Lothar Helm

Office: PH A2 354
EPFLSBISICISIC-DIV

EPFL SB-DO
PH H2 454 (Bâtiment PH)
Station 3
1015 Lausanne

Lothar Helm was born in Gernsbach (Germany) in 1952. He studied physics at the University of Karlsruhe (Germany) and obtained his diploma degree in 1977. He remained in Karlsruhe for his Ph.D. research with Prof. H. G. Hertz and received his degree in physical chemistry in 1980. In 1980 he joined the laboratories of Prof. André Merbach at the University of Lausanne, Switzerland. From 1983 to 2001 he was maître d’enseignement et de recherche at the Faculty of Science of the University of Lausanne. In 2001 he moved, together with the whole chemistry department, from the University of Lausanne to the Ecole Polytechnique Fédérale de Lausanne (EPFL). Since 2006 he is adjunct professor at the Institute of Chemical Sciences and Engineering at EPFL and director of the NMR services of the institute. From 2007 to 2011 he was director of the "Conférence du corps Enseignant" at EPFL. Since 2011 he is member of the School Assembly of EPFL (AE). MAIN RESEARCH INTERESTS: • Physico-chemical studies of contrast agents for medical magnetic resonance imaging (MRI) • Study of reactivity and reaction mechanisms in coordination chemistry by variable temperature and pressure nuclear magnetic resonance • Computer simulation of solvent dynamics on cations and metal complexes in solution Professional course

Publications représentatives

Gold Nanoparticles Functionalized with Gadolinium Chelates as High-Relaxivity MRI Contrast Agents.

Loïck Moriggi, Caroline Cannizzo, Eddy Dumas, Cédric R. Mayer, Alexey Ulianov, and Lothar Helm
Published in J. Am. Chem. Soc., 2009, 131, 10828-10829. in

Nuclear Spin Relaxation Parameters of MRI Contrast Agents – Insight from Quantum Mechanical Calculations.

Oleg V. Yazyev and Lothar Helm
Published in Eur. J. Inorg. Chem., 2008, 201-211, in

Destroying Gadofullerene Aggregates by Salt Addition in Aqueous Solution of Gd@C60(OH)x and Gd@C60[C(COOH2)]10

Sabrina Laus, Balaji Sitharaman, Éva Tóth, Robert D. Bolskar, Lothar Helm, Subashini Asokan, Michael S. Wong, Lon J. Wilson and André E. Merbach
Published in J. Am. Chem. Soc., 2005, 127, 9368-9369 in

Water-soluble Gadofullerenes: Toward High-Relaxivity, pH-responsive MRI Contrast Agents.

Éva Tóth, Robert D. Bolskar, Alain Borel, Gabriel González, Lothar Helm, André E. Merbach, Balaji Sitharaman and Lon J. Wilson
Published in J. Am. Chem. Soc., 2005, 127, 799-805. in

Inorganic and Bioinorganic Solvent Exchange Mechanisms.

Lothar Helm and André E. Merbach.
Published in Chem, Rev., 2005, 105, 1923-1959 in

Water and Proton Exchange Processes on Metal Ions.

Lothar Helm, Gaëlle Nicolle, André E. Merbach
Published in Adv. Inorg. Chem., 2005, 57, 327-379. in

Lanthanide Ions as Magnetic Resonance Imaging Agents. Nuclear and Electronic Relaxation Properties. Applications.

Lothar Helm, Éva Tóth and André E. Merbach.
Published in In Metal Ions in Biological Systems – Vol. 40., Ed. by A. and H. Sigel, eds, M. Dekker, New York, 2003, 589-641. in

Enseignement et PhD

A dirigé les thèses EPFL de

Oleg Yazyev, Loïck Moriggi, Gabriella Eva Bodizs, Hugues Jaccard, Bibimaryam Mousavi, Shima Karimi, Estel Canet Martinez

A co-dirigé les thèses EPFL de

Meriem Benmelouka, Estel Canet Martinez