Pharmacokinetics and biodistribution study of self-assembled Gd-micelles demonstrating blood-pool contrast enhancement for MRI

V. Vorobiev; A. Babic; L. A. Crowe; Y. Van de Looij; S. Lenglet  et al.

MRI micelles self-assembled from synthetic gadolinium-based nano building blocks

A. Babic; V. Vorobiev; G. Trefalt; L. A. Crowe; L. Helm  et al.

The Periodic Table and Kinetics?

L. Helm; A. E. Merbach

Self-Assembled Nanomicelles as MRI Blood-Pool Contrast Agent

A. Babič; V. Vorobiev; C. Xayaphoummine; G. Lapicorey; A.-S. Chauvin  et al.

Carbazole as Linker for Dinuclear Gadolinium-Based MRI Contrast Agents

B. Mousavi; A.-S. Chauvin; L. Moriggi; L. Helm

In-Vivo Detection and Tracking of T Cells in Various Organs in a Melanoma Tumor Model by F-19-Fluorine MRS/MRI

C. Gonzales; H. A. I. Yoshihara; N. Dilek; J. Leignadier; M. Irving  et al.

Collisional cross-section of water molecules in vapour studied by means of H-1 relaxation in NMR

D. Mammoli; E. Canet; R. Buratto; P. Mieville; L. Helm  et al.

Transient versus Static Electron Spin Relaxation in Mn2+ Complexes Relevant as MRI Contrast Agents

C. Platas-Iglesias; D. Esteban-Gomez; L. Helm; M. Regueiro-Figueroa

Evaluation of Water Exchange Kinetics on [Ln(AAZTAPh–NO2)(H2O)q]x Complexes Using Proton Nuclear Magnetic Resonance

S. Karimi; L. Tei; M. Botta; L. Helm

Complexation of [Gd(DTTA–Me)(H2O)2]− by Fluoride and Its Consequences to Water Exchange

S. Karimi; G. Hunter; L. Moriggi; C. Platas-Iglesias; L. Helm

Water Exchange on [Ln(DO3A)(H2O)2] and [Ln(DTTA–Me)(H2O)2]− Studied by Variable Temperature, Pressure, and Magnetic Field NMR

S. Karimi; L. Helm

PEGylated DOTA-AHA-Based Gd-III Chelates: A Relaxometric Study

A. Fontes; S. Karimi; L. Helm; P. M. Ferreira; J. P. Andre

A Pyridine-Based Ligand with Two Hydrazine Functions for Lanthanide Chelation: Remarkable Kinetic Inertness for a Linear, Bishydrated Complex

C. S. Bonnet; S. Laine; F. Buron; G. Tircso; A. Pallier  et al.

Metal Complexes as MRI Contrast Enhancement Agents

É. Tóth; L. Helm; A. Merbach

Dinuclear DOTA-Based Gd-III Chelates - Revisiting a Straightforward Strategy for Relaxivity Improvement

A. Fontes; S. Karimi; L. Helm; M. Yulikov; P. M. Ferreira  et al.

Prototropic Exchange Governs T-1 and T-2 Relaxivities of a Potential MRI Contrast Agent Nanozeolite Gd-LTL with a High pH Responsiveness

W. Zhang; J. A. Peters; F. Mayer; L. Helm; K. Djanashvili

Gold nanoparticles functionalised with fast water exchanging Gd3+ chelates: linker effects on the relaxivity

M. F. Ferreira; J. Goncalves; B. Mousavi; M. I. M. Prata; S. P. J. Rodrigues  et al.

Solvent Exchange and Electron-Spin Relaxation on Homoleptic Acetonitrile Complexes of Trivalent Lanthanides

G. Bodizs; L. Helm

Gd(DOTAlaP): Exploring the Boundaries of Fast Water Exchange in Gadolinium-Based Magnetic Resonance Imaging Contrast Agents

E. Boros; S. Karimi; N. Kenton; L. Helm; P. Caravan

Dynamic aggregation of the mid-sized gadolinium complex {Ph-4[Gd(DTTA)(H2O)(2)](-)(3)}

H. Jaccard; P. Mieville; C. Cannizzo; C. R. Mayer; L. Helm

Relaxivity of gadolinium(III) complexes: theory and mechanism

E. Toth; L. Helm; A. Merbach

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

Speciation of aqueous tellurium(IV) in hydrothermal solutions and vapors, and the role of oxidized tellurium species in Te transport and gold deposition

P. V. Grundler; J. Brugger; B. E. Etschmann; L. Helm; W. Liu  et al.

H-1 and O-17 NMR Relaxometric and Computational Study on Macrocyclic Mn(II) Complexes

G. A. Rolla; C. Platas-Iglesias; M. Botta; L. Tei; L. Helm

Gadolinium complexes of monophosphinic acid DOTA derivatives conjugated to cyclodextrin scaffolds: efficient MRI contrast agents for higher magnetic fields

Z. Kotkova; L. Helm; J. Kotek; P. Hermann; I. Lukes

Hyperfine Coupling Constants on Inner-Sphere Water Molecules of Gd-III-Based MRI Contrast Agents

D. Esteban-Gomez; A. De Blas; T. Rodriguez-Blas; L. Helm; C. Platas-Iglesias

NMR and Electron Paramagnetic Resonance Studies of [Gd(CH3CN)(9)](3+) and [Eu(CH3CN)(9)](2+): Solvation and Solvent Exchange Dynamics in Anhydrous Acetonitrile

G. Bodizs; L. Helm

New Bisaqua Picolinate-Based Gadolinium Complexes as MRI Contrast Agents with Substantial High-Field Relaxivities

A. M. Nonat; C. Gateau; P. H. Fries; L. Helm; M. Mazzanti

Serum Albumin Targeted, pH-Dependent Magnetic Resonance Relaxation Agents

L. Moriggi; M. A. Yaseen; L. Helm; P. Caravan

Isoquinoline-Based Lanthanide Complexes: Bright NIR Optical Probes and Efficient MRI Agents

F. Caillé; C. S. Bonnet; F. Buron; S. Villette; L. Helm  et al.

Pyridine-Based Lanthanide Complexes Combining MRI and NIR Luminescence Activities

C. S. Bonnet; F. Buron; F. Caille; C. M. Shade; B. Drahos  et al.

O-17 NMR and Density Functional Theory Study of the Dynamics of the Carboxylate Groups in DOTA Complexes of Lanthanides in Aqueous Solution

F. Mayer; C. Platas-Iglesias; L. Helm; J. A. Peters; K. Djanashvili

Electronic fine structure calculation of [Gd(DOTA)(H2O)]- using LF-DFT: The zero field splitting

F. Senn; L. Helm; A. Borel; C. A. Daul

Mn2+ Complexes with 12-Membered Pyridine Based Macrocycles Bearing Carboxylate or Phosphonate Pendant Arm: Crystallographic, Thermodynamic, Kinetic, Redox, and 1H/17O Relaxation Studies

B. Drahoš; J. Kotek; I. Cı́Sařová; P. Hermann; L. Helm  et al.

The challenge of T1 contrast agents for high-magnetic field MRI

L. Helm

Gadolinium-Based Bionanomaterials for Magnetic Resonance Imaging

E. Tóth; L. Helm

NMR Study of Ligand Exchange and Electron Self-Exchange between Oxo-Centered Trinuclear Clusters [Fe3(μ3-O)(μ-O2CR)6(4-R´py)3]+/0

G. Novitchi; L. Helm; C. Anson; A. K. Powell; A. Merbach

Synthesis, complexation and NMR relaxation properties of Gd3+ complexes of Mes(DO3A)3

P. Miéville; H. Jaccard; F. Reviriego; R. Tripier; L. Helm

NMR of Insensitive Nuclei Enhanced by Dynamic Nuclear Polarization

P. Miéville; S. Jannin; L. Helm; G. Bodenhausen

Isomerization Mechanisms of Stereolabile tris- and bis-Bidentate Octahedral Cobalt(II) Complexes: X-ray Structure and Variable Temperature and Pressure NMR Kinetic Investigation

F. Riblet; G. Novitchi; R. Scopelliti; L. Helm; A. Gulea  et al.

Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast

J. S. Ananta; B. Godin; R. Sethi; L. Moriggi; X. Liu  et al.

Kinetics of Yttrium-Ligand Complexation Monitored Using Hyperpolarized 89Y as a Model for Gadolinium in Contrast Agents

P. Miéville; S. Jannin; L. Helm; G. Bodenhausen

Optimization of gadolinium-based MRI contrast agents for high magnetic‑field applications

L. Helm

Gadolinium(III) complexes of 1,4,7-triazacyclononane based picolinate ligands: simultaneous optimization of water exchange kinetics and electronic relaxation

A. Nonat; M. Giraud; C. Gateau; P. H. Fries; L. Helm  et al.

Multiple Frequency and Variable Temperature EPR study of Gd(III) polyaminocarboxylates: analysis and comparison of the magnetically dilute powder and the frozen solution spectra

M. Benmelouka; J. Van Tol; A. Borel; S. Nellutla; M. Port  et al.

Gold Nanoparticles Functionalized with Gadolinium Chelates as High-Relaxivity MRI Contrast Agents

L. Moriggi; C. Cannizzo; E. Dumas; C. R. Mayer; A. Ulianov  et al.

Lanthanide chelates of (bis)-hydroxymethyl-substituted DTTA with potential application as contrast agents in magnetic resonance imaging

S. Silvério; S. Torres; A. F. Martins; J. A. Martins; J. P. André  et al.

Synthesis, structures and characterisations of truly homoleptic acetonitrile Ln3+ complexes in solid state and in solution

G. Bodizs; I. Raabe; R. Scopelliti; I. Krossing; L. Helm

A ruthenium-based metallostar: synthesis, sensitized luminescence and 1H relaxivity

L. Moriggi; A. Aebischer; C. Cannizzo; A. Sour; A. Borel  et al.

Mechanism of Pyridine-Ligand Exchanges at the Different Labile Sites of 3d Heterometallic and Mixed Valence μ3-oxo Trinuclear Clusters

G. Novitchi; F. Riblet; R. Scopelliti; L. Helm; A. Gulea  et al.

Nuclear Spin Relaxation Parameters of MRI Contrast Agents – Insight from Quantum Mechanical Calculations

O. V. Yazyev; L. Helm

Ligand exchange and complex formation kinetics studied by NMR exemplified on fac-[(CO)3M(H2O)]+ (M = Mn, Tc, Re)

L. Helm

In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications

P. L. de Sousa; J. B. Livramento; L. Helm; A. E. Merbach; W. Même  et al.

Physicochemical Properties of the High-Field MRI-Relevant [Gd(DTTA-Me)(H2O)2]− Complex

L. Moriggi; C. Cannizzo; C. Prestinari; F. Berrière; L. Helm

Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy

A. Keelara; H. Jaccard; M. Kretzschmar; L. Helm; H. R. Maecke

Comparison of different methods for calculating the paramagnetic relaxation enhancement of nuclear spins as a function of the magnetic field

E. Belorizky; P. H. Fries; L. Helm; J. Kowalewski; D. Kruk  et al.

Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies

S. Torres; M. I. M. Prata; A. C. Santos; J. P. André; J. A. Martins  et al.

A benzene-core trinuclear GdIII complex: towards the optimization of relaxivity for MRI contrast agent applications at high magnetic field

J. B. Livramento; L. Helm; A. Sour; C. O’neil; A. E. Merbach  et al.

Gadonanotubes as Ultrasensitive pH-Smart Probes for Magnetic Resonance Imaging

K. B. Hartman; S. Laus; R. D. Bolskar; R. Muthupillai; L. Helm  et al.

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

A. Borel; J. F. Bean; R. B. Clarkson; L. Helm; L. Moriggi  et al.

Physicochemical and MRI characterization of Gd3+-loaded polyamidoamine and hyperbranched dendrimers

Z. Jászberényi; L. Moriggi; P. Schmidt; C. Weidensteiner; R. Kneuer  et al.

H5EPTPACH2OH: Synthesis, Relaxometric Characterization and 1H NMR Spectroscopic Studies on the Solution Dynamics of Its LnIII Complexes

S. Torres; J. A. Martins; J. P. André; G. A. Pereira; R. Kiraly  et al.

Magnetism induced by single-atom defects in nanographites

O. V. Yazyev; L. Helm

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

O. V. Yazyev; L. Helm

Multiple-frequency EPR spectra of two aqueous Gd3+ polyaminopolypyridinecarboxylate complexes: a study of high field effects

A. Borel; S. Laus; A. Ozarowski; C. Gateau; A. Nonat  et al.

Understanding Paramagnetic Relaxation Phenomena for Water-Soluble Gadofullerenes

S. Laus; B. Sitharaman; E. Tóth; R. D. Bolskar; L. Helm  et al.

Early stages of radiation damage in graphite and carbon nanostructures: A first-principles molecular dynamics study

O. V. Yazyev; I. Tavernelli; U. Rothlisberger; L. Helm

Defect-induced magnetism in graphene

O. V. Yazyev; L. Helm

Gadolinium(III) complexes of mono-and diethyl esters of monophosphinic acid analogue of DOTA as potential MRI contrast agents: solution structures and relaxometric studies

P. Lebduskova; P. Hermann; L. Helm; E. Tóth; J. Kotek  et al.

Design of Gd(III)-Based Magnetic Resonance Imaging Contrast Agents: Static and Transient Zero-Field Splitting Contributions to the Electronic Relaxation and Their Impact on Relaxivity

M. Benmelouka; A. Borel; L. Moriggi; L. Helm; A. E. Merbach

Kinetic studies on the first dihydrogen aquacomplex, [Ru(H2)(H2O)5]2+: Formation under H2 pressure and catalytic H/D isotope exchange in water

P. V. Grundler; O. V. Yazyev; N. Aebischer; L. Helm; G. Laurenczy  et al.

Relevance of the Ligand Exchange Rate and Mechanism of fac-[(CO)3M(H2O)3]+ (M = Mn, Tc, Re) Complexes for New Radiopharmaceuticals

P. V. Grundler; L. Helm; R. Alberto; A. E. Merbach

Unexpected Aggregation of Neutral, Xylene-Cored Dinuclear GdIII Chelates in Aqueous Solution

J. Costa; E. Balogh; V. Turcry; R. Tripier; M. Le Bacon  et al.

Relaxivity in paramagnetic systems: Theory and mechanisms

L. Helm

Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: an 17O and 1H relaxation study of its Gd(III) complex

P. Lebduskova; A. Sour; L. Helm; E. Toth; J. Kotek  et al.

Hyperfine interactions in aqueous solution of Cr3+: an ab initio molecular dynamics study

O. Yazyev; L. Helm

Water-Exchange Study Revealed Unexpected Substitution Behavior of [(CO)2(NO)Re(H2O)3]2+ in Aqueous Media

M.-L. Lehaire; P. V. Grundler; S. Steinhauser; N. Marti; L. Helm  et al.

First in vivo MRI assessment of a self-assembled metallostar compound endowed with a remarkable high field relaxivity

J. B. Livramento; C. Weidensteiner; M. I. M. Prata; P. R. Allegrinin; C. F. G. C. Geraldes  et al.

Isomerization mechanisms of a labile Co(II) octahedral complex

F. Riblet; G. Novichi; L. Helm; A. Gulea; A. E. Merbach

17O nuclear quadrupole coupling constants of water bound to a metal ion: A gadolinium(III) case study

O. Yazyev; L. Helm

A High-Frequency EPR Study of Frozen Solutions of Gd(III) Complexes: Straightforward Determination of the Zero-Field Splitting Parameters and Simulation of the NMRD Profiles

M. Benmelouka; J. Van Tol; A. Borel; M. Port; L. Helm  et al.

Positively Charged GdIII Cryptates: Slow, Associative Water Exchange

L. Burai; É. Tóth; H. Bazin; M. Benmelouka; Z. Jászberényi  et al.

Dinuclear, Bishydrated GdIII Polyaminocarboxylates with a Rigid Xylene Core Display Remarkable Proton Relaxivities

J. Costa; E. Toth; L. Helm; A. E. Merbach

Inorganic and Bioinorganic Solvent Exchange Mechanisms

L. Helm; A. E. Merbach

Rigid M(II)L2Gd(III)2 (M=Fe, Ru) Complexes of a Terpyridine-Based Heteroditopic Chelate: A Class of Candidates for MRI Contrast Agents

J. Costa; R. Ruloff; L. Burai; L. Helm; A. E. Merbach

Water and proton Exchange Processes on Metal Ions

L. Helm; G. Nicolle; A. E. Merbach

The effect of pyridinecarboxylate chelating groups on the stability and electronic relaxation of gadolinium complexes

N. Chatterton; C. Gateau; M. Mazzanti; J. Pécaut; A. Borel  et al.

Water-Soluble Gadofullerenes: Toward High-Relaxivity, pH-Responsive MRI Contrast Agents

É. Tóth; R. D. Bolskar; A. Borel; G. González; L. Helm  et al.

Core spin-polarization correction in pseudopotential-based electronic structure calculations

O. V. Yazyev; I. Tavernelli; L. Helm; U. Rothlisberger

Isotropic Knight shift of metallic carbon nanotubes

O. V. Yazyev; L. Helm

Quantum Chemical Investigation of Hyperfine Coupling Constants on First Coordination Sphere Water Molecule of Gadolinium(III) Aqua Complexes

O. V. Yazyev; L. Helm; V. G. Malkin; O. L. Malkina

Superparamagnetic gadonanotubes are high-performance MRI contrast agents

B. Sitharaman; K. R. Kissell; K. B. Hartman; L. A. Tran; A. Baikalov  et al.

Destroying gadofullerene aggregates by salt addition in aqueous solution of Gd@C60(OH)x and Gd@C60[C(COOH2)]10

S. Laus; B. Sitharaman; E. Toth; R. D. Bolskar; L. Helm  et al.

An unexpected influence of the nature of the amine on the crystal structure of some Co(III)-Bi(III) heterobimetallic complexes

V. Stavila; A. Gulea; S. Shova; Y. A. Simonov; P. Petrenko  et al.

Hybrid ligand-field theory/quantum chemical calculation of the fine structure and ZFS in lanthanide(III) complexes

A. Borel; L. Helm; C. A. E. Daul

Richness of isomerism in labile octahedral Werner-type cobalt(II) complexes demonstrated by 19F NMR spectroscopy: Structure and stability

G. Novitchi; F. Riblet; L. Helm; R. Scopelliti; A. Gulea  et al.

DMSO exchange on [Gd(DMSO)8]3+ - a variable pressure 17O NMR study

R. Dessapt; L. Helm; A. E. Merbach

Molecular dynamics simulations of the internal mobility of Gd3+-based MRI contrast agents: consequences for water proton relaxivity

A. Borel; F. Yerly; L. Helm; A. E. Merbach

Molecular dynamics of Gd(III) complexes in aqueous solution by HF EPR

A. Borel; L. Helm; A. E. Merbach