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Juan Cruz Landoni

juan.landoni@epfl.ch +41 21 693 16 91 https://jclandoni.github.io

Nationality: Argentina

Expertise

Mitochondria, metabolism, mitochondrial DNA, superresolution microscopy, ageing

Mission

Dissecting the dynamic orchestration between mitochondria and metabolism underlying health, disease and ageing using advanced imaging and integrative multi-omics.

Current Work

I am a chemist turned mitochondria enthusiast. Using molecular biology, super-resolution microscopy and smart imaging techniques, I aim to decipher the complex behaviour of the tiny intruders that live inside our cells, mitochondria, and how this affects their genetics, function and the health of the cell as a whole.

Research interest

I am a chemist turned mitochondria enthusiast. Using molecular biology and "smart" super-resolution imaging techniques, I am exploring the complex behavior of the tiny cellular intruders called mitochondria, and how this affects their genetics, function, and the health of the cell as a whole.

Education

Doctor of Philosophy (Ph.D.)

| Integrative Life Sciences

2022 – 2022 Faculty of Medicine, University of Helsinki

Master of Science (M.Sc.)

| Translational Medicine

2019 – 2019 Faculty of Medicine, University of Helsinki

Bachelor of Science (B.Sc.)

| Chemistry

2017 – 2017 Faculty of Science, University of Helsinki

Professionals experiences

Postdoctoral Fellow

2022–2022

Institute of Physics, EPFL

Research Facilitator

2024–2024

Marine Biological Laboratory (MBL) - Woods Hole MA

Doctoral Researcher

2019–2022

Stem Cells & Metabolism, University of Helsinki

Undergraduate/MSc student

2014–2019

Molecular Neurology, University of Helsinki

Selected publications

Pearling Drives Mitochondrial DNA Nucleoid Distribution.

Landoni, J. C.† , Lycas, M., Macuada, J., Jaccard, R., Obara, C., Moore, A., … Manley, S.†  (2025). † co-corresponding author
Published in bioRxiv in 2025

Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation.

Landoni, J. C.† , Erkul, S., Laalo, T., Goffart, S., Kivelä, R., Skube, K., ... Suomalainen, A.†  (2024). †  co-corresponding author
Published in Nature Communications in 2024

Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network

Landoni, J. C.*, Kleele, T.*, Winter, J., Stepp, W., & Manley, S. (2024).
Published in Annual Review of Cell and Developmental Biology in 2024

IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder

Kuukasjärvi, A.*, Landoni, J. C.*, Kaukonen, J., Juhakoski, M., Auranen, M., ... Suomalainen, A. (2021). *co-lead author
Published in European Journal of Human Genetics in 2021

Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias

Hämäläinen, R. H., Landoni, J. C.*, Ahlqvist, K. J.*, Goffart, S., Ryytty, S., ... Suomalainen, A. (2019).
Published in Nature Metabolism in 2019

A complex genomic locus drives mt DNA replicase POLG expression to its disease-related nervous system regions

Nikkanen, J., Landoni, J. C., Balboa, D., Haugas, M., ... Suomalainen, A. (2018).
Published in EMBO molecular medicine in 2018