Deputy of Head of Unit
Fields of expertise
Atoms and Molecules: She completed her MSc. in Chemistry working at the Nanoscience Scale Department of the Max Planck Institute for Solid State Research in Stuttgart. Under the direction of Klaus Kern and Nian Lin, her MSc. thesis was the first in the field of metal-organic coordination at surfaces, opening a new research path that is nowadays followed by many scientists worldwide.
From Single Molecules to 2D assemblies: During her PhD, her curiosity was focused not only on the use molecules and atoms as building blocks for the design of low dimensional structures (bottom-up approach to nanoarchitectonics) but also on understanding the dynamics of molecular recognition on surfaces. She used aminoacids and peptides to track the process of chiral recognition in real-time, visualizing the 60-year-old prediction of Linus Pauling that chiral recognition was developed during the intermolecular interaction (induced fit vs lock and key model). She completed her PhD thesis at MPI and received the Otto Hahn medal 2008 for her contributions to the understanding of the chiral recognition process with submolecular resolution.
From Flatland to 3D structures: After years of extensive work under well controlled ultra-high vacuum conditions, she was ready to delve into the real world of physical chemistry at the liquid/solid interface beyond flatland. She went on to investigate the transfer of chiral information from 2D assemblies to 3D crystals (using a combination of bottom-up and top-down techniques) as a Post-Doctoral Fellow at the Institut de Ciència de Materials de Barcelona (David’s Amabilino group on Stereochemistry and Materials 2009-2011).
In the quest to understand relevant molecular mechanisms under environmental conditions, she crossed the pond once more in 2011 to work at the Molecular Foundry at the Lawrence Berkeley National Laboratory where she used Atomic Force Microscopy and Synchrotron based Spectroscopies at the liquid/solid interface to investigate CO2 sequestration on complex protein assemblies. Working with Jim De Yoreo, she learned that the world is not simply made atom by atom and there is much complexity to be gained from observing how biological systems shape our world.
Her excellent track record in Nanoscience and her passion for problem-oriented interdisciplinary research brought her to lead the MPI-EPFL laboratory for Molecular Nanoscience at EPFL campus, the core of the MPI-EPFL Center for Molecular Nanoscience and Technology, a unique Center created in 2013, at the crossroad between physics, chemistry, engineering and life sciences.
Her current work is focused on tracking fundamental molecular recognition and energy conversion processes in nanostructured materials, across length and timescales and under relevant operando conditions (http://www.a-leaf.eu/project/).
Moreover, she uses surface science tools to explore the coding of biomimetic structures at the nanoscale. Her goal is to unravel and edit nature’s protocols to design hierarchical materials from molecular building blocks that can self-assemble with predictable shapes and functions: BioNanoarchitectonics.
Her research is in close collaboration with theoreticians, organic chemists who synthesize tailor-made molecules incorporating specific chemical groups, and biologists who genetically modify proteins and purify them for later use in functional biointerfaces. Special focus is given to the construction of stimuli-responsive, catalytic, and hybrid organic-inorganic nanostructures for energy applications.
Selected Invited Talks
"BioNanoarchitectonics and the dynamics of alive functional surfaces"ACS
March 2017 Conference on Molecular Nanostructures 2017. Monte Verità, Ascona, Switzerland. "BioNanoarchitectonics: functional nanostructures that build themselves"
Dec 2016 Conference Advance Microscopy and Spectroscopy of Supramolecular and Macromolecular Systems on Surfaces, Hong Kong. "Designing Hybrid Materials Atom by Atom". IAS
Dec 2016 URPP LightChEC Scientific Meeting, Universität Zürich. "BioNanoarchitectonics: principles and aplications".
Nov 2016 Physics Colloquium Instituto Balseiro, Bariloche, Argentina. "BioNanoarchitectonics: Functional Nanostructures that build themselves".IB
Oct 2016 Plenary talk, VII Meeting of Physics and Chemistry of Surfaces, Santa Fé, Argentina. "Nanoarchitectonics: Nanostructures that build themselves"
July 2016 Workshop on Bio-inspired nanosystems for energy conversion. Harnack-Haus der Max-Planck Gesellschaft, Berlin. "Self-assembled Functional Nanostructures in Flatland"
Oct 2015 Scientific Advisory Board meeting 2015, Max Planck Institute for Solid State Research, Stuttgart, Germany. "Smart Supramolecular Nanopores at the liquid/solid interface"
Oct 2015 Conference Chirality at the Nanoscale, Leuven, Belgium
"Tuning the self-assembly of 5-amino helicene on solid surfaces"
Nov 2014 Seminar Talk, Donostia International Physics Center DIPC, Spain
"A molecular interactions roadmap to 2D functional nanostructures"
Oct 2014 Conference Nanoscience for Clean Energy, Schloss Ringberg, Germany
"Biomimetic nanostructures for CO2 sequestration"
Sept 2014 17th International Conference on Solid Films and Surfaces (ICSFS17), Rio de Janeiro, Brazil (session chair CAT1)
"Exploring the Surface Science of Bio-inspired Nanostructures: Tailoring Molecules to Functionality"
April 2014 Conference on Molecular Nanostructures 2014. Monte Verità, Ascona, Switzerland
"A close-up view of biomolecular mechanisms"
March 2014 247th ACS National Meeting, Dallas, TX (session Presider Supramolecular Self-Assembly at Surfaces 16.03.14)
"Bio-inspired nanostructures: Patterning and mechanisms"
Dec 2013 Seminar Talk, Physics of interfaces and Nanomaterials, University of Twente, NL
"Exploring the Surface Science of Bioinspired nanostructures: tailoring molecules to functionality"
“Contrasting Chemistry of Block Copolymer Films Controls the Dynamics of Protein Self-Assembly at the Nanoscale” ACS Nano (2019) DOI: 10.1021/acsnano.8b08013
• 2018 “Celebrating Excellence in Research: 100 Women of Chemistry”
• Bart Stel, Fernando Cometto, Behzad Rad, James J. De Yoreo and Magalí Lingenfelder
Dynamically resolved self-assembly of S-layer proteins on solid surfaces
Chemical Communications 54(73)(2018) DOI: 10.1039/C8CC04597F
Invited Contribution to the collection: Scanning probe frontiers in molecular 2D-architecture world
• Fernando P. Cometto, Zhi Luo, Shun Zhao, Jimena A. Olmos-Asar, Marcelo M. Mariscal, Quy Ong, Klaus Kern, Francesco Stellacci, and Magalí Lingenfelder
On the van der Waals interactions of n-alkanethiol-covered Surfaces: From planar to curved surfaces Angewandte Chemie (2017) DOI: 10.1002/anie.201708735
• F. Cometto, K. Frank, B. Stel, N. Arisnabarreta, K. Kern, and M. Lingenfelder
The STM bias voltage-dependent polymorphism of a binary supramolecular network
Chem.Commun. 53, 11430-11432 (2017)
• J. D. Fuhr, L.J. Cristina, L.M. Rodríguez, M.W. van der Meijden, R. M. Kellogg, J. E. Gayone, H. Ascolani, Magalí Lingenfelder
Chiral expression of adsorbed (MP) 5-Amino  helicenes: from random structures to dense racemic crystals by surface alloying.
Chemical Communications 2016; 53(1). DOI:10.1039/C6CC06785A.
Invited Contribution to the special collection on Chirality at the Nanoscale.
• Fernando P Cometto, Klaus Kern, Magalí Lingenfelder
Local Conformational Switching of Supramolecular Networks at the Solid/Liquid Interface.
ACS Nano 2015; 9(5). DOI:10.1021/acsnano.5b01658
• Rico Gutzler, Sebastian Stepanow, Doris Grumelli, Magalı́ Lingenfelder, Klaus Kern (Review article)
Mimicking Enzymatic Active Sites on Surfaces for Energy Conversion Chemistry.
Accounts of Chemical Research 2015; 48(7). DOI:10.1021/acs.accounts.5b00172
• Shern-Long Lee, Yuan Fang, Gangamallaiah Velpula, Fernando P Cometto, Magalí Lingenfelder, Klaus Müllen, Kunal S Mali, Steven De Feyter
Reversible Local and Global Switching in Multicomponent Supramolecular Networks: Controlled Guest Release and Capture at the Solution/Solid Interface.
ACS Nano 2015; 9(12). DOI:10.1021/acsnano.5b06081
• Hugo Ascolani, Maarten van de Meijden, Lucila J. Cristina, J. Esteban Gayone, Richard M. Kellogg, Javier D. Fuhr, Magalí Lingenfelder
Van der Waals interactions in the self-assembly of 5-amino helicene on Cu(100) and Au(111).
Chemical Communications 2014; 50(90). DOI:10.1039/C4CC04338C.
Invited Contribution to the special collection on Scanning Probe Studies of Molecular Systems. Highlighted in Chimia
• Magalí Lingenfelder, Ángela Bejarano‐Villafuerte, Maarten W. van der Meijden, Richard M. Kellogg, David B. Amabilino
Localised Crystallization of Enantiomeric Organic Compounds on Chiral Micro-patterns from Various Organic Solutions.
Chemistry - A European Journal 2014; 20(33). DOI:10.1002/chem.201303062
• Yeliang Wang, Magalí Lingenfelder, Stefano Fabris, Guido Fratesi, Riccardo Ferrando, Thomas Classen, Klaus Kern, Giovanni Costantini
Programming Hierarchical Supramolecular Nanostructures by Molecular Design.
The Journal of Physical Chemistry C 2013; 117:3440. DOI:10.1021/jp309566s
• Pietro Gambardella, Sebastian Stepanow, Alexandre Dmitriev, Jan Honolka, Frank M F de Groot, Magalí Lingenfelder, Subhra Sen Gupta, D D Sarma, Peter Bencok, Stefan Stanescu, Sylvain Clair, Stéphane Pons, Nian Lin, Ari P Seitsonen, Harald Brune, Johannes V Barth, Klaus Kern
Supramolecular control of the magnetic anisotropy in two-dimensional high-spin Fe arrays at a metal interface.
Nature Materials 2009; 8(3), DOI:10.1038/nmat2376
• Yeliang Wang, Magalí Lingenfelder, Thomas Classen, Giovanni Costantini, Klaus Kern
Ordering of Dipeptide Chains on Cu Surfaces through 2D Cocrystallization.
Journal of the American Chemical Society 2008; 129(51), DOI:10.1021/ja075118v
• Magalí Lingenfelder, Giulia Tomba, Giovanni Costantini, Lucio Colombi Ciacchi, Alessandro De Vita, Klaus Kern
Tracking the Chiral Recognition of Adsorbed Dipeptides at the Single-Molecule Level.
Angewandte Chemie International Edition 2007; 46(24). (VIP and Cover) DOI:10.1002/anie.200700194
• Ari P Seitsonen, Magalí Lingenfelder, Hannes Spillmann, Alexandre Dmitriev, Sebastian Stepanow, Nian Lin, Klaus Kern, Johannes V Barth
Density Functional Theory Analysis of Carboxylate-Bridged Diiron Units in Two-Dimensional Metal−Organic Grids.
Journal of the American Chemical Society 2006; 128(17)., DOI:10.1021/ja060180y
• Sebastian Stepanow, Magalí Lingenfelder, Alexandre Dmitriev, Hannes Spillmann, Erik Delvigne, Nian Lin, Xiaobin Deng, Chengzhi Cai, Johannes V Barth, Klaus Kern
Steering molecular organization and host-guest interactions using two-dimensional nanoporous coordination systems.
Nature Materials 2004; 3(4)., DOI:10.1038/nmat1088
• Magalí A Lingenfelder, Hannes Spillmann, Alexandre Dmitriev, Sebastian Stepanow, Nian Lin, Johannes V Barth, Klaus Kern
Towards Surface-Supported Supramolecular Architectures: Tailored Coordination Assembly of 1,4-Benzenedicarboxylate and Fe on Cu(100).
Chemistry 2004; 10(8)., DOI:10.1002/chem.200305589
More Publications: on Google Scholar
• PhD.Thesis Bart Stel. EPFL 2018. “In situ Studies of Peptide and Protein Assemblies at the Solid-Liquid Interface Hierarchical Self-Assembly, Dynamics and Functional Properties”
• PhD.Thesis Daniel Hurtado. EPFL 2018. “Design of Surface-Supported Bio-inspired Networks for CO2 and O2 Activation at Room Temperature”
• PhD.Thesis Adil Acun. U Twente 2017. “The growth and characterization of silicene, germanene and hexagonal boron nitride”
• Msc.Thesis. Radovan Vanta.Metal-organic coordination networks at the liquid-solid interface , EPFL 2015.
• MSc.Thesis. Bart Stel. “CO2 sequestration using bacterial surface layers””
. University of Twente. LBNL Berkeley and EPFL 2013.
Teaching & PhD