Maria Josefina Marcaida Lopez
maria.marcaidalopez@epfl.ch +41 21 693 72 03
Nationalité : Spanish
EPFL SV IBI-SV UPDALPE
AI 2351.F (Bâtiment AI)
Station 19
CH-1015 Lausanne
Web site: Site web: https://lbm.epfl.ch/
Domaines de compétences
Protein crystallography
Protein-nucleic acid complexes
Kinase-small molecule interactions
Protein-nucleic acid complexes
Kinase-small molecule interactions
FELLOWSHIPS & AWARDS
• Marie Heim-Vögtlin Postdoctoral Fellowship SNSF March 2012-August 2014• CRUS Dual career couples, September 2011 – January 2012
• Human Frontiers Short Term Fellowship, September- December 2009
• Juan de la Cierva Postdoctoral Fellowship 2009-2011
• EMBO Long term Fellowship 2007-2008
• Wellcome Trust Prize Studentship 2001-2005
• Final Year Project Award, Imperial College, 2001
Parcours professionnel
Scientist
Laboratory for Biomolecular Modeling
EPFL
2014-to date
Postdoctoral Fellow
Department of Chemistry and Biochemistry, University of Bern, Switzerland
2011-2014
Postdoctoral Fellow
Macromolecular Crystallography Group
CNIO (Spanish National Cancer Research Centre), Spain
2006-2010
Formation
M.Sci.
Physics
Imperial College London, U.K.
1997-2001
Ph.D.
Biochemistry and protein crystallography
University of Cambridge, U.K.
2001-2005 Ph.D. April 2006
Publications
Publications Infoscience
JOURNAL ARTICLES
D. P. Duarte; A. J. Lamontanara; G. La Sala; S. Jeong; Y.-K. Sohn et al. : Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms; Nature Communications. 2020-05-08. DOI : 10.1038/s41467-020-16128-5.
C. Cao; N. Cirauqui; M. J. Marcaida; E. Buglakova; A. Duperrex et al. : Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores; Nature Communications. 2019-10-29. DOI : 10.1038/s41467-019-12690-9.
G. Fonti; M. J. Marcaida; L. C. Bryan; S. Traeger; A. S. Kalantzi et al. : KAP1 is an antiparallel dimer with a functional asymmetry; Life Science Alliance. 2019-08-01. DOI : 10.26508/lsa.201900349.
J. Alba; M. J. Marcaida; J. Prieto; G. Montoya; R. Molina et al. : Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI; Journal Of Computer-Aided Molecular Design. 2017. DOI : 10.1007/s10822-017-0087-5.
R. Molina; N. Besker; M. J. Marcaida; G. Montoya; J. Prieto et al. : Key Players in I-DmoI Endonuclease Catalysis Revealed from Structure and Dynamics; ACS chemical biology. 2016. DOI : 10.1021/acschembio.5b00730.
F. Kilchmann; M. J. Marcaida; S. Kotak; T. Schick; S. D. Boss et al. : Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening; Journal Of Medicinal Chemistry. 2016. DOI : 10.1021/acs.jmedchem.6b00709.
P. Roethlisberger; A. Istrate; M. J. M. Lopez; R. Visini; A. Stocker et al. : X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair; Chemical Communications. 2016. DOI : 10.1039/c6cc00374e.
R. Molina; M. J. Marcaida; P. Redondo; M. Marenchino; P. Duchateau et al. : Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold; The Journal of biological chemistry. 2015. DOI : 10.1074/jbc.M115.658666.
M. Bartoloni; X. Jin; M. J. Marcaida; J. Banha; I. Dibonaventura et al. : Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability; Chemical Science. 2015. DOI : 10.1039/c5sc01699a.
M. Christen; M. J. Marcaida; C. Lamprakis; W. Aeschimann; J. Vaithilingam et al. : Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor; Journal Of Structural Biology. 2015. DOI : 10.1016/j.jsb.2015.05.001.
J. Yun; M. J. Marcaida; K. K. Eriksson; H. Jamin; S. Fontana et al. : Oxypurinol directly and immediately activates the drug-specific T cells via the preferential use of HLA-B*58:01; Journal of immunology (Baltimore, Md. : 1950). 2014. DOI : 10.4049/jimmunol.1302306.
R. Molina; S. Stella; P. Redondo; H. Gomez; M. J. Marcaida et al. : Visualizing phosphodiester-bond hydrolysis by an endonuclease; Nature structural & molecular biology. 2014. DOI : 10.1038/nsmb.2932.
R. Sánchez; D. Pantoja-Uceda; J. Prieto; T. Diercks; M. J. Marcaida et al. : Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase; The Journal of biological chemistry. 2010. DOI : 10.1074/jbc.M109.069344.
M. J. Marcaida; I. G. Muñoz; F. J. Blanco; J. Prieto; G. Montoya : Homing endonucleases: from basics to therapeutic applications; Cellular and molecular life sciences : CMLS. 2009. DOI : 10.1007/s00018-009-0188-y.
A. Palacios; I. G. Muñoz; D. Pantoja-Uceda; M. J. Marcaida; D. Torres et al. : Molecular basis of histone H3K4me3 recognition by ING4; The Journal of biological chemistry. 2008. DOI : 10.1074/jbc.M710020200.
J. G. Grossmann; A. J. Callaghan; M. J. Marcaida; B. F. Luisi; F. H. Alcock et al. : Complementing structural information of modular proteins with small angle neutron scattering and contrast variation; European biophysics journal : EBJ. 2008. DOI : 10.1007/s00249-008-0278-z.
D. J. Koslover; A. J. Callaghan; M. J. Marcaida; E. F. Garman; M. Martick et al. : The crystal structure of the Escherichia coli RNase E apoprotein and a mechanism for RNA degradation; Structure. 2008. DOI : 10.1016/j.str.2008.04.017.
M. J. Marcaida; J. Prieto; P. Redondo; A. D. Nadra; A. Alibés et al. : Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering; Proceedings of the National Academy of Sciences of the United States of America. 2008. DOI : 10.1073/pnas.0804795105.
J. A. R. Worrall; B. G. Schlarb-Ridley; T. Reda; M. J. Marcaida; R. J. Moorlen et al. : Modulation of heme redox potential in the cytochrome c6 family; Journal of the American Chemical Society. 2007. DOI : 10.1021/ja072346g.
M. J. Marcaida; M. A. DePristo; V. Chandran; A. J. Carpousis; B. F. Luisi : The RNA degradosome: life in the fast lane of adaptive molecular evolution; Trends in biochemical sciences. 2006. DOI : 10.1016/j.tibs.2006.05.005.
M. J. Marcaida; B. G. Schlarb-Ridley; J. A. R. Worrall; J. Wastl; T. J. Evans et al. : Structure of cytochrome c6A, a novel dithio-cytochrome of Arabidopsis thaliana, and its reactivity with plastocyanin: implications for function; Journal of molecular biology. 2006. DOI : 10.1016/j.jmb.2006.05.065.
A. J. Callaghan; M. J. Marcaida; J. A. Stead; K. J. McDowall; W. G. Scott et al. : Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover; Nature. 2005. DOI : 10.1038/nature04084.