Profile picture

Loïc Dayon

Publications représentatives

Probing cysteine reactivity in proteins by mass spectrometric EC-tagging

Dayon L., Roussel C., Girault H.H.
Published in J. Proteome Res. 2006, 5, 793-800 in

Electrochemical multi-tagging of cysteinyl peptides during microspray mass spectrometry: numerical simulation of consecutive reactions in a microchannel

Dayon L., Josserand J., Girault H.H.
Published in Phys. Chem. Chem. Phys. 2005, 7, 4054-4060 in

On-line counting of cysteine residues in peptides during electrospray ionization by electrogenerated tags and their application to protein identification

Dayon L., Roussel C., Prudent M., Lion N., Girault H.H.
Published in Electrophoresis 2005, 26, 238-247 in

Generation of mass tags by the inherent electrochemistry of electrospray for protein mass spectrometry

Roussel C., Dayon L., Lion N., Rohner T.C., Josserand J., Rossier J.S:, Jensen H., Girault H.H.
Published in J. Am. Soc. Mass Spectrom. 2004, 15, 1767-1779 in

On-line cysteine modification for protein analysis: new probes for electrochemical tagging nanospray mass spectrometry

Roussel C., Dayon L., Jensen H., Girault H. H.
Published in J. Electroanal. Chem. 2004, 570, 187-199 in

On-line electrochemical tagging of free cysteines in peptides during nanospray ionisation mass spectrometry: An overview

Dayon L., Roussel C., Girault H.H.
Published in Chimia 2004, 58, 204-207 in

Microfluidic systems in proteomics

Lion N., Rohner T.C., Dayon L., Arnaud I.L., Damoc E., Youhnovski N., Wu Z., Roussel C., Josserand J., Jensen H., Rossier J.S., Przybylski M., Girault H.H.
Published in Electrophoresis 2003, 24, 3533-3562 in

MAIN PUBLICATIONS

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

J. Santo-DomingoS. LassueurA. N. GalindoP. Alvarez-IlleraS. Romero-Sanz  et al.

Journal Of Cell Science. 2023-04-01. DOI : 10.1242/jcs.260049.

The promise of multi-omics approaches to discover biological alterations with clinical relevance in Alzheimer's disease

C. ClarkM. RablL. DayonJ. Popp

Frontiers In Aging Neuroscience. 2022-12-07. DOI : 10.3389/fnagi.2022.1065904.

Blood plasma protein profiles of neuropsychiatric symptoms and related cognitive decline in older people

M. RablC. ClarkL. DayonG. L. BowmanJ. Popp

Journal Of Neurochemistry. 2022-11-15. DOI : 10.1111/jnc.15715.

Proteomics reveals unique plasma signatures in constitutional thinness

O. CominettiA. N. GalindoJ. CorthesyJ. CarayolN. Germain  et al.

Proteomics Clinical Applications. 2022-05-26. DOI : 10.1002/prca.202100114.

Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people

C. ClarkJ. RichiardiB. MarechalG. L. BowmanL. Dayon  et al.

Journal Of Neuroinflammation. 2022-05-28. DOI : 10.1186/s12974-022-02473-3.

Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications

L. DayonO. CominettiM. Affolter

Expert Review Of Proteomics. 2022-05-06. DOI : 10.1080/14789450.2022.2070477.

Assessing normalization methods in mass spectrometry-based proteome profiling of clinical samples

E. DuboisA. N. GalindoL. DayonO. Cominetti

Biosystems. 2022-06-01. DOI : 10.1016/j.biosystems.2022.104661.

Cerebrospinal Fluid Proteome Alterations Associated with Neuropsychiatric Symptoms in Cognitive Decline and Alzheimer's Disease

M. MroczekC. ClarkL. DayonG. L. BowmanJ. Popp

Cells. 2022-03-01. DOI : 10.3390/cells11061030.

Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation

M. Valera-AlberniM. JoffraudJ. Miro-BlanchJ. CapelladesA. Junza  et al.

Cell Reports. 2021-08-24. DOI : 10.1016/j.celrep.2021.109565.

Proteomics of Human Milk: Definition of a Discovery Workflow for Clinical Research Studies

L. DayonC. MacronS. LahrichiA. N. GalindoM. Affolter

Journal Of Proteome Research. 2021-05-07. DOI : 10.1021/acs.jproteome.0c00816.

An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer's disease

C. ClarkL. DayonM. MasoodiG. L. BowmanJ. Popp

Alzheimers Research & Therapy. 2021-04-01. DOI : 10.1186/s13195-021-00814-7.

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

I. ChareyronS. ChristenS. MocoA. ValsesiaS. Lassueur  et al.

Diabetologia. 2020-09-22. DOI : 10.1007/s00125-020-05275-5.

Exploration of human cerebrospinal fluid: A large proteome dataset revealed by trapped ion mobility time-of-flight mass spectrometry

C. MacronR. LavigneA. N. GalindoM. AffolterC. Pineau  et al.

Data In Brief. 2020-08-01. DOI : 10.1016/j.dib.2020.105704.

Progress and pitfalls of using isobaric mass tags for proteome profiling

L. DayonM. Affolter

Expert Review Of Proteomics. 2020-02-23. DOI : 10.1080/14789450.2020.1731309.

Novel Analytical Methods for Allergy-Related Studies

M. Frossard / H. GiraultN. Gasilova (Dir.)

Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7271.

Mass Spectrometry Methods for Bacterial Infection Diagnosis and Cancer Analysis

Y. Zhu / H. GiraultL. Qiao (Dir.)

Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9322.

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

D. MauvoisinF. AtgerL. DayonA. N. GalindoJ. Wang  et al.

Cell Reports. 2017. DOI : 10.1016/j.celrep.2017.07.065.

Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver

J. WangD. MauvoisinE. MartinF. AtgerA. N. Galindo  et al.

Cell Metabolism. 2017. DOI : 10.1016/j.cmet.2016.10.003.

Proteomics of Cerebrospinal Fluid: Throughput and Robustness Using a Scalable Automated Analysis Pipeline for Biomarker Discovery

A. N. GalindoM. KussmannL. Dayon

Analytical Chemistry. 2015. DOI : 10.1021/acs.analchem.5b02748.

Proteomics and circadian rhythms: It's all about signaling!

D. MauvoisinL. DayonF. GachonM. Kussmann

Proteomics. 2015. DOI : 10.1002/pmic.201400187.

Comprehensive and Scalable Highly Automated MS-Based Proteomic Workflow for Clinical Biomarker Discovery in Human Plasma

L. DayonA. N. GalindoJ. CorthesyO. CominettiM. Kussmann

Journal Of Proteome Research. 2014. DOI : 10.1021/pr500635f.

From allergen detection to protein-ligand interactions

N. Gasilova / H. Girault (Dir.)

Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6332.

Combination of Gas-Phase Fractionation and MS3 Acquisition Modes for Relative Protein Quantification with Isobaric Tagging

L. DayonB. SondereggerM. Kussmann

Journal Of Proteome Research. 2012. DOI : 10.1021/pr300519c.

Electrospray Micromixer Chip for On-Line Derivatization and Kinetic Studies

M. AbonnencL. DayonB. PerrucheN. LionH. H. Girault

Analytical Chemistry. 2008. DOI : 10.1021/ac800058h.

Diagonal chromatographic selection of cysteinyl peptides modified with benzoquinones

L. DayonH. H. Girault

Analytical and Bioanalytical Chemistry. 2007. DOI : 10.1007/s00216-007-1492-8.

Multitrack electrospray chips

L. DayonM. AbonnencM. PrudentN. LionH. H. Girault

Journal of Mass Spectrometry. 2006. DOI : 10.1002/jms.1119.

Probing Cysteine Reactivity in Proteins by Mass Spectrometric EC-Tagging

L. DayonC. RousselH. Girault

Journal of Proteome Research. 2006. DOI : 10.1021/pr050365o.

Thiol-targeted microspray mass spectrometry of peptides and proteins through on-line EC-tagging

L. Dayon / H. Girault (Dir.)

Lausanne, EPFL, 2006. DOI : 10.5075/epfl-thesis-3525.

Electrochemical Multi-Tagging of Cysteinyl Peptides during Microspray Mass Spectrometry: Numerical Simulation of Consecutive Reactions in a Microchannel

L. DayonJ. JosserandH. H. Girault

Phys. Chem. Chem. Phys. 2005. DOI : 10.1039/b511334b.

On-Line Counting of Cysteine Residues in Peptides during Electrospray Ionization by Electrogenerated Tags and Their Application to Protein Identification

L. DayonC. RousselM. PrudentN. LionH. H. Girault

Electrophoresis. 2005. DOI : 10.1002/elps.200406144.

On-Line Electrochemical Tagging of Free Cysteines in Peptides during Nanospray Ionisation Mass Spectroscopy: An Overview

L. DayonC. RousselH. H. Girault

Chimia. 2004. DOI : 10.2533/000942904777678028.

On-line cysteine modification for protein analysis: new probes for electrochemical tagging nanospray mass spectrometry

C. RousselL. DayonH. JensenH. H. Girault

Journal of Electroanalytical Chemistry. 2004. DOI : 10.1016/j.jelechem.2004.03.029.

Generation of Mass Tags by the Inherent Electrochemistry of Electrospray for Protein Mass Spectrometry

C. RousselL. DayonN. LionT. C. RohnerJ. Josserand  et al.

Journal of the American Society for Mass Spectrometry. 2004. DOI : 10.1016/j.jasms.2004.08.006.

Microfluidic systems in proteomics

N. LionT. C. RohnerL. DayonI. L. ArnaudE. Damoc  et al.

Electrophoresis. 2003. DOI : 10.1002/elps.200305629.

Enseignement et PhD

Courses

Protein mass spectrometry and proteomics

CH-419

L'analyse protéomique est un pilier essentiel de la biologie des systèmes, permettant une meilleure compréhension du vivant. Les technologies protéomiques, et en particulier celles basées sur la spectrométrie de masse, permettent désormais de cartographier les protéomes à large échelle.