

2012

Interactions between cancer stem cells and their niche govern metastatic colonization

I. Malanchi; A. Santamaria-Martínez; E. Susanto; H. Peng; H.-A. Lehr et al.

Nature. 2012. DOI : 10.1038/nature10694.

Detailed record

β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

H. J. M. Smartt; A. Greenhough; P. Ordóñez-Morán; M. Al-Kharusi; T. J. Collard et al.

British Journal of Cancer. 2012. DOI : 10.1038/bjc.2012.430.

Detailed record

2011

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

H. J. M. Smartt; A. Greenhough; P. Ordóñez-Morán; E. Talero; C. A. Cherry et al.

Gut. 2011. DOI : 10.1136/gutjnl-2011-300817.

Detailed record

Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death

T. Holowacz; J. Huelsken; D. Dufort; D. Van Der Kooy

European Journal of Neuroscience. 2011. DOI : 10.1111/j.1460-9568.2011.07632.x.

Detailed record

2010

SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

T. Hussenet; S. Dali; J. Exinger; B. Monga; B. Jost et al.

PLoS One. 2010. DOI : 10.1371/journal.pone.0008960.

Detailed record

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

G. Jeannet; C. Boudousquié; N. Gardiol; J. Kang; J. Huelsken et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2010. DOI : 10.1073/pnas.0914127107.

Detailed record

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

M. Buchert; D. Athineos; H. E. Abud; Z. D. Burke; M. C. Faux et al.

PLoS genetics. 2010. DOI : 10.1371/journal.pgen.1000816.

Detailed record

2009

Cancer stem cells: never Wnt away from the niche

I. Malanchi; J. Huelsken

Current Opinion in Oncology. 2009. DOI : 10.1097/CCO.0b013e32831d1faf.

Detailed record

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta- catenin signaling pathways in hair follicle induction

Y. Zhang; P. Tomann; T. Andl; N. Gallant; J. Huelsken et al.

Developmental Cell. 2009. DOI : 10.1016/j.devcel.2009.05.011.

Detailed record

Tissue-specific stem cells: friend or foe?

J. Huelsken

Cell Res. 2009. DOI : 10.1038/cr.2009.24.

Detailed record

Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1

A. Braeuning; R. Sanna; J. Huelsken; M. Schwarz

Drug Metab Dispos. 2009. DOI : 10.1124/dmd.108.026179.

Detailed record

Canonical Wnt signalling plays essential roles

J. Huelsken; W. Held

European Journal of Immunology. 2009. DOI : 10.1002/eji.200838982.

Detailed record

2008

Differential requirement for beta-catenin in epithelial and fiber cells during lens development

S. Cain; G. Martinez; M. Kokkinos; K. Turner; R. Richardson et al.

Developmental Biology. 2008. DOI : 10.1016/j.ydbio.2008.07.002.

Detailed record

Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin

G. Jeannet; M. Scheller; L. Scarpellino; S. Duboux; N. Gardiol et al.

Blood. 2008. DOI : 10.1182/blood-2007-07-102558.

Detailed record

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

I. Malanchi; H. Peinado; D. Kassen; T. Hussenet; D. Metzger et al.

Nature. 2008. DOI : 10.1038/nature06835.

Detailed record

Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels

Y. Xu; R. Reboulet; B. Quinn; J. Huelsken; D. Witte et al.

Molecular genetics and metabolism. 2008. DOI : 10.1016/j.ymgme.2008.01.013.

Detailed record

2007

Beta-catenin downregulation is required for adaptive cardiac remodeling

A. Baurand; L. Zelarayan; R. Betney; C. Gehrke; S. Dunger et al.

Circulation Research. 2007. DOI : 10.1161/01.RES.0000266605.63681.5a.

Detailed record

Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells

T. Fevr; S. Robine; D. Louvard; J. Huelsken

Molecular and Cellular Biology. 2007. DOI : 10.1128/MCB.01034-07.

Detailed record

Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

U. Schaeper; R. Vogel; J. Chmielowiec; J. Huelsken; M. Rosario et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2007. DOI : 10.1073/pnas.0702555104.

Detailed record

beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells

M. M. Faraldo; J. Teuliere; M. A. Deugnier; W. Birchmeier; J. Huelsken et al.

FEBS Letters. 2007. DOI : 10.1016/j.febslet.2007.01.053.

Detailed record

2006

Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation

M. Scheller; J. Huelsken; F. Rosenbauer; M. M. Taketo; W. Birchmeier et al.

Nature Immunology. 2006. DOI : 10.1038/ni1387.

Detailed record

2005

Cell-type-specific transcriptomics in chimeric models using transcriptome-based masks

F. Naef; J. Huelsken

Nucleic Acids Res. 2005. DOI : 10.1093/nar/gni104.

Detailed record

Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development

J. Dessimoz; C. Bonnard; J. Huelsken; A. Grapin-Botton

Current Biology. 2005. DOI : 10.1016/j.cub.2005.08.037.

Detailed record

Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival

D. Goux; J. D. Coudert; D. Maurice; L. Scarpellino; G. Jeannet et al.

Blood. 2005. DOI : 10.1182/blood-2005-01-0337.

Detailed record

2004

Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation

K. S. Grossmann; C. Grund; J. Huelsken; M. Behrend; B. Erdmann et al.

Journal of Cell Biology (JCB). 2004. DOI : 10.1083/jcb.200402096.

Detailed record

beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation

J. Teuliere; M. M. Faraldo; M. Shtutman; W. Birchmeier; J. Huelsken et al.

Molecular and Cellular Biology. 2004. DOI : 10.1128/MCB.24.19.8649-8661.2004.

Detailed record

2003

beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis

M. L. Mucenski; S. E. Wert; J. M. Nation; D. E. Loudy; J. Huelsken et al.

Journal of Biological Chemistry. 2003. DOI : 10.1074/jbc.M305892200.

Detailed record

Role of beta-catenin in synaptic vesicle localization and presynaptic assembly

S. X. Bamji; K. Shimazu; N. Kimes; J. Huelsken; W. Birchmeier et al.

Neuron. 2003. DOI : 10.1016/S0896-6273(03)00718-9.

Detailed record

Deletion of beta-catenin impairs T cell development

Y. Xu; D. Banerjee; J. Huelsken; W. Birchmeier; J. M. Sen

Nature Immunology. 2003. DOI : 10.1038/ni1008.

Detailed record

Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

N. Soshnikova; D. Zechner; J. Huelsken; Y. Mishina; R. R. Behringer et al.

Genes & Development. 2003. DOI : 10.1101/gad.263003.

Detailed record

beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

D. Zechner; Y. Fujita; J. Huelsken; T. Muller; I. Walther et al.

Developmental Biology. 2003. DOI : 10.1016/S0012-1606(03)00123-4.

Detailed record

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

M. Morkel; J. Huelsken; M. Wakamiya; J. Ding; M. van de Wetering et al.

Development. 2003. DOI : 10.1242/dev.00859.

Detailed record

2002

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

T. Schwarz-Romond; C. Asbrand; J. Bakkers; M. Kuhl; H. J. Schaeffer et al.

Genes & Development. 2002. DOI : 10.1101/gad.230402.

Detailed record

Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling

M. H. Wong; J. Huelsken; W. Birchmeier; J. I. Gordon

Journal of Biological Chemistry. 2002. DOI : 10.1074/jbc.M200184200.

Detailed record

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

C. Niemann; D. M. Owens; J. Huelsken; W. Birchmeier; F. M. Watt

Development. 2002.

Detailed record

The Wnt signalling pathway

J. Huelsken; J. Behrens

Journal of Cell Science. 2002. DOI : 10.1242/jcs.00089.

Detailed record

2001

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

J. Huelsken; R. Vogel; B. Erdmann; G. Cotsarelis; W. Birchmeier

Cell. 2001. DOI : 10.1016/S0092-8674(01)00336-1.

Detailed record

Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices

R. Schmidt-Ullrich; T. Aebischer; J. Huelsken; W. Birchmeier; U. Klemm et al.

Development. 2001.

Detailed record

2000

Essential role of Gab1 for signaling by the c-Met receptor in vivo

M. Sachs; H. Brohmann; D. Zechner; T. Muller; J. Huelsken et al.

Journal of Cell Biology (JCB). 2000. DOI : 10.1083/jcb.150.6.1375.

Detailed record

Requirement for beta-catenin in anterior-posterior axis formation in mice

J. Huelsken; R. Vogel; V. Brinkmann; B. Erdmann; C. Birchmeier et al.

Journal of Cell Biology (JCB). 2000. DOI : 10.1083/jcb.148.3.567.

Detailed record

1997

Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines

C. Denk; J. Huelsken; E. Schwarz

Cancer Lett. 1997. DOI : 10.1016/S0304-3835(97)00308-X.

Detailed record

1994

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

J. Huelsken; W. Birchmeier; J. Behrens

Journal of Cell Biology (JCB). 1994. DOI : 10.1083/jcb.127.6.2061.

Detailed record

Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development

C. Kraus; T. Liehr; J. Huelsken; J. Behrens; W. Birchmeier et al.

Genomics. 1994. DOI : 10.1006/geno.1994.1493.

Detailed record

Conference Papers

2022

Role Of Outside-In Integrin Signaling In Hematopoietic Development Of Mouse Embryo

A. Biswas; I. Roy; J. Huelsken; A. Lacy-Hulbert; C. Verfaillie et al.

2022. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S62 - S62.

Detailed record

2018

Comprehensive analysis of cancer stemness

T. M. Malta; A. Sokolov; A. J. Gentles; T. Burzykowski; L. Poisson et al.

2018. Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, Apr 14-18, 2018. DOI : 10.1158/1538-7445.AM2018-LB-373.

Detailed record

2016

Successful immunotherapy of cancer stem cells requires memory and the adaptive immune system of the host

P. Schmidt; N. Desbaillets; P. Dessen; N. Thompson; J. Huelsken et al.

2016. DOI : 10.1158/2326-6074.Cricimteatiaacr15-B067.

Detailed record

2015

Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host

P. Schmidt; N. Desbaillets; P. Dessen; N. Thompson; J. Huelsken

2015. 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), New Orleans, LA, MAY 13-16, 2015. p. S167 - S168.

Detailed record

2014

Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation

S. Khurana; N. Van Gastel; A. Santamaria-Martinez; S. Schouteden; J. Huelsken et al.

2014. 43rd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Montreal, CANADA, AUG 21-24, 2014. p. S42 - S42. DOI : 10.1016/j.exphem.2014.07.156.

Detailed record

2013

Putting cancer stem cells in context

I. Malanchi; A. Santamaria-Martinez; J. Huelsken

2013. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam, NETHERLANDS, SEP 27-OCT 01, 2013. p. S7 - S7.

Detailed record

2012

Interactions Between Breast Cancer Stem Cells and their Niche Govern Metastatic Colonization of the Lung

I. Malanchi; A. Santamaria-Martinez; E. Susanto; H. Peng; H. -A. Lehr et al.

2012. 22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN, JUL 07-10, 2012. p. S15 - S15.

Detailed record

Reviews

2014

Complex metastatic niches: already a target for therapy?

P. Ordóñez-Morán; J. Huelsken

Current Opinion in Cell Biology. 2014. DOI : 10.1016/j.ceb.2014.06.012.

Detailed record

2013

Metastasis: New insights into organ-specific extravasation and metastatic niches

A. Irmisch; J. Huelsken

Experimental Cell Research. 2013. DOI : 10.1016/j.yexcr.2013.02.012.

Detailed record

The niche under siege: novel targets for metastasis therapy

A. S. Martínez; J. Huelsken

Journal of internal medicine. 2013. DOI : 10.1111/joim.12024.

Detailed record

2012

Lrig1: a new master regulator of epithelial stem cells

P. Ordóñez-Morán; J. Huelsken

The EMBO Journal. 2012. DOI : 10.1038/emboj.2012.73.

Detailed record

2001

New aspects of Wnt signaling pathways in higher vertebrates

J. Huelsken; W. Birchmeier

Current Opinion in Genetics & Development. 2001. DOI : 10.1016/S0959-437X(00)00231-8.

Detailed record

1995

E-cadherin as an invasion suppressor

W. Birchmeier; J. Huelsken; J. Behrens

Ciba Found Symp. 1995.

Detailed record

Adherens junction proteins in tumour progression

W. Birchmeier; J. Huelsken; J. Behrens

Cancer Surveys. 1995.

Detailed record

1994

Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection

J. Huelsken; J. Behrens; W. Birchmeier

Current Opinion in Cell Biology. 1994. DOI : 10.1016/0955-0674(94)90098-1.

Detailed record

1993

Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas

W. Birchmeier; K. M. Weidner; J. Huelsken; J. Behrens

Seminars in Cancer Biology. 1993.

Detailed record

Theses

2023

Metabolic dependencies of metastasis-initiating cells in breast cancer

C. M. T. Young / J. Hülsken (Dir.)

Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-8855.

Detailed record

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

A. Madurga Alonso / J. Hülsken (Dir.)

Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-9093.

Detailed record

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

M. Girardin / J. Hülsken; B. E. Ferreira De Sousa Correia (Dir.)

Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-8912.

Detailed record

2022

The role of eosinophils in breast cancer

L. Spisak / J. Hülsken (Dir.)

Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8575.

Detailed record

2021

Intestinal stem cells differentiation and its application in cancer therapy

M. Norkin / J. Hülsken (Dir.)

Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8868.

Detailed record

2017

Targeting cancer stem cells by T cell engineering

N. P. Desbaillets / J. Hülsken (Dir.)

Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7960.

Detailed record

2016

Development of microfluidic devices for chemotaxis of primary stem cells

Z. Tatárová / J. Hülsken; S. Maerkl (Dir.)

Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7071.

Detailed record

2014

Identification of tumor-stroma interactions crucial for the establishment of liver metastasis

C. Urech / J. Huelsken (Dir.)

Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6148.

Detailed record

The role of recruited bone-marrow derived mesenchymal stem cells in the establishment of the tumor stroma and a growth-supportive environment

J.-P. Abbühl / J. Huelsken (Dir.)

Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6143.

Detailed record

2012

Asymmetric Cell Division in the Skin

W.-H. Fan / J. Hülsken (Dir.)

Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5024.

Detailed record

Identification of a Novel Wnt Inhibitor

E. Susanto / J. Huelsken (Dir.)

Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5431.

Detailed record

Book Chapters

1996

Epithelial differentiation and the control of metastasis in carcinomas

W. Birchmeier; J. Behrens; K. M. Weidner; J. Huelsken; C. Birchmeier

Attempts to Understand Metastasis Formation II: Regulatory Factors; 1996. p. 117 - 135.

Detailed record

Working Papers

2025

Intestinal Stem and Progenitor Cells Exhibit Distinct Adaptive Responses to Inflammatory Stress in IBD

P. Ordonez-Moran; B. Balasubramanian; S. Patel; W. Dalleywater; N. Hannan et al.

2025

Detailed record

Talks

2008

T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin

G. Jeannet; M. Scheller; L. Scarpellino; S. Duboux; N. Gardiol et al.

Annual Joint Meeting of the Swiss Societies for Pneumology, Paediatric Pneumology, Allergology and Immunology, Thoracic Surgery, Fribourg, April 17-18, 2008.

Detailed record

Patents

2024

Lat-based nk cars and their use

M. Girardin; A. Madurga Alonso; J. Huelsken

WO2024153707 . 2024.

Detailed record

2011

Targeting extracellular matrix molecules for the treatment of cancer

J. Huelsken; I. Malanchi

WO2011024114 . 2011.

Detailed record

Enseignement et PhD

Doctorant·es actuel·les

Pablo Hernandez Lopez, Laura Fabienne Wyss, Krishna Rasik Gajera

A dirigé les thèses EPFL de

Wan-Hung Fan, Evelyn Susanto, Jean-Paul Abbühl, Caroline Dafflon, Zuzana Tatárová, Nicolas Pierre Desbaillets, Maxim Norkin, Luisa Spisak, Mathieu Girardin, Candice Megan T Young, Angela Madurga Alonso

Cours

Cancer biology II

BIO-472

The course covers in detail the interactions of cancer cells with their environment with an emphasis on tumor-angiogenesis, inflammation, adaptive and innate immunity and cancer-induced immune suppression. Additional topics are cancer metabolism, cancer stem cells and metastasis.

Practical - Huelsken Lab

BIO-667

Assessment of signaling mechanisms in cancer. The objectives of the course are: - to understand the importance of signaling and cell-cell interactions in cancer stroma interactions - to learn techniques involved in assessing the function of such interactions in vitro and in vivo.